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43-407: NAA is the second-most-concentrated molecule in the brain after the amino acid glutamate . It is detected in the adult brain in neurons , oligodendrocytes and myelin and is synthesized in the mitochondria from the amino acid aspartic acid and acetyl-coenzyme A . The various functions served by NAA are under investigation, but the primary proposed functions include: In the brain, NAA

86-414: A neurotransmitter in the brain by acting on metabotropic glutamate receptors . Molecule A molecule is a group of two or more atoms that are held together by attractive forces known as chemical bonds ; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics , organic chemistry , and biochemistry , the distinction from ions

129-440: A plane , e.g. graphene ; or three-dimensionally e.g. diamond , quartz , sodium chloride . The theme of repeated unit-cellular-structure also holds for most metals which are condensed phases with metallic bonding . Thus solid metals are not made of molecules. In glasses , which are solids that exist in a vitreous disordered state, the atoms are held together by chemical bonds with no presence of any definable molecule, nor any of

172-565: A certain number of these atoms united by attraction to form a single molecule . In coordination with these concepts, in 1833 the French chemist Marc Antoine Auguste Gaudin presented a clear account of Avogadro's hypothesis, regarding atomic weights, by making use of "volume diagrams", which clearly show both semi-correct molecular geometries, such as a linear water molecule, and correct molecular formulas, such as H 2 O: In 1917, an unknown American undergraduate chemical engineer named Linus Pauling

215-399: A dimension of a few angstroms (Å) to several dozen Å, or around one billionth of a meter. Single molecules cannot usually be observed by light (as noted above), but small molecules and even the outlines of individual atoms may be traced in some circumstances by use of an atomic force microscope . Some of the largest molecules are macromolecules or supermolecules . The smallest molecule

258-435: A graphical type of formula called a structural formula may be needed. Structural formulas may in turn be represented with a one-dimensional chemical name, but such chemical nomenclature requires many words and terms which are not part of chemical formulas. Molecules have fixed equilibrium geometries—bond lengths and angles— about which they continuously oscillate through vibrational and rotational motions. A pure substance

301-1320: A molecule is inherently an operational definition. Philosophically, therefore, a molecule is not a fundamental entity (in contrast, for instance, to an elementary particle ); rather, the concept of a molecule is the chemist's way of making a useful statement about the strengths of atomic-scale interactions in the world that we observe. molecula Look for Molecula on one of Misplaced Pages's sister projects : [REDACTED] Wiktionary (dictionary) [REDACTED] Wikibooks (textbooks) [REDACTED] Wikiquote (quotations) [REDACTED] Wikisource (library) [REDACTED] Wikiversity (learning resources) [REDACTED] Commons (media) [REDACTED] Wikivoyage (travel guide) [REDACTED] Wikinews (news source) [REDACTED] Wikidata (linked database) [REDACTED] Wikispecies (species directory) Misplaced Pages does not have an article with this exact name. Please search for Molecula in Misplaced Pages to check for alternative titles or spellings. You need to log in or create an account and be autoconfirmed to create new articles. Alternatively, you can use

344-401: A regular arrangement of molecules (as in a crystal). Microwave spectroscopy commonly measures changes in the rotation of molecules, and can be used to identify molecules in outer space. Infrared spectroscopy measures the vibration of molecules, including stretching, bending or twisting motions. It is commonly used to identify the kinds of bonds or functional groups in molecules. Changes in

387-402: Is a chemical bond that involves the sharing of electron pairs between atoms. These electron pairs are termed shared pairs or bonding pairs , and the stable balance of attractive and repulsive forces between atoms, when they share electrons, is termed covalent bonding . Ionic bonding is a type of chemical bond that involves the electrostatic attraction between oppositely charged ions, and

430-455: Is a very simple type of chemical formula. It is the simplest integer ratio of the chemical elements that constitute it. For example, water is always composed of a 2:1 ratio of hydrogen to oxygen atoms, and ethanol (ethyl alcohol) is always composed of carbon, hydrogen, and oxygen in a 2:6:1 ratio. However, this does not determine the kind of molecule uniquely – dimethyl ether has the same ratios as ethanol, for instance. Molecules with

473-435: Is composed of molecules with the same average geometrical structure. The chemical formula and the structure of a molecule are the two important factors that determine its properties, particularly its reactivity . Isomers share a chemical formula but normally have very different properties because of their different structures. Stereoisomers , a particular type of isomer, may have very similar physico-chemical properties and at

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516-479: Is derived from French molécule (1678), from Neo-Latin molecula , diminutive of Latin moles "mass, barrier". The word, which until the late 18th century was used only in Latin form, became popular after being used in works of philosophy by Descartes . The definition of the molecule has evolved as knowledge of the structure of molecules has increased. Earlier definitions were less precise, defining molecules as

559-403: Is dropped and molecule is often used when referring to polyatomic ions . A molecule may be homonuclear , that is, it consists of atoms of one chemical element , e.g. two atoms in the oxygen molecule (O 2 ); or it may be heteronuclear , a chemical compound composed of more than one element, e.g. water (two hydrogen atoms and one oxygen atom; H 2 O). In the kinetic theory of gases ,

602-480: Is essential for the understanding of the chemical bond. The simplest of molecules is the hydrogen molecule-ion , H 2 , and the simplest of all the chemical bonds is the one-electron bond . H 2 is composed of two positively charged protons and one negatively charged electron , which means that the Schrödinger equation for the system can be solved more easily due to the lack of electron–electron repulsion. With

645-556: Is the diatomic hydrogen (H 2 ), with a bond length of 0.74 Å. Effective molecular radius is the size a molecule displays in solution. The table of permselectivity for different substances contains examples. The chemical formula for a molecule uses one line of chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, and plus (+) and minus (−) signs. These are limited to one typographic line of symbols, which may include subscripts and superscripts. A compound's empirical formula

688-617: Is the primary interaction occurring in ionic compounds . The ions are atoms that have lost one or more electrons (termed cations ) and atoms that have gained one or more electrons (termed anions ). This transfer of electrons is termed electrovalence in contrast to covalence . In the simplest case, the cation is a metal atom and the anion is a nonmetal atom, but these ions can be of a more complicated nature, e.g. molecular ions like NH 4 or SO 4 . At normal temperatures and pressures, ionic bonding mostly creates solids (or occasionally liquids) without separate identifiable molecules, but

731-529: The Avogadro constant using three different methods, all involving liquid phase systems. First, he used a gamboge soap-like emulsion, second by doing experimental work on Brownian motion , and third by confirming Einstein's theory of particle rotation in the liquid phase. In 1927, the physicists Fritz London and Walter Heitler applied the new quantum mechanics to the deal with the saturable, nondynamic forces of attraction and repulsion, i.e., exchange forces, of

774-463: The article wizard to submit a draft for review, or request a new article . Search for " Molecula " in existing articles. Look for pages within Misplaced Pages that link to this title . Other reasons this message may be displayed: If a page was recently created here, it may not be visible yet because of a delay in updating the database; wait a few minutes or try the purge function . Titles on Misplaced Pages are case sensitive except for

817-469: The Chemical Bond" in which he used quantum mechanics to calculate properties and structures of molecules, such as angles between bonds and rotation about bonds. On these concepts, Pauling developed hybridization theory to account for bonds in molecules such as CH 4 , in which four sp³ hybridised orbitals are overlapped by hydrogen 's 1s orbital, yielding four sigma (σ) bonds . The four bonds are of

860-441: The arrangements of electrons yield absorption or emission lines in ultraviolet, visible or near infrared light, and result in colour. Nuclear resonance spectroscopy measures the environment of particular nuclei in the molecule, and can be used to characterise the numbers of atoms in different positions in a molecule. The study of molecules by molecular physics and theoretical chemistry is largely based on quantum mechanics and

903-484: The development of fast digital computers, approximate solutions for more complicated molecules became possible and are one of the main aspects of computational chemistry . When trying to define rigorously whether an arrangement of atoms is sufficiently stable to be considered a molecule, IUPAC suggests that it "must correspond to a depression on the potential energy surface that is deep enough to confine at least one vibrational state". This definition does not depend on

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946-464: The heavenly bodies. The viewpoint of Leucippus and Empedocles, along with the aether, was accepted by Aristotle and passed to medieval and renaissance Europe. In a more concrete manner, however, the concept of aggregates or units of bonded atoms, i.e. "molecules", traces its origins to Robert Boyle 's 1661 hypothesis, in his famous treatise The Sceptical Chymist , that matter is composed of clusters of particles and that chemical change results from

989-547: The human brain. The levels measured there are decreased in numerous neuropathological conditions ranging from brain injury to stroke to Alzheimer's disease . This fact makes NAA a potential diagnostic molecule for doctors treating patients with brain damage or disease. NAA may be a marker of creativity. High NAA levels in the hippocampus are related to better working memory performance in humans. Whole-brain levels of NAA have also been found to be positively correlated with educational attainment in adults. NAA may function as

1032-581: The hydrogen molecule. Their valence bond treatment of this problem, in their joint paper, was a landmark in that it brought chemistry under quantum mechanics. Their work was an influence on Pauling, who had just received his doctorate and visited Heitler and London in Zürich on a Guggenheim Fellowship . Subsequently, in 1931, building on the work of Heitler and London and on theories found in Lewis' famous article, Pauling published his ground-breaking article "The Nature of

1075-735: The laws governing their structure and properties. In practice, however, this distinction is vague. In molecular sciences, a molecule consists of a stable system ( bound state ) composed of two or more atoms. Polyatomic ions may sometimes be usefully thought of as electrically charged molecules. The term unstable molecule is used for very reactive species, i.e., short-lived assemblies ( resonances ) of electrons and nuclei , such as radicals , molecular ions , Rydberg molecules , transition states , van der Waals complexes , or systems of colliding atoms as in Bose–Einstein condensate . Molecules as components of matter are common. They also make up most of

1118-404: The mass of a neutral carbon-12 ( C isotope ) atom. For network solids , the term formula unit is used in stoichiometric calculations. For molecules with a complicated 3-dimensional structure, especially involving atoms bonded to four different substituents, a simple molecular formula or even semi-structural chemical formula may not be enough to completely specify the molecule. In this case,

1161-448: The minerals that make up the substance of the Earth, sand, clay, pebbles, rocks, boulders, bedrock , the molten interior , and the core of the Earth . All of these contain many chemical bonds, but are not made of identifiable molecules. No typical molecule can be defined for salts nor for covalent crystals , although these are often composed of repeating unit cells that extend either in

1204-537: The nature of molecules and their bonds began in the 17th century. Refined over time by scientists such as Robert Boyle , Amedeo Avogadro , Jean Perrin , and Linus Pauling , the study of molecules is today known as molecular physics or molecular chemistry. According to Merriam-Webster and the Online Etymology Dictionary , the word "molecule" derives from the Latin " moles " or small unit of mass. The word

1247-440: The nature of the interaction between the atoms, but only on the strength of the interaction. In fact, it includes weakly bound species that would not traditionally be considered molecules, such as the helium dimer , He 2 , which has one vibrational bound state and is so loosely bound that it is only likely to be observed at very low temperatures. Whether or not an arrangement of atoms is sufficiently stable to be considered

1290-517: The oceans and atmosphere. Most organic substances are molecules. The substances of life are molecules, e.g. proteins, the amino acids of which they are composed, the nucleic acids (DNA and RNA), sugars, carbohydrates, fats, and vitamins. The nutrient minerals are generally ionic compounds, thus they are not molecules, e.g. iron sulfate. However, the majority of familiar solid substances on Earth are made partly or completely of crystals or ionic compounds, which are not made of molecules. These include all of

1333-411: The rearrangement of the clusters. Boyle argued that matter's basic elements consisted of various sorts and sizes of particles, called "corpuscles", which were capable of arranging themselves into groups. In 1789, William Higgins published views on what he called combinations of "ultimate" particles, which foreshadowed the concept of valency bonds . If, for example, according to Higgins, the force between

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1376-546: The regularity of repeating unit-cellular-structure that characterizes salts, covalent crystals, and metals. Molecules are generally held together by covalent bonding . Several non-metallic elements exist only as molecules in the environment either in compounds or as homonuclear molecules, not as free atoms: for example, hydrogen. While some people say a metallic crystal can be considered a single giant molecule held together by metallic bonding , others point out that metals behave very differently than molecules. A covalent bond

1419-405: The same atoms in different arrangements are called isomers . Also carbohydrates, for example, have the same ratio (carbon:hydrogen:oxygen= 1:2:1) (and thus the same empirical formula) but different total numbers of atoms in the molecule. The molecular formula reflects the exact number of atoms that compose the molecule and so characterizes different molecules. However different isomers can have

1462-404: The same atomic composition while being different molecules. The empirical formula is often the same as the molecular formula but not always. For example, the molecule acetylene has molecular formula C 2 H 2 , but the simplest integer ratio of elements is CH. The molecular mass can be calculated from the chemical formula and is expressed in conventional atomic mass units equal to 1/12 of

1505-405: The same length and strength, which yields a molecular structure as shown below: The science of molecules is called molecular chemistry or molecular physics , depending on whether the focus is on chemistry or physics. Molecular chemistry deals with the laws governing the interaction between molecules that results in the formation and breakage of chemical bonds, while molecular physics deals with

1548-568: The same time different biochemical activities. Molecular spectroscopy deals with the response ( spectrum ) of molecules interacting with probing signals of known energy (or frequency , according to the Planck relation ). Molecules have quantized energy levels that can be analyzed by detecting the molecule's energy exchange through absorbance or emission . Spectroscopy does not generally refer to diffraction studies where particles such as neutrons , electrons, or high energy X-rays interact with

1591-517: The smallest particles of pure chemical substances that still retain their composition and chemical properties. This definition often breaks down since many substances in ordinary experience, such as rocks , salts , and metals , are composed of large crystalline networks of chemically bonded atoms or ions , but are not made of discrete molecules. The modern concept of molecules can be traced back towards pre-scientific and Greek philosophers such as Leucippus and Democritus who argued that all

1634-467: The term molecule is often used for any gaseous particle regardless of its composition. This relaxes the requirement that a molecule contains two or more atoms, since the noble gases are individual atoms. Atoms and complexes connected by non-covalent interactions , such as hydrogen bonds or ionic bonds , are typically not considered single molecules. Concepts similar to molecules have been discussed since ancient times, but modern investigation into

1677-652: The ultimate particle of oxygen and the ultimate particle of nitrogen were 6, then the strength of the force would be divided accordingly, and similarly for the other combinations of ultimate particles. Amedeo Avogadro created the word "molecule". His 1811 paper "Essay on Determining the Relative Masses of the Elementary Molecules of Bodies", he essentially states, i.e. according to Partington 's A Short History of Chemistry , that: The smallest particles of gases are not necessarily simple atoms, but are made up of

1720-409: The universe is composed of atoms and voids . Circa 450 BC Empedocles imagined fundamental elements ( fire ( [REDACTED] ), earth ( [REDACTED] ), air ( [REDACTED] ), and water ( [REDACTED] )) and "forces" of attraction and repulsion allowing the elements to interact. A fifth element, the incorruptible quintessence aether , was considered to be the fundamental building block of

1763-432: The vaporization/sublimation of such materials does produce separate molecules where electrons are still transferred fully enough for the bonds to be considered ionic rather than covalent. Most molecules are far too small to be seen with the naked eye, although molecules of many polymers can reach macroscopic sizes, including biopolymers such as DNA . Molecules commonly used as building blocks for organic synthesis have

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1806-516: Was learning the Dalton hook-and-eye bonding method , which was the mainstream description of bonds between atoms at the time. Pauling, however, was not satisfied with this method and looked to the newly emerging field of quantum physics for a new method. In 1926, French physicist Jean Perrin received the Nobel Prize in physics for proving, conclusively, the existence of molecules. He did this by calculating

1849-420: Was thought to be present predominantly in neuronal cell bodies, where it acts as a neuronal marker, but it is also free to diffuse throughout neuronal fibers. However, the recent discovery of a higher concentration of NAA in myelin and oligodendrocytes than in neurons raises questions about the validity of the use of NAA as a neuronal marker. NAA gives off the largest signal in magnetic resonance spectroscopy of

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