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45-582: National Brain Research Centre is a research institute in Manesar , Gurugram , India . It is an autonomous institute under the Department of Biotechnology , Ministry of Science and Technology , Government of India . The institute is dedicated to research in neuroscience and brain functions in health and diseases using multidisciplinary approaches. This is the first autonomous institute by DBT to be awarded by

90-559: A deal, but denoted quid pro quo. Manesar municipal corporation and Manesar tehsil were established in 2020. In 2023, Manesar municipal area spread over 20 km includes 29 villages. In 2018, the Chief Minister, Manohar Lal Khattar , announced a new city that would adjoin Gurgaon and incorporate an area from Manesar towards Rewari, and also the area around Pataudi. The new city is likely to be spread across at least 50,000 hectares, which

135-1107: A master's degree in any branch related to Neuroscience as mentioned below: Eligibility criteria: NBRC conducts summer training programs wherein trainees attend seminars and journal clubs organized at the institute and get exposure to neuroscience. Research faculty studies the complexities of brain functions and cognition in health and diseases. Research at NBRC is organized into five divisions: 1) Cellular neuroscience and Molecular neuroscience , 2) Systems neuroscience , 3) Cognitive neuroscience , 4) Computational neuroscience , and 5) Translational neuroscience . Nevertheless, faculty collaborates across divisions and other scientists. Research develops therapeutic tools and platforms to assess and cure brain disorders, including Alzheimer's disease , Parkinson's disease , dementia , Japanese encephalitis , Zika virus disease , NeuroAIDS, brain tumor , spinal cord injury , and stroke . The research focuses on detailed understanding of our senses of touch, hearing, speech learning, memory, and spatial navigation. Moreover, basic research helps plan clinical trials for

180-736: A potential factor. Additionally, researchers at NBRC have proposed a novel prospective single-center parallel-arm double-blinded placebo-controlled phase III randomized trial using GSH as a dietary supplement for MCI patients, while monitoring brain GSH levels and cognitive profile using non-invasive MRS and neuropsychological testing, respectively. Considering the elevating cases of depression, obsessive-compulsive disorder, anxiety, and post-traumatic stress disorder in patients with COVID-19, scientists have been mapping brains of patients who recovered from or were asymptomatic to COVID-19. This first global study analyzed structural, spectroscopic, and behavioral changes in

225-469: A research setting to investigate the differences in electrical activity in the brain between normal and neurologically dysfunctional individuals. Neuroimaging comprises a variety of techniques used to observe the activity or the structures of, or within, the nervous system. Positron emission tomography (PET) has been used in animal models, such as non-human primate and rodent, to identify and target molecular mechanisms of neurological disease, and to study

270-578: A treatment for a disorder. In translational neuroscience, gene therapy is the delivery of nucleic acid as a treatment for a neurological disorder. Gene therapy has been proven effective at treating a variety of disorders, including neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) , in rodent and non-human primate models, and in humans, via the application of neurotrophic factors , such as nerve growth factor (NGF) , brain-derived neurotrophic factor (BDNF) , and glial cell line-derived neurotrophic factor (GDNF) , and via

315-495: A type of pluripotent stem cell, has been used as a replacement for damaged neurons, a novel approach that involves the surgical transplantation of fetal stem cells Neurodevelopmental disorders are characterized as disorders where the development of the nervous system was disrupted, and encompasses disorders such as learning disabilities , autism spectrum disorders (ASD) , epilepsy, and certain neuromuscular disorders . Translational neuroscience research involves efforts to uncover

360-460: Is Garhi Harsaru railway station and Gurgaon railway station is nearest major station. Manesar is served by many local buses and Haryana Roadways states buses. The first training center of National Security Guard (NSG), commonly known as Black Cat commandos - a counter-terrorism unit of India, was opened in Manesar which also has a National Bomb Data center. National Brain Research Centre (NBR )

405-579: Is also at Manesar. There are many government and private schools, the former being managed by the Government of Haryana through the Haryana Board of School Education (HBSE). The Heritage Transport Museum is situated on a 3 acres (1.2 ha) plot at Tauru Gurgaon, near Manesar. A built-up area of over 90,000 sq ft (8,400 m ) spread over four floors houses the exhibition galleries, library and reference centre, conference rooms, mini auditorium,

450-568: Is crucial for regulating susceptibility to SARS-CoV-2, whereas S-receptor binding body (RBD) and Orf3a proteins are required for maximal SARS-CoV replication and virulence. The study investigated whether Glycyrrhizin affects SARS-CoV-2 S-RBD- and Orf3a-mediated HMGB1 release and cell death in lung cells expressing SARS-CoV-2 viral proteins. Glycyrrhizin did not only reverse S-RBD- and Orf3a-induced extracellular HMGB1 release but also abrogated caspase-1 activation and rescued cell death. Benefits of anti-inflammatory properties in glycyrrhizin are: 1) Lowering

495-659: Is larger than Chandigarh (11,400 hectares) but smaller than Gurgaon (73,200 hectares). In November 2020, Haryana Chief Minister Manohar Lal Khattar announced the creation of a new municipal corporation in Manesar. In December 2020, the Haryana Government approved the formation of the Manesar Municipal Corporation in a cabinet meeting. Manesar lies on Delhi-Jaipur NH48 , Western Peripheral Expressway (WPE), and Dwarka Expressway . Haryana Orbital Rail Corridor (HORC), other nearest railway station

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540-448: Is now regarded as a cyclic, where public health needs inform basic science research, which then works to discover the mechanisms of public health issues and works towards clinical and public health implementation. The stages of translational neuroscience research are as follows: Electrophysiology is used within translational neuroscience as a means of studying the electric properties of neurons in animal models as well as to investigate

585-436: Is the potential reason behind ZV-induced small head size in infants. Nearly 25 miRNAs, regulating genes and protein expression in cells, were identified as important factors impacting the cell division, proliferation and stemness of the brain stem cells. This work on focused on the regeneration of nervous system, wherein lost neuronal function was found to be restored after injury in roundworm model. The findings established that

630-478: The Indian Penal Code relating to forgery, cheating and criminal conspiracy. These were in connection with alleged irregularities involving land acquisitions at IMT Manesar. Subsequently, in 2018, the former Haryana Chief Minister, Bhupinder Singh Hooda , together with real estate companies, officials of the state government's department of town and country planning and bureaucrats who worked with Hooda while he

675-774: The Ministry of Education , Government of India , formerly known as the Ministry of Human Resource Development, in May 2002. NBRC ( National Brain Research Centre) was dedicated to the nation by the Honorable President of India Dr. A.P.J. Abdul Kalam in December 2003. The founder chairman of NBRC Society is Prof. Prakash Narain Tandon , whereas the founder director Prof. Vijayalakshmi Ravindranath

720-728: The sanskrit language , in which the word "manesar" means the "lord of brain or wisdom" i.e. the Lord Shiva . Earlier Manesar was a sleepy village of about 1000 dwellings on the Delhi-Jaipur highway, then numbered as NH-8 . Since the late 1990s, it has been transformed into a booming town. Its growth has been helped by government's drive to move out factories from Delhi as well as the growth of Gurgaon city and proximity to Delhi's Indira Gandhi International Airport (approximately 40 minutes). Farmers have become millionaires or multi-millionaires by selling their lands. As of 2011 Indian Census ,

765-588: The IMT development from 2011 led to numerous protests and legal challenges from farmers and other residents. These were resolved in 2014 when it bought a total of 688 acres (278 ha) from three villages (Manesar, Nakhrola and Naurangpur ) at a price set by the Punjab and Haryana High Court . On 17 September 2015, the Central Bureau of Investigation (CBI) registered a First Information Report under various sections of

810-526: The Manesar Software Technology Park, which covers 170 acres (69 ha). In 2023, Manesar had 2200 industrial manufacturing units, which employee 300,000 employees including 200,000 living within Manesar and remaining commute daily from outside. Some of the large manufacturing units include Maruti and Honda. Attempts by the Government of Haryana to acquire additional land for expansion of

855-415: The Manesar census town had a total population of 23,448, of which 14,381 were males and 9,067 were females. Population within the age group of 0 to 6 years was 3,382. The total number of literates in Manesar was 18,105, which constituted 77.2% of the population with male literacy of 83.2% and female literacy of 67.8%. The effective literacy rate of 7+ population of Manesar was 90.2%, of which male literacy rate

900-500: The acquisition and grant of land to the developers and directed the CBI to inquire further. The government was instructed to "recover every single pie". Court returned the land to Haryana government. Land would not be returned to the landholders more than the prevailing price. The builders will not be allowed to recover any money they paid to land owners as the deal was done to benefit them and "middlemen". The court said: The acquisition process

945-590: The activity of immune cells, thus stopping interferon production. PF4 acts through its receptor CXCR3, which when blocked with an antagonist AMG487 inhibits dengue and JE replication both in vivo and in vitro. This study indicates the possibility of developing an antiviral agent. This study focused on delineating molecular mechanisms, role of miRNAs, and involvement of ZV E protein in ZV-induced microcephaly. The protein promotes premature but faulty formation of neurons, which affects normal properties of brain stem cells. This

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990-494: The application of enzymes such as glutamic acid decarboxylase (GAD) , which commonly use adeno-associated viruses (AAV) as a vector. Stem cells , particularly induced pluripotent stem cells (iPSCs) , are utilized in translational neuroscience research as not only a treatment for nervous system disorders, but also as the source for models of neural dysfunction. For example, due to the central nervous system's limited regenerative abilities, human embryonic stem cells (hESCs) ,

1035-462: The axon fusion process has functional significance in the maintenance of neuronal integrity throughout the life span of an organism. The researchers also demonstrated how to control this process genetically for treating nerve injuries in humans in future. An active ingredient Glycyrrhizin in Mulethi (liquorice)—a commonly used herb—is a potential source for the development of a drug against COVID-19. HMGB1

1080-469: The brains of recovered/asymptomatic patients using a novel non-invasive MRS neuroimaging technique. Findings suggest that glutamate and GABA levels are potential parameters to monitor mental health and psychiatric disease-associated conditions. Moreover, antioxidants and neurotransmitters in the study have potential implications for psychiatric disorders in COVID-19-affected patients. Scientists studied

1125-552: The burgeoning city of Gurugram has in recent years caused its character and demographics to change dramatically. It has many factories, offices, hotels, IT parks and educational institutes. There are several sightseeing spots around the area, some overlapping with Gurugram . Manesar is 32 kilometres (20 mi) from Indira Gandhi International Airport and is located on National Highway 48 , making it well connected with New Delhi , Gurugram , Rewari , Dharuhera (Rewari) , Jaipur , Ahmedabad and Surat . Manesar gets its name from

1170-412: The crucial role of the thalamus as a major integrative hub in addition to insular network for mediating key cognitive functional dynamics and their role during maintenance of cognitive functions during healthy aging process in the human brain. In this collaborative study, it was discovered that dengue and JE viruses activate platelet inside host and induce them release platelet factor 4 (PF4). PF4 inhibits

1215-634: The development of rational therapy for brain disorders. Researchers have also been studying the implications of SARS-CoV-2 on the brain. Scientists have been studying the early biomarkers for AD using brain chemicals. Monitoring glutathione (GSH), an antioxidant molecule in the brain, aids in the early identification of AD and mapping out therapeutic invention. Scientists have demonstrated that hippocampus, frontal, and cingulate cortical regions responsible for memory and higher cognitive functions, respectively, show significant GSH depletion, leading to cognitive decline. Using 31P MRS, scientists discovered that pH of

1260-488: The following year, a Translational and Clinical Neuroscience Unit was formed along with a Neurology Outpatient Department to Civil Hospital, Gurgaon, to help common people and assess the occurrence of neurological cases in this region. Further, the Centre of Excellence for Epilepsy, jointly administered by NBRC and All India Institute of Medical Sciences , was established in 2005. Two major flagship programs by NBRC were initiated in

1305-498: The industrial units functioning in Manesar are: Translational neuroscience Translational neuroscience research is categorized into stages of research, which are classified using a five tier system (T0-T4), beginning with basic science research and ending with the public health applications of basic scientific discoveries. While once considered a linear progression from basic science to public health application, translational research, and translational neuroscience in particular,

1350-427: The land from the acquisition threat, thus favouring the developers. One of the beneficiary of the scam was Hooda's nephew, Sukhwinder, whose company was given change of land use (CLU) permission for 52 acres land on the same day the government acquisition process had lapsed for the want of release of funds, while at the same time CLU was denied to two other unrelated applicants. The Supreme Court of India cancelled

1395-456: The left hippocampal formation in AD shifts towards alkalinity. Research has also demonstrated the existence of two open-and-closed conformations of GSH in healthy young participants. Presently, they are investigating the role of two GSH conformations and link between iron deposition and oxidative stress (OS) in the hippocampal formation in AD. Although the exact cause of AD remains unknown, OS is considered

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1440-609: The molecular mechanisms for these disorders and work towards cures in patient populations. Additionally, translational neuroscience research has focused on elucidating the cause of neurodevelopmental disorders, whether it be genetic, environmental, or a combination of both, as well as tactics for prevention, if possible. Neurodegenerative disorders are a result of neuronal loss of function over time which lead to cell death. Examples of neurodegenerative disorders include Alzheimer's disease , Parkinson's disease , and Huntington's disease . The focus of translational neuroscience research

1485-574: The museum shop, and a restaurant facility. The operations and training headquarters of the National Security Guards is located in Manesar near NH 48. In January 2020, the Indian Army set up a quarantine camp in Manesar for suspected cases of Coronavirus disease 2019 . 300 Indian students airlifted from Wuhan district of China were quarantined and observed for 14 days, after which those with no symptoms were allowed to go home. Some of

1530-423: The neurological impact of pharmacological drug addiction. Similarly, functional magnetic resonance imaging (fMRI) has been used to investigate the neurological mechanisms of pharmacological drug addiction, the neurological mechanisms of mood and anxiety disorders in elderly populations, and the neurological mechanisms of disorders such as schizophrenia . Gene therapy is the delivery of nucleic acid as

1575-676: The past few years. By 2017, National Dementia Program was initiated under NBRC's leadership, whereas by 2019, a flagship program entitled "Comparative mapping of common mental disorders (CMD) over the lifespan" was launched to understand the science of well-being. NBRC has integrated multidisciplinary teaching programmes in Life Sciences, such as 2-year M.Sc. program in Neuroscience with broad overview of different aspects of Neuroscience. Eligibility criteria: NBRC offers 5-year Ph.D. program in Neuroscience to students from diverse backgrounds who have

1620-472: The properties of human neurological dysfunction. Techniques used in animal models, such as patch-clamp recordings , have been used to investigate how neurons respond to pharmacological agents. Electroencephalography (EEG) and magnetoencephalography (MEG) are both used to measure electrical activity in the human brain, and can be used in clinical settings to localize the source of neurological dysfunction in conditions such as epilepsy , and can also be used in

1665-626: The proposal for founding NBRC was put forward. The creation was subsequently declared on 14 November 1997 as a part of the Golden Jubilee celebrations of India's Independence and the birth date of the former Prime Minister, Jawaharlal Nehru . A Management Advisory Committee was further formed. In 2000, the institute commenced functioning as an autonomous institute of the Department of Biotechnology from its temporary location at International Centre for Genetic Engineering and Biotechnology , New Delhi. NBRC

1710-593: The severity of the disease, 2) Mitigating viral replication by as much as 90%, and 3) Fighting the "storm of cytokines". Manesar Manesar is a town and municipal corporation , known as New gurgaon city i n the Gurugram district of the state of Haryana , India and a part of the National Capital Region (NCR) of Delhi . It is an Industrial Model Township home to factories and industrial activity from multinational corporations . Its proximity to

1755-404: The specific role of the human thalamus as causal outflow hub in reorganizing directed information flow and connectivity among large-scale major neurocognitive networks during brain aging. This reorganization of directed functional connectivity with age during spontaneous activity highlights the importance of subcortical areas even during stimulus independent processing. Outcomes lead to understanding

1800-407: The years,HSIIDC has allotted more than 2,100 plots for setting up of industrial ventures by entrepreneurs. There are several large multinational companies, such as Maruti Suzuki , Jaquar , JBM Auto and Toshiba Eco City. Aadhar 's national Data Center is also located here. Also Indian Institute of Corporate Affairs under Ministry of Corporate Affairs is located here, and it also contains

1845-552: Was 95.4% and female literacy rate was 81.6%. The Scheduled Castes population was 1,774. Manesar had 5074 households in 2011. Manesar was planned in 1980's as Industrial Model Township(IMT) during formation of Maruti Udyog Ltd under Haryana State Industrial and Infrastructure Development Corporation which is under Haryana Government. Land acquisition proceedings for development of IMT Manesar were initiated in 1994–1995. Initial allotments of industrial plots to Maruti Vendors were made in 1997,and,other allotments commenced in 1999. Over

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1890-472: Was Chief Minister were charged. The scam had allegedly resulted in a 15 billion INR loss to farmers in Manesar and the adjoining villages of Naurangpur and Lakhnoula whose land, amounting to 400 acres (160 ha), had been threatened with government purchase for "public purpose". Faced with the threat of government acquisition, farmers sold at knock-down prices, averaging 25 percent of market value, to real estate developers. The Hooda government then released

1935-464: Was awarded the status of Deemed University by Ministry of Education in 2002. On 16 December 2003, NBRC was moved to the foothills of the Aravalli Range in Manesar. In the year 2006, National Neuroimaging facility was established that was fully equipped with state-of-the-art equipment, such as a 3 tesla magnetic resonance imaging scanner, electroencephalography , and evoked potential recording. In

1980-739: Was followed by Prof. Subrata Sinha and Prof. Neeraj Jain. The current director of NBRC is Prof. Krishanu Ray. The National Brain Research Centre (NBRC) is India's only institute dedicated to neuroscience research and education. The institute's primary objectives are to understand brain functions in both healthy and diseased states, train human resources capable of conducting interdisciplinary research in neuroscience , and promote neuroscience in India by networking with national institutions. Scientists and students at NBRC come from diverse academic backgrounds, including biological, computational, mathematical, physical, engineering, and medical sciences. On 5 October 1995,

2025-470: Was withdrawn with fraudulent intentions after the land was purchased by the private builders in active connivance with state functionaries. The builders and private entities were aware that the acquisition would not go through. The entire acquisition proceedings were initiated with mala fide intention, illegally and in violation of the provisions of the Land Acquisition Act. It was not a mere bonanza or

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