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136-493: The McGrath Foundation is a breast cancer support and education charity in Australia , which raises money to place McGrath Breast Care Nurses in communities across Australia and increase breast health awareness. The charity was founded by Australian cricket player Glenn McGrath and his English-born wife, Jane McGrath , in 2005, following Jane's initial diagnosis and recovery from breast cancer. Jane died on 22 June 2008 at
272-498: A breast implant or transferring excess tissue from another part of the body. Chemotherapy reduces the chance of cancer recurring in the next ten years by around a third. However, 1-2% of those on chemotherapy experience life-threatening or permanent side effects. To balance these benefits and risks, chemotherapy is typically offered to those with a higher risk of cancer recurrence. There is no established risk cutoff for offering chemotherapy; determining who should receive chemotherapy
408-693: A southerly buster , a powerful southerly that brings gale winds and a rapid fall in temperature. Since Sydney is downwind of the Great Dividing Range , it occasionally experiences dry, westerly foehn winds typically in winter and early spring (which are the reason for its warm maximum temperatures). Westerly winds are intense when the Roaring Forties (or the Southern Annular Mode ) shift towards southeastern Australia, where they may damage homes and affect flights , in addition to making
544-520: A $ 18.5 million grant to continue funding 44 existing McGrath Breast Care Nurses in communities nationally as well as the placement of up to an additional 10 full-time equivalent McGrath Breast Care Nurse positions. This was extended for a further four years, in November 2016, confirming the positions of 57 Government-funded McGrath Breast Care Nurses until 2021. The first goal of the McGrath Foundation
680-404: A 30–50% increased risk of being diagnosed with breast cancer themselves. In those with zero, one or two affected relatives, the risk of breast cancer before the age of 80 is 7.8%, 13.3%, and 21.1% with a subsequent mortality from the disease of 2.3%, 4.2%, and 7.6% respectively. Women with certain genetic variants are at higher risk of developing breast cancer. The most well known are variants of
816-472: A 50% increased risk of developing breast cancer. Variants in other tumor suppressor genes can also increase one's risk of developing breast cancer, namely p53 (causes Li–Fraumeni syndrome ), PTEN (causes Cowden syndrome ), and PALB1 . Breast changes like atypical ductal hyperplasia found in benign breast conditions such as fibrocystic breast changes , are correlated with an increased breast cancer risk. Diabetes mellitus might also increase
952-561: A Pink Test himself while captaining England's successful 2010-11 Ashes campaign, after Strauss also found himself widowed by cancer. Andrew's wife Ruth, who he had met in Sydney , had passed away from a rare form of lung cancer on 29 December 2018 after Strauss had stepped down as England's director of cricket to look after her. Ahead of the 2019 edition of the Ashes in England , it was announced that Day 2 of
1088-433: A biopsy reveals cells that are cancerous but have not yet spread beyond their original location. This condition, called carcinoma in situ , is often considered "precancerous" rather than a dangerous cancer itself. Those with ductal carcinoma in situ (in the mammary ducts) are at increased risk for developing true invasive breast cancer – around a third develop breast cancer within five years. Lobular carcinoma in situ (in
1224-514: A feature of Sydney's topography. After Phillip's departure in December 1792, the colony's military officers began acquiring land and importing consumer goods from visiting ships. Former convicts engaged in trade and opened small businesses. Soldiers and former convicts built houses on Crown land, with or without official permission, in what was now commonly called Sydney town. Governor William Bligh (1806–08) imposed restrictions on commerce and ordered
1360-661: A few areas of wet sclerophyll forests in the wetter, elevated areas in the north and northeast . These forests are defined by straight, tall tree canopies with a moist understory of soft-leaved shrubs, tree ferns and herbs. The predominant vegetation community in Sydney is the Cumberland Plain Woodland in Western Sydney ( Cumberland Plain ), followed by the Sydney Turpentine-Ironbark Forest in
1496-503: A fresh water supply and a safe harbour, which Philip described as "the finest Harbour in the World ... Here a Thousand Sail of the Line may ride in the most perfect Security". The settlement was planned to be a self-sufficient penal colony based on subsistence agriculture. Trade and shipbuilding were banned in order to keep the convicts isolated. However, the soil around the settlement proved poor and
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#17328697237051632-597: A pattern of resistance that was to be repeated as the colonial frontier expanded . A military garrison was established on the Hawkesbury in 1795. The death toll from 1794 to 1800 was 26 settlers and up to 200 Darug. Conflict again erupted from 1814 to 1816 with the expansion of the colony into Dharawal country in the Nepean region south-west of Sydney. Following the deaths of several settlers, Governor Macquarie dispatched three military detachments into Dharawal lands, culminating in
1768-685: A person's age can also impact prognosis. Breast cancer before age 35 is rare, and is more likely to be associated with genetic predisposition to aggressive cancer. Conversely, breast cancer in those aged over 75 is associated with poorer prognosis. Up to 80% of the variation in breast cancer frequency across countries is due to differences in reproductive history that impact a woman's levels of female sex hormones ( estrogens ). Women who begin menstruating earlier (before age 12) or who undergo menopause later (after 51) are at increased risk of developing breast cancer. Women who give birth early in life are protected from breast cancer – someone who gives birth as
1904-479: A planner to design the street layout of Sydney and commissioned the construction of roads, wharves, churches, and public buildings. Parramatta Road , linking Sydney and Parramatta, was opened in 1811, and a road across the Blue Mountains was completed in 1815, opening the way for large-scale farming and grazing west of the Great Dividing Range . Following the departure of Macquarie, official policy encouraged
2040-651: A prior history of breast cancer, and a family history of breast cancer. About five to ten percent of cases are the result of an inherited genetic predisposition, including BRCA mutations among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply these ducts with milk. Cancers developing from the ducts are known as ductal carcinomas , while those developing from lobules are known as lobular carcinomas . There are more than 18 other sub-types of breast cancer. Some, such as ductal carcinoma in situ , develop from pre-invasive lesions . The diagnosis of breast cancer
2176-423: A rich ceremonial life, part of a belief system centring on ancestral, totemic and supernatural beings. People from different clans and language groups came together to participate in initiation and other ceremonies. These occasions fostered trade, marriages and clan alliances. The earliest British settlers recorded the word ' Eora ' as an Aboriginal term meaning either 'people' or 'from this place'. The clans of
2312-407: A role in the development of breast cancer. Smoking tobacco appears to increase the risk of breast cancer, with the greater the amount smoked and the earlier in life that smoking began, the higher the risk. In those who are long-term smokers, the relative risk is increased by 35% to 50%. A lack of physical activity has been linked to about 10% of cases. Sitting regularly for prolonged periods
2448-514: A second "diagnostic" mammogram and ultrasound – to confirm its presence and location. A biopsy is then taken of the suspected tumor. Breast biopsy is typically done by core needle biopsy , with a hollow needle used to collect tissue from the area of interest. Suspected tumors that appear to be filled with fluid are often instead sampled by fine-needle aspiration . Around 10–20% of breast biopsies are positive for cancer. Most biopsied breast masses are instead caused by fibrocystic breast changes ,
2584-817: A second one. Some respond to a third sequential therapy as well. Adding an mTOR inhibitor , everolimus , can further slow the tumors' progression. Those with HER2-positive metastatic disease can benefit from continued use of trastuzumab, alone, in combination with pertuzumab, or in combination with chemotherapy. Those whose tumors continue to progress on trastuzumab benefit from HER2-targeted antibody drug conjugates (HER2 antibodies linked to chemotherapy drugs) trastuzumab emtansine or trastuzumab deruxtecan . The HER2-targeted antibody margetuximab can also prolong survival, as can HER2 inhibitors lapatinib , neratinib , or tucatinib . Certain therapies are targeted at those whose tumors have particular gene mutations: Alpelisib or capivasertib for those with mutations activating
2720-561: A severe dust storm towards the city . The Greater Sydney Commission divides Sydney into three "cities" and five "districts" based on the 33 LGAs in the metropolitan area. The "metropolis of three cities" comprises Eastern Harbour City , Central River City and Western Parkland City . The Australian Bureau of Statistics also includes City of Central Coast (the former Gosford City and Wyong Shire) as part of Greater Sydney for population counts, adding 330,000 people. The CBD extends about 3 km (1.9 mi) south from Sydney Cove . It
2856-597: A teenager has around a 70% lower risk of developing breast cancer than someone who does not have children. That protection wanes with higher maternal age at first birth, and disappears completely by age 35. Breastfeeding also reduces one's chance of developing breast cancer, with an approximately 4% reduction in breast cancer risk for every 12 months of breastfeeding experience. Those who lack functioning ovaries have reduced levels of estrogens, and therefore greatly reduced breast cancer risk. Hormone replacement therapy for treatment of menopause symptoms can also increase
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#17328697237052992-403: A term that encompasses benign pockets of fluid, cell growth, or fibrous tissue . Breast cancers are classified by several grading systems, each of which assesses a tumor characteristic that impacts a person's prognosis. First, a tumor is classified by the tissue it arises from, or the appearance of the tumor tissue under a microscope. Most breast cancers (85%) are ductal carcinoma – derived from
3128-463: A woman's risk of developing breast cancer, though the effect depends on the type and duration of therapy. Combined progesterone /estrogen therapy increases breast cancer risk – approximately doubling one's risk after 6–7 years of treatment (though the same therapy decreases the risk of colorectal cancer ). Hormone treatment with estrogen alone has no effect on breast cancer risk, but increases one's risk of developing endometrial cancer , and therefore
3264-724: A year have temperatures at or above 30 °C (86 °F) in the central business district (CBD). In contrast, the metropolitan area averages between 35 and 65 days, depending on the suburb. The hottest day in the metropolitan area occurred in Penrith on 4 January 2020, where a high of 48.9 °C (120.0 °F) was recorded. The average annual temperature of the sea ranges from 18.5 °C (65.3 °F) in September to 23.7 °C (74.7 °F) in February. Sydney has an average of 7.2 hours of sunshine per day and 109.5 clear days annually. Due to
3400-412: Is T3. Tumors that extend to the chest wall or to the skin are designated T4. N scores are based on whether the cancer has spread to nearby lymph nodes. N0 indicates no spread to the lymph nodes. N1 is for tumors that have spread to the closest axillary lymph nodes (called "level I" and "level II" axillary lymph nodes, in the armpit). N2 is for spread to the intramammary lymph nodes (on the other side of
3536-604: Is an accepted version of this page Sydney is the capital city of the state of New South Wales and the most populous city in Australia . Located on Australia's east coast, the metropolis surrounds Sydney Harbour and extends about 80 km (50 mi) from the Pacific Ocean in the east to the Blue Mountains in the west, and about 80 km (50 mi) from the Ku-ring-gai Chase National Park and
3672-412: Is another preventive measure in some high risk women. In those who have been diagnosed with cancer, a number of treatments may be used, including surgery, radiation therapy , chemotherapy , hormonal therapy , and targeted therapy . Types of surgery vary from breast-conserving surgery to mastectomy . Breast reconstruction may take place at the time of surgery or at a later date. In those in whom
3808-401: Is assigned a grade based on how distinct it appears from healthy breast. Breast tumors are graded on three features: the proportion of cancer cells that form tubules, the appearance of the cell nucleus , and how many cells are actively replicating. Each feature is scored on a three-point scale, with a higher score indicating less healthy looking tissue. A grade is assigned based on the sum of
3944-796: Is associated with higher mortality from breast cancer. The risk is not negated by regular exercise, though it is lowered. Actions to prevent breast cancer include not drinking alcoholic beverages , maintaining a healthy body composition , avoiding smoking and eating healthy food . Combining all of these (leading the healthiest possible lifestyle) would make almost a quarter of breast cancer cases worldwide preventable. The remaining three-quarters of breast cancer cases cannot be prevented through lifestyle changes. Other risk factors include circadian disruptions related to shift-work and routine late-night eating. A number of chemicals have also been linked, including polychlorinated biphenyls , polycyclic aromatic hydrocarbons , and organic solvents . Although
4080-643: Is binary: M0 indicates no evidence metastases; M1 indicates metastases have been detected. TNM scores are then combined with tumor grades and ER/PR/HER2 status to calculate a cancer case's "prognostic stage group". Stage groups range from I (best prognosis ) to IV (worst prognosis), with groups I, II, and III further divided into subgroups IA, IB, IIA, IIB, IIIA, IIIB, and IIIC. In general, tumors of higher T and N scores and higher grades are assigned higher stage groups. Tumors that are ER, PR, and HER2 positive are slightly lower stage group than those that are negative. Tumors that have metastasized are stage IV, regardless of
4216-528: Is bordered by Farm Cove within the Royal Botanic Garden to the east and Darling Harbour to the west. Suburbs surrounding the CBD include Woolloomooloo and Potts Point to the east, Surry Hills and Darlinghurst to the south, Pyrmont and Ultimo to the west, and Millers Point and The Rocks to the north. Most of these suburbs measure less than 1 km (0.4 sq mi) in area. The Sydney CBD
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4352-451: Is characterised by narrow streets and thoroughfares, created in its convict beginnings. Several localities, distinct from suburbs, exist throughout Sydney's inner reaches. Central and Circular Quay are transport hubs with ferry, rail, and bus interchanges. Chinatown , Darling Harbour, and Kings Cross are important locations for culture, tourism, and recreation. The Strand Arcade , located between Pitt Street Mall and George Street ,
4488-462: Is commonplace in most wealthy nations, but remains uncommon in the world's poorer countries. Still, mammography has its disadvantages. Overall, screening mammograms miss about 1 in 8 breast cancers, they can also give false-positive results, causing extra anxiety and making patients overgo unnecessary additional exams, such as bioposies . Those who have a suspected tumor from a mammogram or physical exam first undergo additional imaging – typically
4624-509: Is confirmed by taking a biopsy of the concerning tissue. Once the diagnosis is made, further tests are carried out to determine if the cancer has spread beyond the breast and which treatments are most likely to be effective. Breast cancer screening can be instrumental, given that the size of a breast cancer and its spread are among the most critical factors in predicting the prognosis of the disease. Breast cancers found during screening are typically smaller and less likely to have spread outside
4760-783: Is controversial. Chemotherapy drugs are typically given in two- to three-week cycles, with periods of drug treatment interspersed with rest periods to recover from the therapies' side effects. Four to six cycles are given in total. Many classes of chemotherapeutic agents are effective for breast cancer treatment, including the DNA alkylating drugs ( cyclophosphamide ), anthracyclines ( doxorubicin and epirubicin ), antimetabolites ( fluorouracil , capecitabine , and methotrexate ), taxanes ( docetaxel and paclitaxel ), and platinum-based chemotherapies ( cisplatin and carboplatin ). Chemotherapies from different classes are typically given in combination, with particular chemotherapy drugs selected based on
4896-425: Is highest among heavy drinkers. Globally, about one in ten cases of breast cancer is caused by women drinking alcoholic beverages. Alcohol use is among the most common modifiable risk factors. Obesity and diabetes increase the risk of breast cancer. A high body mass index (BMI) causes 7% of breast cancers while diabetes is responsible for 2%. At the same time the correlation between obesity and breast cancer
5032-442: Is injected near the tumor site, and several hours later the lymph node the dye accumulates in is removed. After surgery, many undergo radiotherapy to decrease the chance of cancer recurrence . Those who had lumpectomies receive radiation to the whole breast. Those who had a mastectomy and are at elevated risk of tumor spread – tumor greater than five centimeters wide, or cancerous cells in nearby lymph nodes – receive radiation to
5168-413: Is low-dose X-ray imaging of the breast, called mammography . Each breast is pressed between two plates and imaged. Tumors can appear unusually dense within the breast, distort the shape of surrounding tissue, or cause small dense flecks called microcalcifications . Radiologists generally report mammogram results on a standardized scale – the six-point Breast Imaging-Reporting and Data System (BI-RADS)
5304-424: Is not at all linear. Studies show that those who rapidly gain weight in adulthood are at higher risk than those who have been overweight since childhood. Likewise, excess fat in the midriff seems to induce a higher risk than excess weight carried in the lower body. Dietary factors that may increase risk include a high-fat diet and obesity-related high cholesterol levels. Dietary iodine deficiency may also play
5440-486: Is only given to women who have undergone hysterectomies . In the 1980s, the abortion–breast cancer hypothesis posited that induced abortion increased the risk of developing breast cancer. This hypothesis was the subject of extensive scientific inquiry, which concluded that neither miscarriages nor abortions are associated with a heightened risk for breast cancer. The use of hormonal birth control does not cause breast cancer for most women; if it has an effect, it
5576-400: Is placed into a device inserted at the surgical site the tumor was removed from. Fresh radioactive material is added twice a day for five days, then the device is removed. Surgery plus radiation typically eliminates a person's breast tumor. Less than 5% of those treated have their breast tumor grow back. After surgery and radiation, the breast can be surgically reconstructed , either by adding
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5712-462: Is small (on the order of 0.01% per user–year), temporary, and offset by the users' significantly reduced risk of ovarian and endometrial cancers. Among those with a family history of breast cancer, use of modern oral contraceptives does not appear to affect the risk of breast cancer. Drinking alcoholic beverages increases the risk of breast cancer, even among very light drinkers (women drinking less than half of one alcoholic drink per day). The risk
5848-526: Is the leading type of cancer in women, accounting for 25% of all cases. In 2018, it resulted in two million new cases and 627,000 deaths. It is more common in developed countries, and is more than 100 times more common in women than in men . For transgender individuals on gender-affirming hormone therapy , breast cancer is 5 times more common in cisgender women than in transgender men , and 46 times more common in transgender women than in cisgender men. Most people with breast cancer have no symptoms at
5984-401: Is the most common globally – where a higher number corresponds to a greater risk of a cancerous tumor. A mammogram also reveals breast density; dense breast tissue appears opaque on a mammogram and can obscure tumors. BI-RADS categorizes breast density into four categories. Mammography can detect around 90% of breast tumors in the least dense breasts (called "fatty" breasts), but just 60% in
6120-473: Is then provided completely free of charge. The McGrath Foundation needs to raise approximately $ 420,000 to place each McGrath Breast Care Nurse in the community for a three-year period. In 2008, the Australian Government pledged $ 12.6 million to the McGrath Foundation to fund McGrath Breast Care Nurses in 44 communities through to June 2013. This commitment was furthered in 2013 with the announcement of
6256-553: Is to place specialist McGrath Breast Care Nurses wherever they are needed in Australia . McGrath Breast Care Nurses are highly qualified nurses specifically train to supported families experiencing breast cancer. The role of a McGrath Breast Care Nurse is varied and broad. From the time of diagnosis through to referrals and follow up, McGrath Breast Care Nurses play an important role in the psychosocial, emotional and physical wellbeing of patients and their families. The first tertiary-based distance education program for breast care nurses
6392-411: Is typically recommended for at least five years after surgery and chemotherapy, and is sometimes continued for 10 years or longer. Women with breast cancer who had a lumpectomy or a mastectomy and kept their other breast have similar survival rates to those who had a double mastectomy. There seems to be no survival advantage to removing the other breast, with only a 7% chance of cancer occurring in
6528-512: The Appin massacre (April 1816) in which at least 14 Aboriginal people were killed. The New South Wales Legislative Council became a semi-elected body in 1842. Sydney was declared a city the same year, and a governing council established, elected on a restrictive property franchise. The discovery of gold in New South Wales and Victoria in 1851 initially caused economic disruption as men moved to
6664-469: The Australian College of Nursing . The second aim of the McGrath Foundation is to promote breast education among Australians. At only 31 when she was first diagnosed with breast cancer, Jane McGrath was passionate about empowering people to take control of their health by being breast aware. The McGrath Foundation's breast education programme was developed to ensure everyone in Australia is aware of
6800-455: The Australian raven , Australian magpie , crested pigeon , noisy miner and the pied currawong . Introduced bird species ubiquitously found in Sydney are the common myna , common starling , house sparrow and the spotted dove . Reptile species are also numerous and predominantly include skinks . Sydney has a few mammal and spider species, such as the grey-headed flying fox and
6936-492: The BRCA genes BRCA1 and BRCA2 . Women with pathogenic variants in either gene have around a 70% chance of developing breast cancer in their lifetime, as well as an approximately 33% chance of developing ovarian cancer . Pathogenic variants in PALB2 – a gene whose product directly interacts with that of BRCA2 – also increase breast cancer risk; a woman with such a variant has around
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#17328697237057072-459: The Cooks River into Botany Bay. There is no single definition of the boundaries of Sydney. The Australian Statistical Geography Standard definition of Greater Sydney covers 12,369 km (4,776 sq mi) and includes the local government areas of Central Coast in the north, Hawkesbury in the north-west, Blue Mountains in the west, Sutherland Shire in the south, and Wollondilly in
7208-675: The Emerald City and the Harbour City . Aboriginal Australians have inhabited the Greater Sydney region for at least 30,000 years, and their engravings and cultural sites are common. The traditional custodians of the land on which modern Sydney stands are the clans of the Darug , Dharawal and Eora peoples. During his first Pacific voyage in 1770, James Cook charted the eastern coast of Australia, making landfall at Botany Bay . In 1788,
7344-590: The First Fleet of convicts , led by Arthur Phillip , founded Sydney as a British penal colony , the first European settlement in Australia. After World War II, Sydney experienced mass migration and by 2021 over 40 per cent of the population was born overseas. Foreign countries of birth with the greatest representation are mainland China, India, the United Kingdom, Vietnam and the Philippines. Despite being one of
7480-485: The Garden Island Tunnel System , the only tunnel warfare complex in Sydney, and the heritage-listed military fortification systems Bradleys Head Fortification Complex and Middle Head Fortifications , which were part of a total defence system for Sydney Harbour . A post-war immigration and baby boom saw a rapid increase in Sydney's population and the spread of low-density housing in suburbs throughout
7616-484: The HER2 -targeted antibody trastuzumab to chemotherapy reduces the chance of cancer recurrence and death by at least a third. Trastuzumab is given weekly or every three weeks for twelve months. Adding a second HER2-targeted antibody, pertuzumab slightly enhances treatment efficacy. In rare cases, trastuzumab can disrupt heart function, and so it is typically not given in conjunction with anthracyclines, which can also damage
7752-568: The Hawkesbury River in the north and north-west, to the Royal National Park and Macarthur in the south and south-west. Greater Sydney consists of 658 suburbs, spread across 33 local government areas. Residents of the city are colloquially known as "Sydneysiders". The estimated population in June 2023 was 5,450,496, which is about 66% of the state's population. The city's nicknames include
7888-631: The Middle East and Africa becoming major sources. By 2021, the population of Sydney was over 5.2 million, with 40% of the population born overseas. China and India overtook England as the largest source countries for overseas-born residents. Sydney is a coastal basin with the Tasman Sea to the east, the Blue Mountains to the west, the Hawkesbury River to the north, and the Woronora Plateau to
8024-601: The Sydney funnel-web , respectively, and has a huge diversity of marine species inhabiting its harbour and beaches. Under the Köppen–Geiger classification , Sydney has a humid subtropical climate ( Cfa ) with "warm, sometimes hot" summers and "generally mild", to "cool" winters. The El Niño–Southern Oscillation , the Indian Ocean Dipole and the Southern Annular Mode play an important role in determining Sydney's weather patterns: drought and bushfire on
8160-639: The University of New South Wales are ranked 18th and 19th in the world respectively. Sydney has hosted major international sporting events such as the 2000 Summer Olympics , the 2003 Rugby World Cup Final , and the 2023 FIFA Women's World Cup Final . The city is among the top fifteen most-visited, with millions of tourists coming each year to see the city's landmarks. The city has over 1,000,000 ha (2,500,000 acres) of nature reserves and parks , and its notable natural features include Sydney Harbour and Royal National Park . The Sydney Harbour Bridge and
8296-602: The University of Sydney (1854–61), the Australian Museum (1858–66), the Town Hall (1868–88), and the General Post Office (1866–92). Elaborate coffee palaces and hotels were erected. Daylight bathing at Sydney's beaches was banned, but segregated bathing at designated ocean baths was popular. Drought, the winding down of public works and a financial crisis led to economic depression in Sydney throughout most of
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#17328697237058432-590: The "Aborigines of Australia" declared 26 January "A Day of Mourning " for "the whiteman's seizure of our country." With the outbreak of Second World War in 1939, Sydney experienced a surge in industrial development. Unemployment virtually disappeared and women moved into jobs previously typically reserved for males. Sydney was attacked by Japanese submarines in May and June 1942 with 21 killed. Households built air raid shelters and performed drills. Military establishments in response to World War II in Australia included
8568-610: The 1890s. Meanwhile, the Sydney-based premier of New South Wales, George Reid , became a key figure in the process of federation. When the six colonies federated on 1 January 1901, Sydney became the capital of the State of New South Wales. The spread of bubonic plague in 1900 prompted the state government to modernise the wharves and demolish inner-city slums. The outbreak of the First World War in 1914 saw more Sydney males volunteer for
8704-557: The CBD. In the warm season black nor'easters are usually the cause of heavy rain events, though other forms of low-pressure areas , including remnants of ex-cyclones , may also bring heavy deluge and afternoon thunderstorms. 'Snow' was last alleged in 1836, more than likely a fall of graupel , or soft hail; and in July 2008 the Upper North Shore saw a fall of graupel that was mistaken by many for 'snow'. In 2009, dry conditions brought
8840-473: The Cumberland Plain. Immigrants—mostly from Britain and continental Europe—and their children accounted for over three-quarters of Sydney's population growth between 1947 and 1971. The newly created Cumberland County Council oversaw low-density residential developments, the largest at Green Valley and Mount Druitt . Older residential centres such as Parramatta, Bankstown and Liverpool became suburbs of
8976-792: The Inner West and Northern Sydney , the Eastern Suburbs Banksia Scrub in the coastline and the Blue Gum High Forest scantily present in the North Shore – all of which are critically endangered. The city also includes the Sydney Sandstone Ridgetop Woodland found in Ku-ring-gai Chase National Park on the Hornsby Plateau to the north. Sydney is home to dozens of bird species, which commonly include
9112-676: The Lord's Test would benefit the Ruth Strauss Foundation in much the same way that Day 3 of the Sydney Test benefits the McGrath Foundation. The McGrath Foundation used to have a relationship with the greyhound racing industry. After the allegations of live baiting were made in the media in 2015, the McGrath Foundation ceased the relationship. The McGrath Foundation hosts a variety of events and community fundraising initiatives each year to support its vision. Sydney Pink Test – Each January,
9248-673: The Sydney Cricket Ground turns into a sea of pink on day three of the Sydney Pink Test in honour of Jane McGrath. The Sydney Pink Test has become the iconic centrepiece of the Cricket Australia and McGrath Foundation partnership, through the community action program Cricket Cares. Pink Stumps Day – Pink Stumps Day allows people to bring the spirit of the Pink Test into their own community by providing clubs, businesses and schools
9384-577: The Sydney area occupied land with traditional boundaries. There is debate, however, about which group or nation these clans belonged to, and the extent of differences in language and rites. The major groups were the coastal Eora people, the Dharug (Darug) occupying the inland area from Parramatta to the Blue Mountains, and the Dharawal people south of Botany Bay. Darginung and Gundungurra languages were spoken on
9520-442: The Sydney region are grassy woodlands (i.e. savannas ) and some pockets of dry sclerophyll forests, which consist of eucalyptus trees, casuarinas , melaleucas , corymbias and angophoras , with shrubs (typically wattles , callistemons , grevilleas and banksias ), and a semi-continuous grass in the understory . The plants in this community tend to have rough, spiky leaves due to low soil fertility . Sydney also features
9656-621: The Union Jack 165 years earlier, commencing her Australian Royal Tour . It was the first time a reigning monarch stepped onto Australian soil. Increasing high-rise development in Sydney and the expansion of suburbs beyond the "green belt" envisaged by the planners of the 1950s resulted in community protests. In the early 1970s, trade unions and resident action groups imposed green bans on development projects in historic areas such as The Rocks. Federal, State and local governments introduced heritage and environmental legislation. The Sydney Opera House
9792-548: The World Heritage-listed Sydney Opera House are major tourist attractions. Central Station is the hub of Sydney's suburban train, metro and light rail networks and longer-distance services. The main passenger airport serving the city is Kingsford Smith Airport , one of the world's oldest continually operating airports. In 1788, Captain Arthur Phillip , the first governor of New South Wales, named
9928-536: The affected person's health and the different chemotherapeutics' side effects. Anthrocyclines and cyclophosphamide cause leukemia in up to 1% of those treated. Anthrocyclines also cause congestive heart failure in around 1% of people treated. Taxanes cause peripheral neuropathy , which is permanent in up to 5% of those treated. The same chemotherapy agents can be given before surgery – called neoadjuvant therapy – to shrink tumors, making them easier to safely remove. For those whose tumors are HER2-positive, adding
10064-546: The age of 42. The McGrath Foundation was created after Jane McGrath was diagnosed with breast cancer, and the mission of the foundation was based on her experiences with her nurses at that time. Since 2005, the McGrath Foundation has placed 233 McGrath Breast Cancer Nurses in communities across Australia , and has supported over 143,000 families. The majority of all McGrath Breast Care Nurses are in rural and regional areas. People experiencing breast cancer can directly contact their nearest McGrath Breast Care Nurse, whose support
10200-475: The armed forces than the Commonwealth authorities could process, and helped reduce unemployment. Those returning from the war in 1918 were promised "homes fit for heroes" in new suburbs such as Daceyville and Matraville. "Garden suburbs" and mixed industrial and residential developments also grew along the rail and tram corridors. The population reached one million in 1926, after Sydney had regained its position as
10336-563: The arrival of the British, there were 4,000 to 8,000 Aboriginal people in the greater Sydney region. The inhabitants subsisted on fishing, hunting, and gathering plants and shellfish. The diet of the coastal clans was more reliant on seafood whereas hinterland clans ate more forest animals and plants. The clans had distinctive equipment and weapons mostly made of stone, wood, plant materials, bone and shell. They also differed in their body decorations, hairstyles, songs and dances. Aboriginal clans had
10472-553: The breast (nearly two thirds of cases) have the best prognoses – over 99% survive at least five years. Those whose tumors have metastasized to distant sites have relatively poor prognoses – 31% survive at least five years from the time of diagnosis. Triple-negative breast cancer (up to 15% of cases) and inflammatory breast cancer (up to 5% of cases) are particularly aggressive and have relatively poor prognoses. Those with triple-negative breast cancer have an overall five-year survival rate of 77% – 91% for those whose tumors are confined to
10608-431: The breast , with eczema -like red, scaly irritation on the nipple and areola . Advanced tumors can spread (metastasize) beyond the breast, most commonly to the bones, liver, lungs, and brain. Bone metastases can cause swelling, progressive bone pain , and weakening of the bones that leads to fractures . Liver metastases can cause abdominal pain, nausea, vomiting, and skin problems – rash , itchy skin, or yellowing of
10744-597: The breast, a change in breast shape, dimpling of the skin, milk rejection , fluid coming from the nipple , a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease , there may be bone pain , swollen lymph nodes , shortness of breath , or yellow skin . Risk factors for developing breast cancer include obesity , a lack of physical exercise , alcohol consumption, hormone replacement therapy during menopause , ionizing radiation , an early age at first menstruation , having children late in life (or not at all), older age, having
10880-444: The breast, near the chest center), or for axillary lymph nodes that appear attached to each other or to the tissue around them (a sign of more severely affected tissue). N3 designates tumors that have spread to the highest axillary lymph nodes (called "level 3" axillary lymph nodes, above the armpit near the shoulder), to the supraclavicular lymph nodes (along the neck), or to both the axillary and intramammary lymph nodes. The M score
11016-671: The breast. A 2013 Cochrane review found that it was unclear whether mammographic screening does more harm than good, in that a large proportion of women who test positive turn out not to have the disease. A 2009 review for the US Preventive Services Task Force found evidence of benefit in those 40 to 70 years of age, and the organization recommends screening every two years in women 50 to 74 years of age. The medications tamoxifen or raloxifene may be used in an effort to prevent breast cancer in those who are at high risk of developing it. Surgical removal of both breasts
11152-406: The breast; 12% for those with metastases. Those with inflammatory breast cancer are diagnosed after the cancer has already spread to the skin of the breast. They have an overall five-year survival rate of 39%; 19% for those with metastases. The relatively rare tumors with tubular, mucinous, or medullary growth tend to have better prognoses. In addition to the factors that influence cancer staging,
11288-516: The cancer has spread to other parts of the body, treatments are mostly aimed at improving quality of life and comfort. Outcomes for breast cancer vary depending on the cancer type, the extent of disease , and the person's age. The five-year survival rates in England and the United States are between 80 and 90%. In developing countries, five-year survival rates are lower. Worldwide, breast cancer
11424-788: The cancer, another is started. In addition to the chemotherapeutic drugs used for localized cancer, gemcitabine , vinorelbine , etoposide , and epothilones are sometimes effective. Those with bone metastases benefit from regular infusion of the bone-strengthening agents denosumab and the bisphosphonates ; infusion every three months reduces the chance of bone pain, fractures, and bone hypercalcemia . Up to 70% of those with ER-positive metastatic breast cancer benefit from additional endocrine therapy. Therapy options include those used in localized cancer, plus toremifene and fulvestrant , often used in combination with CDK4/6 inhibitors ( palbociclib , ribociclib , or abemaciclib ). When one endocrine therapy fails, most will benefit from transitioning to
11560-427: The chance of detecting potentially dangerous tumors. Regularly feeling one's own breasts for lumps or other abnormalities, called breast self-examination , does not reduce a person's chance of dying from breast cancer. Clinical breast exams, where a health professional feels the breasts for abnormalities, are common; whether they reduce the risk of dying from breast cancer is not known. Regular breast cancer screening
11696-422: The coastal region. The rising sea level between 18,000 and 6,000 years ago flooded the rias to form estuaries and deep harbours. Port Jackson, better known as Sydney Harbour, is one such ria . Sydney features two major soil types: sandy soils (which originate from the Hawkesbury sandstone) and clay (which are from shales and volcanic rocks ), though some soils may be a mixture of the two. Directly overlying
11832-675: The community with workbooks, presentations and videos available for free download from the McGrath Foundation website. In 2008, the McGrath Foundation partnered with Community First Credit Union and developed the McGrath Pink Visa to raise money for McGrath Breast Care Nurses. The McGrath Foundation has a strong corporate partnership programme, and is aligned to several well-known brands that provide fundraising and awareness support. The McGrath Foundation has over 40 corporate partners including Cricket Australia . McGrath also reached out to former Ashes adversary Andrew Strauss , who played in
11968-526: The cove where the first British settlement was established Sydney Cove after Home Secretary Thomas Townshend, 1st Viscount Sydney . The cove was called Warrane by the Aboriginal inhabitants. Phillip considered naming the settlement Albion , but this name was never officially used. By 1790 Phillip and other officials were regularly calling the township Sydney. Sydney was declared a city in 1842. The Gadigal (Cadigal) clan, whose territory stretches along
12104-530: The demolition of buildings erected on Crown land, including some owned by past and serving military officers. The resulting conflict culminated in the Rum Rebellion of 1808, in which Bligh was deposed by the New South Wales Corps . Governor Lachlan Macquarie (1810–1821) played a leading role in the development of Sydney and New South Wales, establishing a bank, a currency and a hospital. He employed
12240-516: The emigration of free British settlers to New South Wales. Immigration to the colony increased from 900 free settlers in 1826–30 to 29,000 in 1836–40, many of whom settled in Sydney. By the 1840s Sydney exhibited a geographic divide between poor and working-class residents living west of the Tank Stream in areas such as The Rocks , and the more affluent residents living to its east. Free settlers, free-born residents and former convicts now represented
12376-693: The first crops failed, leading to several years of hunger and strict rationing. The food crisis was relieved with the arrival of the Second Fleet in mid-1790 and the Third Fleet in 1791. Former convicts received small grants of land, and government and private farms spread to the more fertile lands around Parramatta , Windsor and Camden on the Cumberland Plain . By 1804, the colony was self-sufficient in food. A smallpox epidemic in April 1789 killed about half
12512-461: The fringes of the Sydney area. The first meeting between Aboriginals and British explorers occurred on 29 April 1770 when Lieutenant James Cook landed at Botany Bay (Kamay ) and encountered the Gweagal clan. Two Gweagal men opposed the landing party and one was shot and wounded. Cook and his crew stayed at Botany Bay for a week, collecting water, timber, fodder and botanical specimens and exploring
12648-700: The goldfields. Melbourne soon overtook Sydney as Australia's largest city, leading to an enduring rivalry between the two. However, increased immigration from overseas and wealth from gold exports increased demand for housing, consumer goods, services and urban amenities. The New South Wales government also stimulated growth by investing heavily in railways, trams, roads, ports, telegraph, schools and urban services. The population of Sydney and its suburbs grew from 95,600 in 1861 to 386,900 in 1891. The city developed many of its characteristic features. The growing population packed into rows of terrace houses in narrow streets. New public buildings of sandstone abounded, including at
12784-835: The heart. After their chemotherapy course, those whose tumors are ER-positive or PR-positive benefit from endocrine therapy , which reduces the levels of estrogens and progesterones that hormone receptor-positive breast cancers require to survive. Tamoxifen treatment blocks the ER in the breast and some other tissues, and reduces the risk of breast cancer death by around 40% over the next ten years. Chemically blocking estrogen production with GnRH -targeted drugs ( goserelin , leuprolide , or triptorelin ) and aromatase inhibitors ( anastrozole , letrozole , or exemestane ) slightly improves survival, but has more severe side effects. Side effects of estrogen depletion include hot flashes , vaginal discomfort, and muscle and joint pain. Endocrine therapy
12920-462: The importance of breast health, are confident in detecting changes, are knowledgeable about the risk factors for breast cancer and are checking their breasts regularly. According to the Foundation, the programme "aims to empower young women in particular to look after and know their bodies, and to take action that promotes their health and wellbeing". It includes resources for schools, the workplace and
13056-505: The inland location, frost is recorded early in the morning in Western Sydney a few times in winter. Autumn and spring are the transitional seasons, with spring showing a larger temperature variation than autumn. Sydney experiences an urban heat island effect. This makes certain parts of the city more vulnerable to extreme heat, including coastal suburbs. In late spring and summer, temperatures over 35 °C (95 °F) are not uncommon, though hot, dry conditions are usually ended by
13192-443: The lining of the mammary ducts . 10% are lobular carcinoma – derived from the mammary lobes – or mixed ductal/lobular carcinoma. Rarer types include mucinous carcinoma (around 2.5% of cases; surrounded by mucin ), tubular carcinoma (1.5%; full of small tubes of epithelial cells ), medullary carcinoma (1%; resembling "medullary" or middle-layer tissue), and papillary carcinoma (1%; covered in finger-like growths). Oftentimes
13328-505: The main body of insurgents were routed by about 100 troops and volunteers at Rouse Hill . At least 39 convicts were killed in the uprising and subsequent executions. As the colony spread to the more fertile lands around the Hawkesbury River , north-west of Sydney, conflict between the settlers and the Darug people intensified, reaching a peak from 1794 to 1810. Bands of Darug people, led by Pemulwuy and later by his son Tedbury , burned crops, killed livestock and raided settler stores in
13464-421: The mammary lobes) rarely causes a noticeable lump, and is often found incidentally during a biopsy for another reason. It is commonly spread throughout both breasts. Those with lobular carcinoma in situ also have an increased risk of developing breast cancer – around 1% develop breast cancer each year. However, their risk of dying of breast cancer is no higher than the rest of the population. Invasive tumor tissue
13600-441: The mastectomy scar and chest wall. If cancerous cells have spread to nearby lymph nodes, those lymph nodes will be irradiated as well. Radiation is typically given five days per week, for up to seven weeks. Radiotherapy for breast cancer is typically delivered via external beam radiotherapy , where a device focuses radiation beams onto the targeted parts of the body. Instead, some undergo brachytherapy , where radioactive material
13736-457: The metropolis. Manufacturing, protected by high tariffs, employed over a third of the workforce from 1945 to the 1960s. However, as the long post-war economic boom progressed, retail and other service industries became the main source of new jobs. An estimated one million onlookers, most of the city's population, watched Queen Elizabeth II land in 1954 at Farm Cove where Captain Phillip had raised
13872-677: The most dense breasts (called "extremely dense"). Women with particularly dense breasts can instead be screened by ultrasound , magnetic resonance imaging (MRI), or tomosynthesis , all of which more sensitively detect breast tumors. Regular screening mammography reduces breast cancer deaths by at least 20%. Most medical guidelines recommend annual screening mammograms for women aged 50–70. Screening also reduces breast cancer mortality in women aged 40–49, and some guidelines recommend annual screening in this age group as well. For women at high risk for developing breast cancer, most guidelines recommend adding MRI screening to mammography, to increase
14008-518: The most expensive cities in the world, Sydney frequently ranks in the top ten most liveable cities . It is classified as an Alpha+ city by the Globalization and World Cities Research Network , indicating its influence in the region and throughout the world. Ranked eleventh in the world for economic opportunity, Sydney has an advanced market economy with strengths in education, finance, manufacturing and tourism . The University of Sydney and
14144-518: The most famous. The Nepean River wraps around the western edge of the city and becomes the Hawkesbury River before reaching Broken Bay . Most of Sydney's water storages can be found on tributaries of the Nepean River. The Parramatta River is mostly industrial and drains a large area of Sydney's western suburbs into Port Jackson. The southern parts of the city are drained by the Georges River and
14280-527: The most populous city in Australia. The government created jobs with massive public projects such as the electrification of the Sydney rail network and building the Sydney Harbour Bridge. Sydney was more severely affected by the Great Depression of the 1930s than regional New South Wales or Melbourne. New building almost came to a standstill, and by 1933 the unemployment rate for male workers
14416-543: The navy. The First Fleet of 11 ships under the command of Captain Arthur Phillip arrived in Botany Bay in January 1788. It comprised more than a thousand settlers, including 736 convicts. The fleet soon moved to the more suitable Port Jackson where a settlement was established at Sydney Cove on 26 January 1788. The colony of New South Wales was formally proclaimed by Governor Phillip on 7 February 1788. Sydney Cove offered
14552-489: The nipple. Some may experience unusual discharge from the breasts, or swelling of the lymph nodes under the arms or along the collar bone . Some less common forms of breast cancer cause distinctive symptoms. Up to 5% of people with breast cancer have inflammatory breast cancer , where cancer cells block the lymph vessels of one breast, causing the breast to substantially swell and redden over three to six months. Up to 3% of people with breast cancer have Paget's disease of
14688-628: The older Hawkesbury sandstone is the Wianamatta shale , a geological feature found in western Sydney that was deposited in connection with a large river delta during the Middle Triassic . The Wianamatta shale generally comprises fine grained sedimentary rocks such as shales, mudstones , ironstones , siltstones and laminites , with less common sandstone units. The Wianamatta Group is made up of Bringelly Shale , Minchinbury Sandstone and Ashfield Shale . The most prevalent plant communities in
14824-569: The one hand, and storms and flooding on the other, associated with the opposite phases of the oscillation in Australia . The weather is moderated by proximity to the ocean, and more extreme temperatures are recorded in the inland western suburbs because Sydney CBD is more affected by the oceanic climate drivers than the western suburbs. At Sydney's primary weather station at Observatory Hill , extreme temperatures have ranged from 45.8 °C (114.4 °F) on 18 January 2013 to 2.1 °C (35.8 °F) on 22 June 1932. An average of 14.9 days
14960-433: The opportunity to show off their cricket skills and fundraise for the McGrath Foundation. McGrath Foundation High Tea – Jane McGrath and best friend Tracy Bevan, Ambassador and Director of the McGrath Foundation, hosted a high tea as one of the Foundation's first fundraising initiatives. The McGrath Foundation continues to host high teas in Sydney and Melbourne as a way to connect with supporters and raise funds. Tracy Bevan
15096-438: The other breast over 20 years. For around 1 in 5 people treated for localized breast cancer, their tumors eventually spread to distant body sites – most commonly the nearby bones (67% of cases), liver (41%), lungs (37%), brain (13%), and peritoneum (10%). Those with metastatic disease can receive further chemotherapy, typically starting with capecitabine, an anthracycline, or a taxane. As one chemotherapy drug fails to control
15232-452: The other scored characteristics. The management of breast cancer depends on the affected person's health, the cancer case's molecular characteristics, and how far the tumor has spread at the time of diagnosis. Those whose tumors have not spread beyond the breast often undergo surgery to remove the tumor and some surrounding breast tissue. The surgery method is typically chosen to spare as much healthy breast tissue as possible, removing just
15368-663: The protein PIK3CA . PARP inhibitors ( olaparib and talazoparib ) for those with mutations that inactivate BRCA1 or BRCA2 . The immune checkpoint inhibitor antibody atezolizumab for those whose tumors express PD-L1 . And the similar immunotherapy pembrolizumab for those whose tumors have mutations in various DNA repair pathways. Many breast cancer therapies have side effects that can be alleviated with appropriate supportive care. Chemotherapy causes hair loss , nausea , and vomiting in nearly everyone who receives it. Antiemetic drugs can alleviate nausea and vomiting; cooling
15504-518: The quality of life. Physical activity interventions, yoga and meditation may also have beneficial effects on health related quality of life, cognitive impairment, anxiety, fitness and physical activity in women with breast cancer following adjuvant therapy. Breast cancer prognosis varies widely depending on how far the tumor has spread at the time of diagnosis. Overall, 91% of women diagnosed with breast cancer survive at least five years from diagnosis. Those whose tumor(s) are completely confined to
15640-425: The radiation from mammography is a low dose, it is estimated that yearly screening from 40 to 80 years of age will cause approximately 225 cases of fatal breast cancer per million women screened. Around 10% of those with breast cancer have a family history of the disease or genetic factors that put them at higher risk. Women who have had a first-degree relative (mother or sister) diagnosed with breast cancer are at
15776-604: The region's Indigenous population. In November 1790 Bennelong led a group of survivors of the Sydney clans into the settlement, establishing a continuous presence of Aboriginal Australians in settled Sydney. Phillip had been given no instructions for urban development, but in July 1788 submitted a plan for the new town at Sydney Cove . It included a wide central avenue, a permanent Government House, law courts, hospital and other public buildings, but no provision for warehouses, shops, or other commercial buildings. Phillip promptly ignored his own plan, and unplanned development became
15912-544: The risk of breast cancer. Autoimmune diseases such as lupus erythematosus seem also to increase the risk for the acquisition of breast cancer. Women whose breasts have been exposed to substantial radiation doses before the age of 30 – typically due to repeated chest fluoroscopies or treatment for Hodgkin lymphoma – are at increased risk for developing breast cancer. Radioactive iodine therapy (used to treat thyroid disease) and radiation exposures after age 30 are not associated with breast cancer risk. Sydney This
16048-866: The scalp with a cold cap during chemotherapy treatments may reduce hair loss. Many complain of cognitive issues during chemotherapy treatment . These usually resolve within a few months of the end of chemotherapy treatment. Those on endocrine therapy often experience hot flashes , muscle and joint pain, and vaginal dryness/discomfort that can lead to issues having sex. Around half of women have their hot flashes alleviated by taking antidepressants ; pain can be treated with physical therapy and nonsteroidal anti-inflammatory drugs ; counseling and use of personal lubricants can improve sexual issues. In women with non-metastatic breast cancer, psychological interventions such as cognitive behavioral therapy can have positive effects on outcomes such as cognitive impairment, anxiety, depression and mood disturbance, and can also improve
16184-514: The skin ( jaundice ). Those with lung metastases experience chest pain , shortness of breath, and regular coughing . Metastases in the brain can cause persistent headache , seizures , nausea, vomiting, and disruptions to the affected person's speech, vision, memory, and regular behavior. Breast cancer screening refers to testing otherwise-healthy women for breast cancer in an attempt to diagnose breast tumors early when treatments are more successful. The most common screening test for breast cancer
16320-510: The south-west. The local government area of the City of Sydney covers about 26 square kilometres from Garden island in the east to Bicentennial Park in the west, and south to the suburbs of Alexandria and Rosebery . Sydney is made up of mostly Triassic rock with some recent igneous dykes and volcanic necks (typically found in the Prospect dolerite intrusion , west of Sydney). The Sydney Basin
16456-529: The south. Sydney spans two geographic regions. The Cumberland Plain lies to the south and west of the Harbour and is relatively flat. The Hornsby Plateau is located to the north and is dissected by steep valleys. The flat areas of the south were the first to be developed; it was not until the construction of the Sydney Harbour Bridge that the northern reaches became more heavily populated. Seventy surf beaches can be found along its coastline, with Bondi Beach being
16592-442: The southern shore of Port Jackson from South Head to Darling Harbour , are the traditional owners of the land on which the British settlement was initially established, and call their territory Gadi ( Cadi ). Aboriginal clan names within the Sydney region were often formed by adding the suffix "-gal" to a word denoting the name for their territory, a specific place in their territory, a food source, or totem. Greater Sydney covers
16728-527: The surrounding area. Cook sought to establish relations with the Aboriginal population without success. Britain had been sending convicts to its American colonies for most of the eighteenth century, and the loss of these colonies in 1783 was the impetus to establish a penal colony at Botany Bay. Proponents of colonisation also pointed to the strategic importance of a new base in the Asia-Pacific region and its potential to provide much-needed timber and flax for
16864-439: The temperature seem colder than it actually is . Rainfall has a moderate to low variability and has historically been fairly uniform throughout the year, although in recent years it has been more summer-dominant and erratic. Precipitation is usually higher in summer through to autumn, and lower in late winter to early spring. In late autumn and winter, east coast lows may bring large amounts of rainfall, especially in
17000-865: The three scores. Combined scores of 3, 4, or 5 represent grade 1, a slower-growing cancer. Scores of 6 or 7 represent grade 2. Scores of 8 or 9 represent grade 3, a faster-growing, more aggressive cancer. In addition to grading, tumor biopsy samples are tested by immunohistochemistry to determine if the tissue contains the proteins estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2). Tumors containing either ER or PR are called "hormone receptor-positive" and can be treated with hormone therapies. Around 15 to 20% of tumors contain HER2; these can be treated with HER2-targeted therapies. The remainder that do not contain ER, PR, or HER2 are called "triple-negative" tumors, and tend to grow more quickly than other breast cancer types. After
17136-431: The time of diagnosis; their tumor is detected by a breast cancer screening test. For those who do have symptoms, a new lump in the breast is most common. Most breast lumps are not cancer, though lumps that are painless, hard, and with irregular edges are more likely to be cancerous. Other symptoms include swelling or pain in the breast; dimpling, thickening, redness, or dryness of the breast skin; and pain, or inversion of
17272-502: The traditional lands of 28 known Aboriginal clans. The first people to inhabit the area now known as Sydney were Aboriginal Australians who had migrated from southeast Asia via northern Australia. Flaked pebbles found in Western Sydney's gravel sediments might indicate human occupation from 45,000 to 50,000 years ago, while radiocarbon dating has shown evidence of human activity in the region from around 30,000 years ago. Prior to
17408-434: The tumor ( lumpectomy ) or a larger part of the breast (partial mastectomy ). Those with large or multiple tumors, high genetic risk of subsequent cancers, or who are unable to receive radiation therapy may instead opt for full removal of the affected breast(s) (full mastectomy). To reduce the risk of cancer spreading, women will often have the nearest lymph node removed in a procedure called sentinel lymph node biopsy. Dye
17544-547: The tumor is evaluated, the breast cancer case is staged using the American Joint Committee on Cancer and Union for International Cancer Control 's TNM staging system . Scores are assigned based on characteristics of the tumor (T), lymph nodes (N), and any metastases (M). T scores are determine by the size and extent of the tumor. Tumors less than 2 centimeters (cm) across are designated T1. Tumors 2–5 cm across are T2. A tumor greater than 5 cm across
17680-471: The vast majority of the population of Sydney, leading to increasing public agitation for responsible government and an end to transportation. Transportation to New South Wales ceased in 1840. In 1804, Irish convicts led around 300 rebels in the Castle Hill Rebellion , an attempt to march on Sydney, commandeer a ship, and sail to freedom. Poorly armed, and with their leader Philip Cunningham captured,
17816-401: Was 28 per cent, but over 40 per cent in working class areas such as Alexandria and Redfern. Many families were evicted from their homes and shanty towns grew along coastal Sydney and Botany Bay, the largest being "Happy Valley" at La Perouse . The Depression also exacerbated political divisions. In March 1932, when populist Labor premier Jack Lang attempted to open the Sydney Harbour Bridge he
17952-411: Was also controversial for its cost and disputes between architect Jørn Utzon and government officials. However, soon after it opened in 1973 it became a major tourist attraction and symbol of the city. The progressive reduction in tariff protection from 1974 began the transformation of Sydney from a manufacturing centre to a "world city". From the 1980s, overseas immigration grew rapidly, with Asia ,
18088-402: Was best friend to Jane McGrath and is the official ambassador, as well as a director, of the McGrath Foundation. The McGrath Foundation has had many Australian entertainers and sporting personalities supporting their cause as "Foundation Friends", including: Breast cancer Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a lump in
18224-503: Was formed in the early Triassic period. The sand that was to become the sandstone of today was laid down between 360 and 200 million years ago. The sandstone has shale lenses and fossil riverbeds. The Sydney Basin bioregion includes coastal features of cliffs, beaches, and estuaries. Deep river valleys known as rias were carved during the Triassic period in the Hawkesbury sandstone of
18360-522: Was pioneered by La Trobe University in partnership with Cancer Council Victoria in 1997. McGrath Breast Care Nurses usually have a background in oncology , breast care or women's health and sometimes even psychology . They also require a postgraduate qualification in breast care nursing or cancer nursing, which can be studied at the Australian College of Nursing and La Trobe University. The McGrath Foundation offers four annual scholarships through
18496-544: Was upstaged by Francis de Groot of the far-right New Guard , who slashed the ribbon with a sabre. In January 1938, Sydney celebrated the Empire Games and the sesquicentenary of European settlement in Australia. One journalist wrote, "Golden beaches. Sun tanned men and maidens...Red-roofed villas terraced above the blue waters of the harbour...Even Melbourne seems like some grey and stately city of Northern Europe compared with Sydney's sub-tropical splendours." A congress of
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