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MRC Cancer Unit

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Waters Corporation is an American publicly traded analytical laboratory instrument and software company headquartered in Milford, Massachusetts . The company employs more than 7,800 people, with manufacturing facilities located in Milford, Taunton, Massachusetts ; Wexford , Ireland and Wilmslow , Cheshire . Waters has Sites in 35 countries globally including Frankfurt , Singapore , India, Germany and in Japan.

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23-662: The Medical Research Council Cancer Unit was located in Cambridge and was established in 2001. It was based within the Hutchison/MRC Research Centre, which in turn is situated on the Cambridge Biomedical Campus. The MRC Cancer Unit was established in 2001 (as the MRC Cancer Cell Unit) by Professor Ron Laskey CBE , who was also appointed as the unit's first director. Professor Laskey retired from

46-600: A police station in Framingham, Massachusetts , in 1958. Waters enrolled in the V-12 Navy College Training Program , an officer training program, and graduated from Columbia University as an ensign with a B.S. degree in Physics in 1946. After stints as a university math teacher, Naval officer, project engineer, and entrepreneur, Waters formed Waters Associates in 1958. The fledgling firm's first offices were in

69-1267: A semi-rural 26-acre (110,000 m ) site in Milford, Massachusetts . Waters became chairman, and continued in that role until the company merged with Millipore in 1980, and was rechristened the Waters Chromatograph Division. The sought-for synergies between the two companies never materialized, however. And, in 1993, Waters returned to independence under the leadership of Chairman, President, and Chief Executive Officer Douglas A. Berthiaume. Waters went public through an initial public offering in November 1995. In 1997 Waters entered mass spectrometry market with acquisition of Micromass for $ 176 million. In 2006, Waters acquired Vicam, provider of bioseparation and rapid detection products for improving food safety and quality. On 11 June 2012, Waters India celebrated its silver jubilee anniversary in India. In January 2020, Waters acquired Andrew Alliance, an innovator company in specialty laboratory automation technology, including software and robotics. In September 2020, Waters announced Udit Batra as

92-614: Is advised by a council which directs and oversees corporate policy and science strategy, ensures that the MRC is effectively managed, and makes policy and spending decisions. Council members are drawn from industry, academia, government and the NHS. Members are appointed by the Secretary of State for Business, Energy and Industrial Strategy. Daily management is in the hands of the Executive Chair. Members of

115-639: Is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy . The MRC focuses on high-impact research and has provided

138-486: The British Journal of Clinical Research and Educational Advanced Medicine , the first scientific published medical patrol, as a periodical publication intended to further the progress of science, usually by reporting new research. It contains articles that have been peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity, allow researchers to keep up to date with

161-628: The ALC 100, the first Waters LC system, was brought to market. According to Leslie S. Ettre in a review about Jim Waters, the LC system was formally introduced at the 1968 Pittsburgh Conference. It was a benchtop system equipped with a Milton Roy pump, syringe injection, and two detectors: a Waters differential refractometer and a UV detector from the Laboratory Data Control (LDC) Co. In 1969, Dimitri D’Arbeloff, then president of Millipore Corporation , joined

184-652: The Centre's technology partners Bruker and Waters Corporation . The Centre, led by Imperial College London and King's College London , is funded with two five-year grants of £5 million from the Medical Research Council and the National Institute for Health and Care Research (NIHR) and was officially opened in June 2013. Important work carried out under MRC auspices has included: Scientists associated with

207-470: The MRC have received a total of 32 Nobel Prizes, all in either Physiology or Medicine or Chemistry . The MRC is one of seven Research Councils that are part of UK Research and Innovation , in turn part of the Department for Business, Energy and Industrial Strategy . In the past, the MRC has been answerable to the Office of Science and Innovation , part of the Department of Trade and Industry . The MRC

230-399: The UK : International collaborations : Waters Corporation Waters markets to the laboratory-dependent organization in these market areas: liquid chromatography , mass spectrometry , supercritical fluid chromatography, laboratory informatics , rheometry and microcalorimetry. The business was started by James (Jim) Logan Waters as Waters Associates in an office in the basement of

253-552: The UK, with units addressing medical issues in The Gambia and Uganda managed by the London School of Hygiene & Tropical Medicine . The following is a list of the MRC's institutes, centres and units as of June 2024: Bristol Cambridge Dundee Edinburgh Exeter Glasgow Harwell London Oxford Southampton Multiple sites across UK MRC facilities and resources include, as of June 2024: In

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276-487: The Unit, which cover the following areas: chromosomal instability, Barrett's oesophagus and oesohago-gastric carcinoma, cell fate and cancer, lung tumour evolution, cancer metabolism, lymphatics and the tumour microenvironment, and cancer metastasis. 52°10′37″N 0°08′32″E  /  52.1770°N 0.1422°E  / 52.1770; 0.1422 Medical Research Council (UK) The Medical Research Council ( MRC )

299-465: The company had been self-financed, with proceeds from an earlier business sale, Waters opened Waters Associates to external ownership in 1962. The company's first major break came when Dow Chemical bought one of Waters’ first gel permeation chromatography instruments, Dow Chemical made an additional investment of $ 400,000. By 1979, Dow Chemical had attained nearly 25 percent ownership in Waters. In 1967,

322-683: The company's President and Chief Executive Officer. Waters agreed to acquire Wyatt Technology for $ 1.36 billion in cash in February 2023. The acquisition completed in May 2023. Waters’ main product brands include: ACQUITY UPLC systems, ACQUITY UPC Systems, Xevo mass spectrometry systems, Synapt MS systems, Synapt HDMS systems, XTerra HPLC columns, XBridge columns, ACQUITY UPLC columns, Alliance HPLC systems, Empower chromatography and MassLynx mass spectrometry software , Oasis sample preparation products, NuGenesis lab management system (LMS). A majority of

345-412: The corporation's board of directors. Millipore's venture capital subsidiary made a $ 600,000 equity investment in Waters. Waters next big break came in 1972 when Dr. Helmut Hamberger, chief post-doc for Nobel laureate Robert Woodward of Harvard University, sought Jim Waters’ help to the first synthesis of vitamin B 12 . Dr. Hamberger wanted to purify the positional isomers, which were needed to give him

368-428: The council also chair specialist boards on specific areas of research. For specific subjects, the council convenes committees. As Chief Executives (originally secretaries) served: Following the formation of UK Research and Innovation, the executive chair role replaced the chief executive officer role, and has been held by: MRC CEOs are normally automatically knighted . The MRC has units, centres and institutes in

391-499: The developments of their field and direct their own research. In August 2012, the creation of the MRC-NIHR Phenome Centre, a research centre for personalised medicine, was announced. The MRC-NIHR National Phenome Centre is based at Imperial College London and is a combination of inherited equipment from the anti-doping facilities used to test samples during the 2012 Olympic and Paralympic Games and additional items from

414-535: The directorship in November 2019 to take up a new role as director of the Cancer Science Institute of Singapore. He was succeeded by Professor Rebecca Fitzgerald as the interim director. The MRC Cancer Unit was closed at the end of March 2022. The unit had a general research focus on investigating the early stages of epithelial cancers, with an overall goal of improving the detection and treatment of these cancers. There were seven active research programmes in

437-480: The financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA . Research funded by the MRC has produced 32 Nobel Prize winners to date. The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under

460-507: The rented basement of the Framingham, Mass. police station. During these years, Waters Associates was what is now referred to as a research boutique. Companies would contract Waters and his five employees to build one-of-a-kind instruments for various purposes. Early products included a boiler feedwater flame photometer , a balloon hydrometer , a nerve gas detector, a lab refractometer and process control refractometers. While from its start

483-444: The right compound for the final stages of the synthesis. Working with Dr. Hamberger, the pair took two days to develop a separation, five more days to obtain larger columns to scale up the separation, and three more days to prep his material. In the end, the two had isolated and purified 200 mg of the precursor compound. In 1972, Waters Associates appointed Frank Zenie president. A year later, headquarters moved from Framingham to

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506-680: The terms of the National Insurance Act 1911 . This was a consequence of the recommendation of the Royal Commissions on Tuberculosis , which recommended the creation of a permanent medical research body. The mandate was not limited to tuberculosis, however. In 1920, it became the Medical Research Council under Royal Charter . A supplementary Charter was formally approved by the Queen on 17 July 2003. In March 1933, MRC established

529-686: The unit in 2010. His successor was Professor Ashok Venkitaraman , who had co-directed the unit from 2006 with Professor Laskey. As well as his position as director of the MRC Cancer Unit, Professor Venkitaraman was also the Ursula Zoellner Professor of Cancer Research within the University of Cambridge . In October 2013, the unit joined the University of Cambridge and changed its name to the MRC Cancer Unit. Professor Venkitaraman stepped down from

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