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64-675: John Edward Boulting (21 December 1913 – 17 June 1985) and Roy Alfred Clarence Boulting (21 December 1913 – 5 November 2001), known collectively as the Boulting brothers , were English filmmakers and identical twins who became known for their series of satirical comedies in the 1950s and 1960s. They produced many of their films through their own production company, Charter Film Productions , which they founded in 1937. The twin brothers were born to Arthur Boulting and his wife Rosetta (Rose) née Bennett in Bray , Berkshire , England, on 21 December 1913. John

128-580: A 'Boulting Brothers film'. They were socialists, as John demonstrated with his involvement in the Spanish Civil War (see above), and wanted all film, including comedies, to reflect the real world. In 1937, they set up Charter Film Productions and made several short features, including The Landlady (1937) and Consider Your Verdict (1938), which attracted critical and commercial attention. They made quota quickies such as Trunk Crime (1939) and Inquest (1939). Being eager to speak out against

192-550: A Hollywood studio (in this case MGM) with an imported star ( Gene Kelly ); it was not a big success. The brothers collaborated on a comedy, Josephine and Men (1955) then Roy was hired by United Artists to do an action film with Hollywood stars, Run for the Sun (1956). In the mid-50s, the Boulting brothers became identified with "affectionate" satires on British institutions. The sequence began with John's Private's Progress (1956),

256-474: A biopic of William Friese-Greene and a film containing numerous cameo appearances. It was shown at the 1951 Festival of Britain but on general release the following year proved a box office disappointment. Roy received an offer to direct a World War Two naval film, Sailor of the King (1953), starring Jeffrey Hunter for 20th Century Fox . Seagulls Over Sorrento (1954) was another war naval story financed by

320-562: A considerable amount of money on the film. In 1975, Roy was working on a stage play, The Family Games . He worked on the script for The Kingfisher Caper (1975), starring Mills. In the US, Roy directed The Last Word (1979), a comedy starring Richard Harris that was barely seen. When John died of cancer in 1985, Roy stopped making films. His last credit was directing an episode of the Miss Marple series for TV, The Moving Finger (1985). He

384-490: A greater chance of dizygotic multiple births. In the United States it has been estimated that by 2011 36% of twin births resulted from conception by assisted reproductive technology . The risk of twin birth can vary depending on what types of fertility treatments are used. With in vitro fertilisation (IVF), this is primarily due to the insertion of multiple embryos into the uterus. Ovarian hyperstimulation without IVF has

448-503: A look at army life, starring Attenborough, Terry-Thomas and Ian Carmichael and co written by Frank Harvey . It was the second most commercially successful film in Britain in 1956. They followed it with Lucky Jim (1957), set in academe, adapted from the novel by Kingsley Amis . It starred Carmichael and Terry-Thomas. Brothers in Law (1957) with Carmichael, Attenborough and Thomas, took on

512-503: A more likely explanation. A high twinning rate has also been observed in other places of the world, including: The widespread use of fertility drugs causing hyperovulation (stimulated release of multiple eggs by the mother) has caused what some call an "epidemic of multiple births ". In 2001, for the first time ever in the US , the twinning rate exceeded 3% of all births. Nevertheless, the rate of monozygotic twins remains at about 1 in 333 across

576-460: A pair of monozygotic twins reproduces with another pair or with the same person), rather than first cousins. Identical twins do not have the same fingerprints however, because even within the confines of the womb, the fetuses touch different parts of their environment, giving rise to small variations in their corresponding prints and thus making them unique. Monozygotic twins always have the same genotype . Normally due to an environmental factor or

640-521: A passionate anti-isolationist allegory distinguished by imaginative cinematography and a theatrical but highly atmospheric lighthouse setting. It was financed by MGM . In 1941, Roy joined the Army Film Unit , where he was responsible for Desert Victory , which won the Academy Award for Best Documentary in 1944. He also worked on Tunisian Victory (1944) and Burma Victory (1945). John joined

704-532: A performance by Peter Sellers as trade union foreman Fred Kite. It was the most popular film at the British box office in 1959. Suspect (1960) was a return to the thriller genre for the brothers. A French Mistress (1960) was a comedy farce. Heavens Above! (1963) looked at religion in Britain, starring Sellers and Carmichael. It was a minor hit. Rotten to the Core (1965) was a heist comedy which attempted to make

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768-541: A rate of about 3 in every 1000 deliveries worldwide. The likelihood of a single fertilization resulting in monozygotic twins is uniformly distributed in all populations around the world. This is in marked contrast to dizygotic twinning, which ranges from about six per thousand births in Japan (almost similar to the rate of identical twins, which is around 4–5) to 15 and more per thousand in some parts of India and up to over 20 in some Central African countries. The exact cause for

832-406: A separate fetus, rather than by the embryo splitting while hatching from the zona pellucida (the gelatinous protective coating around the blastocyst). Monozygotic twins may also be created artificially by embryo splitting. It can be used as an expansion of in vitro fertilization (IVF) to increase the number of available embryos for embryo transfer . Monozygotic twinning occurs in birthing at

896-664: A short entitled Ripe Earth (1938), about the village of Thaxted , Essex , narrated by Leo Genn . From January to November 1937, John served on the Republican side in the Spanish Civil War as an ambulance driver with the Spanish Medical Aid Committee (not, as sometimes reported, with the International Brigades ), where — according to Richard Attenborough — he was nearly captured. John also served with

960-437: A star of Anton Rodgers in a Peter Sellers-type role, playing multiple parts. It featured a young Charlotte Rampling . The Boultings directed and produced the northern comedy The Family Way (1966), starring John Mills and his teenage daughter Hayley. Roy Boulting and Hayley Mills began a relationship during the shoot despite a 33-year age difference; they married in 1971. Roy wrote and directed Twisted Nerve (1968),

1024-541: A study in 2012 found that it is possible for a polar body to result in a healthy fetus. In 2003, a study argued that many cases of triploidy arise from sesquizygotic (semi-identical) twinning which happens when a single egg is fertilized by two sperm and splits the three sets of chromosomes into two separate cell sets. The degree of separation of the twins in utero depends on if and when they split into two zygotes. Dizygotic twins were always two zygotes. Monozygotic twins split into two zygotes at some time very early in

1088-410: A teenager, Roy emigrated to Canada , working for a while as a shop assistant, but also writing dialogue for at least one Canadian film. He worked his passage home aboard a cattle freighter in about 1933, working first in film sales before moving into film production as assistant director on a 1936 comedy quickie Apron Fools . The money he made on his passage home went to finance the brothers' first work,

1152-443: A third son. With his first wife, Veronica, daughter of Irish barrister, John Craig Nelson Davidson, he had sons Norris (b. 1941) and Nicholas (b. 1943). Norris is the father of TV presenter and journalist Ned Boulting . With his second wife, Jacqueline (Jackie), he had three daughters: Jody, Emma & Lucy; the last of whom, Lucy Boulting Hill, has become a successful casting director . John's grandson, Jordan Stephens (son of Emma),

1216-575: A thriller starring Mills and Hywel Bennett . The brothers had a massive hit with There's a Girl in My Soup (1970) starring Sellers and Goldie Hawn . Roy was called in to replace the director on Mr. Forbush and the Penguins (1971), and he brought in Mills to star. The movie was not successful. Neither was the comedy Soft Beds, Hard Battles (1974) made by the brothers starring Peter Sellers. Roy Boulting lost

1280-474: A very high risk of multiple birth. Reversal of anovulation with clomifene (trade names including Clomid ) has a relatively less but yet significant risk of multiple pregnancy. A 15-year German study of 8,220 vaginally delivered twins (that is, 4,110 pregnancies) in Hesse yielded a mean delivery time interval of 13.5 minutes. The delivery interval between the twins was measured as follows: The study stated that

1344-557: Is a genetically linked tendency to hyper- ovulate . There is no known genetic link for identical twinning. Other factors that increase the odds of having fraternal twins include maternal age, fertility drugs and other fertility treatments, nutrition, and prior births. Some women intentionally turn to fertility drugs in order to conceive twins. The vast majority of twins are either dizygotic (fraternal) or monozygotic (identical). In humans dizygotic twins occur more often than monozygotic twins. Less common variants are discussed further down

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1408-446: Is fertilized to form one zygote (hence, "monozygotic") which then divides into two separate embryos . The chances of having identical twins is relatively rare – around 3 or 4 in every 1,000 births. Regarding spontaneous or natural monozygotic twinning, a 2007 theory related to in vitro fertilization (IVF) proposes that monozygotic twins may be formed when a blastocyst contains two inner cell masses (ICM), each of which will lead to

1472-750: Is one half of British hip hop duo Rizzle Kicks . Roy Boulting was married five times. He had seven children, all sons: two by his second marriage; three by his third; one through his relationship with Victoria Vaughan; and one by his fourth. With his second wife, Jean Capon (née Gamage), he had sons Jonathan (b. 1944) and Laurence (b. 1945), the latter becoming a successful film producer and director in his own right. With his second marriage, in March 1951, to Enid Munnik (née Groenewald/Grünewald), he had three children: first, Fitzroy (b. 1951); then identical twins Edmund and Rupert (b. 1952). The couple divorced in 1964. Enid, an established fashion model and later fashion editor at

1536-419: Is the most common type of twin. Dizygotic twins, like any other siblings, will practically always have different sequences on each chromosome, due to chromosomal crossover during meiosis . Dizygotic twins share on average 50 percent of each other's genes, the same as siblings that are conceived and born at different times. Like any other siblings , dizygotic twins may look similar , particularly as they are

1600-654: The British Film Unit as an officer in the Royal Air Force during the Second World War . Roy served as a captain in the British Army , first with a tank regiment for more than a year and then with the Army Film Unit , where he made several short documentaries. The brothers constituted a producer-director team. For most of their careers one produced while the other directed, but the product remained essentially

1664-520: The Mohave Desert ) and in Orlando, Florida . The British recognized the dubious nature of the film, though they themselves were guilty of the same recreations in wartime propaganda films. The direction of the final version involved no less than five individuals: Frank Capra , John Huston , Anthony Veiller , Hugh Stewart and Roy Boulting . This article about a documentary film on World War II

1728-566: The RAF Film Unit , where he made Journey Together in 1945, a dramatised documentary about the training and combat experience of a bomber crew with Richard Attenborough in the lead part. Terence Rattigan worked on the script. After the war, the Boultings made the drama Fame Is the Spur (1947) with Redgrave. More successful at the box-office was Brighton Rock (1947), starring Attenborough as

1792-630: The Radcliffe Infirmary , Oxford ; both died of cancer. A still from The Family Way was used for The Smiths single " I Started Something I Couldn't Finish ". Identical twin In contrast, a fetus that develops alone in the womb (the much more common case in humans) is called a singleton , and the general term for one offspring of a multiple birth is a multiple . Unrelated look-alikes whose resemblance parallels that of twins are referred to as doppelgänger . The human twin birth rate in

1856-683: The Third Reich , the brothers made their film, Pastor Hall (1940), a biopic of Martin Niemöller , a German preacher who refused to kowtow to the Nazis. Roy directed and John produced. The film had to have its initial release delayed by the British Government, which was not yet ready to be openly critical of Nazism. Once released, the film was well received by the critics and the public. They followed up with Thunder Rock (1942) with Michael Redgrave ,

1920-668: The Yoruba to 10% for Linha São Pedro, a tiny Brazilian settlement which belongs to the city of Cândido Godói . In Cândido Godói, one in five pregnancies has resulted in twins. The Argentine historian Jorge Camarasa has put forward the theory that experiments of the Nazi doctor Josef Mengele could be responsible for the high ratio of twins in the area. His theory was rejected by Brazilian scientists who had studied twins living in Linha São Pedro; they suggested genetic factors within that community as

1984-462: The blastocysts have fused. Monochorionic twins share the same placenta , and thus have a risk of twin-to-twin transfusion syndrome . Monoamniotic twins are always monozygotic . The survival rate for monoamniotic twins is somewhere between 50% and 60%. Monoamniotic twins, as with diamniotic monochorionic twins, have a risk of twin-to-twin transfusion syndrome . Also, the two umbilical cords have an increased chance of being tangled around

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2048-522: The French magazine Elle , married the 9th Earl of Hardwicke in April 1970. The model and actress Ingrid Boulting is Enid's daughter from her first marriage, to Cornelius Munnik. Following his split with his third wife, Roy entered into a relationship with another fashion model, Victoria Vaughan. They had one son together. The relationship ended with his involvement with Hayley Mills . In 1971, Roy married, for

2112-560: The United States rose 76% from 1980 through 2009, from 9.4 to 16.7 twin sets (18.8 to 33.3 twins) per 1,000 births. The Yoruba people have the highest rate of twinning in the world, at 45–50 twin sets (90–100 twins) per 1,000 live births, possibly because of high consumption of a specific type of yam containing a natural phytoestrogen which may stimulate the ovarys to release an egg from each side. In Central Africa , there are 18–30 twin sets (or 36–60 twins) per 1,000 live births. In South America , South Asia , and Southeast Asia ,

2176-409: The acrimony between the British and US film makers on the project. Most of the actual American combat footage taken during Operation Torch was destroyed when the ship carrying it was sunk, requiring many "battle scenes" to be reshot in the U.S. by director John Huston . Huston restaged several battles and liberations to achieve high quality footage, even going so far as to film some air battle scenes (in

2240-462: The article. Fraternal twins can be any of the following: Among non-twin births, male singletons are slightly (about five percent) more common than female singletons. The rates for singletons vary slightly by country. For example, the sex ratio of birth in the US is 1.05 males/female, while it is 1.07 males/female in Italy. However, males are also more susceptible than females to die in utero , and since

2304-473: The babies. Because of this, there is an increased chance that the newborns may be miscarried or suffer from cerebral palsy due to lack of oxygen. When the division of the developing zygote into 2 embryos occurs, 99% of the time it is within 8 days of fertilization. Mortality is highest for conjoined twins due to the many complications resulting from shared organs. A 2006 study has found that insulin-like growth factor present in dairy products may increase

2368-549: The campaign. Miles and Meredith, playing the roles of soldiers, talk separately until the end of the film when they have a dialogue, agree to co-operate after the end of the war, and with the other Allied nations create a more just and peaceful post-war order. The film was intended as a follow-up to the successful British documentary film Desert Victory (1943). Frederic Krome's article "Tunisian Victory" and Anglo-American Film Propaganda in World War II from The Historian details

2432-450: The chance of dizygotic twinning. Specifically, the study found that vegan mothers (who exclude dairy from their diets) are one-fifth as likely to have twins as vegetarian or omnivore mothers, and concluded that "Genotypes favoring elevated IGF and diets including dairy products, especially in areas where growth hormone is given to cattle, appear to enhance the chances of multiple pregnancies due to ovarian stimulation." From 1980 to 1997,

2496-406: The deactivation of different X chromosomes in female monozygotic twins, and in some extremely rare cases, due to aneuploidy , twins may express different sexual phenotypes , normally from an XXY Klinefelter syndrome zygote splitting unevenly. Monozygotic twins, although genetically very similar, are not genetically exactly the same. The DNA in white blood cells of 66 pairs of monozygotic twins

2560-413: The death rate in utero is higher for twins, it leads to female twins being more common than male twins. Zygosity is the degree of identity in the genome of twins. Dizygotic ( DZ ) or fraternal twins (also referred to as "non-identical twins", "dissimilar twins", "biovular twins", and, informally in the case of females, "sororal twins") usually occur when two fertilized eggs are implanted in

2624-408: The differences detected in this study would have occurred during embryonic cell-division (after the point of fertilization). If they occur early in fetal development, they will be present in a very large proportion of body cells. Another cause of difference between monozygotic twins is epigenetic modification , caused by differing environmental influences throughout their lives. Epigenetics refers to

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2688-405: The early stages of embryonic development. A 1981 study of a deceased XXX twin fetus without a heart showed that although its fetal development suggested that it was an identical twin, as it shared a placenta with its healthy twin, tests revealed that it was probably a polar body twin. The authors were unable to predict whether a healthy fetus could result from a polar body twinning. However,

2752-682: The epigenetic difference of three-year-old twins. Twins who had spent their lives apart (such as those adopted by two different sets of parents at birth) had the greatest difference. However, certain characteristics become more alike as twins age, such as IQ and personality. In January 2021, new research from a team of researchers in Iceland was published in the journal Nature Genetics suggesting that identical twins may not be quite as identical as previously thought. The four-year study of monozygotic (identical) twins and their extended families revealed that these twins have genetic differences that begin in

2816-544: The fourth time, Hayley Mills, 33 years his junior, whom he had met on the set of The Family Way . Their son is musician and filmmaker Crispian Mills . The couple separated in 1975, and divorced in 1977. His fifth and final marriage, in October 1978, was to actress Sandra Payne . They divorced in 1984. John Boulting died on 17 June 1985 at his home in Sunningdale , Berkshire, and Roy Boulting 16 years later on 5 November 2001 in

2880-468: The gangster "Pinkie" from the novel by Graham Greene . Also well liked was The Guinea Pig (1948), starring Richard Attenborough as a young working-class boy sent to a public school. It was made for Pilgrim Pictures who the Boultings left shortly afterwards. The Boultings co-directed the thriller Seven Days to Noon (1950), which won an Oscar for Best Story. It led to a less popular sequel, High Treason (1951). John directed The Magic Box (1951),

2944-475: The globe. In a study on the maternity records of 5750 Hausa women living in the Savannah zone of Nigeria , there were 40 twins and 2 triplets per 1000 births. Twenty-six percent of twins were monozygotic. The incidence of multiple births, which was about five times higher than that observed in any western population, was significantly lower than that of other ethnic groups, who live in the hot and humid climate of

3008-542: The legal profession. They had a break from satirising institutions with Happy Is the Bride (1958), an adaptation of Quiet Wedding , then returned to it with Carlton-Browne of the F.O. (1959), focusing on diplomacy. The Boultings took on increasingly powerful trade unions and ever corrupt board room power with I'm All Right Jack (1959), a sequel to Private's Progress with Carmichael, Thomas and Attenborough reprising their roles, and Harvey co-writing. The film featured

3072-536: The level of activity of any particular gene. A gene may become switched on, switched off, or could become partially switched on or off in an individual. This epigenetic modification is triggered by environmental events. Monozygotic twins can have markedly different epigenetic profiles. A study of 80 pairs of monozygotic twins ranging in age from three to 74 showed that the youngest twins have relatively few epigenetic differences. The number of epigenetic differences increases with age. Fifty-year-old twins had over three times

3136-406: The lowest mortality risk at about 9 percent, although that is still significantly higher than that of singletons. Monochorionic twins generally have two amniotic sacs (called Monochorionic–Diamniotic "MoDi"), which occurs in 60–70% of the pregnancies with monozygotic twins, and in 0.3% of all pregnancies. Monochorionic-Diamniotic twins are almost always monozygotic, with a few exceptions where

3200-459: The lowest rates are found; only 6 to 9 twin sets per 1,000 live births. North America and Europe have intermediate rates of 9 to 16 twin sets per 1,000 live births. Multiple pregnancies are much less likely to carry to full term than single births, with twin pregnancies lasting on average 37 weeks, three weeks less than full term. Women who have a family history of fraternal twins have a higher chance of producing fraternal twins themselves, as there

3264-525: The number of twin births in the United States rose 52%. This rise can at least partly be attributed to the increasing popularity of fertility drugs and procedures such as IVF, which result in multiple births more frequently than unassisted fertilizations do. It may also be linked to the increase of growth hormones in food. About 1 in 90 human births (1.1%) results from a twin pregnancy. The rate of dizygotic twinning varies greatly among ethnic groups , ranging as high as about 45 per 1000 births (4.5%) for

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3328-414: The occurrence of complications "was found to be more likely with increasing twin-to-twin delivery time interval" and suggested that the interval be kept short, though it noted that the study did not examine causes of complications and did not control for factors such as the level of experience of the obstetrician, the wish of the women giving birth, or the "management strategies" of the procedure of delivering

3392-473: The pregnancy. The timing of this separation determines the chorionicity (the number of placentae) and amniocity (the number of sacs) of the pregnancy. Dichorionic twins either never divided (i.e.: were dizygotic) or they divided within the first 4 days. Monoamnionic twins divide after the first week. In very rare cases, twins become conjoined twins . Non-conjoined monozygotic twins form up to day 14 of embryonic development, but when twinning occurs after 14 days,

3456-408: The rate of monozygotic twins) to 14 and more per thousand in some African countries. Dizygotic twins are also more common for older mothers, with twinning rates doubling in mothers over the age of 35. With the advent of technologies and techniques to assist women in getting pregnant, the rate of fraternals has increased markedly. Monozygotic ( MZ ) or identical twins occur when a single egg

3520-444: The same age. However, dizygotic twins may also look very different from each other (for example, be of opposite sexes). Studies show that there is a genetic proclivity for dizygotic twinning. However, it is only the mother who has any effect on the chances of having such twins; there is no known mechanism for a father to cause the release of more than one ovum . Dizygotic twinning ranges from six per thousand births in Japan (similar to

3584-457: The second twin. There have also been cases in which twins are born a number of days apart. Possibly the worldwide record for the duration of the time gap between the first and the second delivery was the birth of twins 97 days apart in Cologne, Germany, the first of which was born on November 17, 2018. Tunisian Victory Tunisian Victory is a 1944 Anglo - American propaganda film about

3648-455: The southern part of the country. The incidence of multiple births was related to maternal age but did not bear any association to the climate or prevalence of malaria . Twins are more common in people of African descent. The predisposing factors of monozygotic twinning are unknown. Dizygotic twin pregnancies are slightly more likely when the following factors are present in the woman: Women undergoing certain fertility treatments may have

3712-414: The splitting of a zygote or embryo is unknown. IVF techniques are more likely to create dizygotic twins. For IVF deliveries, there are nearly 21 pairs of twins for every 1,000. Monozygotic twins are genetically nearly identical and they are the same chromosomal sex unless there has been a mutation during development. The children of monozygotic twins test genetically as half-siblings (or full siblings, if

3776-436: The twins will likely be conjoined. Furthermore, there can be various degrees of shared environment of twins in the womb, potentially leading to pregnancy complications . It is a common misconception that two placentas automatically implies dizygotic twins, but if monozygotic twins separate early enough, the arrangement of sacs and placentas in utero is in fact indistinguishable from that of dizygotic twins. DiDi twins have

3840-466: The uterus wall at the same time. When two eggs are independently fertilized by two different sperm cells , fraternal twins result. The two eggs, or ova , form two zygotes , hence the terms dizygotic and biovular . Fraternal twins are, essentially, two ordinary siblings who happen to develop in the womb together and who are born at the same time, since they arise from two separate eggs fertilized by two separate sperm , just like ordinary siblings. This

3904-488: The victories in the North Africa Campaign of World War II . The film follows both armies from the planning of Operation Torch and Operation Acrobat (the latter of which was canceled), to the liberation of Tunis . Interspersed in the documentary format are the narrative voices of supposed American and British soldiers (voiced by Burgess Meredith and Bernard Miles respectively), recounting their experience in

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3968-420: Was analyzed for 506,786 single-nucleotide polymorphisms known to occur in human populations. Polymorphisms appeared in 2 of the 33 million comparisons, leading the researchers to extrapolate that the blood cells of monozygotic twins may have on the order of one DNA-sequence difference for every 12 million nucleotides, which would imply hundreds of differences across the entire genome. The mutations producing

4032-544: Was the elder by half an hour. John was named Joseph Edward John Boulting and Roy was named Alfred Fitzroy Clarence Boulting. Their elder brother Sydney Boulting became an actor and stage producer as Peter Cotes ; he was the original director of The Mousetrap . A younger brother, Guy, died aged eight. Both twins were educated at Reading School , where they formed a film society. They were extras in Anthony Asquith 's 1931 film Tell England while still at school. As

4096-547: Was working on an adaptation of Terence Rattigan 's play Deja Vu when he died. When the National Film Theatre mounted its biggest retrospective to date of British cinema in the late 1980s, Roy who launched it, introduced Desert Victory . The Boulting Brother's films have been described as being "a sensitive barometer of the changing times". John Boulting was married four times. He had six children: two sons by his first marriage; three daughters by his second. He also had

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