106-455: 35°53′23″S 140°05′37″E / 35.889850°S 140.093530°E / -35.889850; 140.093530 ( Ninety Mile Desert ) The Ninety Mile Desert is an area in the Australian state of South Australia . It is described either as a desert or as a plain and which has been officially known as Coonalpyn Downs since 1949. This South Australia geography article
212-659: A Learning City . The number of international students studying in Adelaide has increased rapidly in recent years to 30,726 in 2015, of which 1,824 were secondary school students. Foreign institutions have been attracted to set up campuses to increase its attractiveness as an education hub. Adelaide is the birthplace of three Nobel laureates, more than any other Australian city : physicist William Lawrence Bragg and pathologists Howard Florey and Robin Warren , all of whom completed secondary and tertiary education at St Peter's College and
318-507: A circular mitochondrial genome. Medusozoa and calcarea clades however include species with linear mitochondrial chromosomes. With a few exceptions, animals have 37 genes in their mitochondrial DNA: 13 for proteins , 22 for tRNAs , and 2 for rRNAs . Mitochondrial genomes for animals average about 16,000 base pairs in length. The anemone Isarachnanthus nocturnus has the largest mitochondrial genome of any animal at 80,923 bp. The smallest known mitochondrial genome in animals belongs to
424-585: A database) to determine maternal lineage. Most often, the comparison is made with the revised Cambridge Reference Sequence . Vilà et al. have published studies tracing the matrilineal descent of domestic dogs from wolves. The concept of the Mitochondrial Eve is based on the same type of analysis, attempting to discover the origin of humanity by tracking the lineage back in time. Entities subject to uniparental inheritance and with little to no recombination may be expected to be subject to Muller's ratchet ,
530-500: A donor female, and nuclear DNA from the mother and father. In the spindle transfer procedure, the nucleus of an egg is inserted into the cytoplasm of an egg from a donor female which has had its nucleus removed, but still contains the donor female's mtDNA. The composite egg is then fertilized with the male's sperm. The procedure is used when a woman with genetically defective mitochondria wishes to procreate and produce offspring with healthy mitochondria. The first known child to be born as
636-571: A eukaryotic cell; most of the DNA is in the cell nucleus , and, in plants and algae, the DNA also is found in plastids , such as chloroplasts . Human mitochondrial DNA was the first significant part of the human genome to be sequenced. This sequencing revealed that human mtDNA has 16,569 base pairs and encodes 13 proteins . As in other vertebrates, the human mitochondrial genetic code differs slightly from nuclear DNA. Since animal mtDNA evolves faster than nuclear genetic markers, it represents
742-435: A finding that has been rejected by other scientists. In sexual reproduction , mitochondria are normally inherited exclusively from the mother; the mitochondria in mammalian sperm are usually destroyed by the egg cell after fertilization. Also, mitochondria are present solely in the midpiece, which is used for propelling the sperm cells, and sometimes the midpiece, along with the tail, is lost during fertilization. In 1999 it
848-413: A four-yearly basis, are responsible for local roads and stormwater management, waste collection, planning and development, fire prevention and hazard management, dog and cat management and control, parking control, public health and food inspections, and other services for their local communities. Councils have the power to raise revenue for their activities, which is mostly achieved through "council rates",
954-434: A genome suggests that complete gene loss is possible, and transferring mitochondrial genes to the nucleus has several advantages. The difficulty of targeting remotely-produced hydrophobic protein products to the mitochondrion is one hypothesis for why some genes are retained in mtDNA; colocalisation for redox regulation is another, citing the desirability of localised control over mitochondrial machinery. Recent analysis of
1060-545: A healthy human sperm has been reported to contain on average 5 molecules), degradation of sperm mtDNA in the male genital tract and in the fertilized egg; and, at least in a few organisms, failure of sperm mtDNA to enter the egg. Whatever the mechanism, this single parent ( uniparental inheritance ) pattern of mtDNA inheritance is found in most animals, most plants and also in fungi. In a study published in 2018, human babies were reported to inherit mtDNA from both their fathers and their mothers resulting in mtDNA heteroplasmy ,
1166-481: A long history of human occupation by numerous tribes and languages. The South Australian Company established a temporary settlement at Kingscote , Kangaroo Island , on 26 July 1836, five months before Adelaide was founded. The guiding principle behind settlement was that of systematic colonisation , a theory espoused by Edward Gibbon Wakefield that was later employed by the New Zealand Company . The goal
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#17328977718521272-405: A mainstay of phylogenetics and evolutionary biology . It also permits tracing the relationships of populations, and so has become important in anthropology and biogeography . Nuclear and mitochondrial DNA are thought to have separate evolutionary origins, with the mtDNA derived from the circular genomes of bacteria engulfed by the ancestors of modern eukaryotic cells. This theory is called
1378-542: A mutation in mtDNA has been used to help diagnose prostate cancer in patients with negative prostate biopsy . mtDNA alterations can be detected in the bio-fluids of patients with cancer. mtDNA is characterized by the high rate of polymorphisms and mutations. Some of which are increasingly recognized as an important cause of human pathology such as oxidative phosphorylation (OXPHOS) disorders, maternally inherited diabetes and deafness (MIDD), Type 2 diabetes mellitus, Neurodegenerative disease , heart failure and cancer. Though
1484-626: A mutational (contrary to the selective one) explanation for the observation that long-lived species have GC-rich mtDNA: long-lived species become GC-rich simply because of their biased process of mutagenesis. An association between mtDNA mutational spectrum and species-specific life-history traits in mammals opens a possibility to link these factors together discovering new life-history-specific mutagens in different groups of organisms. Deletion breakpoints frequently occur within or near regions showing non-canonical (non-B) conformations, namely hairpins, cruciforms and cloverleaf-like elements. Moreover, there
1590-521: A result of mitochondrial donation was a boy born to a Jordanian couple in Mexico on 6 April 2016. The concept that mtDNA is particularly susceptible to reactive oxygen species generated by the respiratory chain due to its proximity remains controversial. mtDNA does not accumulate any more oxidative base damage than nuclear DNA. It has been reported that at least some types of oxidative DNA damage are repaired more efficiently in mitochondria than they are in
1696-507: A role in the mitochondrial bottleneck, exploiting cell-to-cell variability to ameliorate the inheritance of damaging mutations. According to Justin St. John and colleagues, "At the blastocyst stage, the onset of mtDNA replication is specific to the cells of the trophectoderm . In contrast, the cells of the inner cell mass restrict mtDNA replication until they receive the signals to differentiate to specific cell types." The two strands of
1802-435: A species and also for identifying and quantifying the phylogeny (evolutionary relationships; see phylogenetics ) among different species. To do this, biologists determine and then compare the mtDNA sequences from different individuals or species. Data from the comparisons is used to construct a network of relationships among the sequences, which provides an estimate of the relationships among the individuals or species from which
1908-623: A stabilisation or reduction in mutant load between generations. The mechanism underlying the bottleneck is debated, with a recent mathematical and experimental metastudy providing evidence for a combination of the random partitioning of mtDNAs at cell divisions and the random turnover of mtDNA molecules within the cell. Male mitochondrial DNA inheritance has been discovered in Plymouth Rock chickens . Evidence supports rare instances of male mitochondrial inheritance in some mammals as well. Specifically, documented occurrences exist for mice, where
2014-723: A tax based on property valuations. Council rates make up about 70% of council revenue, but account for less than 4% of total taxes paid by Australians. As at December 2021 the population of South Australia was 1,806,599. A majority of the state's population lives within Greater Adelaide 's metropolitan area which had an estimated population of 1,333,927 in June 2017. Other significant population centres include Mount Gambier (29,505), Victor Harbor - Goolwa (26,334), Whyalla (21,976), Murray Bridge (18,452), Port Lincoln (16,281), Port Pirie (14,267), and Port Augusta (13,957). At
2120-448: A wide range of mtDNA genomes suggests that both these features may dictate mitochondrial gene retention. Across all organisms, there are six main mitochondrial genome types, classified by structure (i.e. circular versus linear), size, presence of introns or plasmid like structures , and whether the genetic material is a singular molecule or collection of homogeneous or heterogeneous molecules. In many unicellular organisms (e.g.,
2226-440: Is a stub . You can help Misplaced Pages by expanding it . South Australia South Australia (commonly abbreviated as SA ) is a state in the southern central part of Australia . With a total land area of 984,321 square kilometres (380,048 sq mi), it is the fourth-largest of Australia's states and territories by area, which includes some of the most arid parts of the continent, and with 1.8 million people it
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#17328977718522332-532: Is a linear genome made up of homogeneous DNA molecules (type 5). Great variation in mtDNA gene content and size exists among fungi and plants, although there appears to be a core subset of genes present in all eukaryotes (except for the few that have no mitochondria at all). In Fungi, however, there is no single gene shared among all mitogenomes. Some plant species have enormous mitochondrial genomes, with Silene conica mtDNA containing as many as 11,300,000 base pairs. Surprisingly, even those huge mtDNAs contain
2438-467: Is a well-established marker of oxidative DNA damage. In persons with amyotrophic lateral sclerosis (ALS), the enzymes that normally repair 8-oxoG DNA damages in the mtDNA of spinal motor neurons are impaired. Thus oxidative damage to mtDNA of motor neurons may be a significant factor in the etiology of ALS. Over the past decade, an Israeli research group led by Professor Vadim Fraifeld has shown that strong and significant correlations exist between
2544-472: Is also the world's fourth-largest remaining copper deposit, and the world's fifth largest gold deposit. There was a proposal to vastly expand the operations of the mine, making it the largest open-cut mine in the world, but in 2012 the BHP Billiton board decided not to go ahead with it at that time due to then lower commodity prices. The remote town of Coober Pedy produces more opal than anywhere else in
2650-487: Is data supporting the involvement of helix-distorting intrinsically curved regions and long G-tetrads in eliciting instability events. In addition, higher breakpoint densities were consistently observed within GC-skewed regions and in the close vicinity of the degenerate sequence motif YMMYMNNMMHM. Unlike nuclear DNA, which is inherited from both parents and in which genes are rearranged in the process of recombination , there
2756-582: Is flanked by the Southern Ocean , but official international consensus defines the Southern Ocean as extending north from the pole only to 60°S or 55°S, at least 17 degrees of latitude further south than the most southern point of South Australia. Thus the south coast is officially adjacent to the south-most portion of the Indian Ocean. See Southern Ocean: Existence and definitions . The southern part of
2862-514: Is observed in bivalve mollusks. In those species, females have only one type of mtDNA (F), whereas males have F type mtDNA in their somatic cells, but M type of mtDNA (which can be as much as 30% divergent) in germline cells. Paternally inherited mitochondria have additionally been reported in some insects such as fruit flies , honeybees , and periodical cicadas . An IVF technique known as mitochondrial donation or mitochondrial replacement therapy (MRT) results in offspring containing mtDNA from
2968-540: Is severely degraded. Autosomal cells only have two copies of nuclear DNA, but can have hundreds of copies of mtDNA due to the multiple mitochondria present in each cell. This means highly degraded evidence that would not be beneficial for STR analysis could be used in mtDNA analysis. mtDNA may be present in bones, teeth, or hair, which could be the only remains left in the case of severe degradation. In contrast to STR analysis, mtDNA sequencing uses Sanger sequencing . The known sequence and questioned sequence are both compared to
3074-547: Is the Mount Lofty - Flinders Ranges system, which extends north about 800 kilometres (500 mi) from Cape Jervis to the northern end of Lake Torrens . The highest point in the state is not in those ranges; Mount Woodroffe (1,435 metres (4,708 ft)) is in the Musgrave Ranges in the extreme northwest of the state. The south-western portion of the state consists of the sparsely inhabited Nullarbor Plain , fronted by
3180-425: Is the fifth-largest of the states and territories by population. This population is the second-most highly centralised in the nation after Western Australia , with more than 77% of South Australians living in the capital Adelaide or its environs. Other population centres in the state are relatively small; Mount Gambier , the second-largest centre, has a population of 26,878. South Australia shares borders with all
3286-485: Is the first multicellular organism known to have this absence of aerobic respiration and live completely free of oxygen dependency. There are three different mitochondrial genome types in plants and fungi. The first type is a circular genome that has introns (type 2) and may range from 19 to 1000 kbp in length. The second genome type is a circular genome (about 20–1000 kbp) that also has a plasmid-like structure (1 kb) (type 3). The final genome type found in plants and fungi
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3392-452: Is used in an analogous way to determine the patrilineal history.) This is usually accomplished on human mitochondrial DNA by sequencing the hypervariable control regions (HVR1 or HVR2), and sometimes the complete molecule of the mitochondrial DNA, as a genealogical DNA test . HVR1, for example, consists of about 440 base pairs. These 440 base pairs are compared to the same regions of other individuals (either specific people or subjects in
3498-510: Is usually no change in mtDNA from parent to offspring. Although mtDNA also recombines, it does so with copies of itself within the same mitochondrion. Because of this and because the mutation rate of animal mtDNA is higher than that of nuclear DNA, mtDNA is a powerful tool for tracking ancestry through females ( matrilineage ) and has been used in this role to track the ancestry of many species back hundreds of generations. mtDNA testing can be used by forensic scientists in cases where nuclear DNA
3604-517: The POLG2 gene. The replisome machinery is formed by DNA polymerase, TWINKLE and mitochondrial SSB proteins . TWINKLE is a helicase , which unwinds short stretches of dsDNA in the 5' to 3' direction. All these polypeptides are encoded in the nuclear genome. During embryogenesis , replication of mtDNA is strictly down-regulated from the fertilized oocyte through the preimplantation embryo. The resulting reduction in per-cell copy number of mtDNA plays
3710-710: The Adelaide Hills . Tomatoes , capsicums , cucumbers , brassicas , lettuce and carrots are grown on the Northern Adelaide Plains at Virginia . Almonds , citrus and stone fruit are grown in the Riverland . Potatoes , onions and carrots are grown in the Murray Mallee region. Potatoes are grown on Kangaroo Island . South Australia produces more than half of all Australian wine, including almost 80% of Australia's premium wines. South Australia has
3816-565: The British Parliament passed the South Australia Act 1834 ( Foundation Act ), which empowered His Majesty to erect and establish a province or provinces in southern Australia. The act stated that the land between 132° and 141° east longitude and from 26° south latitude to the southern ocean would be allotted to the intended colony, and it would be convict-free. In contrast to the rest of Australia, terra nullius did not apply to
3922-727: The Councillors of India . The coastline of South Australia was first mapped by Matthew Flinders and Nicolas Baudin in 1802, excepting the inlet later named the Port Adelaide River which was first discovered in 1831 by Captain Collet Barker and later accurately charted in 1836–37 by Colonel William Light , leader of the South Australian Colonization Commissioners' 'First Expedition' and first Surveyor-General of South Australia. The land which now forms
4028-656: The Governor of South Australia as his representative. It is a state of the Commonwealth of Australia . The bicameral Parliament of South Australia consists of the lower house known as the House of Assembly and the upper house known as the Legislative Council . General elections are held every four years, the last being the 2022 election . Initially, the Governor of South Australia held almost total power, derived from
4134-627: The Hornsdale Wind Farm in South Australia's Mid-North region. At the time of construction in late 2017, it was billed as the largest lithium-ion battery in the world. The Olympic Dam mine near Roxby Downs in northern South Australia is the largest deposit of uranium in the world, possessing more than a third of the world's low-cost recoverable reserves and 70% of Australia's. The mine, owned and operated by BHP , presently accounts for 9% of global uranium production. The Olympic Dam mine
4240-593: The Koonalda Cave on the Nullarbor Plain . In addition wooden spears and tools were made in an area now covered in peat bog in the South East. Kangaroo Island was inhabited long before the island was cut off by rising sea levels . According to mitochondrial DNA research, Aboriginal people reached Eyre Peninsula 49,000-45,000 years ago from both the east (clockwise, along the coast, from northern Australia) and
4346-699: The Riverland and the Adelaide Hills . See South Australian wine . South Australia has boundaries with every other Australian mainland state and territory except the Australian Capital Territory and the Jervis Bay Territory . The Western Australia border has a history involving the South Australian government astronomer, G.F. Dodwell, and the Western Australian Government Astronomer , H.B. Curlewis , marking
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4452-511: The University of Adelaide . Adelaide is home to research institutes, including the Royal Institution of Australia , established in 2009 as a counterpart to the two-hundred-year-old Royal Institution of Great Britain. Most of the research organisations are clustered in the Adelaide metropolitan area: South Australia is a constitutional monarchy with King Charles III as sovereign, and
4558-518: The ciliate Tetrahymena and the green alga Chlamydomonas reinhardtii ), and in rare cases also in multicellular organisms (e.g. in some species of Cnidaria ), the mtDNA is linear DNA . Most of these linear mtDNAs possess telomerase -independent telomeres (i.e., the ends of the linear DNA ) with different modes of replication, which have made them interesting objects of research because many of these unicellular organisms with linear mtDNA are known pathogens . Most ( bilaterian ) animals have
4664-499: The endosymbiotic theory . In the cells of extant organisms, the vast majority of the proteins in the mitochondria (numbering approximately 1500 different types in mammals ) are coded by nuclear DNA , but the genes for some, if not most, of them are thought to be of bacterial origin, having been transferred to the eukaryotic nucleus during evolution . The reasons mitochondria have retained some genes are debated. The existence in some species of mitochondrion-derived organelles lacking
4770-534: The 2016 census, 78.2% of the population spoke only English at home. The other languages most commonly spoken at home were Italian (1.7%), Standard Mandarin (1.7%), Greek (1.4%), Vietnamese (1.1%), and Cantonese (0.6%). At the 2016 census , overall 53.9% of responses identified some variant of Christianity . 9% of respondents chose not to state a religion. The most commonly nominated responses were 'No Religion' (35.4%), Catholicism (18%), Anglicanism (10%) and Uniting Church (7.1%). South Australia
4876-417: The 2016 census, the most commonly nominated ancestries were: 28.9% of the population was born overseas at the 2016 census. The five largest groups of overseas-born were from England (5.8%), India (1.6%), China (1.5%), Italy (1.1%) and Vietnam (0.9%). 2% of the population, or 34,184 people, identified as Indigenous Australians ( Aboriginal Australians and Torres Strait Islanders ) in 2016. At
4982-572: The 2020–21 financial year. This was the first time since the Australian Bureau of Statistics began collecting data in 1990 that South Australia had outperformed the other states. The recovery was driven in part by growth in the agricultural sector, which increased its production by almost 24% thanks to the end of a drought. Wheat , barley , oats , rye , peas , beans , chickpeas , lentils and canola are grown in South Australia. Apples , pears , cherries and strawberries are grown in
5088-591: The City of Adelaide is currently located. The first immigrants arrived at Holdfast Bay (near the present day Glenelg ) in November 1836. The commencement of colonial government was proclaimed on 28 December 1836, now known as Proclamation Day . South Australia is the only Australian state to have never received British convicts. Another free settlement, Swan River colony was established in 1829 but Western Australia later sought convict labour, and in 1849 Western Australia
5194-557: The German Lutheran church to this day. South Australia was the location of the first Muslim mosque in Australia. Mitochondrial DNA Mitochondrial DNA ( mtDNA and mDNA ) is the DNA located in the mitochondria organelles in a eukaryotic cell that converts chemical energy from food into adenosine triphosphate (ATP). Mitochondrial DNA is a small portion of the DNA contained in
5300-574: The Imperial Parliament enacted the Australian Colonies Government Act , which allowed for the election of representatives to each of the colonial legislatures and the drafting of a constitution to properly create representative and responsible government in South Australia. Later that year, propertied male colonists were allowed to vote for 16 members on a new 24 seat Legislative Council. Eight members continued to be appointed by
5406-558: The Revised Cambridge Reference Sequence to generate their respective haplotypes. If the known sample sequence and questioned sequence originated from the same matriline, one would expect to see identical sequences and identical differences from the rCRS. Cases arise where there are no known samples to collect and the unknown sequence can be searched in a database such as EMPOP. The Scientific Working Group on DNA Analysis Methods recommends three conclusions for describing
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#17328977718525512-543: The accumulation of deleterious mutations until functionality is lost. Animal populations of mitochondria avoid this through a developmental process known as the mtDNA bottleneck . The bottleneck exploits random processes in the cell to increase the cell-to-cell variability in mutant load as an organism develops: a single egg cell with some proportion of mutant mtDNA thus produces an embryo in which different cells have different mutant loads. Cell-level selection may then act to remove those cells with more mutant mtDNA, leading to
5618-419: The accumulation of mtDNA damage in several organs of rats. For example, dietary restriction prevented age-related accumulation of mtDNA damage in the cortex and decreased it in the lung and testis. Increased mt DNA damage is a feature of several neurodegenerative diseases . The brains of individuals with Alzheimer's disease have elevated levels of oxidative DNA damage in both nuclear DNA and mtDNA, but
5724-501: The border on the ground in the 1920s. In 1863, that part of New South Wales to the north of South Australia was annexed to South Australia, by letters patent, as the "Northern Territory of South Australia", which became shortened to the Northern Territory on 6 July 1863 . The Northern Territory was handed to the federal government in 1911 and became a separate territory. According to Australian maps, South Australia's south coast
5830-604: The cliffs of the Great Australian Bight . Features of the coast include Spencer Gulf and the Eyre and Yorke Peninsulas that surround it. The Temperate Grassland of South Australia is situated to the east of Gulf St Vincent . The principal industries and exports of South Australia are wheat, wine and wool. More than half of Australia's wines are produced in the South Australian wine regions which principally include Barossa Valley , Clare Valley , McLaren Vale , Coonawarra ,
5936-456: The coding instructions for some proteins, which may have an effect on organism metabolism and/or fitness. Mutations of mitochondrial DNA can lead to a number of illnesses including exercise intolerance and Kearns–Sayre syndrome (KSS), which causes a person to lose full function of heart, eye, and muscle movements. Some evidence suggests that they might be major contributors to the aging process and age-associated pathologies . Particularly in
6042-434: The comb jelly Vallicula multiformis , which consist of 9,961 bp. In February 2020, a jellyfish-related parasite – Henneguya salminicola – was discovered that lacks a mitochondrial genome but retains structures deemed mitochondrion-related organelles. Moreover, nuclear DNA genes involved in aerobic respiration and in mitochondrial DNA replication and transcription were either absent or present only as pseudogenes . This
6148-581: The community and enforce government regulations. Their principal role was to run the first temporary gaol, a two-room hut. The current flag of South Australia was adopted on 13 January 1904, and is a British blue ensign defaced with the state badge. The badge is described as a piping shrike with wings outstretched on a yellow disc. The state badge is believed to have been designed by Robert Craig of Adelaide's School of Design . The terrain consists largely of arid and semi-arid rangelands, with several low mountain ranges . The most important (but not tallest)
6254-714: The context of disease, the proportion of mutant mtDNA molecules in a cell is termed heteroplasmy . The within-cell and between-cell distributions of heteroplasmy dictate the onset and severity of disease and are influenced by complicated stochastic processes within the cell and during development. Mutations in mitochondrial tRNAs can be responsible for severe diseases like the MELAS and MERRF syndromes. Mutations in nuclear genes that encode proteins that mitochondria use can also contribute to mitochondrial diseases. These diseases do not follow mitochondrial inheritance patterns, but instead follow Mendelian inheritance patterns. Recently
6360-403: The differences between a known mtDNA sequence and a questioned mtDNA sequence: exclusion for two or more differences between the sequences, inconclusive if there is one nucleotide difference, or cannot exclude if there are no nucleotide differences between the two sequences. The rapid mutation rate (in animals) makes mtDNA useful for assessing genetic relationships of individuals or groups within
6466-626: The differences in animal species maximum life spans in a multiplicative manner (i.e., species maximum life span = their mtDNA GC% * metabolic rate). To support the scientific community in carrying out comparative analyses between mtDNA features and longevity across animals, a dedicated database was built named MitoAge . De novo mutations arise either due to mistakes during DNA replication or due to unrepaired damage caused in turn by endogenous and exogenous mutagens. It has been long believed that mtDNA can be particularly sensitive to damage caused by reactive oxygen species (ROS), however G>T substitutions,
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#17328977718526572-556: The establishment of their whale and seal fisheries, the South Australian Company sought, and obtained, the Commissioners' permission to send Company ships to South Australia, in advance of the surveys and ahead of the Commissioners' colonists. The company's settlement of seven vessels and 636 people was temporarily made at Kingscote on Kangaroo Island, until the official site of the capital was selected by William Light, where
6678-479: The first in the world to allow women to stand for election. In 1897 Catherine Helen Spence was the first woman in Australia to be a candidate for political office when she was nominated to be one of South Australia's delegates to the conventions that drafted the constitution. South Australia became an original state of the Commonwealth of Australia on 1 January 1901. Although the lower house had universal suffrage,
6784-403: The genetic distances of distantly related species. Statistical models that treat substitution rates among codon positions separately, can thus be used to simultaneously estimate phylogenies that contain both closely and distantly related species Mitochondrial DNA was admitted into evidence for the first time ever in a United States courtroom in 1996 during State of Tennessee v. Paul Ware . In
6890-497: The government is the party or coalition that exerts a majority in the House of Assembly. The Legislative Council remained a predominantly conservative chamber elected by property owners. Women's suffrage in Australia took a leap forward – enacted in 1895 and taking effect from the 1896 colonial election , South Australia was the first government in Australia and only the second in the world after New Zealand to allow women to vote, and
6996-526: The governor. The main responsibility of this body was to draft a constitution for South Australia. The body drafted the most democratic constitution ever seen in the British Empire and provided for universal manhood suffrage . It created the bicameral Parliament of South Australia . For the first time in the colony, the executive was elected by the people, and the colony used the Westminster system , where
7102-477: The hallmark of the oxidative damage in the nuclear genome, are very rare in mtDNA and do not increase with age. Comparing the mtDNA mutational spectra of hundreds of mammalian species, it has been recently demonstrated that species with extended lifespans have an increased rate of A>G substitutions on single-stranded heavy chain. This discovery led to the hypothesis that A>G is a mitochondria-specific marker of age-associated oxidative damage. This finding provides
7208-421: The human mitochondrial DNA are distinguished as the heavy strand and the light strand. The heavy strand is rich in guanine and encodes 12 subunits of the oxidative phosphorylation system, two ribosomal RNAs (12S and 16S), and 14 transfer RNAs (tRNAs). The light strand encodes one subunit, and 8 tRNAs. So, altogether mtDNA encodes for two rRNAs, 22 tRNAs, and 13 protein subunits , all of which are involved in
7314-524: The idea is controversial, some evidence suggests a link between aging and mitochondrial genome dysfunction. In essence, mutations in mtDNA upset a careful balance of reactive oxygen species (ROS) production and enzymatic ROS scavenging (by enzymes like superoxide dismutase , catalase , glutathione peroxidase and others). However, some mutations that increase ROS production (e.g., by reducing antioxidant defenses) in worms increase, rather than decrease, their longevity. Also, naked mole rats , rodents about
7420-462: The initiation of the transcription of the heavy and light strands are located in the main non-coding region of the mtDNA called the displacement loop, the D-loop . There is evidence that the transcription of the mitochondrial rRNAs is regulated by the heavy-strand promoter 1 (HSP1), and the transcription of the polycistronic transcripts coding for the protein subunits are regulated by HSP2. Measurement of
7526-403: The lead over other Australian states for its commercialisation and commitment to renewable energy . It is now the leading producer of wind power in Australia. Renewable energy is a growing source of electricity in South Australia, and there is potential for growth from this particular industry of the state's economy. The Hornsdale Power Reserve is a bank of grid-connected batteries adjacent to
7632-456: The least amount of federal funding for its local road network of all states on a per capita and a per kilometre basis. During 2019-20: South Australia's gross state product (GSP) fell 1.4% in chain volume (real) terms (nationally, gross domestic product (GDP) fell 0.3%). South Australia came out of the COVID-19 recession better than the other Australian states, with the economy growing by 3.9% in
7738-656: The letters patent of the imperial government to create the colony. He was accountable only to the British Colonial Office , and thus democracy did not exist in the colony. A new body was created to advise the governor on the administration of South Australia in 1843 called the Legislative Council. It consisted of three representatives of the British Government and four colonists appointed by the governor. The governor retained total executive power. In 1851,
7844-415: The levels of the mtDNA-encoded RNAs in bovine tissues has shown that there are major differences in the expression of the mitochondrial RNAs relative to total tissue RNA. Among the 12 tissues examined the highest level of expression was observed in heart, followed by brain and steroidogenic tissue samples. As demonstrated by the effect of the trophic hormone ACTH on adrenal cortex cells, the expression of
7950-443: The longevity of species. The application of a mitochondrial-specific ROS scavenger, which lead to a significant longevity of the mice studied, suggests that mitochondria may still be well-implicated in ageing. Extensive research is being conducted to further investigate this link and methods to combat ageing. Presently, gene therapy and nutraceutical supplementation are popular areas of ongoing research. Bjelakovic et al. analyzed
8056-424: The male-inherited mitochondria were subsequently rejected. It has also been found in sheep, and in cloned cattle. Rare cases of male mitochondrial inheritance have been documented in humans. Although many of these cases involve cloned embryos or subsequent rejection of the paternal mitochondria, others document in vivo inheritance and persistence under lab conditions. Doubly uniparental inheritance of mtDNA
8162-525: The mitochondrial genes may be strongly regulated by external factors, apparently to enhance the synthesis of mitochondrial proteins necessary for energy production. Interestingly, while the expression of protein-encoding genes was stimulated by ACTH, the levels of the mitochondrial 16S rRNA showed no significant change. In most multicellular organisms , mtDNA is inherited from the mother (maternally inherited). Mechanisms for this include simple dilution (an egg contains on average 200,000 mtDNA molecules, whereas
8268-480: The mtDNA base composition and animal species-specific maximum life spans. As demonstrated in their work, higher mtDNA guanine + cytosine content ( GC% ) strongly associates with longer maximum life spans across animal species. An additional observation is that the mtDNA GC% correlation with the maximum life spans is independent of the well-known correlation between animal species metabolic rate and maximum life spans. The mtDNA GC% and resting metabolic rate explain
8374-833: The mtDNA has approximately 10-fold higher levels than nuclear DNA. It has been proposed that aged mitochondria is the critical factor in the origin of neurodegeneration in Alzheimer's disease. Analysis of the brains of AD patients suggested an impaired function of the DNA repair pathway, which would cause reduce the overall quality of mtDNA. In Huntington's disease , mutant huntingtin protein causes mitochondrial dysfunction involving inhibition of mitochondrial electron transport , higher levels of reactive oxygen species and increased oxidative stress . Mutant huntingtin protein promotes oxidative damage to mtDNA, as well as nuclear DNA, that may contribute to Huntington's disease pathology . The DNA oxidation product 8-oxoguanine (8-oxoG)
8480-558: The mtDNAs were taken. mtDNA can be used to estimate the relationship between both closely related and distantly related species. Due to the high mutation rate of mtDNA in animals, the 3rd positions of the codons change relatively rapidly, and thus provide information about the genetic distances among closely related individuals or species. On the other hand, the substitution rate of mt-proteins is very low, thus amino acid changes accumulate slowly (with corresponding slow changes at 1st and 2nd codon positions) and thus they provide information about
8586-657: The new province. The Letters Patent , which used the enabling provisions of the South Australia Act 1834 to fix the boundaries of the Province of South Australia, provided that "nothing in those our Letters Patent shall affect or be construed to affect the rights of any Aboriginal Natives of the said Province to the actual occupation and enjoyment in their own Persons or in the Persons of their Descendants of any Lands therein now actually occupied or enjoyed by such Natives." Although
8692-472: The nucleus. mtDNA is packaged with proteins which appear to be as protective as proteins of the nuclear chromatin. Moreover, mitochondria evolved a unique mechanism which maintains mtDNA integrity through degradation of excessively damaged genomes followed by replication of intact/repaired mtDNA. This mechanism is not present in the nucleus and is enabled by multiple copies of mtDNA present in mitochondria. The outcome of mutation in mtDNA may be an alteration in
8798-542: The other mainland states. It is bordered to the west by Western Australia , to the north by the Northern Territory , to the north-east by Queensland , to the east by New South Wales , to the south-east by Victoria , and to the south by the Great Australian Bight . The state comprises less than 8% of the Australian population and ranks fifth in population among the six states and two territories. The majority of its people reside in greater Metropolitan Adelaide. Most of
8904-487: The oxidative phosphorylation process. Between most (but not all) protein-coding regions, tRNAs are present (see the human mitochondrial genome map ). During transcription, the tRNAs acquire their characteristic L-shape that gets recognized and cleaved by specific enzymes. With the mitochondrial RNA processing, individual mRNA, rRNA, and tRNA sequences are released from the primary transcript. Folded tRNAs therefore act as secondary structure punctuations. The promoters for
9010-519: The patent guaranteed land rights under force of law for the indigenous inhabitants, it was ignored by the South Australian Company authorities and squatters. Despite strong reference to the rights of the native population in the initial proclamation by the Governor, there were many conflicts and deaths in the Australian Frontier Wars in South Australia. Survey was required before settlement of
9116-466: The plant and fungal genomes also exist in some protists, as do two unique genome types. One of these unique types is a heterogeneous collection of circular DNA molecules (type 4) while the other is a heterogeneous collection of linear molecules (type 6). Genome types 4 and 6 each range from 1–200 kbp in size. The smallest mitochondrial genome sequenced to date is the 5,967 bp mtDNA of the parasite Plasmodium falciparum . Endosymbiotic gene transfer,
9222-495: The process by which genes that were coded in the mitochondrial genome are transferred to the cell's main genome, likely explains why more complex organisms such as humans have smaller mitochondrial genomes than simpler organisms such as protists. Mitochondrial DNA is replicated by the DNA polymerase gamma complex which is composed of a 140 kDa catalytic DNA polymerase encoded by the POLG gene and two 55 kDa accessory subunits encoded by
9328-470: The province, and the Colonization Commissioners for South Australia appointed William Light as the leader of its 'First Expedition', tasked with examining 1500 miles of the South Australian coastline and selecting the best site for the capital, and with then planning and surveying the site of the city into one-acre Town Sections and its surrounds into 134-acre Country Sections. Eager to commence
9434-463: The remainder are settled in fertile areas along the south-eastern coast and River Murray . The state's colonial origins are unique in Australia as a freely settled, planned British province , rather than as a convict settlement. Colonial government commenced on 28 December 1836, when the members of the council were sworn in near the Old Gum Tree . As with the rest of the continent, the region has
9540-409: The results of 78 studies between 1977 and 2012, involving a total of 296,707 participants, and concluded that antioxidant supplements do not reduce all-cause mortality nor extend lifespan, while some of them, such as beta carotene, vitamin E, and higher doses of vitamin A, may actually increase mortality. In a recent study, it was shown that dietary restriction can reverse ageing alterations by affecting
9646-442: The same number and kinds of genes as related plants with much smaller mtDNAs. The genome of the mitochondrion of the cucumber ( Cucumis sativus ) consists of three circular chromosomes (lengths 1556, 84 and 45 kilobases), which are entirely or largely autonomous with regard to their replication . Protists contain the most diverse mitochondrial genomes, with five different types found in this kingdom. Type 2, type 3 and type 5 of
9752-500: The size of mice , live about eight times longer than mice despite having reduced, compared to mice, antioxidant defenses and increased oxidative damage to biomolecules. Once, there was thought to be a positive feedback loop at work (a 'Vicious Cycle'); as mitochondrial DNA accumulates genetic damage caused by free radicals, the mitochondria lose function and leak free radicals into the cytosol . A decrease in mitochondrial function reduces overall metabolic efficiency. However, this concept
9858-538: The state has a Mediterranean climate , while the rest of the state has either an arid or semi-arid climate . South Australia's main temperature range is 29 °C (84 °F) in January and 15 °C (59 °F) in July. The highest maximum temperature ever recorded was 50.7 °C (123.3 °F) at Oodnadatta on 2 January 1960, which is the highest official temperature recorded in Australia. The lowest minimum temperature
9964-449: The state of South Australia was claimed for Britain in 1788 as part of the colony of New South Wales . Although the new colony included almost two-thirds of the continent, early settlements were all on the eastern coast and only a few intrepid explorers ventured this far west. It took more than forty years before any serious proposal to establish settlements in the south-western portion of New South Wales were put forward. On 15 August 1834,
10070-578: The state's upper house with the balance of power controlled by a variety of minor parties and independents. Local government in South Australia is established by the Constitution Act 1934 (SA), the Local Government Act 1999 (SA), and the Local Government (Elections) Act 1999 (SA). South Australia contains 68 councils and 6 Aboriginal and outback communities . Local councils, elected on
10176-520: The upper house, the Legislative Council, remained the exclusive domain of property owners until the Labor government of Don Dunstan managed to achieve reform of the chamber in 1973. Property qualifications were removed and the Council became a body elected via proportional representation by a single state-wide electorate. Since the following 1975 South Australian state election , no one party has had control of
10282-686: The west (anti-clockwise). The first recorded European sighting of the South Australian coast was in 1627 when the Dutch ship the Gulden Zeepaert , captained by François Thijssen , examined and mapped a section of the coastline as far east as the Nuyts Archipelago . Thijssen named the whole of the country eastward of the Leeuwin "Nuyts Land", after a distinguished passenger on board; the Hon. Pieter Nuyts , one of
10388-447: The world. Opal was first discovered near the town in 1915, and the town became the site of an opal rush, enticing immigrants from southern and eastern Europe in the aftermath of World War II . Higher education and research in Adelaide forms an important part of South Australia's economy. The South Australian Government and educational institutions have attempted to position Adelaide as Australia's education hub and have marketed it as
10494-410: Was conclusively disproved when it was demonstrated that mice, which were genetically altered to accumulate mtDNA mutations at accelerated rate do age prematurely, but their tissues do not produce more ROS as predicted by the 'Vicious Cycle' hypothesis. Supporting a link between longevity and mitochondrial DNA, some studies have found correlations between biochemical properties of the mitochondrial DNA and
10600-492: Was formally constituted as a penal colony. Although South Australia was constituted such that convicts could never be transported to the Province, some emancipated or escaped convicts or expirees made their own way there, both prior to 1836, or later, and may have constituted 1–2% of the early population. The plan for the province was that it would be an experiment in reform, addressing the problems perceived in British society. There
10706-460: Was reported that paternal sperm mitochondria (containing mtDNA) are marked with ubiquitin to select them for later destruction inside the embryo . Some in vitro fertilization techniques, particularly injecting a sperm into an oocyte , may interfere with this. The fact that mitochondrial DNA is mostly maternally inherited enables genealogical researchers to trace maternal lineage far back in time. ( Y-chromosomal DNA , paternally inherited,
10812-461: Was the first Australian colony not to have an official state religion, and the colony became attractive to people who had experienced religious discrimination, including Methodists and Unitarians . South Australia also had thousands of Prussian Old Lutheran immigrants, some of whom established their own form of Lutheranism. As a result, the Lutheran Church of Australia remains separate from
10918-470: Was to be religious freedom and no established religion. Sales of land to colonists created an Emigration Fund to pay the costs of transferring a poor young labouring population to South Australia. In early 1838 the colonists became concerned after it was reported that convicts who had escaped from the eastern states may make their way to South Australia. The South Australia Police was formed in April 1838 to protect
11024-564: Was to establish the province as a centre of civilisation for free immigrants, promising civil liberties and religious tolerance. Although its history has been marked by periods of economic hardship, South Australia has remained politically innovative and culturally vibrant. Today, it is known for its fine wine and numerous cultural festivals. The state's economy is dominated by the agricultural, manufacturing and mining industries. Evidence of human activity in South Australia dates back as far as 20,000 years, with flint mining activity and rock art in
11130-559: Was upgraded to AAA by Standard & Poor's in September 2004 and to AAA by Moody's in November 2004, the highest credit ratings achievable by any company or sovereign. The state had previously lost these ratings in the State Bank collapse. However, in 2012 Standard & Poor's downgraded the state's credit rating to AA+ due to declining revenues, new spending initiatives and a weaker than expected budgetary outlook. South Australia receives
11236-769: Was −8.2 °C (17.2 °F) at Yongala on 20 July 1976. The region's overall dry weather is owed to the Australian High on the Great Australian Bight. As of 2016, South Australia had 746,105 people employed out of a total workforce of 806,593, giving an unemployment rate of 7.5%. South Australia's largest employment sector is health care and social assistance, making up 14.8% of the state's total employment, followed by retail (10.7%), education and training (8.6%), manufacturing (8%), and construction (7.6%). South Australia's economy relies on exports more than any other state in Australia. South Australia's credit rating
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