The goal of the Pacific Health Summit is to connect science, industry, and policy for a healthier world. Traditionally, the main work of the Summit has been an annual meeting, where top decision makers convene to discuss how to realize the dream of a healthier future through the effective utilization of scientific advances, combined with industrial innovation and appropriate policies. In autumn of 2012 on the heels of its eight major conference, the Summit shifted its focus from an annual meeting to more targeted work that builds on the past themes and concrete outcomes. As it has since 2005, the Summit will continue to provide a year-round forum for world leaders to grapple with problems and solutions, share best practices, and forge effective collaborations.
28-597: The first Pacific Health Summit was held in Seattle, Washington, in 2005 with foundational support from the Bill & Melinda Gates Foundation and the Russell Family Foundation . It was the co-creation of 2001 Nobel Prize in physiology or medicine winner Leland H. Hartwell , businessman and philanthropist George F. Russell Jr., Co-chair of the Bill & Melinda Gates Foundation William H. Gates Sr. , and Founding Director of
56-544: A $ 265 million initial public offering in 2014, was started based on inventions made at the center. As of 2015, about twenty companies had been started based on center inventions since 1975, including Immunex and Icos . The institute's main campus consists of 13 buildings that are on fifteen acres (6.1 ha) in the South Lake Union neighborhood of Seattle. In 1987, the center began exploring possible new homes to replace its 9-building campus on First Hill that it
84-753: Is the Chairman of the Scientific Advisory Board at the Canary Foundation , a non-profit organization dedicated to developing new technologies for the early detection of cancer. He is also a founding co-chair of the Pacific Health Summit , and a member of its executive committee. In September 2009, it was announced that Hartwell would join the faculty of Arizona State University as the Virginia G. Piper Chair of Personalized Medicine and co-director of
112-822: The Albert Lasker Award for Basic Medical Research , and the Massry Prize from the Keck School of Medicine , University of Southern California in 2000. On July 9, 2003, Washington Governor Gary Locke awarded the Medal of Merit, the state's highest honor, to Hartwell. He is also a recipient of the Komen Brinker Award for Scientific Distinction . His earliest publications focused on the isolation of temperature sensitive yeast mutants disabled in basic biological processes, including DNA, RNA and protein synthesis. This led to
140-564: The Biodesign Institute 's Center for Sustainable Health with Dr. Michael Birt. He is also adjunct faculty at Amrita University in India. This award is given to scientists whose research in yeast has made the most impact in the broader areas of biology. Recipients of the award also give a lecture at the biennial Yeast Genetics Meeting. Fred Hutchinson Cancer Research Center The Fred Hutchinson Cancer Center , formerly known as
168-635: The California Institute of Technology in 1961. In 1964, he received his PhD in biology from the Massachusetts Institute of Technology . From 1965 to 1968, he worked at the University of California, Irvine as a professor. He moved to the University of Washington in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the cell division cycle ( CDC ) genes in baker's yeast ( Saccharomyces cerevisiae ). These genes regulate
196-666: The Fred Hutchinson Cancer Research Center and also known as Fred Hutch or The Hutch , is a cancer research institute established in 1975 in Seattle , Washington . The center grew out of the Pacific Northwest Research Foundation , founded in 1956 by William B. Hutchinson (1909–1997). The Foundation was dedicated to the study of heart surgery , cancer, and diseases of the endocrine system . Hutchinson's younger brother Fred (1919–1964)
224-609: The Nobel Prize in Physiology or Medicine : The center is active in technology transfer . In 2013, it was one of the top ten biomedical research institutions in the field (excluding universities); it made 18 new deals with companies to develop inventions made at the center, and earned $ 10,684,882 in income from past deals it had signed. Most notably, Juno Therapeutics , a company developing CAR-T immunotherapy for cancer and that raised $ 314 million in venture capital investments and had
252-544: The 1980s and early 1990s, patients were not informed about all the risks of the study, nor about the study doctors' financial interest in study outcome. The paper also alleged that this financial interest may have contributed to the doctors' failure to halt the studies despite evidence that patients were dying sooner and more frequently than expected. In response, the center formed a panel of independent experts to review its existing research practices, leading to adoption of new conflict-of-interest rules. In 2010 Lawrence Corey
280-541: The 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Tim Hunt , for their discoveries of protein molecules that control the division (duplication) of cells. Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle—the progression through G1. Hartwell attended Glendale High School in Glendale, California , and then received his Bachelor of Science from
308-476: The Center publishes a ‘Calls for Collaboration’ report. The publication contains submissions from organizations inviting Summit participants to partner and collaborate around specific areas of need. Leland H. Hartwell Leland Harrison " Lee " Hartwell (born October 30, 1939) is an American former president and director of the Fred Hutchinson Cancer Research Center in Seattle , Washington . He shared
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#1733084469537336-648: The Foundation as the Summit's third co-presenting organization. In 2008, the Wellcome Trust joined the Summit as the fourth official co-presenting organization, and trust director, Sir Mark Walport , joined the executive committee. Both Sir William Castell , chairman of the Wellcome Trust, who has participated in the Summit since its first year, and Sir Mark provided crucial leadership as the Summit began its rotation in London for
364-571: The Fred Hutchinson Cancer Research Center became independent 1972 and its building opened three years later in 1975. The center was named an NCI-designated Comprehensive Cancer Center in 1976. In 1998, the center formed the Seattle Cancer Care Alliance (SCCA), a separate nonprofit corporation, with University of Washington School of Medicine (UW Medicine), and Seattle Children's . This solidified
392-531: The National Bureau of Asian Research’s Center for Health and Aging Michael Birt. NBR has been the Secretariat of the Summit since the inaugural 2005 conference. Birt, founding executive director of the Summit, stepped down from his role as NBR’s Center for Health and Aging director in 2009, and from his role as executive director in 2012, handing the mantle to Claire Topal, the Summit's managing director, who ran
420-477: The Summit and managed the team from 2009-2012. She now serves as senior advisor for international health to NBR. Nualchan Sakchalathorn, the Summit’s project director, served on the Summit team from 2007-2012. Building on Bill Gates Sr.'s strong personal support, in 2007 Tachi Yamada , then president of Global Health at the Bill & Melinda Gates Foundation, took on a decisive leadership role and formally established
448-666: The Summit have helped to lead to the establishment of the MSD Wellcome Trust Hilleman Laboratories , the Access to Nutrition Index , the Critical Path to TB Drug Regimens , and a cervical cancer vaccination deal between Merck & Co. and Qiagen . Additionally, the denial of a US visa for 2009 Summit participant Paul Thorn of the Tuberculosis Survival Project, due to his HIV positive status, became
476-600: The Summit’s legacy in the years to come. The Summit has been a catalyst for partnerships, and the setting of several global health announcements. In 2007, during a speech at the Summit, Margaret Chan , Director-General of the World Health Organization , publicized “a new initiative to establish a world stockpile of vaccines to prepare for the threat of pandemic influenza.” At the Summit in 2009, Sanofi bolstered that stockpile with 100 million donated doses of flu vaccine. Other partnerships furthered by, or formed at,
504-429: The annual meeting. Out of this initial foundation of leadership, the Summit grew into one of the world's premier global health gatherings every year. In 2012, eight years after the inaugural meeting, which was never designed to take place in perpetuity, global health is in an exciting new place. The Summit’s interactive format has proliferated, and decision-makers across all sectors and geographies are collaborating on all
532-432: The annual meeting. Peter Neupert, then corporate vice president for health solutions strategy for Microsoft, and Craig Mundie , chief research and strategy officer of Microsoft, consistently provided a private sector perspective to the Summit's strategic discussions. Additionally, GE Healthcare, through Bill Castell in 2005, has always provided critical advice and perspective, as well as the critical founding sponsorship for
560-609: The cell cycle and mutations in the genes are involved in some types of cancer. In addition to the Nobel Prize , Hartwell has received awards and honors including the Louisa Gross Horwitz Prize from Columbia University in 1995. He became a member of the National Academy of Sciences in 1987. In 1996, Hartwell joined the faculty of Fred Hutchinson Cancer Research Center and in 1997 became its president and director until he retired in 2010. In 1998 he received
588-637: The center's reach into clinical care and was essential for it retaining its NCI comprehensive center designation; the designation was extended to the center's consortium including the SCCA in 2003. SCCA's outpatient clinic first opened in January 2001. In 2001, The Seattle Times published a series of articles alleging that investigators at the center (including the center's co-founder E. Donnall Thomas ) were conducting unethical clinical studies on cancer patients. The paper alleged that in two cancer studies conducted in
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#1733084469537616-422: The critical global health issues the Summit sought to address: health technology, pandemic flu, MDR-TB, vaccines, malnutrition, maternal and newborn health, and many more. While the Summit is proud of eight years of transformational conversations, countless new friendships, and exciting partnerships, there is still much work to do – and so much momentum on which to build. NBR is looking forward and excited to build on
644-488: The identification of the CDC (Cell Division Cycle) genes, which function in promoting the progression through cell division, most notably CDC28, which encodes the yeast Cdk kinase. Other significant discoveries include introduction of the concept of cell cycle "checkpoints", which delay cell division when cellular insults are generated and also the identification and characterization of the mating signal transduction pathway. Hartwell
672-497: The impetus behind the repeal of a US travel restriction law on individuals carrying the HIV/AIDs virus. The Summit Secretariat, the Center for Health and Aging at The National Bureau of Asian Research, publishes reports , videos , and photos of Summit sessions and workshops. The organization also produces expert interviews and thought pieces with Summit participants on past themes and current global health topics. Prior to each Summit,
700-464: The organization adopt its longtime local nickname, "Fred Hutch", as its official name as part of a rebranding. On April 1, 2022, Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance (SCCA) merged to form Fred Hutchinson Cancer Center , a unified adult cancer research and care center that is clinically integrated with University of Washington (UW) Medicine and UW Medicine's cancer program. The center has employed three recipients of
728-634: Was a major league pitcher and manager who died of lung cancer at age 45. The next year, William Hutchinson established the Fred Hutchinson Cancer Research Center as a division of the Pacific Northwest Research Foundation. In 1972, with the help of Senator Warren G. Magnuson , PNRF received federal funding under the National Cancer Act of 1971 to create in Seattle one of the 15 new NCI-designated Cancer Centers aimed at conducting basic research called for under 1971 Act;
756-493: Was appointed as the fourth President, following the retirement of Lee Hartwell . He was followed by Gary Gilliland in 2015 as president, who led the institute until 2020. Under his leadership the center announced that it would expand into the former Lake Union steam plant, which previously housed ZymoGenetics . The move was completed in October 2020. In February 2020, Thomas J. Lynch Jr. took over as director. The year 2014 saw
784-513: Was set to outgrow. A site in the South Lake Union neighborhood, envisioned by the city as a future high-tech and biotechnology hub, was chosen in September 1988 after a deal to move to Fremont fell through earlier that year. The first phase of the campus, designed by firm Zimmer Gunsul Frasca Partnership , began construction in 1991 and opened on June 1, 1993, in a ceremony that included
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