115-494: Cochrane is a British international charitable organisation formed to synthesize medical research findings to facilitate evidence-based choices about health interventions involving health professionals, patients and policy makers. It includes 53 review groups that are based at research institutions worldwide. Cochrane has over 37,000 volunteer experts from around the world. The group conducts systematic reviews of healthcare interventions and diagnostic tests and publishes them in
230-907: A National Guideline Clearinghouse that followed the principles of evidence-based policies was created by AHRQ, the AMA, and the American Association of Health Plans (now America's Health Insurance Plans). In 1999, the National Institute for Clinical Excellence (NICE) was created in the UK. In the area of medical education, medical schools in Canada, the US, the UK, Australia, and other countries now offer programs that teach evidence-based medicine. A 2009 study of UK programs found that more than half of UK medical schools offered some training in evidence-based medicine, although
345-402: A 6-monthly periodical that provided brief summaries of the current state of evidence about important clinical questions for clinicians. By 2000, use of the term evidence-based had extended to other levels of the health care system. An example is evidence-based health services, which seek to increase the competence of health service decision makers and the practice of evidence-based medicine at
460-453: A book or article; in cases where the credited author or the publisher or both wish to conceal the ghostwriter's role, the ghostwriter may be asked to sign a nondisclosure contract that legally forbids any mention of the writer's role in a project. Some have made the distinction between "author" and "writer", as ghostwriter Kevin Anderson explains in a Washington Post interview: "A ghostwriter
575-534: A book will be entirely written by a ghostwriter, and the celebrity (e.g., a well-known musician or sports star) will be credited as author. Publishing companies use this strategy to increase the marketability of a book by associating it with a celebrity or well-known figure. In several countries before elections, candidates commission ghostwriters to produce autobiographies for them so as to gain visibility and exposure. One of John F. Kennedy 's books ( Profiles in Courage )
690-658: A definition that emphasized quantitative methods: "the use of mathematical estimates of the risk of benefit and harm, derived from high-quality research on population samples, to inform clinical decision-making in the diagnosis, investigation or management of individual patients." The two original definitions highlight important differences in how evidence-based medicine is applied to populations versus individuals. When designing guidelines applied to large groups of people in settings with relatively little opportunity for modification by individual physicians, evidence-based policymaking emphasizes that good evidence should exist to document
805-431: A generation of physicians to retire or die and be replaced by physicians who were trained with more recent evidence. Physicians may also reject evidence that conflicts with their anecdotal experience or because of cognitive biases – for example, a vivid memory of a rare but shocking outcome (the availability heuristic ), such as a patient dying after refusing treatment. They may overtreat to "do something" or to address
920-592: A ghostwriter for artists such as Justin Bieber , John Legend and Brandy . Currently in hip-hop, the credit given to ghostwriters varies: "silent pens might sign confidentiality clauses, appear obliquely in the liner notes, or discuss their participation freely." In some cases, liner notes credit individuals for "vocal arrangement", which may be a euphemism for ghostwriting. In the early 2010s, hip-hop ghostwriting services like Rap Rebirth appeared online, which provide recording artists who wish to purchase ghostwritten rhymes
1035-525: A ghostwriter to write a book on a topic in their professional area, to establish or enhance credibility as an expert in their field. Public officials and politicians employ "correspondence officers" to respond to the large volume of official correspondence. A number of papal encyclicals have been written by ghostwriters. A controversial and scientifically unethical practice is medical ghostwriting, where biotech or pharmaceutical companies pay professional writers to produce papers and then recruit (via payment or as
1150-399: A greater degree of anonymity. Ghost authorship also applies to the visual arts, most commonly paintings. The extent of the master artist's contribution varies widely, as little as composition adjustments and corrective brush strokes, or as much as entire works. A common practice is the use of art instruction class milieu in which the master artist makes significant contributions to the work of
1265-481: A high incidence of ghostwriting and honorary authorship. In some cases Cochrane's internal structure may make it difficult to publish studies that run against the preconceived opinions of internal subject matter experts. Cochrane maintains an official relationship with the World Health Organization that affords Cochrane the right to appoint nonvoting representatives to WHO meetings, including sessions of
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#17328799310891380-401: A lack of motivation to finish the next album), an experienced songwriter may be discreetly brought in to help. In other cases, a ghostwriter writes lyrics and a melody in the style of the credited musician, with little or no input from the credited musician. A ghostwriter providing this type of service may be thanked, without reference to the service provided, in the album credits, or they may be
1495-416: A length would have been much harder to sell before digital reader-technologies became widely available, but is now quite acceptable. Writers on the level of Ian McEwan have celebrated this recent change, mainly for artistic reasons. As a consequence, the shorter format makes a project potentially more affordable for the client/author. Manhattan Literary, a ghostwriting company, states that "book projects on
1610-644: A major part of the evaluation of particular treatments. The Cochrane Collaboration is one of the best-known organisations that conducts systematic reviews. Like other producers of systematic reviews, it requires authors to provide a detailed study protocol as well as a reproducible plan of their literature search and evaluations of the evidence. After the best evidence is assessed, treatment is categorized as (1) likely to be beneficial, (2) likely to be harmful, or (3) without evidence to support either benefit or harm. A 2007 analysis of 1,016 systematic reviews from all 50 Cochrane Collaboration Review Groups found that 44% of
1725-534: A marketing, public relations, or lobbying tool. However, since these individuals are typically too busy to write their blog posts, they hire discreet ghostwriters to post to the blog under the celebrity or executive's name. As with nonfiction ghostwriting, the blog ghostwriter models their writing style, content and tone on that of the credited author. This goes for social media as well. Many public figures have ghostwriters at least partially handle their Facebook and Twitter accounts, among others. Wolfgang Amadeus Mozart
1840-453: A multi-album contract with them and two of the songs that Neudorf worked on with her became commercial hits in Canada. In 1991, Neudorf was invited to work with McLachlan again on her second album, Solace . In 1993, he filed a lawsuit against McLachlan and her label, alleging that he had made a significant and uncredited contribution to the songwriting on Touch , and alleging that he was not paid properly for work done on Solace . The judge in
1955-798: A nominal stipend and travel expenses to support a Wikipedian in Residence at Cochrane. In 2014, the Cochrane blog hosted a rebuttal, written by four Misplaced Pages medical editors, of an article published in the Journal of the American Osteopathic Association that was critical of the accuracy of Misplaced Pages medical content. Cochrane receives funding from governments, supranational organizations , non-governmental organizations , academic institutions, hospitals, and foundations, while avoiding funding from corporate interests. Primary government donors include
2070-408: A number of assistants to do work on a piece that is credited to a single artist; Andy Warhol engaged in this practice, supervising an assembly line silk screen process for his artwork. However, when credit is established for the writer, the acknowledgment of their contribution is public domain and the writer in question would not be considered a ghostwriter. A consultant or career-switcher may pay
2185-422: A number of limitations and criticisms of evidence-based medicine. Two widely cited categorization schemes for the various published critiques of EBM include the three-fold division of Straus and McAlister ("limitations universal to the practice of medicine, limitations unique to evidence-based medicine and misperceptions of evidence-based-medicine") and the five-point categorization of Cohen, Stavri and Hersh (EBM
2300-472: A patient's emotional needs. They may worry about malpractice charges based on a discrepancy between what the patient expects and what the evidence recommends. They may also overtreat or provide ineffective treatments because the treatment feels biologically plausible. It is the responsibility of those developing clinical guidelines to include an implementation plan to facilitate uptake. The implementation process will include an implementation plan, analysis of
2415-479: A perk) other scientists or physicians to attach their names to these articles before they are published in medical or scientific journals. Some university and college students hire ghostwriters from essay mills to write entrance essays, term papers, theses, and dissertations. This is largely considered unethical unless the actual ghostwriting work is just light editing. Ghostwriters are hired for numerous reasons. In many cases, celebrities or public figures do not have
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#17328799310892530-472: A positive impact on evidence-based knowledge, skills, attitude and behavior. As a form of e-learning, some medical school students engage in editing Misplaced Pages to increase their EBM skills, and some students construct EBM materials to develop their skills in communicating medical knowledge. Ghostwriting A ghostwriter is a person hired to write literary or journalistic works, speeches, or other texts that are putatively credited to another person as
2645-467: A professor believes to be ghostwritten. If the student is unfamiliar with the content of an essay that he or she has submitted, then the student can be charged with academic fraud. With medical ghostwriting, pharmaceutical companies pay professional writers to produce papers and then pay other scientists or physicians to attach their names to these papers before they are published in medical or scientific journals. Medical ghostwriting has been criticized by
2760-483: A recent project involved people in helping identify research priorities to inform future Cochrane Reviews. The representation of women as editors in Cochrane was found to be better than that of other organizations. Evidence-based medicine Evidence-based medicine ( EBM ) is "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. ... [It] means integrating individual clinical expertise with
2875-425: A rough draft of an autobiography or a "how-to" book. In other cases, the ghostwriter will write an entire book or article based on information, stories, notes, an outline , or interview sessions with the celebrity or public figure. The credited author also indicates to the ghostwriter what type of style, tone, or "voice" they want in the book. In some cases, such as with some "how-to" books, diet guides, or cookbooks,
2990-473: A series of 28 published in JAMA between 1990 and 1997 on formal methods for designing population-level guidelines and policies. The term 'evidence-based medicine' was introduced slightly later, in the context of medical education. In the autumn of 1990, Gordon Guyatt used it in an unpublished description of a program at McMaster University for prospective or new medical students. Guyatt and others first published
3105-418: A series of ghostwriters who write books in the same style using a template of basic information about the book's characters and their fictional universe (names, dates, speech patterns), and about the tone and style that are expected in the book (for more information, see pseudonyms and pen names ). In addition, ghostwriters are often given copies of several of the previous books in the series to help them match
3220-541: A successful salesperson hoping to become a motivational speaker on selling may pay a ghostwriter to write a book on sales techniques. Often this type of book is published by a self-publishing press (or " vanity press "), which means that the author is paying to have the book published. This type of book is typically given away to prospective clients as a promotional tool, rather than being sold in bookstores. Ghostwriters are employed by fiction publishers for several reasons. In some cases, publishers use ghostwriters to increase
3335-492: A systematic review, to consider the impact of different factors on their confidence in the results. Authors of GRADE tables assign one of four levels to evaluate the quality of evidence, on the basis of their confidence that the observed effect (a numeric value) is close to the true effect. The confidence value is based on judgments assigned in five different domains in a structured manner. The GRADE working group defines 'quality of evidence' and 'strength of recommendations' based on
3450-541: A test's or treatment's effectiveness. In the setting of individual decision-making, practitioners can be given greater latitude in how they interpret research and combine it with their clinical judgment. In 2005, Eddy offered an umbrella definition for the two branches of EBM: "Evidence-based medicine is a set of principles and methods intended to ensure that to the greatest extent possible, medical decisions, guidelines, and other types of policies are based on and consistent with good evidence of effectiveness and benefit." In
3565-464: A treatment is either not safe or not effective, it may take many years for other treatments to be adopted. There are many factors that contribute to lack of uptake or implementation of evidence-based recommendations. These include lack of awareness at the individual clinician or patient (micro) level, lack of institutional support at the organisation level (meso) level or higher at the policy (macro) level. In other cases, significant change can require
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3680-437: A true 'ghost', with no acknowledgement in the album. Legal disputes have arisen when musical ghostwriters have tried to claim royalties when an allegedly ghostwritten song becomes a money-making hit. In 1987, Darryl Neudorf was asked to work on a project for Nettwerk Productions involving newly signed artist Sarah McLachlan . This recording, the album Touch , resulted in garnering the interest of Arista Records . She signed
3795-409: A variety of professional organizations representing the drug industry, publishers, and medical societies, and it may violate American laws prohibiting off-label promotion by drug manufacturers as well as anti-kickback provisions within the statutes governing Medicare. Recently, it has attracted scrutiny from the lay press and from lawmakers, as well. It is permitted at some institutions, including
3910-413: A website. Nonetheless, the style, tone and content is modeled on that of the credited author. Many website ghostwriters are freelance but some are freelancers who work under contract, as with radio presenters and television presenters. Occasionally a "house pseudonym", or collective name is used by the author of the website. Some celebrities, executives, or public figures set up blog websites—sometimes as
4025-526: A wide range of biases and constraints, from trials only being able to study a small set of questions amenable to randomisation and generally only being able to assess the average treatment effect of a sample, to limitations in extrapolating results to another context, among many others outlined in the study. Despite the emphasis on evidence-based medicine, unsafe or ineffective medical practices continue to be applied, because of patient demand for tests or treatments, because of failure to access information about
4140-599: Is a confidentiality clause in the contract between the ghostwriter and the credited author (or publisher) that obligates the former to remain anonymous, or obligates the latter to not reveal the ghostwriter. Sometimes the ghostwriter is acknowledged by the author or publisher for their writing services, euphemistically called a "researcher" or "research assistant", but often the ghostwriter is not credited. Ghostwriting (or simply "ghosting") also occurs in other creative fields. Composers have long hired ghostwriters to help them to write musical pieces and songs; Wolfgang Amadeus Mozart
4255-419: Is a poor philosophic basis for medicine, defines evidence too narrowly, is not evidence-based, is limited in usefulness when applied to individual patients, or reduces the autonomy of the doctor/patient relationship). In no particular order, some published objections include: A 2018 study, "Why all randomised controlled trials produce biased results", assessed the 10 most cited RCTs and argued that trials face
4370-399: Is a tool that helps in visualizing the hierarchy of evidence in medicine, from least authoritative, like expert opinions, to most authoritative, like systematic reviews. Medicine has a long history of scientific inquiry about the prevention, diagnosis, and treatment of human disease. In the 11th century AD, Avicenna , a Persian physician and philosopher, developed an approach to EBM that
4485-541: Is accepted as legitimate by organisations such as the World Association of Medical Editors and the British Medical Journal . Moreover, professional medical writers' expertise in presenting scientific data may be of benefit in producing better quality papers. Some websites, including blogs , are ghostwritten, because not all authors have the information technology skills or the time to dedicate to running
4600-546: Is almost entirely credited to ghostwriters. Donald Trump 's autobiography Trump: The Art of the Deal was produced by a ghostwriter. Several of Hillary Clinton's books were produced by ghostwriters. Nelson Mandela 's autobiography ( Long Walk to Freedom ) was also produced by a ghostwriter. A consultant or career-switcher may pay to have a book ghostwritten on a topic in their professional area, to establish or enhance their credibility as an "expert" in their field. For example,
4715-414: Is also common in television, as composers listed on cue sheets are entitled to music royalties every time an episode or theme score appears on television. A 1998 investigation by The Hollywood Reporter revealed that it was especially prevalent among animation companies such as Saban Entertainment , DiC , Ruby-Spears Productions and Hanna-Barbera , which often listed company executives as musicians for
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4830-433: Is an example of a well-known composer who was paid to ghostwrite music for wealthy patrons. Ghosting also occurs in popular music. A pop music ghostwriter writes lyrics and a melody in the style of the credited musician. In hip hop music, the increasing use of ghostwriters by high-profile hip-hop stars has led to controversy. In the visual arts, it is not uncommon in both fine art and commercial art such as comics for
4945-421: Is an example of a well-known composer who was paid to ghostwrite music for wealthy patrons. In the film industry, a music ghostwriter is a "person who composes music for another composer but is not credited on the cue sheet or in the final product in any way." The practice is considered one of the "dirty little secrets of the film and television music business" that is considered unethical, but has been common since
5060-444: Is an expert (however, some critics have argued that expert opinion "does not belong in the rankings of the quality of empirical evidence because it does not represent a form of empirical evidence" and continue that "expert opinion would seem to be a separate, complex type of knowledge that would not fit into hierarchies otherwise limited to empirical evidence alone."). Several organizations have developed grading systems for assessing
5175-434: Is an interpreter and a translator, not an author, which is why our clients deserve full credit for authoring their books." Ghostwriters are widely used by celebrities and public figures who wish to publish their autobiographies or memoirs. The degree of involvement of the ghostwriter in nonfiction writing projects ranges from minor to substantial. In some cases, a ghostwriter may be called in just to clean up, edit, and polish
5290-462: Is considered to be academic dishonesty and can lead to repercussions if detected by universities, although it is not illegal in the United States, United Kingdom and Germany. There are ghostwriting companies and freelancers that sell entrance essays, term papers, theses and dissertations to students. Such services are commonly known as " essay mills ". Although academic ghostwriting involves
5405-437: Is provided by systematic review of randomized , well-blinded, placebo-controlled trials with allocation concealment and complete follow-up involving a homogeneous patient population and medical condition. In contrast, patient testimonials, case reports , and even expert opinion have little value as proof because of the placebo effect, the biases inherent in observation and reporting of cases, and difficulties in ascertaining who
5520-448: The Bay of Biscay . Lind divided the sailors participating in his experiment into six groups, so that the effects of various treatments could be fairly compared. Lind found improvement in symptoms and signs of scurvy among the group of men treated with lemons or oranges. He published a treatise describing the results of this experiment in 1753. An early critique of statistical methods in medicine
5635-598: The Campbell Collaboration joined with the CEMG to form the Campbell & Cochrane Economics Methods Group (CCEMG). In 2013 the organization published an editorial describing its efforts to train people in developing nations to perform Cochrane reviews. A 2017 editorial briefly discussed the history of Cochrane methodological approaches, such as including studies that use methodologies in lieu of randomised control trials and
5750-599: The Cochrane Library . According to the Library, articles are available via one-click access, but some require paid subscription or registration before reading. A few reviews, in occupational health for example, incorporate results from non-randomised observational studies as well as controlled before–after (CBA) studies and interrupted time-series studies. Cochrane, previously known as the Cochrane Collaboration,
5865-649: The University of Washington School of Medicine , while it is prohibited and considered a particularly pernicious form of plagiarism at others, such as Tufts University School of Medicine . Professional medical writers can write papers without being listed as authors of the paper and without being considered ghostwriters, provided their role is acknowledged. The European Medical Writers Association have published guidelines which aim to ensure professional medical writers carry out this role in an ethical and responsible manner. The use of properly acknowledged medical writers
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#17328799310895980-983: The World Health Assembly , and make statements on WHO resolutions. In 2014, the Cochrane-Misplaced Pages partnership was formalised. This supports the inclusion of relevant evidence within all Misplaced Pages medical articles, as well as processes to help ensure that medical information included in Misplaced Pages is of the highest quality and accuracy. Misplaced Pages and Cochrane collaborate to increase the incorporation of Cochrane research into Misplaced Pages articles and provide Misplaced Pages editors with resources for interpreting medical data. Cochrane and John Wiley and Sons, publisher of Cochrane reviews, make one hundred free Cochrane accounts available to Misplaced Pages medical editors—the financial value of which has been estimated by Cochrane at between thirty thousand and eighty thousand US dollars per annum—and pay
6095-437: The "perversion of hip-hop by commerce." This is because of the limiting definition of "rapping" as "expressing yourself through your own words, not someone else's." Chuck D of Public Enemy thinks this point of view is mistaken because "not everyone is equipped to be a lyricist and not everyone is equipped to be a vocalist." He points out that creating a rap song may require multiple talents. Frank Ocean started his career as
6210-603: The American College of Physicians, and voluntary health organizations such as the American Heart Association, wrote many evidence-based guidelines. In 1991, Kaiser Permanente , a managed care organization in the US, began an evidence-based guidelines program. In 1991, Richard Smith wrote an editorial in the British Medical Journal and introduced the ideas of evidence-based policies in the UK. In 1993,
6325-513: The Cochrane Collaboration created a network of 13 countries to produce systematic reviews and guidelines. In 1997, the US Agency for Healthcare Research and Quality (AHRQ, then known as the Agency for Health Care Policy and Research, or AHCPR) established Evidence-based Practice Centers (EPCs) to produce evidence reports and technology assessments to support the development of guidelines. In the same year,
6440-556: The Evidence-Based Medicine Working Group at McMaster University published the methods to a broad physician audience in a series of 25 "Users' Guides to the Medical Literature" in JAMA . In 1995 Rosenberg and Donald defined individual-level, evidence-based medicine as "the process of finding, appraising, and using contemporaneous research findings as the basis for medical decisions." In 2010, Greenhalgh used
6555-608: The General of the Society of Jesus who had chosen Gundlach and Desbuquois for the project. The draft encyclical was delivered to the Vatican in September 1938. Sebastian Tromp , a Dutch Jesuit, a Thomist theologian and close to Pius XII , is considered to be the main ghostwriter of Mystici corporis . Michel-Louis Guérard des Lauriers , one of the Vatican's leading theologians of that time,
6670-673: The Gerber Foundation. Cochrane involves patients and the public via community curation , to produce systematic reviews and other outputs. Tasks can be organised as 'entry level' or higher. Tasks include: A recent systematic review of how people were involved in systematic reviews aimed to document the evidence-base relating to stakeholder involvement in systematic reviews and to use this evidence to describe how stakeholders have been involved in systematic reviews. Thirty per cent involved patients and/or carers. While there has been some criticism of how Cochrane prioritises systematic reviews,
6785-763: The United Kingdom's National Institute for Health and Care Research (NIHR), the Danish Health Authority , the Federal Ministry of Health (Germany) , and the National Institutes of Health (NIH). Academic funders include McMaster University , Amsterdam University Medical Centers , Kazan Federal University , and University of Copenhagen , among others. Funding from foundations includes the National Research Foundation (South Africa) and
6900-439: The amount of payment to the book ghostwriter for whom the credit has its own intrinsic value. Also, the ghostwriter can be cited as a co-author of a book, or listed in the movie or film credits when having ghostwritten the script or screenplay for film production. For nonfiction books, the ghostwriter may be credited as a "contributor" or a "research assistant". In other cases, the ghostwriter receives no official credit for writing
7015-617: The area of evidence-based guidelines and policies, the explicit insistence on evidence of effectiveness was introduced by the American Cancer Society in 1980. The U.S. Preventive Services Task Force (USPSTF) began issuing guidelines for preventive interventions based on evidence-based principles in 1984. In 1985, the Blue Cross Blue Shield Association applied strict evidence-based criteria for covering new technologies. Beginning in 1987, specialty societies such as
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#17328799310897130-579: The author. Celebrities, executives, participants in timely news stories, and political leaders often hire ghostwriters to draft or edit autobiographies , memoirs , magazine articles, or other written material. Memoir ghostwriters often pride themselves in "disappearing" when impersonating others since such disappearance signals the quality of their craftsmanship. In music, ghostwriters are often used to write songs, lyrics, and instrumental pieces. Screenplay authors can also use ghostwriters to either edit or rewrite their scripts to improve them. Usually, there
7245-399: The basis for governmentality in health care, and consequently play a central role in the governance of contemporary health care systems. The steps for designing explicit, evidence-based guidelines were described in the late 1980s: formulate the question (population, intervention, comparison intervention, outcomes, time horizon, setting); search the literature to identify studies that inform
7360-449: The best available external clinical evidence from systematic research." The aim of EBM is to integrate the experience of the clinician, the values of the patient , and the best available scientific information to guide decision-making about clinical management. The term was originally used to describe an approach to teaching the practice of medicine and improving decisions by individual physicians about individual patients. The EBM Pyramid
7475-563: The best available external clinical evidence from systematic research." This branch of evidence-based medicine aims to make individual decision making more structured and objective by better reflecting the evidence from research. Population-based data are applied to the care of an individual patient, while respecting the fact that practitioners have clinical expertise reflected in effective and efficient diagnosis and thoughtful identification and compassionate use of individual patients' predicaments, rights, and preferences. Between 1993 and 2000,
7590-407: The board to cut two appointed members in order to comply with the ratio of elected to appointed members required by the organization's charter. Gøtzsche announced that this had happened via an open letter, in which he said there is a "growing top-down authoritarian culture and an increasingly commercial business model" taking root at Cochrane that "threaten the scientific, moral and social objectives of
7705-580: The challenge of having evidence adopted in practice. During its 2018 annual meeting, the Cochrane board expelled Peter C. Gøtzsche , board member and director of Cochrane's Nordic center, from the organization, telling Nature that it had received "numerous complaints" about Gøtzsche after he co-authored an article in BMJ Evidence-Based Medicine alleging bias in Cochrane's May 2018 review of HPV vaccines . Gøtzsche's expulsion led four elected board members to resign in protest, which in turn led
7820-611: The context, identifying barriers and facilitators and designing the strategies to address them. Training in evidence based medicine is offered across the continuum of medical education. Educational competencies have been created for the education of health care professionals. The Berlin questionnaire and the Fresno Test are validated instruments for assessing the effectiveness of education in evidence-based medicine. These questionnaires have been used in diverse settings. A Campbell systematic review that included 24 trials examined
7935-418: The early stages of the film industry. In the early years of film, David Raksin worked as music ghostwriter and orchestrator for Charlie Chaplin ; even though Chaplin was credited as the score writer, he was considered to be a "hummer" (pejorative film industry slang for a person who purports to be a film score composer but who in fact only gives a general idea of the melodies to a ghostwriter). The practice
8050-403: The effectiveness of e-learning in improving evidence-based health care knowledge and practice. It was found that e-learning, compared to no learning, improves evidence-based health care knowledge and skills but not attitudes and behaviour. No difference in outcomes is present when comparing e-learning with face-to-face learning. Combining e-learning and face-to-face learning (blended learning) has
8165-465: The end of the 1980s, a group at RAND showed that large proportions of procedures performed by physicians were considered inappropriate even by the standards of their own experts. David M. Eddy first began to use the term 'evidence-based' in 1987 in workshops and a manual commissioned by the Council of Medical Specialty Societies to teach formal methods for designing clinical practice guidelines. The manual
8280-416: The evidence, or because of the rapid pace of change in the scientific evidence. For example, between 2003 and 2017, the evidence shifted on hundreds of medical practices, including whether hormone replacement therapy was safe, whether babies should be given certain vitamins, and whether antidepressant drugs are effective in people with Alzheimer's disease . Even when the evidence unequivocally shows that
8395-521: The extent to which it is feasible to incorporate individual-level information in decisions. Thus, evidence-based guidelines and policies may not readily "hybridise" with experience-based practices orientated towards ethical clinical judgement, and can lead to contradictions, contest, and unintended crises. The most effective "knowledge leaders" (managers and clinical leaders) use a broad range of management knowledge in their decision making, rather than just formal evidence. Evidence-based guidelines may provide
8510-497: The following system: GRADE guideline panelists may make strong or weak recommendations on the basis of further criteria. Some of the important criteria are the balance between desirable and undesirable effects (not considering cost), the quality of the evidence, values and preferences and costs (resource utilization). Despite the differences between systems, the purposes are the same: to guide users of clinical research information on which studies are likely to be most valid. However,
8625-449: The future of book publishing. So, with its appearance the starting price for the professional book writer has come down by about half, but only if this shorter format makes sense for the client. On the upper end of the spectrum, with celebrities that can all but guarantee a publisher large sales, the fees can be much higher. In 2001, The New York Times stated that the fee that the ghostwriter for Hillary Clinton 's memoirs would receive
8740-431: The individual studies still require careful critical appraisal. Evidence-based medicine attempts to express clinical benefits of tests and treatments using mathematical methods. Tools used by practitioners of evidence-based medicine include: Evidence-based medicine attempts to objectively evaluate the quality of clinical research by critically assessing techniques reported by researchers in their publications. There are
8855-537: The lack of controlled trials supporting many practices that had previously been assumed to be effective. In 1973, John Wennberg began to document wide variations in how physicians practiced. Through the 1980s, David M. Eddy described errors in clinical reasoning and gaps in evidence. In the mid-1980s, Alvin Feinstein, David Sackett and others published textbooks on clinical epidemiology , which translated epidemiological methods to physician decision-making. Toward
8970-417: The medical policy documents of major US private payers were informed by Cochrane systematic reviews, there was still scope to encourage the further use. Evidence-based medicine categorizes different types of clinical evidence and rates or grades them according to the strength of their freedom from the various biases that beset medical research. For example, the strongest evidence for therapeutic interventions
9085-424: The methods and content varied considerably, and EBM teaching was restricted by lack of curriculum time, trained tutors and teaching materials. Many programs have been developed to help individual physicians gain better access to evidence. For example, UpToDate was created in the early 1990s. The Cochrane Collaboration began publishing evidence reviews in 1993. In 1995, BMJ Publishing Group launched Clinical Evidence,
9200-408: The name of well-known, highly marketable authors, or to quickly release a topical book that ties in with a recent or upcoming newsworthy event. Ghostwriters will often spend from several months to a full year researching, writing, and editing non-fiction and fiction works for a client, and they are paid based on a price per hour, per word, or per page, with a flat fee, a percentage of the royalties of
9315-573: The number of books that can be published each year by a well-known, highly marketable author. Ghostwriters mostly pen fictional works for well-known "name" authors in genres such as detective fiction, mysteries, and teen fiction. Additionally, publishers use ghostwriters to write new books for established series where the "author" is a pseudonym. For example, the purported authors of the Nancy Drew and Hardy Boys mysteries, " Carolyn Keene " and " Franklin W. Dixon ", respectively, are actually pseudonyms for
9430-589: The organization". Gøtzsche remains an outspoken critic of Cochrane's relationship with the pharmaceutical industry. The Cochrane board stated that Gøtzsche was expelled for his behavior, which had been reviewed by an independent counsel hired by Cochrane. A 2004 editorial in the Canadian Medical Association Journal noted that Cochrane reviews appear to be more up to date and of better quality than other reviews, describing them as "the best single resource for methodologic research and for developing
9545-682: The organizational or institutional level. The multiple tributaries of evidence-based medicine share an emphasis on the importance of incorporating evidence from formal research in medical policies and decisions. However, because they differ on the extent to which they require good evidence of effectiveness before promoting a guideline or payment policy, a distinction is sometimes made between evidence-based medicine and science-based medicine, which also takes into account factors such as prior plausibility and compatibility with established science (as when medical organizations promote controversial treatments such as acupuncture ). Differences also exist regarding
9660-479: The others to yours; I will cure them without blood-letting and sensible evacuation; but you do, as ye know ... we shall see how many Funerals both of us shall have... The first published report describing the conduct and results of a controlled clinical trial was by James Lind , a Scottish naval surgeon who conducted research on scurvy during his time aboard HMS Salisbury in the Channel Fleet , while patrolling
9775-399: The policy to evidence instead of standard-of-care practices or the beliefs of experts. The pertinent evidence must be identified, described, and analyzed. The policymakers must determine whether the policy is justified by the evidence. A rationale must be written." He discussed evidence-based policies in several other papers published in JAMA in the spring of 1990. Those papers were part of
9890-467: The previous steps; implement the guideline. For the purposes of medical education and individual-level decision making, five steps of EBM in practice were described in 1992 and the experience of delegates attending the 2003 Conference of Evidence-Based Health Care Teachers and Developers was summarized into five steps and published in 2005. This five-step process can broadly be categorized as follows: Systematic reviews of published research studies are
10005-546: The process of finding evidence feasible and its results explicit. In 2011, an international team redesigned the Oxford CEBM Levels to make them more understandable and to take into account recent developments in evidence ranking schemes. The Oxford CEBM Levels of Evidence have been used by patients and clinicians, as well as by experts to develop clinical guidelines, such as recommendations for the optimal use of phototherapy and topical therapy in psoriasis and guidelines for
10120-439: The purpose of royalties. In the late 1990s, several composers threatened a multimillion-dollar lawsuit against Saban Entertainment president Haim Saban , for allegedly taking ownership and credit for their musical compositions. Musical ghostwriting also occurs in popular music . When a record company wants to market an inexperienced young singer as a singer-songwriter, or help a veteran bandleader coping with writer's block (or
10235-403: The quality as two different concepts that are commonly confused with each other. Systematic reviews may include randomized controlled trials that have low risk of bias, or observational studies that have high risk of bias. In the case of randomized controlled trials, the quality of evidence is high but can be downgraded in five different domains. In the case of observational studies per GRADE,
10350-422: The quality of evidence starts off lower and may be upgraded in three domains in addition to being subject to downgrading. Meaning of the levels of quality of evidence as per GRADE: In guidelines and other publications, recommendation for a clinical service is classified by the balance of risk versus benefit and the level of evidence on which this information is based. The U.S. Preventive Services Task Force uses
10465-619: The quality of evidence. For example, in 1989 the U.S. Preventive Services Task Force (USPSTF) put forth the following system: Another example are the Oxford CEBM Levels of Evidence published by the Centre for Evidence-Based Medicine . First released in September 2000, the Levels of Evidence provide a way to rank evidence for claims about prognosis, diagnosis, treatment benefits, treatment harms, and screening, which most grading schemes do not address. The original CEBM Levels were Evidence-Based On Call to make
10580-411: The question; interpret each study to determine precisely what it says about the question; if several studies address the question, synthesize their results ( meta-analysis ); summarize the evidence in evidence tables; compare the benefits, harms and costs in a balance sheet; draw a conclusion about the preferred practice; write the guideline; write the rationale for the guideline; have others review each of
10695-405: The recent shift into the digital age (15–20% world market share of books by 2015) has brought some changes, by opening newer markets that bring their own opportunities for authors and writers —especially on the more affordable side of the ghostwriting business. One such market is the shorter book, best represented at the moment by Amazon's Kindle Singles imprint: texts of 30,000 words and under. Such
10810-399: The reviews concluded that the intervention was likely to be beneficial, 7% concluded that the intervention was likely to be harmful, and 49% concluded that evidence did not support either benefit or harm. 96% recommended further research. In 2017, a study assessed the role of systematic reviews produced by Cochrane Collaboration to inform US private payers' policymaking; it showed that although
10925-735: The sale of academic texts that are written on demand, it differs from plagiarism in that it does not involve an undisclosed appropriation of existing texts. As opposed to cases of plagiarism that stem from a copy-and-paste reuse of previous work, essays and assignments that are obtained through ghostwriting services as a rule have the originality of their text confirmed by plagiarism detection software packages or online services that are widely used by universities. Universities have developed strategies to combat such academic services, which can be associated with academic fraud , that are offered to students and researchers. Some universities allow professors to give students oral examinations on papers which
11040-492: The sales, or some combination thereof. In 2013, literary agent Madeleine Morel stated that the average ghostwriter's advance for work for major book publishers was "between $ 40,000 and $ 70,000". These benchmark prices are mirrored approximately in the film industry by the Writers Guild, where a Minimum Basic Agreement gives a starting price for the screenplay writer of $ 37,073 (non-original screenplay, no treatment). However,
11155-691: The same pseudonym. The first two books in the Tom Clancy's Splinter Cell franchise were written by Raymond Benson under the pseudonym David Michaels . Sometimes famous authors will ghostwrite for other celebrities, such as when H. P. Lovecraft ghostwrote "Imprisoned with the Pharaohs" (also known as "Under the Pyramids") for Harry Houdini in Weird Tales in the 1920s. A number of papal encyclicals have been written by ghostwriters. Pascendi , for instance,
11270-452: The science of meta- epidemiology " and crediting them with leading to methodological improvements in the medical literature. Studies comparing the quality of Cochrane meta-analyses in the fields of infertility , physiotherapy , and orthodontics to those published by other sources have concluded that Cochrane reviews incorporate superior methodological rigor. A broader analysis across multiple therapeutic areas reached similar conclusions but
11385-470: The shorter side, tailored to new markets like the Kindle Singles imprint and others (30,000–42,000 words) start at a cost of $ 15,000". And this shorter book appears to be here to stay. It was once financially impractical for publishers to produce such novella -length texts (they would have to charge too much); but this new market is, by 2015, already substantial and has been projected to be a solid part of
11500-444: The student who then signs that work as his or her own. Services addressing complete works have historically been highly confidential. Less prevalent are advertised commercial services which may use the term "vanity artwork" as suggestive of "vanity publishing". In countries where freedom of speech is not upheld and authors that have somehow displeased the ruling regime are "blacklisted" (i.e. forbidden from having their works published),
11615-461: The style. The estate of gothic novelist V. C. Andrews hired ghostwriter Andrew Neiderman to continue writing novels after her death, under her name and in a similar style to her original works. Many of action writer Tom Clancy 's books from the 2000s bear the names of two people on their covers, with Clancy's name in larger print and the other author's name in smaller print. Various books bearing Clancy's name were written by different authors under
11730-508: The suit eventually ruled in McLachlan's favour on the songs; stating that although Neudorf may have contributed to the songwriting, neither regarded each other as joint authors. The judge ruled in Neudorf's favour on the payment issue. In hip hop music , the increasing use of ghostwriters by high-profile hip hop stars has led to controversy. Critics view the increasing use of hip hop ghostwriters as
11845-403: The term two years later (1992) to describe a new approach to teaching the practice of medicine. In 1996, David Sackett and colleagues clarified the definition of this tributary of evidence-based medicine as "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. ... [It] means integrating individual clinical expertise with
11960-428: The time, discipline, or writing skills to write and research a several hundred-page autobiography or "how-to" book. Even if a celebrity or public figure has the writing skills to pen a short article, they may not know how to structure and edit a several hundred-page book so that it is captivating and well-paced. In other cases, publishers use ghostwriters to increase the number of books that can be published each year under
12075-526: The use of the BCLC staging system for diagnosing and monitoring hepatocellular carcinoma in Canada. In 2000, a system was developed by the Grading of Recommendations Assessment, Development and Evaluation ( GRADE ) working group. The GRADE system takes into account more dimensions than just the quality of medical research. It requires users who are performing an assessment of the quality of evidence, usually as part of
12190-421: The writer comes from a culture and first language that are entirely different from the client's. In some cases, ghostwriters are allowed to share credit. For example, a common method is to put the client/author's name on a book cover as the main byline (by [a uthor's name ]) and then to put the ghostwriter's name underneath it (with [g hostwriter's name ]). Sometimes this is done in lieu of pay or to decrease
12305-626: Was eventually published by the American College of Physicians . Eddy first published the term 'evidence-based' in March 1990, in an article in the Journal of the American Medical Association ( JAMA ) that laid out the principles of evidence-based guidelines and population-level policies, which Eddy described as "explicitly describing the available evidence that pertains to a policy and tying
12420-682: Was founded in 1993 under the leadership of Iain Chalmers . It was developed in response to Archie Cochrane 's call for up-to-date, systematic reviews of all relevant randomised controlled trials in the field of healthcare. In 1998, the Cochrane Economics Methods Group (CEMG) was established to facilitate the basing of decisions on health economics , evidence-based medicine , and systematic reviews . Cochrane's suggestion that methods used to prepare and maintain reviews of controlled trials in pregnancy and childbirth be applied more widely
12535-597: Was mostly similar to current ideas and practises. The concept of a controlled clinical trial was first described in 1662 by Jan Baptist van Helmont in reference to the practice of bloodletting . Wrote Van Helmont: Let us take out of the Hospitals, out of the Camps, or from elsewhere, 200, or 500 poor People, that have fevers or Pleuritis. Let us divide them in Halfes, let us cast lots, that one halfe of them may fall to my share, and
12650-527: Was performed by Cochrane authors. Compared to non-Cochrane reviews, those from Cochrane are less likely to reach a positive conclusion about the utility of medical interventions. Key criticisms that have been directed at Cochrane's studies include a failure to include a sufficiently large number of unpublished studies, failure to pre-specify or failure to abide by pre-specified rules for endpoint or trial inclusion, insufficiently frequent updating of reviews, an excessively high percentage of inconclusive reviews, and
12765-517: Was probably about $ 500,000 of her book's $ 8 million advance, which "is near the top of flat fees paid to collaborators". A recent availability also exists, of outsourcing many kinds of jobs, including ghostwriting, to offshore locations like India, China, and the Philippines where the customer can save money. The true tests of credibility—the writer's track record, and samples of his or her craft—become even more important in these instances, when
12880-523: Was published in 1835, in Comtes Rendus de l’Académie des Sciences, Paris, by a man referred to as "Mr Civiale". The term 'evidence-based medicine' was introduced in 1990 by Gordon Guyatt of McMaster University . Alvan Feinstein 's publication of Clinical Judgment in 1967 focused attention on the role of clinical reasoning and identified biases that can affect it. In 1972, Archie Cochrane published Effectiveness and Efficiency , which described
12995-593: Was responsible for the critical study of the New Mass of Pope Paul VI , commonly known as the Ottaviani Intervention , after the supposed attribution to Cardinals Alfredo Ottaviani and Antonio Bacci . The Vatican later answered these accusations and Cardinal Ottaviani later regretted that his name was misused to berate the pope, of which, his questions about the Pauline Mass were already clarified. Ghostwriting
13110-562: Was taken up by the Research and Development Programme, initiated to support the National Health Service . Through the NHS research and development programme, led by Michael Peckham , funds were provided to establish a "Cochrane Centre", to collaborate with others, in the UK and elsewhere, to facilitate systematic reviews of randomised controlled trials across all areas of healthcare. In 2004,
13225-612: Was written by Joseph Lemius (1860–1923), the procurator in Rome of the Oblates of Mary Immaculate . In June 1938, Pius XI summoned American Jesuit John La Farge , who began to prepare a draft of Humani generis unitas , which LaFarge and two other Jesuits—Gustav Gundlach and Gustave Desbuquois —on in Paris; the draft was approximately 100 pages long. Another Jesuit translated the draft encyclical into Latin, presenting it to Wlodimir Ledóchowski , then
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