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126-627: The U.S. state of Ohio was among the first states in the United States that shut everything down at the beginning of the COVID-19 pandemic , giving Ohio Governor Mike DeWine and then-health director Amy Acton both praise and criticism for their swift response, as Ohio's outbreak of COVID-19 over the long-term was small compared to other states, especially with Ohio's relatively large population (ranked 7th nationally) compared to states of similar geographic size. On May 12, 2021, DeWine announced he

252-708: A bill in Congress to admit Ohio to the Union retroactive to March 1, 1803, the date on which the Ohio General Assembly first convened. At a special session at the old state capital in Chillicothe , the Ohio state legislature approved a new petition for statehood, which was delivered to Washington, D.C. , on horseback, and approved that August. Ohio has had three capital cities: Chillicothe, Zanesville , and Columbus . Chillicothe

378-747: A conclusion. In 1774, Britain passed the Quebec Act , which formally annexed Ohio and other western lands to the Province of Quebec in order to provide a civil government and to centralize British administration of the Montreal -based fur trade. The prohibition of settlement west of the Appalachians remained, contributing to the American Revolution. By the start of the American Revolutionary War ,

504-658: A decisive victor. In the Treaty of Paris in 1783, Britain ceded all claims to Ohio Country to the new United States after its victory in the American Revolutionary War . The United States created the Northwest Territory under the Northwest Ordinance of 1787. Slavery was not permitted in the new territory. Settlement began with the founding of Marietta by the Ohio Company of Associates , which had been formed by

630-409: A disease has ceased to be endemic to a population, then natural infections no longer contribute to a reduction in the fraction of the population that is susceptible. Only vaccination contributes to this reduction. The relation between vaccine coverage and effectiveness and disease incidence can be shown by subtracting the product of the effectiveness of a vaccine and the proportion of the population that

756-479: A disease, written as V c . Vaccines are usually imperfect however, so the effectiveness, E , of a vaccine must be accounted for: From this equation, it can be observed that if E is less than (1 − 1/ R 0 ), then it is impossible to eliminate a disease, even if the entire population is vaccinated. Similarly, waning vaccine-induced immunity, as occurs with acellular pertussis vaccines , requires higher levels of booster vaccination to sustain herd immunity. If

882-432: A greater risk of developing complications from infection because of their medical status, but they may still be protected if a large enough percentage of the population is immune. High levels of immunity in one age group can create herd immunity for other age groups. Vaccinating adults against pertussis reduces pertussis incidence in infants too young to be vaccinated, who are at the greatest risk of complications from

1008-712: A group of American Revolutionary War veterans. Following the Ohio Company, the Miami Company (also referred to as the " Symmes Purchase ") claimed the southwestern section, and the Connecticut Land Company surveyed and settled the Connecticut Western Reserve in present-day Northeast Ohio . Territorial surveyors from Fort Steuben began surveying an area of eastern Ohio called the Seven Ranges at about

1134-429: A large decline in union membership: 17.4% of Ohioan workers were union members in 2000, while 12.8% were union members in 2022. In the wake of these economic changes, Ohio's state government has looked to promoting new industries to offset manufacturing losses, such as the production of solar energy and electric vehicles . One major program the state government launched was the "Third Frontier" program, created during

1260-401: A level beyond what can be predicted from direct protection alone, indicating that herd immunity contributed to the reduction. When serotype replacement is accounted for, it reduces the predicted benefits of vaccination. Herd immunity was recognized as a naturally occurring phenomenon in the 1930s when it was observed that after a significant number of children had become immune to measles ,

1386-423: A limited number of other individuals. In these networks, transmission only occurs between those who are geographically or physically close to one another. The shape and size of a network is likely to alter a disease's HIT, making incidence either more or less common. Mathematical models can use contact matrices to estimate the likelihood of encounters and thus transmission. In heterogeneous populations, R 0

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1512-529: A national model of success. Ohio's economy was also heavily afflicted by the Great Recession , as the state's unemployment rate rose from 5.6% in the first two months of 2008 up to a peak of 11.1% in December 2009 and January 2010. It took until August 2014 for the unemployment rate to return to 5.6%. From December 2007 to September 2010, Ohio lost 376,500 jobs. In 2009, Ohio had 89,053 foreclosures filings,

1638-441: A pathogen are transferred from one individual to another. This can occur naturally, whereby maternal antibodies, primarily immunoglobulin G antibodies, are transferred across the placenta and in colostrum to fetuses and newborns. Passive immunity can also be gained artificially, when a susceptible person is injected with antibodies from the serum or plasma of an immune person. Protection generated from passive immunity

1764-409: A person that he or she may not need to be vaccinated, since a sufficient percentage of others are already immune. Individuals who are immune to a disease act as a barrier in the spread of disease, slowing or preventing the transmission of disease to others. An individual's immunity can be acquired via a natural infection or through artificial means, such as vaccination. When a critical proportion of

1890-442: A population for a sufficient time, the disease is inevitably eliminated – no more endemic transmissions occur. If elimination is achieved worldwide and the number of cases is permanently reduced to zero, then a disease can be declared eradicated. Eradication can thus be considered the final effect or end-result of public health initiatives to control the spread of contagious disease. In cases in which herd immunity

2016-653: A potential market for Ohio machinery exports. In July 1979, Rhodes led a State of Ohio Trade Mission to China. The trip resulted in developing economic ties, a sister state-province relationship with Hubei province , long-running Chinese exhibitions at the Ohio State Fair , and major academic exchanges between Ohio State University and Wuhan University . Beginning in the 1980s, the state entered into international economic and resource cooperation treaties and organizations with other Midwestern states, as well as New York , Pennsylvania , Ontario , and Quebec , including

2142-577: A proportionate increase in disease incidence though, since NVTs were less invasive than VTs. Since then, pneumococcal vaccines that provide protection from the emerging serotypes have been introduced and have successfully countered their emergence. The possibility of future shifting remains, so further strategies to deal with this include expansion of VT coverage and the development of vaccines that use either killed whole-cells , which have more surface antigens, or proteins present in multiple serotypes. If herd immunity has been established and maintained in

2268-650: A riot in downtown Kent and the burning of an ROTC building. The main cause of the protests was the United States' invasion of Cambodia during the Vietnam War . Ohio was an important state in the developing ties between the United States and the People's Republic of China in the late 1970s and early 1980s. Relations between the two countries normalized in 1979, during the second term of Ohio governor Jim Rhodes . Rhodes sought to encourage economic ties, viewing China as

2394-467: A specific population for medical reasons, but if both effectiveness and coverage are high enough then herd immunity can protect these individuals. Vaccine effectiveness is often, but not always, adversely affected by passive immunity, so additional doses are recommended for some vaccines while others are not administered until after an individual has lost his or her passive immunity. Individual immunity can also be gained passively, when antibodies to

2520-403: A then-record for the state. The median household income dropped 7% from 2006–07 to 2008–09, and the poverty rate ballooned to 13.5% by 2009. By 2015, Ohio gross domestic product was $ 608.1 billion, the seventh-largest economy among the 50 states . In 2015, Ohio's total GDP accounted for 3.4% of U.S. GDP and 0.8% of world GDP. Politically, Ohio has been long regarded as a swing state , but

2646-435: A variety of reasons, including the belief that vaccines are ineffective, or that the risks associated with vaccines are greater than those associated with infection, mistrust of vaccines or public health officials, bandwagoning or groupthinking , social norms or peer pressure , and religious beliefs. Certain individuals are more likely to choose not to receive vaccines if vaccination rates are high enough to convince

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2772-574: Is composed of the executive branch, led by the governor ; the legislative branch, consisting of the bicameral Ohio General Assembly ; and the judicial branch, led by the state Supreme Court . Ohio occupies 15 seats in the United States House of Representatives , the seventh-largest delegation. Seven presidents of the United States have come from Ohio , earning it the moniker "the Mother of Presidents". Archeological evidence of spear points of both

2898-768: Is compromised, on the contrary, disease outbreaks among the unvaccinated population are likely to occur. The benefits of eradication include ending all morbidity and mortality caused by the disease, financial savings for individuals, health care providers, and governments, and enabling resources used to control the disease to be used elsewhere. To date, two diseases have been eradicated using herd immunity and vaccination: rinderpest and smallpox . Eradication efforts that rely on herd immunity are currently underway for poliomyelitis , though civil unrest and distrust of modern medicine have made this difficult. Mandatory vaccination may be beneficial to eradication efforts if not enough people choose to get vaccinated. Herd immunity

3024-651: Is considered to be a measure of the number of cases generated by a "typical" contagious person, which depends on how individuals within a network interact with each other. Interactions within networks are more common than between networks, in which case the most highly connected networks transmit disease more easily, resulting in a higher R 0 and a higher HIT than would be required in a less connected network. In networks that either opt not to become immune or are not immunized sufficiently, diseases may persist despite not existing in better-immunized networks. The cumulative proportion of individuals who get infected during

3150-623: Is defined by the Ohio River . Ohio's neighbors are Pennsylvania to the east, Michigan to the northwest, Lake Erie to the north, Indiana to the west, Kentucky on the south, and West Virginia on the southeast. Ohio's borders were defined by metes and bounds in the Enabling Act of 1802 as follows: Bounded on the east by the Pennsylvania line, on the south by the Ohio River, to the mouth of

3276-417: Is fully aquatic and breathes almost entirely through its skin. Due to this, it is only found in pristine, cool, clear, fast flowing streams and rivers. It is highly threatened by habitat loss , water pollution , and sedimentation due to logging and other human activities. The climate of Ohio is a humid continental climate ( Köppen climate classification Dfa/Dfb ) throughout most of the state, except in

3402-407: Is homogeneous, or well-mixed, meaning each individual is equally likely to come into contact with any other susceptible individual in the population, and S , the proportion of the population who are susceptible to infection, and setting this product to be equal to 1: S can be rewritten as (1 − p ), where p is the proportion of the population that is immune so that p + S equals one. Then,

3528-515: Is immediate, but wanes over the course of weeks to months, so any contribution to herd immunity is temporary. For diseases that are especially severe among fetuses and newborns, such as influenza and tetanus, pregnant women may be immunized in order to transfer antibodies to the child. In the same way, high-risk groups that are either more likely to experience infection, or are more likely to develop complications from infection, may receive antibody preparations to prevent these infections or to reduce

3654-402: Is immune to a disease in excess of that disease's HIT, the number of cases reduces at a faster rate, outbreaks are even less likely to happen, and outbreaks that occur are smaller than they would be otherwise. If the population immunity falls below the herd immunity threshold, where the effective reproduction number increases to above 1, the population is said to have an "immunity gap", and then

3780-405: Is integral, began as a way to immunize every person in a "ring" around an infected individual to prevent outbreaks from spreading. Since the adoption of mass and ring vaccination, complexities and challenges to herd immunity have arisen. Modeling of the spread of contagious disease originally made a number of assumptions, namely that entire populations are susceptible and well-mixed, which is not

3906-562: Is known as the Tornado Alley . Severe lake effect snowstorms are also not uncommon on the southeast shore of Lake Erie , which is located in an area designated as the Snowbelt . Although predominantly not in a subtropical climate, some warmer-climate flora and fauna do reach well into Ohio. For instance, some trees with more southern ranges, such as the blackjack oak , Quercus marilandica , are found at their northernmost in Ohio just north of

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4032-745: Is more severe in the elderly than in younger age groups, but influenza vaccines lack effectiveness in this demographic due to a waning of the immune system with age. The prioritization of school-age children for seasonal flu immunization, which is more effective than vaccinating the elderly, however, has been shown to create a certain degree of protection for the elderly. For sexually transmitted infections (STIs), high levels of immunity in heterosexuals of one sex induces herd immunity for heterosexuals of both sexes. Vaccines against STIs that are targeted at heterosexuals of one sex result in significant declines in STIs in heterosexuals of both sexes if vaccine uptake in

4158-478: Is nicknamed the "Buckeye State" after its Ohio buckeye trees , and Ohioans are also known as "Buckeyes". Ohio derives its name from the Ohio River that forms its southern border, which, in turn, originated from the Seneca word ohiːyo' , meaning "good river", "great river", or "large creek". The state was home to several ancient indigenous civilizations, with humans present as early as 10,000 BCE. It arose from

4284-543: Is vaccinated, p v , from the herd immunity threshold equation as follows: It can be observed from this equation that, all other things being equal (" ceteris paribus "), any increase in either vaccine coverage or vaccine effectiveness, including any increase in excess of a disease's HIT, further reduces the number of cases of a disease. The rate of decline in cases depends on a disease's R 0 , with diseases with lower R 0 values experiencing sharper declines. Vaccines usually have at least one contraindication for

4410-415: Is vulnerable to the free rider problem . Individuals who lack immunity, including those who choose not to vaccinate, free ride off the herd immunity created by those who are immune. As the number of free riders in a population increases, outbreaks of preventable diseases become more common and more severe due to loss of herd immunity. Individuals may choose to free ride or be hesitant to vaccinate for

4536-458: Is when mutations accumulate in the portion of the viral genome that encodes for the virus's surface antigen , typically a protein of the virus capsid , producing a change in the viral epitope . Alternatively, the reassortment of separate viral genome segments, or antigenic shift , which is more common when there are more strains in circulation, can also produce new serotypes . When either of these occur, memory T cells no longer recognize

4662-711: The Appalachian Regional Development Act , an attempt to "address the persistent poverty and growing economic despair of the Appalachian Region". It defines 29 Ohio counties as part of Appalachia. While 1/3 of Ohio's land mass is part of the federally defined Appalachian region, only 12.8% of Ohioans live there (1.476 million people.) Significant Ohio rivers include the Cuyahoga River , Great Miami River , Maumee River , Muskingum River , and Scioto River . The rivers in northern Ohio drain into

4788-612: The Canadian provinces of Manitoba , Alberta and Quebec . Ohio itself introduced Vax-2-School , with the incentive of higher education scholarships, on September 23, 2021. A study by researchers at the Boston University School of Medicine suggests that Vax-a-Million and similar lotteries "are of limited value in increasing vaccine uptake." However, a later study by researchers at the Institute for Applied Computational Science at

4914-653: The Charles Young Buffalo Soldiers National Monument and Perry's Victory and International Peace Memorial . Ohio has wide variety of unique animal species. Rare and endangered species include the Eastern Hellbender , which is found in the Southeastern Appalachian region of Ohio and is classified as state endangered. The Eastern Hellbender is the 3rd largest amphibian in the world, and can grow up to 27 inches in length. It

5040-795: The Dayton Triangles beat the Columbus Panhandles 14–0 in Dayton. Canton was enshrined as the home of the Pro Football Hall of Fame in 1963. During the 1930s, the Great Depression struck the state hard. By 1933, more than 40% of factory workers and 67% of construction workers were unemployed in Ohio. Approximately 50% of industrial workers in Cleveland and 80% in Toledo became unemployed, with

5166-622: The Enabling Act of 1802 . In regard to the Leni Lenape natives, Congress decided that 10,000 acres on the Muskingum River in the present state of Ohio would "be set apart and the property thereof be vested in the Moravian Brethren  ... or a society of the said Brethren for civilizing the Indians and promoting Christianity". Rufus Putnam served in important military capacities in both

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5292-601: The French and Indian War and the American Revolutionary War . He was one of the most highly respected men in the early years of the United States. In 1776, Putnam created a method of building portable fortifications, which enabled the Continental Army to drive the British from Boston. George Washington was so impressed that he made Putnam his chief engineer. After the war, Putnam and Manasseh Cutler were instrumental in creating

5418-498: The Great Black Swamp . This glaciated region in the northwest and central state is bordered to the east and southeast first by a belt known as the glaciated Allegheny Plateau , and then by another belt known as the unglaciated Allegheny Plateau . Most of Ohio is of low relief, but the unglaciated Allegheny Plateau features rugged hills and forests . Ohio's rugged southeastern quadrant, stretching in an outward bow-like arc along

5544-529: The Great Dayton Flood , the entire Miami River watershed flooded, including the downtown business district of Dayton . As a result, the Miami Conservancy District was created as the first major floodplain engineering project in Ohio and the United States. The highest recorded temperature was 113  °F (45  °C ), near Gallipolis on July 21, 1934. The lowest recorded temperature

5670-815: The Great Lakes Charter , Great Lakes Compact , and the Council of Great Lakes Governors . Ohio's economy has undergone significant change in the 21st century, as the trend of deindustrialization has greatly impacted the American Midwest and the Rust Belt . Manufacturing in the Midwest experienced a stark decline during the early 21st century, a trend that greatly impacted Ohio. From 1990 to 2019, it lost over 300,000 manufacturing jobs, but added over 1,000,000 non-manufacturing jobs. Coinciding with this decline, Ohio has seen

5796-522: The Great Miami River , on the west by the line drawn due north from the mouth of the Great Miami aforesaid, and on the north by an east and west line drawn through the southerly extreme of Lake Michigan , running east after intersecting the due north line aforesaid, from the mouth of the Great Miami until it shall intersect Lake Erie or the territorial line, and thence with the same through Lake Erie to

5922-522: The Harvard John A. Paulson School of Engineering and Applied Sciences states that "[a]n additional 114,553 individuals received vaccinations as a result of Ohio's vaccine lottery at a cost of approximately $ 49 per Ohioan vaccinated." Ohio Ohio ( / oʊ ˈ h aɪ . oʊ / oh- HY -oh ) is a state in the Midwestern region of the United States . It borders Lake Erie to

6048-408: The Northwest Ordinance , which opened up the Northwest Territory for settlement. This land was used to serve as compensation for what was owed to Revolutionary War veterans. Putnam organized and led the Ohio Company of Associates , who settled at Marietta, Ohio , where they built a large fort, Campus Martius . He set substantial amounts of land aside for schools. In 1798, he created the plan for

6174-471: The Western Confederacy , was forced to cede extensive territory, including much of present-day Ohio, in the Treaty of Greenville in 1795. Under the Northwest Ordinance , areas could be defined and admitted as states once their population reached 60,000. Although Ohio's population was only 45,000 in December 1801, Congress determined that it was growing rapidly enough and accelerated the process via

6300-756: The Whittlesey Culture and the Monongahela Culture . All three disappeared in the 17th century. Their origins are unknown. The Shawnees may have absorbed the Fort Ancient people. It is also possible that the Monongahela held no land in Ohio during the Colonial Era. The Mississippian culture was close to and traded extensively with the Fort Ancient people. Indians in the Ohio Valley were greatly affected by

6426-554: The basic reproduction number of the disease. An example of a disease with a high threshold was the measles, with a HIT exceeding 95%. The term "herd immunity" was first used in 1894 by American veterinary scientist and then Chief of the Bureau of Animal Industry of the US Department of Agriculture Daniel Elmer Salmon to describe the healthy vitality and resistance to disease of well-fed herds of hogs. In 1916 veterinary scientists inside

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6552-613: The first American to orbit the Earth , and Neil Armstrong becoming the first human to walk on the Moon . In 1967, Carl Stokes was elected mayor of Cleveland and became the first African American mayor of one of the nation's 10 most populous cities. In 1970, an Ohio Army National Guard unit fired at students during an antiwar protest at Kent State University , killing four and wounding nine. The Guard had been called onto campus after several protests in and around campus became violent, including

6678-845: The fur trade . Some of the Indigenous nations that historically inhabited Ohio include the Iroquoian, the Algonquian, and the Siouan. Ohio country was also the site of Indian massacres, such as the Yellow Creek massacre and the Gnadenhutten massacre . After the War of 1812 , when Natives suffered serious losses such as at Tippecanoe , most Native tribes either left Ohio or had to live on only limited reservations. By 1842, all remaining Natives were forced out of

6804-433: The measles vaccine began in the 1960s. Mass vaccination, discussions of disease eradication, and cost–benefit analyses of vaccination subsequently prompted more widespread use of the term herd immunity . In the 1970s, the theorem used to calculate a disease's herd immunity threshold was developed. During the smallpox eradication campaign in the 1960s and 1970s, the practice of ring vaccination , to which herd immunity

6930-614: The Adena culture is the Great Serpent Mound , located in Adams County, Ohio . Around 100 BC, the Adena evolved into the Hopewell people, who were also mound builders. Their complex, large and technologically sophisticated earthworks can be found in modern-day Marietta , Newark , and Circleville . They were also a prolific trading society, their trading network spanning a third of

7056-681: The American Revolution, Britain thinly exercised sovereignty over Ohio Country by lackadaisical garrisoning of the French forts. Just beyond Ohio Country was the great Miami capital of Kekionga , which became the center of British trade and influence in Ohio Country and throughout the future Northwest Territory . By the Royal Proclamation of 1763 , British lands west of Appalachia were forbidden to settlement by colonists. The Treaty of Fort Stanwix in 1768 explicitly reserved lands north and west of

7182-613: The COVID-19 vaccines that are required to be spent on such programs. After debate on whether or not such a lottery would be considered taxable, it was decided that it would count towards income tax , and a Form 1099 will be issued from the Ohio Lottery to each winner. DeWine stated in an editorial that he himself created the initial design of the contest after hearing a suggestion from his chief adviser. All permanent Ohio residents aged 18 or older who have received at least one vaccination by

7308-425: The East to migrate west against their will, including all remaining tribes in Ohio. In 1835, Ohio fought with the Michigan Territory in the Toledo War , a mostly bloodless boundary war over the Toledo Strip. Only one person was injured in the conflict. Congress intervened, making Michigan 's admittance as a state conditional on ending the conflict. In exchange for giving up its claim to the Toledo Strip, Michigan

7434-507: The Folsom and Clovis types indicate that the Ohio Valley was inhabited by nomadic people as early as 13,000 BC. These early nomads disappeared from Ohio by 1,000 BC. Between 1,000 and 800 BC, the sedentary Adena culture emerged. The Adena established "semi-permanent" villages because they domesticated plants, including sunflowers, and "grew squash and possibly corn"; with hunting and gathering, this cultivation supported more settled, complex villages. The most notable remnant of

7560-406: The HIT for a disease with an R 0 of 2 is theoretically only 50%, whereas a disease with an R 0 of 10 the theoretical HIT is 90%. When the effective reproduction number R e of a contagious disease is reduced to and sustained below 1 new individual per infection, the number of cases occurring in the population gradually decreases until the disease has been eliminated. If a population

7686-424: The Lenape Indian capital of Coshocton ; a detachment of one hundred of George Rogers Clark 's troops that were ambushed near the Ohio River by Indians led by Joseph Brant in the same year; a British and Native American attack on the U.S.' Fort Laurens ; and the 1782 detainment and murder of 96 Moravian Lenape pacifists by Pennsylvania militiamen in the Gnadenhutten massacre . The western theatre never had

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7812-461: The Northeast to the Midwest, much cargo and business traffic passes through its borders along its well-developed highways. Ohio has the nation's 10th-largest highway network and is within a one-day drive of 50% of North America's population and 70% of North America's manufacturing capacity. To the north, Ohio has 312 miles (502 km) of coastline with Lake Erie, which allows for numerous cargo ports such as Cleveland and Toledo. Ohio's southern border

7938-424: The Ohio Lottery and the Ohio Department of Health (and respective family members from both agencies) are not eligible to participate. Minors registering for the scholarships were allowed to register on their own, but their parents or legal guardian would be required to verify their information. Each entrant is only required to register once, with the registration system automatically deleting multiple entries from

8064-403: The Ohio Lottery decided to make an exception for minors. Instead of being awarded money, those who have been vaccinated that are aged 12-17 would be rewarded with a full-ride scholarship to any four-year public university in Ohio of their choice up to a Bachelor's degree . The funding for the contest is coming from a surplus of Ohio's portion of the CARES Act to educate the general public about

8190-402: The Ohio River from the West Virginia Panhandle to the outskirts of Cincinnati, forms a distinct socioeconomic unit. Geologically similar to parts of West Virginia and southwestern Pennsylvania, this area's coal mining legacy, dependence on small pockets of old manufacturing establishments, and distinctive regional dialect set this section off from the rest of the state. In 1965, Congress passed

8316-449: The Ohio River were attacked and ransacked in Morgan's Raid , starting in Harrison in the west and culminating in the Battle of Salineville near West Point in the far east. While this raid was overall insignificant to the Confederacy, it aroused fear among people in Ohio and Indiana as it was the furthest advancement of troops from the South in the war. Almost 35,000 Ohioans died in the conflict, and 30,000 were physically wounded. By

8442-434: The Ohio River. Also evidencing this climatic transition from a subtropical to a continental climate, several plants such as the Southern magnolia ( Magnolia grandiflora ) , Albizia julibrissin (mimosa), Crape Myrtle , and even the occasional Needle Palm are hardy landscape materials regularly used as street, yard, and garden plantings in the Bluegrass region of Ohio; but these same plants will simply not thrive in much of

8568-412: The Ohio as Native lands. British military occupation in the region contributed to the outbreak of Pontiac's War in 1763. Ohio tribes participated in the war until an armed expedition in Ohio led by Brigadier General Henry Bouquet brought about a truce. Another colonial military expedition into the Ohio Country in 1774 brought Lord Dunmore's War , kicked off by the Yellow Creek massacre in Ohio, to

8694-424: The Pennsylvania line aforesaid. Ohio is bounded by the Ohio River, but nearly all of the river belongs to Kentucky and West Virginia. In 1980, the U.S. Supreme Court held that, based on the wording of the cessation of territory by Virginia (which at the time included what is now Kentucky and West Virginia), the boundary between Ohio and Kentucky (and, by implication, West Virginia) is the northern low-water mark of

8820-448: The Shawnee, excluding the Pekowi in Southwest Ohio, were forcibly relocated west. Ohio played a key role in the War of 1812, as it was on the front line in the Western theater and the scene of several notable battles both on land and in Lake Erie . On September 10, 1813, the Battle of Lake Erie , one of the major battles, took place near Put-in-Bay, Ohio . The British eventually surrendered to Oliver Hazard Perry . Ultimately, after

8946-479: The Sunday prior to each drawing were eligible, while meeting other eligibility requirements. Initially, Ohio planned to have the entrants names pulled from the voter registration list with non-voters having to register on a separate website. However, on May 17, it was announced that all Ohio residents would be required to register on the site or by phone, while also giving those who don't want to participate an option to opt-out. Convicted felons as well as employees of

9072-530: The U.S. government used the Indian Removal Act of 1830 to force countless Native American tribes on the Trail of Tears , where all the southern states except for Florida were successfully emptied of Native peoples, the government panicked because most tribes did not want to be forced out of their own lands. Fearing further wars between Native tribes and American settlers, they pushed all remaining Native tribes in

9198-578: The aggressive tactics of the Iroquois Confederation , based in central and western New York. After the Beaver Wars in the mid-17th century, the Iroquois claimed much of the Ohio country as hunting and, more importantly, beaver-trapping ground. After the devastation of epidemics and war in the mid-17th century, which largely emptied the Ohio country of Indigenous people by the mid-to-late 17th century,

9324-597: The build up of immunity in populations to diseases such as diphtheria, scarlet fever, and influenza. Herd immunity was recognized as a naturally occurring phenomenon in the 1930s when A. W. Hedrich published research on the epidemiology of measles in Baltimore , and took notice that after many children had become immune to measles, the number of new infections temporarily decreased, including among susceptible children. In spite of this knowledge, efforts to control and eliminate measles were unsuccessful until mass vaccination using

9450-417: The communicable pathogen cannot maintain itself in the population, its low incidence thereby reducing the likelihood of infection for individuals who lack immunity. Once the herd immunity has been reached, disease gradually disappears from a population and may result in eradication or permanent reduction of infections to zero if achieved worldwide. Herd immunity created via vaccination has contributed to

9576-524: The construction of the Muskingum Academy (now Marietta College ). In 1780, the directors of the Ohio Company appointed him superintendent of all its affairs relating to the settlement north of the Ohio River. In 1796, President George Washington commissioned him as Surveyor-General of United States Lands. In 1788, he served as a judge in the Northwest Territory's first court. In 1802, he served in

9702-580: The continent. The Hopewell disappeared from the Ohio Valley about 600 AD. The Mississippian culture rose as the Hopewell culture declined. Many Siouan-speaking peoples from the plains and east coast claim them as ancestors and say they lived throughout the Ohio region until approximately the 13th century. There were three other cultures contemporaneous with the Mississippians: the Fort Ancient people,

9828-540: The convention to form a constitution for the State of Ohio. On February 19, 1803, U.S. President Thomas Jefferson signed an act of Congress that approved Ohio's boundaries and constitution. But Congress had not passed a formal resolution admitting Ohio as the 17th state. Although no formal resolution of admission was required, when the oversight was discovered in 1953, as Ohio began preparations for celebrating its sesquicentennial, Ohio congressman George H. Bender introduced

9954-458: The course of a disease outbreak can exceed the HIT. This is because the HIT does not represent the point at which the disease stops spreading, but rather the point at which each infected person infects fewer than one additional person on average. When the HIT is reached, the number of additional infections does not immediately drop to zero. The excess of the cumulative proportion of infected individuals over

10080-513: The disease is neither in a steady state nor decreasing in incidence , but is actively spreading through the population and infecting a larger number of people than usual. An assumption in these calculations is that populations are homogeneous, or well-mixed, meaning that every individual is equally likely to come into contact with any other individual, when in reality populations are better described as social networks as individuals tend to cluster together, remaining in relatively close contact with

10206-494: The disease. The critical value, or threshold, in a given population, is the point where the disease reaches an endemic steady state , which means that the infection level is neither growing nor declining exponentially . This threshold can be calculated from the effective reproduction number R e , which is obtained by taking the product of the basic reproduction number R 0 , the average number of new infections caused by each case in an entirely susceptible population that

10332-523: The disease. This is especially important for close family members, who account for most of the transmissions to young infants. In the same manner, children receiving vaccines against pneumococcus reduces pneumococcal disease incidence among younger, unvaccinated siblings. Vaccinating children against pneumococcus and rotavirus has had the effect of reducing pneumococcus - and rotavirus -attributable hospitalizations for older children and adults, who do not normally receive these vaccines. Influenza (flu)

10458-555: The diseases they protect against and severe adverse effects are significantly less common than complications from natural infections. The immune system does not distinguish between natural infections and vaccines, forming an active response to both, so immunity induced via vaccination is similar to what would have occurred from contracting and recovering from the disease. To achieve herd immunity through vaccination, vaccine manufacturers aim to produce vaccines with low failure rates, and policy makers aim to encourage their use . After

10584-485: The end of the Civil War, the Union's top three generals— Ulysses S. Grant , William Tecumseh Sherman , and Philip Sheridan —were all from Ohio. During much of the 19th century, industry was rapidly introduced to complement an existing agricultural economy. One of the first iron manufacturing plants, Hopewell Furnace, opened near Youngstown in 1804. By the mid-19th century, 48 blast furnaces were operating in Ohio, most in

10710-496: The equation can be rearranged to place p by itself as follows: With p being by itself on the left side of the equation, it can be renamed as p c , representing the critical proportion of the population needed to be immune to stop the transmission of disease, which is the same as the "herd immunity threshold" HIT. R 0 functions as a measure of contagiousness, so low R 0 values are associated with lower HITs, whereas higher R 0 s result in higher HITs. For example,

10836-492: The extreme southern counties of Ohio's Bluegrass region section, which are located on the northern periphery of the humid subtropical climate ( Cfa ) and Upland South region of the United States. Summers are typically hot and humid throughout the state, while winters generally range from cool to cold. Precipitation in Ohio is moderate year-round. Severe weather is not uncommon in the state, although there are typically fewer tornado reports in Ohio than in states located in what

10962-757: The first successful airplane. Ohio was hit by its greatest natural disaster in the Great Flood of 1913 , resulting in at least 428 fatalities and hundreds of millions of dollars in property damage, particularly around the Great Miami River basin. The National Football League was originally founded in Canton, Ohio in 1920 as the American Professional Football Conference. It included Ohio League teams in five Ohio cities (Akron, Canton, Cleveland, Columbus, and Dayton), none of which still exist. The first official game occurred on October 3, 1920, when

11088-669: The governorship of Bob Taft , which aimed to increase investment in Ohio and boost its technology sector. As of 2010, the Ohio Department of Development attributes the creation of 9,500 jobs to this program, with an average salary of $ 65,000, while having a $ 6.6 billion economic impact with a return on investment of 9:1. In 2010 the state won the International Economic Development Council 's Excellence in Economic Development Award, celebrated as

11214-453: The land gradually became repopulated by the mostly Algonquian . Many of these Ohio-country nations were multiethnic (sometimes multi-linguistic) societies born out of the earlier devastation brought about by disease, war, and subsequent social instability. They subsisted on agriculture (corn, sunflowers, beans, etc.) supplemented by seasonal hunts. By the 18th century, they were part of a larger global economy brought about by European entry into

11340-537: The lands west of the Appalachian Mountains that were contested by various native tribes and European colonists from the 17th century through the Northwest Indian Wars of the late 18th century. Ohio was partitioned from the Northwest Territory , the first frontier of the new United States, becoming the 17th state admitted to the Union on March 1, 1803, and the first under the Northwest Ordinance . It

11466-483: The lottery, becoming the state with the largest monetary incentive for vaccination at the time the program was implemented. However, the lottery has received its fair share of criticism, including a debate over the legality of using federal funds to fund a lottery. Since the introduction of Vax-A-Million, several other U.S. states have created similar contests, including Colorado , New York , California , Oregon , New Mexico , West Virginia and Maryland , as well as

11592-525: The movement of Natives and Americans between the Ohio Country and Thirteen Colonies had resulted in tension. Fort Pitt in Pennsylvania had become the main fort where expeditions into Ohio started. Intrusions into the area included General Edward Hand 's 1778 movement of 500 Pennsylvania militiamen from Fort Pitt towards Mingo towns on the Cuyahoga River , where the British stored military supplies which they distributed to Indian raiding parties; Colonel Daniel Brodhead 's invasion in 1780 and destruction of

11718-503: The north, Pennsylvania to the east, West Virginia to the southeast, Kentucky to the southwest, Indiana to the west, and Michigan to the northwest. Of the 50 U.S. states , it is the 34th-largest by area . With a population of nearly 11.8 million, Ohio is the seventh-most populous and tenth-most densely populated state . Its capital and most populous city is Columbus , with other large population centers including Cleveland , Cincinnati , Dayton , Akron , and Toledo . Ohio

11844-583: The northern Atlantic Ocean via Lake Erie and the St. Lawrence River , and those in southern Ohio drain into the Gulf of Mexico via the Ohio River and the Mississippi . Ohio also includes Bass Islands and Kelleys Island . Grand Lake St. Marys in the west-central part of the state was constructed as a supply of water for canals in the canal-building era of 1820–1850. This body of water, over 20 square miles (52 km ),

11970-421: The number of disease cases averted by vaccination. Study designs done to estimate herd immunity's benefit include recording disease incidence in households with a vaccinated member, randomizing a population in a single geographic area to be vaccinated or not, and observing the incidence of disease before and after beginning a vaccination program. From these, it can be observed that disease incidence may decrease to

12096-431: The number of new infections temporarily decreased. Mass vaccination to induce herd immunity has since become common and proved successful in preventing the spread of many contagious diseases. Opposition to vaccination has posed a challenge to herd immunity, allowing preventable diseases to persist in or return to populations with inadequate vaccination rates. The exact herd immunity threshold (HIT) varies depending on

12222-465: The original Warner Brothers , who set up their first movie theatre in Youngstown before the company relocated to California. The state produced many popular musicians, including Dean Martin , Doris Day , The O'Jays , Marilyn Manson , Dave Grohl , Devo , Macy Gray and The Isley Brothers . Two Ohio astronauts completed significant milestones in the space race in the 1960s: John Glenn becoming

12348-420: The population becomes immune, called the herd immunity threshold (HIT) or herd immunity level (HIL), the disease may no longer persist in the population, ceasing to be endemic . The theoretical basis for herd immunity generally assumes that vaccines induce solid immunity, that populations mix at random, that the pathogen does not evolve to evade the immune response, and that there is no non-human vector for

12474-450: The production of novel strains, referred to as escape mutants, that are able to evade herd immunity and infect previously immune individuals. The evolution of new strains is known as serotype replacement, or serotype shifting, as the prevalence of a specific serotype declines due to high levels of immunity, allowing other serotypes to replace it. At the molecular level, viruses escape from herd immunity through antigenic drift , which

12600-819: The reduction of many diseases. Some individuals either cannot develop immunity after vaccination or for medical reasons cannot be vaccinated. Newborn infants are too young to receive many vaccines, either for safety reasons or because passive immunity renders the vaccine ineffective. Individuals who are immunodeficient due to HIV/AIDS , lymphoma , leukemia , bone marrow cancer, an impaired spleen , chemotherapy , or radiotherapy may have lost any immunity that they previously had and vaccines may not be of any use for them because of their immunodeficiency. A portion of those vaccinated may not develop long-term immunity. Vaccine contraindications may prevent certain individuals from being vaccinated. In addition to not being immune, individuals in one of these groups may be at

12726-475: The rest of the state. This interesting change may be observed while traveling through Ohio on Interstate 75 from Cincinnati to Toledo ; the observant traveler of this diverse state may even catch a glimpse of Cincinnati's common wall lizard , one of the few examples of permanent "subtropical" fauna in Ohio. The worst weather disaster in Ohio history occurred along the Great Miami River in 1913. Known as

12852-523: The river as it existed in 1792. Ohio has only that portion of the river between the river's 1792 low-water mark and the present high-water mark. The border with Michigan has also changed, as a result of the Toledo War , to angle slightly northeast to the north shore of the mouth of the Maumee River. Much of Ohio features glaciated till plains , with an exceptionally flat area in the northwest being known as

12978-459: The same Bureau of Animal Industry used the term to refer to the immunity arising following recovery in cattle infected with brucellosis, also known as "contagious abortion." By 1923 it was being used by British bacteriologists to describe experimental epidemics with mice, experiments undertaken as part of efforts to model human epidemic disease. By the end of the 1920s the concept was used extensively - particularly among British scientists - to describe

13104-532: The same person. It also asks where the individual received their COVID-19 vaccination, giving the Ohio Department of Health permission to verify with the pharmacy or health care provider that the individual had been vaccinated. The drawings are being done two days before they are announced as to give the Ohio Department of Health time to verify a potential winner's vaccination. Ohio residents are not required to have received their vaccine in Ohio, but it does require that residents be "permanent" residents, and would use

13230-492: The same requirements issued by the Ohio Bureau of Motor Vehicles for driver's licenses or vehicle registrations . Less than a week after the announcement, the vaccination rate in Ohio, which had been stagnant, started to climb back up. Some proponents of the lottery have said that the giveaway has helped Ohio approach herd immunity faster by giving residents an incentive to get vaccinated. Ohio received national attention for

13356-662: The same time. The old Northwest Territory originally included areas previously known as Ohio Country and Illinois Country . As Ohio prepared for statehood, the Indiana Territory was created, reducing the Northwest Territory to approximately the size of present-day Ohio plus the eastern half of the Lower Peninsula of Michigan and the eastern tip of the Upper Peninsula and a sliver of southeastern Indiana called "The Gore". The coalition of Native American tribes, known as

13482-487: The severity of symptoms. Herd immunity is often accounted for when conducting cost–benefit analyses of vaccination programs. It is regarded as a positive externality of high levels of immunity, producing an additional benefit of disease reduction that would not occur had no herd immunity been generated in the population. Therefore, herd immunity's inclusion in cost–benefit analyses results both in more favorable cost-effectiveness or cost–benefit ratios, and an increase in

13608-571: The southern part of the state. Discovery of coal deposits aided the further development of Ohio's steel industry, and by 1853 Cleveland was the nation's third-largest iron and steel producer. The first Bessemer converter was purchased by the Cleveland Rolling Mill Company , which became part of the U.S. Steel Corporation after the merger of Federal Steel Company and Carnegie Steel , the first billion-dollar American corporation. The first open-hearth furnace used for steel production

13734-424: The state throughout the 20th century and often moved to other cities that were larger centers for their work. They included Zane Grey , Milton Caniff , George Bellows , Art Tatum , Roy Lichtenstein , and Roy Rogers . Alan Freed , who emerged from the swing dance culture in Cleveland, hosted the first live rock 'n roll concert in Cleveland in 1952. Famous filmmakers include Steven Spielberg , Chris Columbus and

13860-667: The state unemployment rate reaching a high of 37.3%. American Jews watched the rise of Nazi Germany with apprehension. Cleveland residents Jerry Siegel and Joe Shuster created the Superman comic character in the spirit of the Jewish golem . Many of their comics portrayed Superman fighting and defeating the Nazis . Approximately 839,000 Ohioans served in the U.S. armed forces during World War II , of whom over 23,000 died or were missing in action. Artists, writers, musicians and actors developed in

13986-610: The state, sometimes assimilating in part. Starting around 1809, the Shawnee pressed resistance to encroachment again. Under Chief Tecumseh , Tecumseh's War officially began in Ohio in 1811. When the War of 1812 began, the British decided to attack from Upper Canada into Ohio and merge their forces with the Shawnee. This continued until Tecumseh was killed at the Battle of the Thames in 1813. Most of

14112-541: The state. During the 18th century, the French set up a system of trading posts to control the fur trade in the region. Beginning in 1754, the Kingdom of France and Kingdom of Great Britain fought in the French and Indian War , with various Native American tribes on each side. As a result of the Treaty of Paris , the French ceded control of Ohio and the remainder of the Old Northwest to Great Britain in 1763. Before

14238-560: The success of many Republican candidates in Ohio since the late 2000s has led many to question whether Ohio remains an electoral battleground. On March 9, 2020, the COVID-19 pandemic reached Ohio, with three cases reported. As of February 2023, over 41,600 Ohioans have died from COVID-19. Ohio's economy was also heavily impacted by the pandemic, as the state saw large job losses in 2020, as well as large amounts of subsequent stimulus spending . Ohio's location has proven to be an asset for economic growth and expansion. Because it links

14364-404: The successful introduction and widespread use of a vaccine, sharp declines in the incidence of diseases it protects against can be observed, which decreases the number of hospitalizations and deaths caused by such diseases. Assuming a vaccine is 100% effective, then the equation used for calculating the herd immunity threshold can be used for calculating the vaccination level needed to eliminate

14490-585: The target sex is high. Herd immunity from female vaccination does not, however, extend to males who have sex with males. High-risk behaviors make eliminating STIs difficult because, even though most infections occur among individuals with moderate risk, the majority of transmissions occur because of individuals who engage in high-risk behaviors. For this reason, in certain populations it may be necessary to immunize high-risk individuals regardless of sex. Herd immunity itself acts as an evolutionary pressure on pathogens, influencing viral evolution by encouraging

14616-471: The theoretical HIT is known as the overshoot . The primary way to boost levels of immunity in a population is through vaccination. Vaccination is originally based on the observation that milkmaids exposed to cowpox were immune to smallpox, so the practice of inoculating people with the cowpox virus began as a way to prevent smallpox. Well-developed vaccines provide protection in a far safer way than natural infections, as vaccines generally do not cause

14742-701: The virus, so people are not immune to the dominant circulating strain. For both influenza and norovirus , epidemics temporarily induce herd immunity until a new dominant strain emerges, causing successive waves of epidemics. As this evolution poses a challenge to herd immunity, broadly neutralizing antibodies and "universal" vaccines that can provide protection beyond a specific serotype are in development. Initial vaccines against Streptococcus pneumoniae significantly reduced nasopharyngeal carriage of vaccine serotypes (VTs), including antibiotic-resistant types, only to be entirely offset by increased carriage of non-vaccine serotypes (NVTs). This did not result in

14868-482: The war. It contributed more soldiers per capita than any other state in the Union. In 1862, the state's morale was badly shaken in the aftermath of the Battle of Shiloh , a costly victory in which Ohio forces suffered 2,000 casualties. Later that year, when Confederate troops under the leadership of Stonewall Jackson threatened Washington, D.C., Ohio governor David Tod recruited 5,000 volunteers to provide three months of service. From July 13 to 26, 1863, towns along

14994-634: Was constructed by the Otis Steel Company in Cleveland, and by 1892, Ohio was the second-largest steel-producing state, behind Pennsylvania. Republic Steel was founded in Youngstown in 1899 and was at one point the nation's third-largest producer. Armco , now AK Steel, was founded in Middletown in 1899. The state legislature officially adopted the flag of Ohio on May 9, 1902. Dayton natives Orville and Wilbur Wright made four brief flights at Kitty Hawk, North Carolina , on December 17, 1903, inventing

15120-456: Was given the western two-thirds of the Upper Peninsula , in addition to the eastern third, which was already considered part of the territory. Ohio's central position and its population gave it an important place in the Civil War . The Ohio River was a vital artery for troop and supply movements, as were Ohio's railroads. Ohio's industry made it one of the most important states in the Union during

15246-520: Was lifting all health orders June 2, he also announced the Ohio Vax-A-Million contest. As part of the contest, five Ohioans aged 18 years or older would be selected individually over a five-week period would be rewarded $ 1 million as long as they had been vaccinated at least once. As with all other states with a state lottery , the Ohio Lottery normally only issues prizes to those aged 18 or older. As vaccines are being issued to those as young as 12,

15372-487: Was lifting all health orders as of June 2. This included the wearing of face masks in accordance with updated guidelines from the Center for Disease Control . Around the same time, the administering of the COVID-19 vaccine had started to level off to the point where supply was greater than demand, even with walk-in appointments becoming the norm for the vaccine. Therefore, during the same press conference when DeWine announced he

15498-403: Was the capital from 1803 to 1810. The capital was then moved to Zanesville for two years as part of a state legislative compromise to get a bill passed. The capital was then moved back to Chillicothe from 1812 to 1816. Finally, the capital was moved to Columbus, to be near the state's geographic center. Although many Native Americans migrated west to evade American encroachment, others remained in

15624-525: Was the first post-colonial free state admitted to the union and became one of the earliest and most influential industrial powerhouses during the 20th century. Although it has transitioned to a more information- and service-based economy in the 21st century, it remains an industrial state, ranking seventh in GDP as of 2019 , with the third-largest manufacturing sector and second-largest automobile production. Modeled on its federal counterpart, Ohio's government

15750-741: Was the largest artificial lake in the world when completed in 1845. Ohio's canal-building projects were not the economic fiasco that similar efforts were in other states. Some cities, such as Dayton, owe their industrial emergence to their location on canals, and as late as 1910 interior canals carried much of the bulk freight of the state. Areas under the protection of the National Park Service include Cuyahoga Valley National Park , Hopewell Culture National Historical Park , Dayton Aviation Heritage National Historical Park , First Ladies National Historic Site , James A. Garfield National Historic Site , William Howard Taft National Historic Site , and

15876-527: Was −39 °F (−39 °C), at Milligan on February 10, 1899, during the Great Blizzard of 1899 . Herd immunity Herd immunity (also called herd effect , community immunity , population immunity , or mass immunity ) is a form of indirect protection that applies only to contagious diseases . It occurs when a sufficient percentage of a population has become immune to an infection, whether through previous infections or vaccination , that

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