52-487: Nicholas John Henderson LVO OBE (born 10 December 1950) is a British racehorse trainer . He has been British jump racing Champion Trainer six times. His father was Johnny Henderson who was one of the founders of the Racecourse Holdings Trust as well as earlier in life being Aide-de-camp to Field Marshal Montgomery . In 2005 two years after Johnny Henderson's death Cheltenham renamed one of
104-669: A cosmetic active to reduce the appearance of inflammation and hyperpigmentation. Tranexamic acid is a zwitterion amino acid, and has a low permeability coefficient in the stratum corneum . Tranexamic acid can be combined with penetration enhancers and microneedling to overcome this limitation. Cosmetic uses may also employ lipophilic derivatives of tranexamic acid (ester prodrugs like Cetyl tranexamate mesylate ) that are not zwitterionic and thus have improved skin permeability. Side effects are rare. Some reported adverse events include seizures , changes in color vision , blood clots , and allergic reactions such as anaphylaxis . Whether
156-597: A fifth win in the race, equalling the record held by Peter Easterby . Zaynar, another horse he trained, also won at the 2009 Cheltenham Festival in the Triumph Hurdle . He was Champion Trainer in the 1985/86 and 1986/87 seasons. His record at the Cheltenham Festival is particularly good and amongst currently active trainers only Willie Mullins has won more races at the Festival than Henderson. His main stable jockey
208-429: A general rule, individuals can derive precedence from their fathers or husbands, but not from their mothers or wives. appointment age age age Tranexamic acid Tranexamic acid is a medication used to treat or prevent excessive blood loss from major trauma , postpartum bleeding , surgery, tooth removal , nosebleeds , and heavy menstruation . It is also used for hereditary angioedema . It
260-669: A higher level of medal or be appointed to a grade of the order itself, they may continue to wear their original medal along with the new insignia. The order's ribbon is blue with red-white-red stripe edging, the only difference being that for foreigners appointed into the society, their ribbon bears an additional central white stripe. For Knights Grand Cross, the ribbon is 82.5 millimetres (3.25 in) wide, for Dames Grand Cross 57.1 millimetres (2.25 in), for Knights and Dames Commander 44.4 millimetres (1.75 in), and for all other members 31.7 millimetres (1.25 in). At formal events, or collar days , of which there are 34 throughout
312-474: A mare he trains for the Queen, failed a drugs test. Henderson admitted to three of the four charges he faced in relation to the case, in which a prohibited anti-bleeding drug was found in the horse's bloodstream. Henderson accepted that the drug should not have been administered, but argued that it had been done so for the horse's welfare, and that he had not been attempting to enhance performance. A further hearing
364-578: A suspension rather than a ban) but was not allowed to enter horses for the period of his ban. The majority of his flat horses were sent to his friend and fellow Lambourn trainer Barry Hills, highest profile of these horses being Caracciola. He caused a little controversy when he attended Royal Ascot when the horse ran but was not breaking any rules as he had not been "warned off" and he was a guest of Barry Hills. [REDACTED] Great Britain [REDACTED] Ireland [REDACTED] France [REDACTED] United States Lieutenant of
416-566: A win in the Gold Cup. This was despite Henderson raising concerns about the suitability of the soft ground before the race started. Henderson was appointed Officer of the Order of the British Empire (OBE) in the 2020 New Year Honours for services to horse racing. In June 2009, Henderson was found guilty by a British Horseracing Authority panel of breaching the rules of racing, after Moonlit Path,
468-517: Is Victoria. The order's official day is 20 June. The order's chapel is the Savoy Chapel in London . There is no limit on the number of individuals honoured at any grade. Admission is at the sole discretion of the monarch. Each of the order's five grades represent different levels of service, as does the medal, which has three levels of service. While all those honoured may use the prescribed styles of
520-613: Is an antifibrinolytic medication. Tranexamic acid was first made in 1962 by Japanese researchers Shosuke and Utako Okamoto . It is on the World Health Organization's List of Essential Medicines . Tranexamic acid is available as a generic drug . Tranexamic acid is frequently used following major trauma. Tranexamic acid is used to prevent and treat blood loss in a variety of situations, such as dental procedures, heavy menstrual bleeding, and surgeries with high risk of blood loss. Tranexamic acid has been found to decrease
572-606: Is first patented and marketed by Lion Corporation in Japan, where it is still sold. Presence of unauthorized TXA has led to the Canadian recall of a Yunnan Baiyao toothpaste in 2019. There is not enough evidence to support the routine use of tranexamic acid to prevent bleeding in people with blood cancers. However, there are several trials that are currently assessing this use of tranexamic acid. For people with inherited bleeding disorders (e.g. von Willebrand's disease ), tranexamic acid
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#1732894161841624-473: Is often given. It has also been recommended for people with acquired bleeding disorders (e.g., directly acting oral anticoagulants (DOACs)) to treat serious bleeding. The use of tranexamic acid, applied directly to the area that is bleeding or taken by mouth, appears useful to treat nose bleeding compared to packing the nose with cotton pledgets alone. It decreases the risk of rebleeding within 10 days. Tranexamic acid can be used in skincare products as
676-455: Is reduced in women receiving tranexamic acid. In the United States, tranexamic acid is FDA approved for short-term use in people with severe bleeding disorders who are about to have dental surgery. Tranexamic acid is used for a short period of time before and after the surgery to prevent major blood loss and decrease the need for blood transfusions. Tranexamic acid is used in dentistry in
728-455: Is taken either by mouth , injection into a vein , or by intramuscular injection. Tranexamic acid is a synthetic analog of the amino acid lysine . It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen . This decreases the conversion of plasminogen to plasmin, preventing fibrin degradation and preserving the framework of fibrin's matrix structure. Tranexamic acid has roughly eight times
780-476: Is the badge, which is a Maltese cross with a central medallion depicting on a red background the Royal Cypher of Queen Victoria surrounded by a blue ring bearing the motto of the order – victoria (victory) – and surmounted by a Tudor crown . However, there are variations on the badge for each grade of the order: Knights and Dames Grand Cross on certain formal occasions (see below) wear the badge suspended from
832-690: The Cesarewitch Handicap flat race at Newmarket in 2008 at odds of 50/1 as an 11-year-old, despite mainly being a National Hunt horse. Caracciola followed up this success by winning the Queen Alexandra Stakes at Royal Ascot in 2009 as a 12-year-old with Eddie Ahern riding on both occasions. Henderson claimed his second winner at the famous Royal Ascot meeting when Veiled won the 2011 Ascot Stakes at 11/2. In 2013 Henderson had another important win with his horse Bobs Worth (bought for only £20,000) continuing his unbeaten streak at Cheltenham with
884-673: The Champion Hurdle in 1985, 1986 and 1987; Remittance Man , winner of the Queen Mother Champion Chase in 1992; Punjabi , winner of the Smurfit Kappa Champion Hurdle in 2009 at the Cheltenham Festival , Binocular , winner of the 2010 Champion Hurdle, Long Run , winner of the 2011 Cheltenham Gold Cup and Bobs Worth , winner of the 2013 Cheltenham Gold Cup. Binocular's Champion Hurdle gave Henderson
936-618: The lieutenant governors . The practice of notifying the Prime Minister of Canada of nominees ended in 1982, to distance the order as far from politics as possible. It was reported in 2008 that some in the Chancellery of Honours at Rideau Hall wished to eliminate the Royal Victorian Order from the Canadian honours system and sometimes contested when a Canadian was appointed; however, no formal changes were ever planned. In Canada,
988-450: The Faith), and Ind. Imp. ( Empress of India ). The chain supports a larger octagonal medallion with a blue enamel surface edged in red and charged with a saltire , over which is an effigy of Queen Victoria; members of the order suspend from this medallion their insignia as a badge apendant . Though after the death of a Knight or Dame Grand Cross their insignia may be retained by their family,
1040-546: The King's Chapel of the Savoy is ex officio the Chaplain to the Royal Victorian Order. The current incumbent is Canon Thomas Woodhouse. Membership in the Royal Victorian Order is conferred by the monarch without ministerial advice on those who have performed personal service for the sovereign. Foreign members will generally be admitted as honorary members of the Royal Victorian Order when
1092-466: The Maltese cross is rendered in white enamel with gold edging, while that for Knights and Dames Commander (on the star) and Members (the badge itself) is in silver. Further, the size of the badge varies by rank, that for the higher classes being larger, and Knights and Dames Grand Cross and Knights and Dames Commander have their crosses surrounded by a star: for the former, an eight-pointed silver star, and for
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#17328941618411144-575: The Mayor of Nice being the first foreigners to receive the honour in 1896. The reigning monarch is at the apex of the Royal Victorian Order as its Sovereign, followed by the Grand Master ; the latter position was created in 1937 and was occupied by Queen Elizabeth (later the Queen Mother) from that date until her death in 2002. Queen Elizabeth II then appointed her daughter, Anne, Princess Royal , to
1196-422: The Order's collar (chain), but otherwise on a sash passing from the right shoulder to the left hip; Knight Commanders and male Commanders wear the badge on a ribbon at the neck; male Lieutenants and Members wear the badge from a ribbon on the left chest; and women in all grades below Dame Grand Cross wear the badge on a bow pinned at the left shoulder. For Knights and Dames Grand Cross, Commanders, and Lieutenants,
1248-663: The Philippines, its capsule form is marketed as Hemostan and in Israel as Hexakapron. The US Food and Drug Administration (FDA) approved tranexamic acid oral tablets (brand name Lysteda) for treatment of heavy menstrual bleeding in November 2009. In March 2011, the status of tranexamic acid for the treatment of heavy menstrual bleeding was changed in the UK, from POM (Prescription only Medicines) to P (Pharmacy Medicines) and became available over
1300-506: The Royal Victorian Order The Royal Victorian Order ( French : Ordre royal de Victoria ) is a dynastic order of knighthood established in 1896 by Queen Victoria . It recognises distinguished personal service to the monarch, members of the royal family, or to any viceroy or senior representative of the monarch. The present monarch, King Charles III , is the sovereign of the order. The order's motto
1352-423: The Royal Victorian Order as a junior and personal order of knighthood that allowed her to bestow directly to an empire-wide community honours for personal services. The organisation was founded a year before Victoria's Diamond Jubilee , so as to give the Queen time to complete a list of first inductees. The order's official day was made 20 June of each year, marking the anniversary of Queen Victoria's accession to
1404-409: The Savoy chapel can no longer accommodate the gathering of members held every four years, and St. George's Chapel, Windsor Castle is now employed for the event. The Sovereign and Knights and Dames Grand Cross of the order are allotted stalls in the Savoy chapel's choir, and on the back of each stall is affixed a brass plate displaying the occupant's name, coat of arms , and date of admission into
1456-563: The antifibrinolytic activity of an older analogue, ε-aminocaproic acid . Tranexamic acid also directly inhibits the activity of plasmin with weak potency ( IC 50 = 87 mM), and it can block the active-site of urokinase plasminogen activator (uPA) with high specificity ( Ki = 2 mM), one of the highest among all the serine proteases . Side effects are rare. Some include changes in color vision , seizures , blood clots , and allergic reactions . Tranexamic acid appears to be safe for use during pregnancy and breastfeeding. Tranexamic acid
1508-450: The collar must be returned. Knights and Dames Grand Cross also wear a mantle of dark blue satin edged with red satin and lined with white satin, bearing a representation of the order's star on the left side. Since 1938, the chapel of the Royal Victorian Order has been the King's Chapel of the Savoy , in central London , England . However, the population of the order has grown to the point that
1560-711: The counter in UK pharmacies under the brand names of Cyklo-F and Femstrual. Tranexamic acid might alleviate neuroinflammation in some experimental settings. Tranexamic acid can be used in case of postpartum hemorrhage; it can decrease the risk of death due to bleeding by one third according to the WHO. Tentative evidence supports the use of tranexamic acid in hemoptysis . In hereditary angioedema In hereditary hemorrhagic telangiectasia : tranexamic acid has been shown to reduce frequency of epistaxis in patients with severe and frequent nosebleed episodes from hereditary hemorrhagic telangiectasia. In melasma : tranexamic acid
1612-504: The dose does not need to be adjusted in females who are between ages 12 and 16. In a 10-year study, tranexamic acid and other oral medicines (mefenamic acid) were found to be as effective as the levonorgestrel intrauterine coil ; the same proportion of women had not had surgery for heavy bleeding and had similar improvements in their quality of life. Tranexamic acid is sometimes used (often in conjunction with oxytocin ) to reduce bleeding after childbirth. Death due to postpartum bleeding
Nicky Henderson - Misplaced Pages Continue
1664-492: The form of a 5% mouth rinse after extractions or surgery in patients with prolonged bleeding time; e.g., from acquired or inherited disorders. In China, tranexamic acid is allowed in over-the-counter toothpastes, with six products using the drug. As of 2018 , there are no limits on dosage, nor requirements for labeling the concentration. 0.05% TXA in toothpaste is allowed OTC in Hong Kong. <5% TXA in over-the-counter toothpaste
1716-562: The gift of the monarch, the appointment of Canadians to the order resumed in 1972 and eligibility was extended to those who render services to the monarch's representatives in the country; officials within the provincial spheres being included after 1984. Originally, the sovereign chose inductees personally, though the Governor General of Canada and the Canadian Secretary to the King could provide suggestions, some passed to them by
1768-438: The grades of Lieutenant and Member were classified as Members (fourth class) and Members (fifth class) , respectively, but both with the post-nominals MVO . On 31 December of that year, Queen Elizabeth II declared that those in the grade of Member (fourth class) would henceforth be Lieutenants with the post-nominals LVO . Upon admission into the Royal Victorian Order, members are given various insignia. Common for all members
1820-644: The group has, since 2008, gathered biennially. As the Royal Victorian Order is open to the citizens of fifteen countries, each with their own system of orders, decorations, and medals, the RVO's place of precedence varies from country to country. Some are as follows: In the United Kingdom, the wives of male members of all classes also feature on the order of precedence, as do sons, daughters and daughters-in-law of Knights Grand Cross and Knights Commanders; relatives of Dames, however, are not assigned any special precedence. As
1872-596: The latter, an eight-pointed silver Maltese cross with silver rays between each arm. The medal bears the effigy and name of the reigning sovereign at the time of its awarding, as well as the phrase DEI • GRATIA • REX (or REGINA) • F.D. (by the grace of God, King (or Queen), Defender of the Faith ), and on the reverse is the Royal Cypher upon an ornamental shield within a laurel wreath . Bars may be awarded to each class of medal for further services, and should recipients be awarded
1924-534: The order has come to be colloquially dubbed as the "Royal Visit Order", as the majority of appointments had been made by the then sovereign during her tours of the country . The Royal Victorian Order Association of Canada exists for all Canadians appointed to the order or who have received the Royal Victorian Medal; it is the only such organisation in the Commonwealth realms . Founded by Michael Jackson,
1976-460: The order – the top two grades grant titles of knighthood, and all grades accord distinct post-nominal letters – the Royal Victorian Order's precedence amongst other honours differs from realm to realm and admission to some grades may be barred to citizens of those realms by government policy. Prior to the close of the 19th century, most general honours within the British Empire were bestowed by
2028-408: The order, divided into five levels: the highest two conferring accolades of knighthood and all having post-nominal letters and, lastly, the holders of the Royal Victorian Medal in gold, silver or bronze. Foreigners may be admitted as honorary members. There are no limits to the number of any grade, and promotion is possible. The styles of knighthood are not used by princes, princesses, or peers in
2080-583: The organisation. Upon the occupant's death, the plate is retained, leaving the stalls festooned with a record of the order's Knights and Dames Grand Cross since 1938. The only heraldic banners normally on display in the chapel are those of the Sovereign of the Royal Victorian Order and of the Grand Master of the Royal Victorian Order as there is insufficient space in the chapel for more knights' and dames' banners or other heraldic devices. The Chaplain of
2132-1100: The position in 2007. Below the Grand Master are five officials of the organisation: the Chancellor , held by the Lord Chamberlain ; the Secretary , held by the Keeper of the Privy Purse and Treasurer to the King; the Registrar, held by the Secretary to the Central Chancery of the Orders of Knighthood ; the Chaplain , held by the Chaplain of the King's Chapel of the Savoy ; and the Genealogist . Thereafter follow those honoured with different grades of
Nicky Henderson - Misplaced Pages Continue
2184-539: The races at the Cheltenham Festival in his honour as the Johnny Henderson Grand Annual Chase . In 2006 Nicky Henderson won this race with a horse called Greenhope. Henderson, educated at Eton College, has been a trainer since 1978, based at Seven Barrows near Lambourn , Berkshire . Previously he was an amateur jockey , and assistant trainer to Fred Winter between 1974 and 1978. His most notable successes have come with See You Then , winner of
2236-507: The risk of venous thromboembolism (blood clots) is actually increased is a matter of debate. The risk is mentioned in the product literature, and they were reported in post marketing experience . Despite this, and the inhibitory effect of tranexamic acid on blood clot breakdown, large studies of the use of tranexamic acid have not shown an increase in the risk of venous or arterial thrombosis, even in people who had previously experienced thrombosis under other circumstances. Tranexamic acid
2288-511: The risk of death due to any cause in people who have significant bleeding due to trauma . It is most effective if taken within the first three hours following major trauma. It also decreases the risk of death if given within the first three hours of brain injury. Tranexamic acid is sometimes used to treat heavy menstrual bleeding. When taken by mouth it both safely and effectively treats regularly occurring heavy menstrual bleeding and improves quality of life. Another study demonstrated that
2340-550: The sovereign is making a state visit to the individual's country or a head of state is paying a state visit to the United Kingdom. As admission to the top two levels of the organisation provides for an honorary prefix, Canadians are not normally appointed to these levels as long as the monarch's Canadian ministry adheres to the Nickle Resolution of 1919. As it was deemed by the Canadian Cabinet to be an honour within
2392-716: The sovereign on the advice of her British ministers , who sometimes forwarded advice from ministers of the Crown in the Dominions and colonies (appointments to the then most senior orders of chivalry, the Order of the Garter and the Order of the Thistle , had been made on ministerial advice since the 18th century and were not restored to the personal gift of the sovereign until 1946 and 1947, respectively ). Queen Victoria thus established on 21 April 1896
2444-547: The throne. In 1902, King Edward VII created the Royal Victorian Chain "as a personal decoration for royal personages and a few eminent British subjects" and it was the highest class of the Royal Victorian Order. It is today distinct from the order, though it is officially issued by the chancery of the Royal Victorian Order. The order was open to foreigners from its inception, with the Prefect of Alpes-Maritimes and
2496-528: The uppermost ranks of the society, save for when their names are written in their fullest forms for the most official occasions. Retiring Deans of the Royal Peculiars of St. George's Chapel, Windsor Castle and Westminster Abbey are customarily inducted as Knights Commander; clergymen appointed to the higher levels of the Royal Victorian Order do not use the associated styles, however, and honorary members are not permitted to hold them at all. Prior to 1984,
2548-460: The year, such as New Year's Day and royal anniversaries, Knights and Dames Grand Cross wear the Royal Victorian Order's livery collar , consisting of an alternating string of octagonal gold pieces depicting a gold rose on a blue field and gold oblong frames within which are one of four inscriptions: Victoria , Britt. Reg. (Queen of the Britons), Def. Fid. ( fidei defensor , or Defender of
2600-518: Was Mick Fitzgerald until Fitzgerald was forced to retire by an injury sustained in the 2008 Grand National ; from the 2008–09 season until the 2014–15 season Barry Geraghty was Henderson's principal jockey in Britain. At the start of the 2015–16 season Nico de Boinville became Henderson's principal jockey after Geraghty replaced Tony McCoy as the principal jockey of J P McManus . One of Henderson's most popular horses in recent years, Caracciola, won
2652-1171: Was first synthesized in 1962 by Japanese researchers Shosuke and Utako Okamoto . It is on the World Health Organization's List of Essential Medicines . Tranexamic acid is marketed in the US and Australia in tablet form as Lysteda and in Australia, Sweden and Jordan it is marketed in an IV form and tablet form as Cyklokapron, in the UK and Sweden as Cyclo-F. In the UK it is also marketed as Femstrual, in Asia as Transcam, in Bangladesh as Intrax & Tracid, in India as Pause, in Pakistan as Transamin, in Indonesia as Kalnex, in South America as Espercil, in Japan as Nicolda, in France, Poland, Belgium and Romania as Exacyl and in Egypt as Kapron. In
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#17328941618412704-532: Was held in July 2009 to determine the sanction to be applied, and Henderson was fined £40,000 (a record penalty for the sport in the UK) and banned from running horses for three months (11 July to 10 October 2009). However, as Henderson is primarily a jumps trainer and this ban was during the flat season it caused him little inconvenience. He was allowed to continue training during the "ban" (which could more accurately be described as
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