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109-454: The network produces newscasts specifically for Los Angeles called Noticias 22 Milenio . The newscasts air weekdays from 11 a.m. to 12 p.m., weekends from 4 to 5 p.m., daily from 7 to 8 p.m. and daily from 10 to 11 p.m. (Pacific Time) on KWHY-TV 22. During 2012, Milenio Television began broadcasting on Digital Television on 12.2 of XHAW-TDT; until 2015 it moved to 12.2 of XHSAW-TDT. In 2017, it changes to channel 13.2. In February 2018, due to

218-593: A gross metropolitan product of over $ 1.0 trillion, making it the city with the third-largest GDP in the world, after New York and Tokyo . Los Angeles hosted the Summer Olympics in 1932 and 1984 , and will also host in 2028 . Despite a business exodus from Downtown Los Angeles since the COVID-19 pandemic , the city's urban core is evolving as a cultural center with the world's largest showcase of architecture designed by Frank Gehry . On September 4, 1781,

327-625: A healthy diet are also recommended. Supportive care in severe cases includes treatment to relieve symptoms , fluid therapy , oxygen support and prone positioning , and medications or devices to support other affected vital organs. More severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address

436-615: A variant of concern (VoC) or a variant of interest (VoI). Many of these variants have shared the more infectious D614G . As of May 2023, the WHO had downgraded all variants of concern to previously circulating as these were no longer detected in new infections. Sub-lineages of the Omicron variant (BA.1 – BA.5) were considered separate VoCs by the WHO until they were downgraded in March 2023 as no longer widely circulating. As of 24 September 2024 ,

545-493: A comprehensive international study. Such deaths include deaths due to healthcare capacity constraints and priorities, as well as reluctance to seek care (to avoid possible infection). Further research may help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with

654-527: A diverse economy with a broad range of industries. Despite a steep exodus of film and television production since the COVID-19 pandemic , Los Angeles is still one of the largest hubs of American film production , the world's largest by revenue; the city is an important site in the history of film . It also has one of the busiest container ports in the Americas. In 2018, the Los Angeles metropolitan area had

763-597: A group of 44 settlers known as " Los Pobladores " founded the pueblo (town) they called El Pueblo de Nuestra Señora la Reina de los Ángeles , 'The Town of Our Lady the Queen of the Angels';. The original name of the settlement is disputed; the Guinness Book of World Records rendered it as "El Pueblo de Nuestra Señora la Reina de los Ángeles del Río Porciúncula "; other sources have shortened or alternate versions of

872-590: A large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged. The end of a pandemic or other epidemic only rarely involves the total disappearance of a disease, and historically, much less attention has been given to defining the ends of epidemics than their beginnings. The ends of particular epidemics have been defined in a variety of ways, differing according to academic field, and differently based on location and social group. An epidemic's end can be considered

981-448: A median range of 0.24% to 1.49%. IFRs rise as a function of age (from 0.002% at age 10 and 0.01% at age 25, to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85). These rates vary by a factor of ≈10,000 across the age groups. For comparison, the IFR for middle-aged adults is two orders of magnitude higher than the annualised risk of a fatal automobile accident and much higher than

1090-425: A profit; the other, according to an analysis of contemporary newspaper reports, was the 1932 Summer Olympics , also held in Los Angeles. Racial tensions erupted on April 29, 1992, with the acquittal by a Simi Valley jury of four Los Angeles Police Department (LAPD) officers captured on videotape beating Rodney King , culminating in large-scale riots . In 1994, the magnitude 6.7 Northridge earthquake shook

1199-815: A random sample have consistently found that total infections considerably exceed the reported case counts. Many countries, early on, had official policies to not test those with only mild symptoms. The strongest risk factors for severe illness are obesity, complications of diabetes , anxiety disorders, and the total number of conditions. During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested. A retrospective cohort study in China found that children and adults were just as likely to be infected. Among more thorough studies, preliminary results from 9 April 2020 found that in Gangelt ,

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1308-603: A series of battles, culminating with the signing of the Treaty of Cahuenga on January 13, 1847. The Mexican Cession was formalized in the Treaty of Guadalupe Hidalgo in 1848, which ceded Los Angeles and the rest of Alta California to the United States. Railroads arrived with the completion of the transcontinental Southern Pacific line from New Orleans to Los Angeles in 1876 and the Santa Fe Railroad in 1885. Petroleum

1417-507: A single type, where industrial uses were prohibited. The proscriptions included barns, lumber yards, and any industrial land use employing machine-powered equipment. These laws were enforced against industrial properties after the fact. These prohibitions were in addition to existing activities that were already regulated as nuisances. These included explosives warehousing, gas works, oil drilling, slaughterhouses, and tanneries . Los Angeles City Council also designated seven industrial zones within

1526-457: A social phenomenon, not just a biological one. Time reported in March 2024 that expert opinions differ on whether or not COVID-19 is considered endemic or pandemic, and that the WHO continued to call the disease a pandemic on its website. During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus", "the coronavirus outbreak" and

1635-451: A test. Conversely, deaths of people who died from underlying conditions following a positive test may be included. Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts. Official death counts have been claimed to underreport the actual death toll, because excess mortality (the number of deaths in a period compared to a long-term average) data show an increase in deaths that

1744-593: A trend in California to give places Spanish, or Spanish-sounding, names and pronunciations. In 1908, librarian Charles Fletcher Lummis , who argued for the name's pronunciation with a hard g ( / ɡ / ), reported that there were at least 12 pronunciation variants. In the early 1900s, the Los Angeles Times advocated for pronouncing it Loce AHNG-hayl-ais ( / l oʊ s ˈ ɑː ŋ h eɪ l eɪ s / ), approximating Spanish [los ˈaŋxeles] , by printing

1853-438: Is Mount San Antonio , locally known as Mount Baldy, which reaches 10,064 feet (3,068 m). Further afield, the highest point in southern California is San Gorgonio Mountain , 81 miles (130 km) east of downtown Los Angeles, with a height of 11,503 feet (3,506 m). The Los Angeles River , which is largely seasonal, is the primary drainage channel . It was straightened and lined in 51 miles (82 km) of concrete by

1962-707: Is a common problem in this population. Although Serieys et al. 2014 find selection of immune genetics at several loci they do not demonstrate that this produces a real difference which helps the bobcats to survive future mange outbreaks . Los Angeles is subject to earthquakes because of its location on the Pacific Ring of Fire . The geologic instability has produced numerous faults , which cause approximately 10,000 earthquakes annually in Southern California, though most of them are too small to be felt. The strike-slip San Andreas Fault system, which sits at

2071-518: Is associated with COVID-19 and is reported in as many as 88% of cases. The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol ) that infected people exhale as they breathe, talk, cough, sneeze, or sing. Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors. SARS‑CoV‑2 belongs to

2180-513: Is available at stations in those cities. Los Angeles Los Angeles , often referred to by its initials L.A. , is the most populous city in the U.S. state of California . With an estimated 3,820,914 residents within the city limits as of 2023 , it is the second-most populous city in the United States, behind only New York City ; it is also the commercial, financial and cultural center of Southern California . Los Angeles has an ethnically and culturally diverse population, and

2289-452: Is complicated by rugged terrain, which has necessitated having different grids for each of the valleys that Los Angeles covers. Major streets are designed to move large volumes of traffic through many parts of the city, many of which are extremely long; Sepulveda Boulevard is 43 miles (69 km) long, while Foothill Boulevard is over 60 miles (97 km) long, reaching as far east as San Bernardino. Drivers in Los Angeles suffer from one of

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2398-503: Is discouraged altogether by the WHO, due to limited evidence of its efficacy. The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold . In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalisation. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died,

2507-437: Is divided into many different districts and neighborhoods, some of which had been separately incorporated cities that eventually merged with Los Angeles. These neighborhoods were developed piecemeal, and are well-defined enough that the city has signage which marks nearly all of them. The city's street patterns generally follow a grid plan , with uniform block lengths and occasional roads that cut across blocks. However, this

2616-491: Is expected to continue to drop in the coming years because of aggressive steps to reduce it, which include electric and hybrid cars, improvements in mass transit , and other measures. The number of Stage 1 smog alerts in Los Angeles has declined from over 100 per year in the 1970s to almost zero in the new millennium. Despite improvement, the 2006 and 2007 annual reports of the American Lung Association ranked

2725-439: Is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID-19 ). Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated

2834-485: Is not explained by COVID-19 deaths alone. Using such data, estimates of the true number of deaths from COVID-19 worldwide have included a range from 18.2 to 33.5 million (≈27.4 million) by 18 November 2023 by The Economist , as well as over 18.5 million by 1 April 2023 by the Institute for Health Metrics and Evaluation and ≈18.2 million (earlier) deaths between 1 January 2020, and 31 December 2021, by

2943-482: Is rich in native plant species partly because of its diversity of habitats, including beaches, wetlands , and mountains. The most prevalent plant communities are coastal sage scrub , chaparral shrubland, and riparian woodland . Native plants include: the California poppy , matilija poppy , toyon , Ceanothus , Chamise , Coast Live Oak , sycamore , willow and Giant Wildrye . Many of these native species, such as

3052-550: Is the principal city of a metropolitan area of 12.8 million people (2023). Greater Los Angeles , which includes the Los Angeles and Riverside–San Bernardino metropolitan areas, is a sprawling metropolis of over 18.3 million residents. The majority of the city proper lies in a basin in Southern California adjacent to the Pacific Ocean in the west and extending partly through the Santa Monica Mountains and north into

3161-452: Is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals. Based on Johns Hopkins University statistics, the global CFR was 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023. The number varies by region and has generally declined over time. Several variants have been named by WHO and labelled as

3270-406: Is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and the original SARS-CoV . The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test , which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited". The test

3379-614: Is typically done on respiratory samples obtained by a nasopharyngeal swab ; however, a nasal swab or sputum sample may also be used. The WHO has published several testing protocols for the disease. Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching

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3488-413: The 1916 New York City Zoning Ordinance did. Second, the residential zones did not distinguish types of housing; they treated apartments, hotels, and detached-single-family housing equally. In 1910, Hollywood merged into Los Angeles, with 10 movie companies already operating in the city at the time. By 1921, more than 80 percent of the world's film industry was concentrated in L.A. The money generated by

3597-762: The Army Corps of Engineers to act as a flood control channel. The river begins in the Canoga Park district of the city, flows east from the San Fernando Valley along the north edge of the Santa Monica Mountains, and turns south through the city center, flowing to its mouth in the Port of Long Beach at the Pacific Ocean. The smaller Ballona Creek flows into the Santa Monica Bay at Playa del Rey . Los Angeles

3706-529: The Hillside Stranglers murder cases in 1977–1978. In early 1984, the city surpassed Chicago in population, thus becoming the second largest city in the United States. In 1984, the city hosted the Summer Olympic Games for the second time . Despite being boycotted by 14 Communist countries , the 1984 Olympics became more financially successful than any previous, and the second Olympics to turn

3815-501: The Huanan Seafood Wholesale Market there, but it is possible that human-to-human transmission began earlier. Molecular clock analysis suggests that the first cases were likely to have been between October and November 2019. The scientific consensus is that the virus is most likely of a zoonotic origin, from bats or another closely related mammal. While other explanations such as speculations that SARS-CoV-2

3924-407: The Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions. One measure that public health officials and policymakers have used to monitor the pandemic and guide decision-making is the test positivity rate ("percent positive"). According to Johns Hopkins in 2020, one benchmark for a "too high" per cent positive is 5%, which was used by

4033-536: The Los Angeles sunflower , have become so rare as to be considered endangered. Mexican Fan Palms , Canary Island Palms , Queen Palms , Date Palms , and California Fan Palms are common in the Los Angeles area, although only the last is native to California, though still not native to the City of Los Angeles. Los Angeles has a number of official flora: The city has an urban population of bobcats ( Lynx rufus ). Mange

4142-550: The San Fernando Valley , with the city bordering the San Gabriel Valley to its east. It covers about 469 square miles (1,210 km ), and is the county seat of Los Angeles County , which is the most populous county in the United States with an estimated 9.86 million residents as of 2022 . It is the third-most visited city in the U.S. with over 2.7 million visitors as of 2023. The area that became Los Angeles

4251-597: The basic reproduction number (R 0 ) for COVID-19 in January 2020 were between 1.4 and 2.5, but a subsequent analysis claimed that it may be about 5.7 (with a 95 per cent confidence interval of 3.8 to 8.9). In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28   December, 282,790,822 individuals worldwide had been confirmed as infected. As of 14 April 2022 , over 500 million cases were confirmed globally. Most cases are unconfirmed, with

4360-496: The respelling under its masthead for several years. This did not find favor. Since the 1930s, / l ɔː s ˈ æ n dʒ əl ə s / has been most common. In 1934, the United States Board on Geographic Names decreed that this pronunciation be used by the federal government. This was also endorsed in 1952 by a "jury" appointed by Mayor Fletcher Bowron to devise an official pronunciation. Common pronunciations in

4469-450: The variants of interest as specified by the WHO are BA.2.86 and JN.1, and the variants under monitoring are JN.1.7, KP.2, KP.3, KP.3.1.1, JN.1.18, LB.1, and XEC. Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste , nasal congestion and runny nose , cough, muscle pain , sore throat , fever, diarrhoea , and breathing difficulties . People with

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4578-429: The "Wuhan coronavirus outbreak", with the disease sometimes called "Wuhan pneumonia ". In January 2020, the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma . WHO finalised

4687-503: The 20th century, Los Angeles substantially reduced the amount of housing that could be built by drastically downzoning the city. In 1960, the city had a total zoned capacity for approximately 10 million people. By 1990, that capacity had fallen to 4.5 million as a result of policy decisions to ban housing through zoning. Racial tensions led to the Watts riots in 1965, resulting in 34 deaths and over 1,000 injuries. In 1969, California became

4796-453: The Angels'. The present-day city has the largest Roman Catholic archdiocese in the United States. Two-thirds of the Mexican or ( New Spain ) settlers were mestizo or mulatto , a mixture of African, indigenous and European ancestry. The settlement remained a small ranch town for decades, but by 1820, the population had increased to about 650 residents. Today, the pueblo is commemorated in

4905-621: The Los Angeles area include the 1933 Long Beach , 1971 San Fernando , 1987 Whittier Narrows , and the 1994 Northridge events. All but a few are of low intensity and are not felt. The USGS has released the UCERF California earthquake forecast , which models earthquake occurrence in California. Parts of the city are also vulnerable to tsunamis ; harbor areas were damaged by waves from Aleutian Islands earthquake in 1946, Valdivia earthquake in 1960, Alaska earthquake in 1964, Chile earthquake in 2010 and Japan earthquake in 2011. The city

5014-498: The Los Angeles area was the headquarters of six of the country's major aircraft manufacturers ( Douglas Aircraft Company , Hughes Aircraft , Lockheed , North American Aviation , Northrop Corporation , and Vultee ). During the war, more aircraft were produced in one year than in all the pre-war years since the Wright brothers flew the first airplane in 1903, combined. Manufacturing in Los Angeles skyrocketed, and as William S. Knudsen , of

5123-534: The Los Angeles region. In 1846, during the wider Mexican-American war , marines from the United States occupied the pueblo. This resulted in the siege of Los Angeles where 150 Mexican militias fought the occupiers which eventually surrendered. Mexican rule ended during following the American Conquest of California , part of the larger Mexican-American War . Americans took control from the Californios after

5232-675: The Los Angeles/Long Beach port complex, Los Angeles suffers from air pollution in the form of smog. The Los Angeles Basin and the San Fernando Valley are susceptible to atmospheric inversion , which holds in the exhausts from road vehicles, airplanes, locomotives, shipping, manufacturing, and other sources. The smog season lasts from approximately May to October. While other large cities rely on rain to clear smog, Los Angeles gets only 15 inches (380 mm) of rain each year: pollution accumulates over many consecutive days. Issues of air quality in Los Angeles and other major cities led to

5341-509: The National Defense Advisory Commission put it, "We won because we smothered the enemy in an avalanche of production, the like of which he had never seen, nor dreamed possible." After the end of World War II Los Angeles grew more rapidly than ever, sprawling into the San Fernando Valley . The expansion of the state owned Interstate Highway System during the 1950s and 1960s helped propel suburban growth and signaled

5450-667: The San Fernando Valley. Other hilly parts of Los Angeles include the Mt. Washington area north of Downtown, eastern parts such as Boyle Heights , the Crenshaw district around the Baldwin Hills , and the San Pedro district. Surrounding the city are much higher mountains. Immediately to the north lie the San Gabriel Mountains , which is a popular recreation area for Angelenos. Its high point

5559-518: The Southern Californian coast, is subject to a late spring/early summer weather phenomenon called " June Gloom ". This involves overcast or foggy skies in the morning that yield to sun by early afternoon. More recently, statewide droughts in California have further strained the city's water security . Downtown Los Angeles averages 14.67 in (373 mm) of precipitation annually, mainly occurring between November and March, generally in

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5668-739: The Spanish founded the Pueblo de Los Ángeles . Iyáangẚ has also been translated as "the valley of smoke". Maritime explorer Juan Rodríguez Cabrillo claimed the area of southern California for the Spanish Empire in 1542, while on an official military exploring expedition, as he was moving northward along the Pacific coast from earlier colonizing bases of New Spain in Central and South America. Gaspar de Portolà and Franciscan missionary Juan Crespí reached

5777-476: The United Kingdom include / l ɒ s ˈ æ n dʒ ɪ l iː z , - l ɪ z , - l ɪ s / loss AN -jil-eez, -⁠iz, -⁠iss . Phonetician Jack Windsor Lewis described the most common one, / l ɒ s ˈ æ n dʒ ɪ l iː z / , as a spelling pronunciation based on analogy to Greek words ending in -‍es , "reflecting a time when the classics were familiar if Spanish

5886-636: The WHO in the past. As of 10 March 2023, more than 6.88   million deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020. These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, time since the initial outbreak, and population characteristics, such as age, sex, and overall health. Multiple measures are used to quantify mortality. Official death counts typically include people who died after testing positive. Such counts exclude deaths without

5995-419: The WHO, US, European Union, and Australia. On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines. On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics , in

6104-730: The birthplace of the Internet, as the first ARPANET transmission was sent from the University of California, Los Angeles (UCLA) to the Stanford Research Institute in Menlo Park . In 1973, Tom Bradley was elected as the city's first African American mayor, serving for five terms until retiring in 1993. Other events in the city during the 1970s included the Symbionese Liberation Army 's South Central standoff in 1974 and

6213-616: The boundary between the Pacific Plate and the North American Plate , passes through the Los Angeles metropolitan area. The segment of the fault passing through Southern California experiences a major earthquake roughly every 110 to 140 years, and seismologists have warned about the next "big one", as the last major earthquake was the 1857 Fort Tejon earthquake . The Los Angeles basin and metropolitan area are also at risk from blind thrust earthquakes . Major earthquakes that have hit

6322-480: The boundary of a Mediterranean climate ( Köppen : Csb on the coast, Csa otherwise). Daytime temperatures are generally temperate all year round. In winter, they average around 68 °F (20 °C). Autumn months tend to be hot, with major heat waves a common occurrence in September and October, while the spring months tend to be cooler and experience more precipitation. Los Angeles has plenty of sunshine throughout

6431-448: The broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ≈34%). SARS-CoV-2

6540-630: The centre of a major infection cluster in Germany, 15 per cent of a population sample tested positive for antibodies . Screening for COVID-19 in pregnant women in New York City , and blood donors in the Netherlands, found rates of positive antibody tests that indicated more infections than reported. Seroprevalence -based estimates are conservative as some studies show that persons with mild symptoms do not have detectable antibodies. Initial estimates of

6649-648: The change of XHAW-TDT from 12.1 to 6.1, XHSAW-TDT returns to 12.1 and Milenio Television in 12.2. In 2016, Milenio Televisión's open signal increased when it received authorization from the IFT to be transmitted as part of the multiprogramming of the main channel in the cities of: Torreón, León, Nuevo Laredo, Ciudad Victoria, Tampico and Matamoros. As a result of the IFT-6 tender, Multimedia won frequencies in Mexico City, Guadalajara, Durango, Ciudad Juarez and Monclova, Milenio Televisión

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6758-404: The city as the most polluted in the country with short-term particle pollution and year-round particle pollution. In 2008, the city was ranked the second most polluted and again had the highest year-round particulate pollution. The city met its goal of providing 20 percent of the city's power from renewable sources in 2010. The American Lung Association's 2013 survey ranks the metro area as having

6867-521: The city is 342 miles (550 km). Los Angeles is both flat and hilly. The highest point in the city proper is Mount Lukens at 5,074 ft (1,547 m), located in the foothills of the San Gabriel Mountains at the north extent of the Crescenta Valley . The eastern end of the Santa Monica Mountains stretches from Downtown to the Pacific Ocean and separates the Los Angeles Basin from

6976-746: The city of Shanghai, China. For the first two years of the pandemic, no specific and effective treatment or cure was available. In 2021, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor , Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir ), to treat adult patients. FDA later gave it an EUA. Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), adequate intake of oral fluids and rest. Good personal hygiene and

7085-550: The city, causing $ 12.5 billion in damage and 72 deaths. The century ended with the Rampart scandal , one of the most extensive documented cases of police misconduct in American history. In 2002, Mayor James Hahn led the campaign against secession, resulting in voters defeating efforts by the San Fernando Valley and Hollywood to secede from the city. In 2022 , Karen Bass became the city's first female mayor , making Los Angeles

7194-487: The city. However, between 1908 and 1915, the Los Angeles City Council created various exceptions to the broad proscriptions that applied to these three residential zones, and as a consequence, some industrial uses emerged within them. There are two differences between the 1908 Residence District Ordinance and later zoning laws in the United States. First, the 1908 laws did not establish a comprehensive zoning map as

7303-588: The continued growth of the city. Because of clauses in the city's charter that prevented the City of Los Angeles from selling or providing water from the aqueduct to any area outside its borders, many adjacent cities and communities felt compelled to join Los Angeles. Los Angeles created the first municipal zoning ordinance in the United States. On September 14, 1908, the Los Angeles City Council promulgated residential and industrial land use zones. The new ordinance established three residential zones of

7412-480: The cumulative number of infected individuals (including asymptomatic and undiagnosed infections and excluding vaccinated infected individuals). It is expressed in percentage points. Other studies refer to this metric as the infection fatality risk . In November 2020, a review article in Nature reported estimates of population-weighted IFRs for various countries, excluding deaths in elderly care facilities, and found

7521-470: The demise of the city's privately owned electrified rail system , once the world's largest. As a consequence of World War II, suburban growth, and population density, many amusement parks were built and operated in this area. An example is Beverly Park , which was located at the corner of Beverly Boulevard and La Cienega before being closed and substituted by the Beverly Center . In the second half of

7630-441: The development of various vaccine platforms during early 2020. The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic and severe illness. The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. As of March 2023, more than 5.5 billion people had received one or more doses (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine

7739-549: The difference between the average daily low and the average daily high is over 30 °F (17 °C). The average annual temperature of the sea is 63 °F (17 °C), from 58 °F (14 °C) in January to 68 °F (20 °C) in August. Hours of sunshine total more than 3,000 per year, from an average of 7 hours of sunshine per day in December to an average of 12 in July. Due to

7848-513: The eyes, nose, or mouth with unwashed hands. Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items. A COVID-19 vaccine

7957-407: The form of moderate rain showers, but sometimes as heavy rainfall during winter storms. Rainfall is usually higher in the hills and coastal slopes of the mountains because of orographic uplift. Summer days are usually rainless. Rarely, an incursion of moist air from the south or east can bring brief thunderstorms in late summer, especially to the mountains. The coast gets slightly less rainfall, while

8066-474: The general public beginning in December 2020, made available through government and international programs such as COVAX , aiming to provide vaccine equity . Treatments include novel antiviral drugs and symptom control. Common mitigation measures during the public health emergency included travel restrictions , lockdowns , business restrictions and closures, workplace hazard controls , mask mandates , quarantines, testing systems, and contact tracing of

8175-475: The historic district of Los Angeles Pueblo Plaza and Olvera Street , the oldest part of Los Angeles. New Spain achieved its independence from the Spanish Empire in 1821, and the pueblo now existed within the new Mexican Republic . During Mexican rule, Governor Pío Pico made Los Angeles the regional capital of Alta California . By this time, the new republic introduced more secularization acts within

8284-493: The industry kept the city insulated from much of the economic loss suffered by the rest of the country during the Great Depression . By 1930, the population surpassed one million. In 1932, the city hosted the Summer Olympics . During World War II Los Angeles was a major center of wartime manufacturing, such as shipbuilding and aircraft. Calship built hundreds of Liberty Ships and Victory Ships on Terminal Island, and

8393-599: The infected. The pandemic caused severe social and economic disruption around the world, including the largest global recession since the Great Depression . Widespread supply shortages , including food shortages , were caused by supply chain disruptions and panic buying . Reduced human activity led to an unprecedented temporary decrease in pollution . Educational institutions and public areas were partially or fully closed in many jurisdictions, and many events were cancelled or postponed during 2020 and 2021. Telework became much more common for white-collar workers as

8502-516: The inland and mountain areas get considerably more. Years of average rainfall are rare. The usual pattern is a year-to-year variability, with a short string of dry years of 5–10 in (130–250 mm) rainfall, followed by one or two wet years with more than 20 in (510 mm). Wet years are usually associated with warm water El Niño conditions in the Pacific, dry years with cooler water La Niña episodes. A series of rainy days can bring floods to

8611-484: The issue of respiratory failure. Existing drugs such as hydroxychloroquine , lopinavir/ritonavir , and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect. The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and

8720-570: The largest U.S. city to have ever had a woman as mayor. Los Angeles will host the 2028 Summer Olympics and Paralympic Games , making Los Angeles the third city to host the Olympics three times. The city of Los Angeles covers a total area of 502.7 square miles (1,302 km ), comprising 468.7 square miles (1,214 km ) of land and 34.0 square miles (88 km ) of water. The city extends for 44 miles (71 km) from north to south and for 29 miles (47 km) from east to west. The perimeter of

8829-505: The longer name. The local English pronunciation of the name of the city has varied over time. A 1953 article in the journal of the American Name Society asserts that the pronunciation / l ɔː s ˈ æ n dʒ əl ə s / lawss AN -jəl-əs was established following the 1850 incorporation of the city and that since the 1880s the pronunciation / l oʊ s ˈ æ ŋ ɡ əl ə s / lohss ANG -gəl-əs emerged from

8938-490: The lowest is 28 °F (−2 °C), on January 4, 1949. Within the City of Los Angeles, the highest temperature ever officially recorded is 121 °F (49 °C), on September 6, 2020, at the weather station at Pierce College in the San Fernando Valley neighborhood of Woodland Hills . During autumn and winter, Santa Ana winds sometimes bring much warmer and drier conditions to Los Angeles, and raise wildfire risk. Owing to geography, heavy reliance on automobiles, and

9047-505: The lowlands and mudslides to the hills, especially after wildfires have denuded the slopes. Both freezing temperatures and snowfall are extremely rare in the city basin and along the coast, with the last occurrence of a 32 °F (0 °C) reading at the downtown station being January 29, 1979; freezing temperatures occur nearly every year in valley locations while the mountains within city limits typically receive snowfall every winter. The greatest snowfall recorded in downtown Los Angeles

9156-576: The majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services . A December 2022 WHO study estimated excess deaths from the pandemic during 2020 and 2021, again concluding ≈14.8 million excess early deaths occurred, reaffirming and detailing their prior calculations from May as well as updating them, addressing criticisms. These numbers do not include measures like years of potential life lost and may make

9265-532: The mountainous terrain of the surrounding region, the Los Angeles area contains a large number of distinct microclimates , causing extreme variations in temperature in close physical proximity to each other. For example, the average July maximum temperature at the Santa Monica Pier is 70 °F (21 °C) whereas it is 95 °F (35 °C) in Canoga Park, 15 miles (24 km) away. The city, like much of

9374-477: The nation's worst smog, and fourth in both short-term and year-round pollution amounts. COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic ), caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), began with an outbreak of COVID-19 in Wuhan , China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared

9483-495: The official names COVID-19 and SARS-CoV-2 on 11 February 2020. Tedros Adhanom Ghebreyesus explained: CO   for corona , VI   for virus , D   for disease and 19 for when the outbreak was first identified (31 December 2019). WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications. WHO named variants of concern and variants of interest using Greek letters . The initial practice of naming them according to where

9592-534: The outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat , nocturnal cough , and fatigue. Transmission of the virus is often through airborne particles . Mutations have produced many strains (variants) with varying degrees of infectivity and virulence . COVID-19 vaccines were developed rapidly and deployed to

9701-407: The pandemic 2021's leading cause of death . The time between symptom onset and death ranges from   6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. The infection fatality ratio (IFR) is the cumulative number of deaths attributed to the disease divided by

9810-491: The pandemic evolved. Misinformation circulated through social media and mass media , and political tensions intensified . The pandemic raised issues of racial and geographic discrimination , health equity , and the balance between public health imperatives and individual rights . The WHO ended the PHEIC for COVID-19 on 5 May 2023. The disease has continued to circulate, but as of 2024, experts were uncertain as to whether it

9919-507: The passage of early national environmental legislation, including the Clean Air Act . When the act was passed, California was unable to create a State Implementation Plan that would enable it to meet the new air quality standards, largely because of the level of pollution in Los Angeles generated by older vehicles. More recently, the state of California has led the nation in working to limit pollution by mandating low-emission vehicles . Smog

10028-415: The population's age structure and the age-specific pattern of infections. There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV. For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19. Another metric in assessing death rate is the case fatality ratio (CFR), which

10137-474: The present site of Los Angeles on August 2, 1769. In 1771, Franciscan friar Junípero Serra directed the building of the Mission San Gabriel Arcángel , the first mission in the area. On September 4, 1781, a group of 44 settlers known as " Los Pobladores " founded the pueblo (town) they called El Pueblo de Nuestra Señora la Reina de los Ángeles , 'The Town of Our Lady the Queen of

10246-527: The rest of California were purchased as part of the Treaty of Guadalupe Hidalgo and became part of the United States. Los Angeles was incorporated as a municipality on April 4, 1850, five months before California achieved statehood . The discovery of oil in the 1890s brought rapid growth to the city. The city was further expanded with the completion of the Los Angeles Aqueduct in 1913, which delivers water from Eastern California . Los Angeles has

10355-554: The rest of the surrounding landscape. Most construction is done in separate units, rather than wall-to-wall . However, Downtown Los Angeles itself has many buildings over 30 stories, with fourteen over 50 stories, and two over 70 stories, the tallest of which is the Wilshire Grand Center . Los Angeles has a two-season semi-arid climate ( Köppen : BSh ) with dry summers and very mild winters, but it receives more annual precipitation than most semi-arid climates, narrowly missing

10464-458: The risk of dying from seasonal influenza . In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in

10573-496: The same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum , shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhoea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell

10682-411: The time from symptom onset to death has ranged from two to eight weeks. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to intensive care units (ICU). Between 5% and 50% of COVID-19 patients experience long COVID , a condition characterised by long-term consequences persisting after

10791-694: The typical convalescence period of the disease. The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise , headaches, shortness of breath , loss of smell, muscle weakness , low fever and cognitive dysfunction . Many countries attempted to slow or stop the spread of COVID-19 by recommending, mandating or prohibiting behaviour changes, while others relied primarily on providing information. Measures ranged from public advisories to stringent lockdowns. Outbreak control strategies are divided into elimination and mitigation. Experts differentiate between elimination strategies (known as " zero-COVID ") that aim to completely stop

10900-543: The variants were identified (e.g. Delta began as the " Indian variant") is no longer common. A more systematic naming scheme reflects the variant's PANGO lineage (e.g., Omicron 's lineage is B.1.1.529) and is used for other variants. SARS-CoV-2 is a virus closely related to bat coronaviruses , pangolin coronaviruses, and SARS-CoV . The first known outbreak (the 2019–2020 COVID-19 outbreak in mainland China ) started in Wuhan , Hubei, China, in December 2019. Many early cases were linked to people who had visited

11009-635: The worst rush hour periods in the world, according to an annual traffic index by navigation system maker, TomTom . LA drivers spend an additional 92 hours in traffic each year. During the peak rush hour, there is 80% congestion, according to the index. Los Angeles is often characterized by the presence of low-rise buildings, in contrast to New York City. Outside of a few centers such as Downtown , Warner Center , Century City , Koreatown , Miracle Mile , Hollywood, and Westwood , skyscrapers and high-rise buildings are not common in Los Angeles. The few skyscrapers built outside of those areas often stand out above

11118-572: The year, with an average of only 35 days with measurable precipitation annually. Temperatures in the coastal basin exceed 90 °F (32 °C) on a dozen or so days in the year, from one day a month in April, May, June and November to three days a month in July, August, October and to five days in September. Temperatures in the San Fernando and San Gabriel Valleys are considerably warmer. Temperatures are subject to substantial daily swings; in inland areas

11227-497: Was 2.0 inches (5 cm) on January 15, 1932. While the most recent snowfall occurred in February 2019, the first snowfall since 1962, with snow falling in areas adjacent to Los Angeles as recently as January 2021. Brief, localized instances of hail can occur on rare occasions, but are more common than snowfall. At the official downtown station, the highest recorded temperature is 113 °F (45 °C) on September 27, 2010, while

11336-443: Was accidentally released from a laboratory have been proposed, as of 2021 these were not supported by evidence. Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease. Due to the effect of sampling bias , studies which obtain a more accurate number by extrapolating from

11445-435: Was discovered in the city and surrounding area in 1892, and by 1923, the discoveries had helped California become the country's largest oil producer, accounting for about one-quarter of the world's petroleum output. By 1900, the population had grown to more than 102,000, putting pressure on the city's water supply . The completion of the Los Angeles Aqueduct in 1913, under the supervision of William Mulholland , ensured

11554-505: Was not". The settlement of Indigenous Californians in the modern Los Angeles Basin and the San Fernando Valley was dominated by the Tongva (now also known as the Gabrieleño since the era of Spanish colonization). The historic center of Tongva power in the region was the settlement of Yaanga ( Tongva : Iyáangẚ ), meaning "place of the poison oak ", which would one day be the site where

11663-585: Was originally inhabited by the indigenous Tongva people and later claimed by Juan Rodríguez Cabrillo for Spain in 1542. The city was founded on September 4, 1781, under Spanish governor Felipe de Neve , on the village of Yaanga . It became a part of the First Mexican Empire in 1821 following the Mexican War of Independence . In 1848, at the end of the Mexican–American War , Los Angeles and

11772-457: Was still a pandemic. Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 30 November 2024, COVID-19 has caused 7,075,455 confirmed deaths. The COVID-19 pandemic ranks as the fifth- deadliest pandemic or epidemic in history . In epidemiology , a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting

11881-445: Was the most widely used. According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021. On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster Nuvaxovid ) was authorised for use in adults in the United Kingdom. It has subsequently received endorsement/authorisation from

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