The National Laboratory Animal Center ( NLAC ; Chinese : 國家實驗動物中心 ) is a research institute in Taiwan which is part of the National Applied Research Laboratories .
6-498: The National Laboratory Animal Center was established in 1994 as the first large scale domestic supplier of specific pathogen free (SPF) laboratory rodents . In June 2003 it was brought under the umbrella of the National Applied Research Laboratories. NLAC supports Taiwan's biomedical industry. In 2015 NLAC succeeded in breeding their first advanced severe immuno deficiency (ASID) mouse which they established
12-493: A commercial line off of. The mice cost NT$ 3,000 to produce which was a significant savings over imported mice from the US and Japan which cost between NT$ 15,000 and NT$ 30,000. In 2019 NLAC inaugurated a new NT$ 2 billion (US$ 64.64 million) research center built in Taipei's National Biotechnology Research Park . As well as being a research center the new facility also serves as a repository for
18-540: Is desirable when investigating a drug's effect on lung function. The animals can be born through a caesarian section then special care taken so the newborn does not acquire infections, such as use of sterile isolation units with a positive pressure differential to keep all outside air and pathogens from entering. Everything that needs to be inserted into the isolator, such as food, water and equipment needs to be completely sterilized and disinfected, and inserted through an airlock that can be disinfected before opening from
24-716: The fertilized eggs of rare mice. As of 2019 the repository held 830,000 fertilized eggs. NLAC operates a preclinical testing lab at the Hsinchu Biomedical Science Park and a preclinical animal care and surgery facility at the Southern Taiwan Science Park . Specific pathogen free Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens . Use of SPF animals ensures that specified diseases do not interfere with an experiment. For example, absence of respiratory pathogens such as influenza
30-438: The inside. A disadvantage is that any contact with pathogens may be fatal. This is because the animals have no protective bacterial microbiota on the skin or in the intestine or respiratory tract , and because they have no natural immunity to common infections as they have never been exposed to them. To certify SPF, the population is checked for presence of ( antibodies against) the specified pathogens. For SPF eggs
36-1000: The specific pathogens are: Avian Adenovirus Group I, Avian Adenovirus Group II (HEV), Avian Adenovirus Group III (EDS), Avian Encephalomyelitis, Avian Influenza (Type A), Avian Nephritis Virus, Avian Paramyxovirus Type 2, Avian Reovirus S 1133, Avian Rhinotracheitis Virus; Avian Rotavirus; Avian Tuberculosis M. avium; Chicken Anemia Virus; Endogenous GS Antigen; Fowl Pox; Hemophilus paragallinarum Serovars A, B, C; Infectious Bronchitis - Ark; Infectious Bronchitis - Conn; Infectious Bronchitis - JMK; Infectious Bronchitis - Mass; Infectious Bursal Disease Type 1; Infectious Bursal Disease Type 2; Infectious Laryngotracheitis; Lymphoid Leukosis A, B; Avian Lymphoid Leukosis Virus; Lymphoid Leukosis Viruses A, B, C, D, E, J; Marek's Disease (Serotypes 1,2, 3); Mycoplasma gallisepticum; Mycoplasma synoviae; Newcastle Disease LaSota; Reticuloendotheliosis Virus; Salmonella pullorum-gallinarum; Salmonella species; When by accident some infection does occur,
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