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141-450: Lethal injection is the practice of injecting one or more drugs into a person (typically a barbiturate , paralytic , and potassium solution) for the express purpose of causing rapid death . The main application for this procedure is capital punishment , but the term may also be applied in a broader sense to include euthanasia and other forms of suicide . The drugs cause the person to become unconscious, stops their breathing, and causes
282-495: A humid continental climate while western Nebraska is primarily semi-arid . The state has wide variations between winter and summer temperatures; the variations decrease in southern Nebraska. Violent thunderstorms and tornadoes occur primarily during spring and summer, and sometimes in autumn. The Chinook wind tends to warm the state significantly in the winter and early spring. Indigenous peoples, including Omaha , Missouria , Ponca , Pawnee , Otoe , and various branches of
423-619: A chemical paralytic ." The Chapman protocol was approved by anesthesiologist Stanley Deutsch, formerly Head of the Department of Anaesthesiology of the Oklahoma University Medical School, the On August 29, 1977, Texas adopted the new method of execution, switching from electrocution. On December 7, 1982, Texas became the first U.S. state and territory in the world to use lethal injection to carry out capital punishment, for
564-638: A common practice anymore, however, owing to the dangers of long-term use of barbiturates; they have been replaced by the benzodiazepines and Z-drug such as zolpidem, zaleplon and eszopiclone for sleep. The final class of barbiturates are known as long-acting barbiturates (the most notable one being phenobarbital, which has a half-life of roughly 92 hours). This class of barbiturates is used almost exclusively as anticonvulsants , although on rare occasions they are prescribed for daytime sedation. Barbiturates in this class are not used for insomnia, because, owing to their extremely long half-life, patients would awake with
705-420: A day or more, and subsequently result in bioaccumulation of the drug in the system. The therapeutic and recreational effects of long-acting barbiturates wear off significantly faster than the drug can be eliminated, allowing the drug to reach toxic concentrations in the blood following repeated administration (even when taken at the therapeutic or prescribed dose) despite the user feeling little or no effects from
846-474: A derivative of barbituric acid, or any salt of a derivative of barbituric acid" (all other barbiturates) were designated as being schedule III . Under the original CSA, no barbiturates were placed in schedule I, II, or V; however, amobarbital, pentobarbital, and secobarbital are now schedule II controlled substances unless they are in a suppository dosage form. In 1971, the Convention on Psychotropic Substances
987-683: A doctor, owing to the high lethality and relatively sudden onset of the withdrawal. Attempting to quit "cold turkey" may result in neurological damage due to excitotoxicity, severe physical injuries received during convulsions, and even death resulting from arrhythmias during grande Mal seizures, paralleling death caused by delirium tremens. Some symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgement, drowsiness, shallow breathing, staggering, and, in severe cases, coma or death. The lethal dosage of barbiturates varies greatly with tolerance and from one individual to another. The lethal dose
1128-459: A form of execution intended to supplant electrocution , gas inhalation , hanging and firing squad , that were considered to be less humane. It is now the most common form of legal execution in the United States. Lethal injection was proposed on January 17, 1888, by Julius Mount Bleyer , a New York doctor who praised it as being cheaper than hanging . Bleyer's idea was never used, due to
1269-451: A hazard to the prison personnel in case of an accidental needle stick injury. Following connection of the lines, saline drips are started in both arms. This, too, is standard medical procedure: it must be ascertained that the IV lines are not blocked, ensuring the chemicals have not precipitated in the IV lines and blocked the needle, preventing the drugs from reaching the subject. A heart monitor
1410-749: A heart arrhythmia , in that order. First developed in the United States , it has become a legal means of execution in Mainland China , Thailand (since 2003), Guatemala , Taiwan , the Maldives , Nigeria , and Vietnam , though Guatemala abolished the death penalty in civil cases in 2017 and has not conducted an execution since 2000 and the Maldives has never carried out an execution since its independence. Although Taiwan permits lethal injection as an execution method, no executions have been carried out in this manner;
1551-491: A higher overall number. Since 2016, data for births of White Hispanic origin are not collected, but included in one Hispanic group; persons of Hispanic origin may be of any race. The religious affiliations of the people of Nebraska are predominantly Christian, according to a 2014 survey by the Pew Research Center. At the 2020 Public Religion Research Institute survey, 73% of the population identified as Christian. At
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#17328690128481692-420: A lethal injection machine designed by Massachusetts -based Fred A. Leuchter consisting of two components: the delivery module and the control module. The delivery module is in the execution chamber. It must be pre-loaded with the proper chemicals and operates the timing of the dosage. The control module is in the control room. This is the portion which officially starts the procedure. This is done by first arming
1833-585: A long history of civil rights activism. Blacks encountered discrimination from other Americans in Omaha and especially from recent European immigrants who were also competing for the same jobs as well. During the early 20th century, In 1912, African Americans founded the Omaha chapter of the National Association for the Advancement of Colored People to work for improved conditions in the city and state. During
1974-491: A manner similar to long-acting benzodiazepines such as diazepam and clonazepam . Often polysubstance use occurs and barbiturates are consumed with or substituted by other available substances, most commonly alcohol. People who use substances tend to prefer short-acting and intermediate-acting barbiturates. The most commonly used are amobarbital (Amytal), pentobarbital (Nembutal), and secobarbital (Seconal). A combination of amobarbital and secobarbital (called Tuinal )
2115-401: A patient "under" in emergency surgery situations. Doctors can also bring a patient out of anesthesia just as quickly, should complications arise during surgery. The middle two classes of barbiturates are often combined under the title "short/intermediate-acting." These barbiturates are also employed for anesthetic purposes, and are also sometimes prescribed for anxiety or insomnia . This is not
2256-518: A percentage of the total population) in the nation. Nebraska is also home to the largest Polish American population in the Great Plains. German Americans are the largest ancestry group in most of the state, particularly in the eastern counties. Thurston County (made up entirely of the Omaha and Winnebago reservations) has an American Indian majority, and Butler County is one of only two counties in
2397-613: A point formed by its intersection with the forty-third degree of north latitude [the Western border, which is the Panhandle]; thence east along said forty-third degree of north latitude to the Keya Paha river; thence down the middle of the channel of said river, with its meanderings, to its junction with the Niobrara River; thence down the middle of the channel of said Niobrara River, and following
2538-546: A point formed by its intersection with the twenty-fifth degree of longitude west from Washington [the Southern border]; thence north along said twenty-fifth degree of longitude, to a point formed by its intersection with the forty-first degree of north latitude; thence west along said forty-first degree of north latitude to a point formed by its intersection with the twenty-seventh degree of longitude west from Washington; thence north along said twenty-seventh degree of west longitude, to
2679-428: A population of fewer than 1,000. Regional population declines have forced many rural schools to consolidate. Fifty-three of Nebraska's 93 counties reported declining populations between 1990 and 2000, ranging from a 0.06% loss ( Frontier County ) to a 17.04% loss ( Hitchcock County ). More urbanized areas of the state have experienced substantial growth. In 2000, the city of Omaha had a population of 390,007; in 2005,
2820-524: A reference number. Metropolitan Class City (300,000 or more) Primary Class City (100,000–299,999) First Class City (5,000–99,999) Second Class Cities (800–4,999) and Villages (100–800) make up the rest of the communities in Nebraska. There are 116 second-class cities and 382 villages in the state. Metropolitan areas 2017 estimate data Micropolitan areas 2012 estimate data Other areas The 2020 United States Census reported that
2961-494: A residual "hang-over" effect and feel groggy. Barbiturates can in most cases be used either as the free acid or as salts of sodium, calcium, potassium, magnesium, lithium, etc. Codeine - and dionine -based salts of barbituric acid have been developed. During World War II , military personnel in the Pacific region were given "goofballs" to improve their tolerance of the heat and humidity of daily working conditions. Goofballs reduced
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#17328690128483102-482: A series of botched executions and the eventual rise of public disapproval in electrocutions. Lethal injections were first used by Nazi Germany to execute prisoners during World War II . Nazi Germany developed the Action T4 euthanasia program led by Karl Brandt as one method to dispose of Lebensunwertes Leben (" life unworthy of life "). During the war, lethal injections were also administered to children detained at
3243-478: A violation of medical ethics, such as the Geneva Promise , and such physicians would be thrown out of the medical community and shunned for engaging in such deeds, even if they could not lawfully be stripped of their license. On December 8, 2009, Kenneth Biros became the first person executed using Ohio's new single-drug execution protocol. He was pronounced dead at 11:47 am EST, 10 minutes after receiving
3384-418: Is 0.2 mg/kg and the duration of paralysis is around 4 to 8 hours. Paralysis of respiratory muscles will lead to death in a considerably shorter time. Pancuronium bromide is a derivative of the alkaloid malouetine from the plant Malouetia bequaertiana . Instead of pancuronium, other drugs in use are succinylcholine chloride and tubocurarine chloride . Potassium is an electrolyte , 98% of which
3525-535: Is a landlocked state in the Midwestern region of the United States . It borders South Dakota to the north; Iowa to the east and Missouri to the southeast, both across the Missouri River ; Kansas to the south; Colorado to the southwest; and Wyoming to the west. Nebraska is the 16th-largest state by land area , with just over 77,220 square miles (200,000 km ). With a population of over 1.9 million, it
3666-505: Is also highly used. Short-acting and intermediate-acting barbiturates are usually prescribed as sedatives and sleeping pills. These pills begin acting fifteen to forty minutes after they are swallowed, and their effects last from five to six hours. Slang terms for barbiturates include barbs, barbies, bluebirds, dolls, wallbangers, yellows, downers, goofballs, sleepers, 'reds & blues', and tooties. (it lacks oxygen at #2 position of generic barbiturate structure) (the oxygen at #2 position
3807-523: Is also in response to executions being horrifying to the public. Lethal injections are less expensive than firing squads, with a single dose costing 300 yuan compared to 700 yuan for a shooting execution. Prior to 2013, shooting was the primary method of execution in Vietnam . The use of lethal injection method was approved by the government in 2010, adopted in 2011, and then started being used in 2013. Urges to adopt other methods than lethal injection to replace
3948-455: Is also key to achieve the desired effects in the appropriate order: administration of the pentobarbital renders the person unconscious; the infusion of the pancuronium bromide induces complete paralysis, including that of the lungs and diaphragm rendering the person unable to breathe. If the person being executed were not already completely unconscious, the injection of a highly concentrated solution of potassium chloride could cause severe pain at
4089-415: Is an extended process often consisting of converting the patient to a long-acting benzodiazepine (i.e. Valium ), followed by slowly tapering off the benzodiazepine. Mental cravings for barbiturates can last for months or years in some cases and counselling/support groups are highly encouraged by addiction specialists. Patients should never try to tackle the task of discontinuing barbiturates without consulting
4230-507: Is an ultra-short acting barbiturate, often used for anesthesia induction and for medically induced coma. The typical anesthesia induction dose is 0.35 grams. Loss of consciousness is induced within 30–45 seconds at the typical dose, while a 5 gram dose (14 times the normal dose) is likely to induce unconsciousness in 10 seconds. A full medical dose of thiopental reaches the brain in about 30 seconds. This induces an unconscious state. Five to twenty minutes after injection, approximately 15% of
4371-405: Is an ultra-short-acting barbiturate that is marketed under the name Sodium Pentothal. It is often mistaken for " truth serum ", or sodium amytal , an intermediate-acting barbiturate that is used for sedation and to treat insomnia, but was also used in so-called sodium amytal "interviews" where the person being questioned would incorrectly be thought to be more likely to provide the truth whilst under
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4512-424: Is associated with significant morbidity. One study found that 11% of males and 23% of females with a sedative - hypnotic misuse die by suicide. Other effects of barbiturate intoxication include drowsiness , lateral and vertical nystagmus , slurred speech and ataxia , decreased anxiety, and loss of inhibitions. Barbiturates are also used to alleviate the adverse or withdrawal effects of illicit drug use, in
4653-489: Is attached to the inmate. In most states, the intravenous injection is a series of drugs given in a set sequence, designed to first induce unconsciousness followed by death through paralysis of respiratory muscles and/or by cardiac arrest through depolarization of cardiac muscle cells. The execution of the condemned in most states involves three separate injections (in sequential order): The drugs are not mixed externally to avoid precipitation . A sequential injection
4794-404: Is considered one of the most dangerous withdrawals of any known addictive substance. Similarly to benzodiazepines, the longer acting barbiturates produce a less severe withdrawal syndrome than short acting and ultra-short acting barbiturates. Withdrawal symptoms are dose-dependent with heavier users being more affected than lower-dose addicts. The pharmacological treatment of barbiturate withdrawal
4935-478: Is given. The usual intravenous dose of 10–20 mEq per hour is given slowly since it takes time for the electrolyte to equilibrate into the cells. When used in state-sanctioned lethal injection, bolus potassium injection affects the electrical conduction of heart muscle and ultimately leads to cardiac arrest. The potassium bolus delivered for lethal injection causes a rapid onset of elevated extracellular potassium, also known as hyperkalemia , causing depolarization of
5076-420: Is highly variable among different members of the class, with superpotent barbiturates such as pentobarbital being potentially fatal in considerably lower doses than the low-potency barbiturates such as butalbital. Even in inpatient settings, the development of tolerance is still a problem, as dangerous and unpleasant withdrawal symptoms can result when the drug is stopped after dependence has developed. Tolerance to
5217-407: Is intracellular. The 2% remaining outside the cell has great implications for cells that generate action potentials. Doctors prescribe potassium for patients when potassium levels in the blood are insufficient, called hypokalemia . The potassium can be given orally, which is the safest route; or it can be given intravenously, in which case strict rules and hospital protocols govern the rate at which it
5358-570: Is one of only two states that divide electoral college votes by district, and is not winner-take-all. Nebraska is composed of two major land regions: the Dissected Till Plains and the Great Plains . The Dissected Till Plains region consists of gently rolling hills and contains the state's largest cities, Omaha and Lincoln. The Great Plains region, occupying most of western Nebraska, is characterized by treeless prairie . Eastern Nebraska has
5499-667: Is preferred. The following is a Dutch protocol for parenteral (intravenous) administration to obtain euthanasia, with the old protocol listed first and the new protocol listed second: Barbiturate Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid . They are effective when used medically as anxiolytics , hypnotics , and anticonvulsants , but have physical and psychological addiction potential as well as overdose potential among other possible adverse effects. They have been used recreationally for their anti-anxiety and sedative effects, and are thus controlled in most countries due to
5640-491: Is replaced by a sulfur) Thiopental is a barbiturate with one of the C=O double bonds (with the carbon being labelled 2 in the adjacent diagram) replaced with a C=S double bond, R being CH 2 CH 3 (ethyl) and R3) being CH(CH 3 )CH 2 CH 2 CH 3 ( sec -pentyl). Thiopental is no longer available in the United States. Nebraska Nebraska ( / n ə ˈ b r æ s k ə / nə- BRASS -kə )
5781-429: Is somewhat more complex than telling the truth, especially under the influence of a sedative-hypnotic drug. The memory-impairing effects and cognitive impairments induced by sodium thiopental are thought to reduce a subject's ability to invent and remember lies. This practice is no longer considered legally admissible in court, owing to findings that subjects undergoing such interrogations may form false memories, putting
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5922-417: Is specifically exempted from controlled substance status, while its sibling Fiorinal , which contains aspirin instead of paracetamol and may contain codeine phosphate, remains a schedule III drug. Recreational users report that a barbiturate high gives them feelings of relaxed contentment and euphoria . Physical and psychological dependence may also develop with repeated use. Chronic misuse of barbiturates
6063-543: Is the 38th-most populous state and the eighth-least densely populated . Its capital is Lincoln , and its most populous city is Omaha , which is on the Missouri River . Nebraska was admitted into the United States in 1867, two years after the end of the American Civil War . The Nebraska Legislature is unlike any other American legislature in that it is unicameral , and its members are elected without any official reference to political party affiliation . Nebraska
6204-626: Is the principal excitatory neurotransmitter in the mammalian CNS. Taken together, the findings that barbiturates potentiate inhibitory GABA A receptors and inhibit excitatory AMPA receptors can explain the superior CNS-depressant effects of these agents to alternative GABA potentiating agents such as benzodiazepines and quinazolinones . At higher concentration, they inhibit the Ca -dependent release of neurotransmitters such as glutamate via an effect on P / Q-type voltage-dependent calcium channels . Barbiturates produce their pharmacological effects by increasing
6345-533: Is the sole method allowed, but no penalties have been carried out since 2000 when the country experienced the live televised double executions of Amílcar Cetino Pérez and Tomás Cerrate Hernández . The export of drugs to be used for lethal injection was banned by the European Union (EU) in 2011, together with other items under the EU Torture Regulation. Since then, pentobarbital followed thiopental in
6486-476: Is therefore about 3 times more than the dose used in euthanasia. The Ohio protocol, developed after the incomplete execution of Romell Broom , aims to ensure the rapid and painless onset of anesthesia by only using sodium thiopental and eliminating the use of Pavulon and potassium as the second and third drugs, respectively. It also provides for a secondary fail-safe measure using intramuscular injection of midazolam, followed by sufentanil or hydromorphone in
6627-624: Is using the single drug sodium thiopental to execute someone. The first state to switch to this method was Ohio, on December 8, 2009. In 2011, after pressure by activist organizations, the manufacturers of pentobarbital and sodium thiopental halted the supply of the drugs to U.S. prisons performing lethal injections and required all resellers to do the same. In the past, the People's Republic of China executed prisoners primarily by means of shooting . In recent years, lethal injection has become more common. The specific lethal injection procedures, including
6768-466: The Midwestern United States . Residents in Nebraska had passed an initiative in 1934, then the first session in the unicameral was held in 1937. Kay Orr was elected Nebraska's first female governor on November 4, 1986. The state is bordered by South Dakota to the north; Iowa to the east and Missouri to the southeast, across the Missouri River ; Kansas to the south; Colorado to
6909-475: The Homestead Act , thousands of settlers migrated into Nebraska to claim free land granted by the federal government. Because so few trees grew on the prairies , many of the first farming settlers built their homes of sod , as had Native Americans such as the Omaha. The first wave of settlement gave the territory a sufficient population to apply for statehood. Nebraska became the 37th state on March 1, 1867, and
7050-625: The Lakota ( Sioux ) tribes, lived in the region for thousands of years before European discovery and exploration . The state is crossed by many historic trails, including that of the Lewis and Clark Expedition . The completion of the Transcontinental Railroad through Nebraska and passage of the Homestead Acts led to rapid growth in the population of American settlers in the 1870s and 1880s and
7191-651: The Niobrara River flows through the northern part, and the Republican River runs across the southern part. The first Constitution of Nebraska in 1866 described Nebraska's boundaries as follows (The description of the Northern border is no longer accurate, since the Keya Paha River and the Niobrara River no longer form the boundary of the state of Nebraska. Instead, Nebraska's Northern border now extends east along
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#17328690128487332-457: The Omaha Race Riots in 1919 , many white rioters protested throughout Omaha due to there being an incident in which a black man was accused of sexually assaulting a white women. The Great Depression also had greatly affected the residents of Nebraska at the time. From 1930 to 1936 the dust bowl was common in the state due to there being a drought, wind, and dirt being dug up throughout all of
7473-492: The Rocky Mountains provide a temporary moderating effect on temperatures in the state's western portion during the winter. Thus, average January maximum temperatures are highest at around 43 °F or 6.1 °C in southwestern Dundy County , and lowest at about 30 °F or −1.1 °C around South Sioux City in the northeast. Average annual precipitation decreases east to west from about 31.5 inches (800 mm) in
7614-558: The Sisak concentration camp by the camp's commander, the physician Antun Najžer . Royal Commission on Capital Punishment 1949–1953 also considered lethal injection, but eventually ruled it out after pressure from the British Medical Association (BMA). On May 10, 1977, Oklahoma became the first U.S. state to approve lethal injection as Governor David Boren signed a bill into law. Episcopal Reverend Bill Wiseman had introduced
7755-466: The United Methodist Church (109,283). Nebraska has a progressive income tax . The portion of income from $ 0 to $ 2,400 is taxed at 2.56%; from $ 2,400 to $ 17,500, at 3.57%; from $ 17,500 to $ 27,000, at 5.12%; and income over $ 27,000, at 6.84%. The standard deduction for a single taxpayer is $ 5,700; the personal exemption is $ 118. Nebraska has a state sales and use tax of 5.5%. In addition to
7896-577: The Wildcat Hills . Panorama Point , at 5,424 feet (1,653 m), is Nebraska's highest point; though despite its name and elevation, it is a relatively low rise near the Colorado and Wyoming borders. A past tourism slogan for the state of Nebraska was "Where the West Begins" (it has since been changed to "Honestly, it's not for everyone"). Locations given for the beginning of the "West" in Nebraska include
8037-637: The execution of Carey Dean Moore on August 14, 2018, the State of Nebraska used a novel drug cocktail comprising diazepam , fentanyl , cisatracurium , and potassium chloride , over the strong objections of the German pharmaceutical company Fresenius Kabi . Potassium acetate had been incorrectly used in place of potassium chloride in Oklahoma in January 2015 for the execution of Charles Frederick Warner . In August 2017,
8178-490: The 1690s, Spain established trade connections with the Apache , whose territory then included western Nebraska. By 1703, France had developed a regular trade with native peoples along the Missouri River in Nebraska, and by 1719 had signed treaties with several of these peoples. After war broke out between the two countries, Spain dispatched an armed expedition to Nebraska under Lieutenant General Pedro de Villasur in 1720. The party
8319-568: The 1970s most barbiturates were replaced by benzodiazepines . Barbituric acid itself does not have any direct effect on the central nervous system and chemists have derived over 2,500 compounds from it that possess pharmacologically active qualities. The broad class of barbiturates is further broken down and classified according to speed of onset and duration of action. Ultrashort-acting barbiturates are commonly used for anesthesia because their extremely short duration of action allows for greater control. These properties allow doctors to rapidly put
8460-753: The 2014 Pew Research Center's survey, 20% of the population were religiously unaffiliated; in 2020, the Public Religion Research Institute determined 22% of the population became religiously unaffiliated. The largest single denominations by number of adherents in 2010 were the Roman Catholic Church (372,838), the Lutheran Church–Missouri Synod (112,585), the Evangelical Lutheran Church in America (110,110) and
8601-456: The 2016 American Community Survey , 10.2% of Nebraska's population were of Hispanic or Latino origin (of any race): Mexican (7.8%), Puerto Rican (0.2%), Cuban (0.2%), and other Hispanic or Latino origin (2.0%). The largest ancestry groups were: German (36.1%), Irish (13.1%), English (7.8%), Czech (4.7%), Swedish (4.3%), and Polish (3.5%). Nebraska has the largest Czech American and non-Mormon Danish American population (as
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#17328690128488742-596: The European Union's ban. By early 2014, a number of botched executions involving lethal injection, and a rising shortage of suitable drugs, had some U.S. states reconsidering lethal injection as a form of execution. Tennessee , which had previously offered inmates a choice between lethal injection and the electric chair , passed a law in May 2014 which gave the state the option to use the electric chair if lethal injection drugs are either unavailable or declared unconstitutional. At
8883-488: The GABA A receptor at multiple homologous transmembrane pockets located at subunit interfaces, which are binding sites distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. In addition to this GABAergic effect, barbiturates also block AMPA and kainate receptors , subtypes of ionotropic glutamate receptor . Glutamate
9024-665: The GABA A receptor channel is only one of several representatives. This Cys-loop receptor superfamily of ion channels includes the neuronal nACh receptor channel, the 5-HT 3 receptor channel, and the glycine receptor channel. However, while GABA A receptor currents are increased by barbiturates (and other general anesthetics), ligand-gated ion channels that are predominantly permeable for cationic ions are blocked by these compounds. For example, neuronal nAChR channels are blocked by clinically relevant anesthetic concentrations of both thiopental and pentobarbital. Such findings implicate (non-GABA-ergic) ligand-gated ion channels, e.g.
9165-681: The Missouri River, the intersection of 13th and O Streets in Lincoln (where it is marked by a red brick star), the 100th meridian , and Chimney Rock . Areas under the management of the National Park Service include: Areas under the management of the National Forest Service include: Two major climatic zones are represented in Nebraska. The eastern two-thirds of the state has a humid continental climate ( Köppen Dfa ), although
9306-411: The State of Florida first used the drug in the execution of Mark James Asay using a combination of etomidate , rocuronium bromide , and potassium acetate as part of a new protocol. In the United States, the typical lethal injection begins with the condemned person being strapped onto a gurney ; two intravenous cannulas ("IVs") are then inserted, one in each arm. Only one is necessary to carry out
9447-515: The United States illegally as children (also known as Dreamers). The state legislature lifted the ban in December 2016. Mexico , India , China , Guatemala , and El Salvador are top countries of origin for Nebraska's immigrants. As of 2011, 31.0% of Nebraska's population younger than age one were minorities. Note: For 2013–2015, births in table don't add up, because Hispanics are counted both by their ethnicity and by their race, giving
9588-617: The anxiolytic and sedative effects of barbiturates tends to develop faster than tolerance to their effects on smooth muscle, respiration, and heart rate, making them generally unsuitable for a long time psychiatric use. Tolerance to the anticonvulsant effects tends to correlate more with tolerance to physiological effects, however, meaning that they are still a viable option for long-term epilepsy treatment. Barbiturates in overdose with other CNS (central nervous system) depressants (e.g. alcohol, opiates, benzodiazepines) are even more dangerous owing to additive CNS and respiratory depressant effects. In
9729-434: The basic structure, mainly in position 5 on the ring. In modern chemistry the barbiturates are often presented by its Hirshfeld surface representations showing its intermolecular interactions [1] calculated with CrystalExplorer Program. Sodium barbital and barbital have also been used as pH buffers for biological research, e.g., in immuno-electrophoresis or in fixative solutions. Barbiturates are classified based on
9870-531: The capital was moved from Omaha to the center at Lancaster, later renamed Lincoln after the recently assassinated President of the United States, Abraham Lincoln . The battle of Massacre Canyon , on August 5, 1873, was the last major battle between the Pawnee and the Sioux . During the 1870s to the 1880s, Nebraska experienced a large growth in population. Several factors contributed to attracting new residents. The first
10011-496: The case of benzodiazepines, not only do they have additive effects, barbiturates also increase the binding affinity of the benzodiazepine binding site, leading to exaggerated benzodiazepine effects. (ex. If a benzodiazepine increases the frequency of channel opening by 300%, and a barbiturate increases the duration of their opening by 300%, then the combined effects of the drugs increases the channels' overall function by 900%, not 600%). The longest-acting barbiturates have half-lives of
10152-568: The city's estimated population was 414,521 (427,872 including the recently annexed city of Elkhorn ), a 6.3% increase over five years. The 2010 census showed that Omaha has a population of 408,958. The city of Lincoln had a 2000 population of 225,581 and a 2010 population of 258,379, a 14.5% increase. As of the 2010 census, there were 530 cities and villages in the state of Nebraska. There are five classifications of cities and villages in Nebraska, which are based upon population. All population figures are 2017 Census Bureau estimates unless flagged by
10293-592: The class possess relevant enzyme induction capabilities, the degree of induction overall as well as the impact on each specific enzyme span a broad range, with phenobarbital and secobarbital being the most potent enzyme inducers and butalbital and talbutal being among the weakest enzyme inducers in the class. People who are known to have killed themselves by barbiturate overdose include Stefan Zweig , Charles Boyer , Ruan Lingyu , Dalida , Jeannine Deckers , Felix Hausdorff , Abbie Hoffman , Phyllis Hyman , C. P. Ramanujam , George Sanders , Jean Seberg , Lupe Vélez and
10434-466: The consequences of barbiturate withdrawal (she was hospitalized with burns, the doctors treating her not being aware of her barbiturate addiction). The use of Barbiturates is contraindicated in the following conditions: Barbiturates act as positive allosteric modulators and, at higher doses, as agonists of GABA A receptors . GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system (CNS). Barbiturates bind to
10575-476: The current states of Colorado , North Dakota , South Dakota , Wyoming , and Montana . The territorial capital of Nebraska was Omaha . Late 19th century In the 1860s, after the U.S. government forced many of the American Indian tribes to cede their lands and settle on reservations , it opened large tracts of land to agricultural development by European immigrants and American settlers . Under
10716-569: The demand on the respiratory system, as well as maintaining blood pressure. Many soldiers returned with addictions that required several months of rehabilitation before discharge. This led to growing dependency problems, often exacerbated by indifferent physicians prescribing high doses to unknowing patients through the 1950s and 1960s. In the late 1950s and 1960s, an increasing number of published reports of barbiturate overdoses and dependence problems led physicians to reduce their prescription, particularly for spurious requests. This eventually led to
10857-541: The development of a large agriculture sector for which the state is known to this day. Nebraska's name is the result of anglicization of the archaic Otoe Ñí Brásge (contemporary Otoe: Ñíbrahge ; pronounced [ɲĩbɾasꜜkɛ] ), or the Omaha Ní Btháska , (pronounced [nĩbɫᶞasꜜka] ), meaning "flat water", after the Platte River which flows through the state. Indigenous peoples lived in
10998-416: The drug is in the brain, with the rest in other parts of the body. The half-life of this drug is about 11.5 hours, and the concentration in the brain remains at around 5–10% of the total dose during that time. When a 'mega-dose' is administered, as in state-sanctioned lethal injection, the concentration in the brain during the tail phase of the distribution remains higher than the peak concentration found in
11139-554: The drug or drugs used, are a state secret and not publicly known. Lethal injection in China was legalized in 1996. The number of shooting executions slowly decreased; and, in February 2009, the Supreme People's Court ordered the discontinuation of firing squads by the following year under the conclusion that injections were more humane to the prisoner. It has been suggested that the switch
11280-403: The drug passes through the placenta to the fetus. After the baby is born, it may experience withdrawal symptoms and have trouble breathing. In addition, nursing mothers who take barbiturates may transmit the drug to their babies through breast milk. A rare adverse reaction to barbiturates is Stevens–Johnson syndrome , which primarily affects the mucous membranes. With regular use, tolerance to
11421-489: The duration of action. Examples of each class include: Indications for the use of barbiturates include: There are special risks to consider for older adults, and women who are pregnant. When a person ages, the body becomes less able to rid itself of barbiturates. As a result, people over the age of sixty-five are at higher risk of experiencing the harmful effects of barbiturates, including drug dependence and accidental overdose. When barbiturates are taken during pregnancy,
11562-636: The duration of chloride ion channel opening at the GABA A receptor (pharmacodynamics: This increases the efficacy of GABA), whereas benzodiazepines increase the frequency of the chloride ion channel opening at the GABA A receptor (pharmacodynamics: This increases the potency of GABA). The direct gating or opening of the chloride ion channel is the reason for the increased toxicity of barbiturates compared to benzodiazepines in overdose. Further, barbiturates are relatively non-selective compounds that bind to an entire superfamily of ligand-gated ion channels, of which
11703-448: The effects of barbiturates develops. Research shows tolerance can develop with even one administration of a barbiturate. As with all GABAergic drugs, barbiturate withdrawal produces potentially fatal effects such as seizures, in a manner reminiscent of delirium tremens and benzodiazepine withdrawal although its more direct mechanism of GABA agonism makes barbiturate withdrawal even more severe than that of alcohol or benzodiazepines. It
11844-448: The electric chair unconstitutional). On May 11, 1977, the day after the new method had become state law, Oklahoma 's state medical examiner Jay Chapman proposed making the process a new, less painful method of execution, known as Chapman's protocol: "An intravenous saline drip shall be started in the prisoner's arm, into which shall be introduced a lethal injection consisting of an ultrashort-acting barbiturate in combination with
11985-492: The event intravenous administration of the sodium thiopental proves problematic. The first state to switch to use midazolam as the first drug in a new three-drug protocol was Florida on October 15, 2013. Then on November 14, 2013, Ohio made the same move. In the brief for the U.S. courts written by accessories, the State of Ohio implies that they were unable to find any physicians willing to participate in development of protocols for executions by lethal injection, as this would be
12126-454: The execution of Charles Brooks, Jr. The People's Republic of China began using this method in 1997, Guatemala in 1996, the Philippines in 1999, Thailand in 2003, and Taiwan in 2005. Vietnam first used this method in 2013. The Philippines abolished the death penalty in 2006, with their last execution being in 2000. Guatemalan law still allows for the death penalty and lethal injection
12267-516: The execution; the other is reserved as a backup in the event the primary line fails. A line leading from the IV line in an adjacent room is attached to the prisoner's IV and secured so that the line does not snap during the injections. The arm of the condemned person is swabbed with alcohol before the cannula is inserted. The needles and equipment used are sterilized. Questions have been raised about why these precautions against infection are performed despite
12408-410: The executioner(s) (either prison staff or private citizens depending on the jurisdiction) then manually inject the three drugs in sequence. During the execution, the condemned's cardiac rhythm is monitored. Death is pronounced after cardiac activity stops. Death usually occurs within seven minutes, although, due to complications in finding a suitable vein, the whole procedure can take up to two hours, as
12549-716: The first U.S. Army post west of the Missouri River, just east of present-day Fort Calhoun . The army abandoned the fort in 1827 as migration moved further west. European-American settlement was scarce until 1848 and the California Gold Rush . On May 30, 1854, the U.S. Congress created the Kansas and the Nebraska territories, divided by the Parallel 40° North , under the Kansas–Nebraska Act . The Nebraska Territory included parts of
12690-494: The first phase of hyperkalemia. This progresses into a broadening and lengthening of the P wave and PR interval, then eventually disappearance of the P wave, widening of the QRS complex, and finally, asystole . This process can occur in the span of 30 to 60 seconds, but there have been cases of 'botched' procedures, leading to one inmate gasping for air for approximately 10 to 13 minutes. Sodium thiopental (US trade name: Sodium Pentothal)
12831-416: The forty-third degree of north latitude until it meets the Missouri River directly.): The State of Nebraska shall consist of all the territory included within the following boundaries, to-wit: Commencing at a point formed by the intersection of the western boundary of the State of Missouri, with the fortieth degree of north latitude; extending thence due west along said fortieth degree of north latitude, to
12972-589: The heart, and midazolam for sedation. Pancuronium bromide (Trade name: Pavulon): The related drug curare , like pancuronium, is a non-depolarizing muscle relaxant (a paralytic agent) that blocks the action of acetylcholine at the motor end-plate of the neuromuscular junction . Binding of acetylcholine to receptors on the end-plate causes depolarization and contraction of the muscle fiber; non-depolarizing neuromuscular blocking agents like pancuronium stop this binding from taking place The typical dose for pancuronium bromide in capital punishment by lethal injection
13113-426: The induction dose for anesthesia, because repeated doses—or a single very high dose as in lethal injection—accumulate in high concentrations in body fat, from which the thiopental is gradually released. This is the reason why an ultra-short acting barbiturate, such as thiopental, can be used for long-term induction of medical coma . Historically, thiopental has been one of the most commonly used and studied drugs for
13254-413: The induction of coma. Protocols vary for how it is given, but the typical doses are anywhere from 500 mg up to 1.5 grams. It is likely that this data was used to develop the initial protocols for state-sanctioned lethal injection, according to which one gram of thiopental was used to induce the coma. Now, most states use 5 grams to be absolutely certain the dosage is effective. Pentobarbital
13395-432: The influence of the drug. When dissolved in water, sodium amytal can be swallowed, or it can be administered by intravenous injection. The drug does not itself force people to tell the truth, but is thought to decrease inhibitions and slow creative thinking, making subjects more likely to be caught off guard when questioned, and increasing the possibility of the subject revealing information through emotional outbursts. Lying
13536-479: The injection. On September 10, 2010, Washington became the second state to use the single-drug Ohio protocol with the execution of Cal Coburn Brown , who was proclaimed dead within two minutes after receiving the single-drug injection of sodium thiopental. Seven states ( Arizona , Georgia , Idaho , Missouri , Ohio, South Dakota , and Texas ) have used the single-drug execution protocol. The state of Washington used this single drug method, but stopped when execution
13677-423: The lack of guarantee that the victim will be unconscious in every individual case. There have been instances in which condemned individuals have been injected with paralytics, and then a cardiac arrest -inducing agent, while still conscious; this has been compared to torture . Proponents often say that there is no reasonable or less cruel alternative. Lethal injection gained popularity in the late 20th century as
13818-497: The latter are less toxic in drug overdose . However, barbiturates are still used as anticonvulsants (e.g., phenobarbital and primidone ) and general anesthetics (e.g., sodium thiopental ). Barbiturates in high doses are used for medical aid in dying , and in combination with a muscle relaxant for euthanasia and for capital punishment by lethal injection . Barbiturates are frequently employed as euthanizing agents in small-animal veterinary medicine . Sodium thiopental
13959-495: The lethal drugs for the main line and syringes 1, 3 and 5 containing the injections for the backup line. The system was used in New Jersey before the abolition of the death penalty in 2007. Illinois previously used the computer, and Missouri and Delaware use the manual injection switch on the delivery panel. Eleven states have switched, or have stated their intention to switch, to a one-drug lethal injection protocol. A one-drug method
14100-530: The machine, and then with station members simultaneously pressing each of their buttons on the panel to activate the delivery. The computer then deletes who actually started the syringes, so the participants are not aware if their syringe contained saline or one of the drugs necessary for execution (to assuage guilt in a manner similar to the blank cartridge in execution by firing squad ). The delivery module has eight syringes. The end syringes (i.e., syringes 7 and 8) containing saline, syringes 2, 4 and 6 containing
14241-509: The meanderings thereof to its junction with the Missouri River [the Northern border]; thence down the middle of the channel of said Missouri River, and following the meanderings thereof to the place of beginning [the Eastern border, which is the Missouri River]. Nebraska is composed of two major land regions: the Dissected Till Plains and the Great Plains . The easternmost portion of the state
14382-614: The members of Heaven's Gate cult. Others who have died as a result of barbiturate overdose include Pier Angeli , Brian Epstein , Judy Garland , Jimi Hendrix , Marilyn Monroe , Inger Stevens , Dinah Washington , Ellen Wilkinson , and Alan Wilson ; in some cases these have been speculated to be suicides as well. Those who died of a combination of barbiturates and other drugs include Rainer Werner Fassbinder , Dorothy Kilgallen , Malcolm Lowry , Edie Sedgwick and Kenneth Williams . Dorothy Dandridge died of either an overdose or an unrelated embolism . Ingeborg Bachmann may have died of
14523-599: The mentioned shortening of the refractory period. At approximately 8 mEq/L and beyond, the shortened refractory period and increased resting membrane potential diminishes the quantity of voltage-gated sodium channels ready to contribute to rapid phase 0 depolarization due to the inactivation gate requiring further repolarization to open back up. At potassium concentrations beyond 14mEq/L, enough sodium channels remain inactivated to no longer generate an action potential, ultimately leading to no heart beat. Heart potassium levels after lethal injection can reach 160.0 mEq/L. Depolarizing
14664-565: The method into the Oklahoma legislature, where it passed and was quickly sent to the Governor's desk (Title 22, Section 1014(A)). The next day, Texas became the second U.S. state to approve a lethal injection law. Since then, until 2004, 37 of the 38 states using capital punishment introduced lethal injection statutes (the last state, Nebraska , maintaining electrocution as its single method until adopting injection in 2009, after its Supreme Court deemed
14805-415: The muscle cell inhibits its ability to fire by reducing the available number of sodium channels (they are placed in an inactivated state). ECG changes vary depending on serum potassium concentrations and on the individual. Peaked T-waves signifying faster repolarization and potentially instances of early-repolarization and phase 2 re-entry (Brugada, Short QT, and Early-Repolarization Syndromes) are evident in
14946-444: The nation with a Czech-American plurality. In recent years, Nebraska has become home to many refugee communities. In 2016, it welcomed more refugees per capita than any other state. Nebraska, and in particular Lincoln, is the largest home of Yazidis refugees and Yazidi Americans in the United States. Notably, Nebraska was the last of all 50 states to maintain a ban on the issuance of driver's licenses to adults who had entered
15087-470: The native peoples of Nebraska. Spain dispatched two trading expeditions up the Missouri River in 1794 and 1795; the second, under James Mackay, established the first European settlement in Nebraska near the mouth of the Platte River. Later that year, Mackay's party built a trading post, dubbed Fort Carlos IV (Fort Charles), near present-day Homer . In 1819, the United States established Fort Atkinson as
15228-464: The needle, while a second prison employee orders, prepares, and loads the drugs into the lethal injection syringes. Two other staff members take each of the three syringes and secure them into the IVs. After the curtain is opened to allow the witnesses to see inside the chamber, the condemned person is then permitted to make a final statement. Following this, the warden signals that the execution may commence, and
15369-465: The neuronal nAChR channel, in mediating some of the (side) effects of barbiturates. This is the mechanism responsible for the (mild to moderate) anesthetic effect of barbiturates in high doses when used in anesthetic concentration. Drug interactions with barbiturates are: Caution is needed in people using: Caution is also required in patients with: Barbituric acid was first synthesized 27 November 1864, by German chemist Adolf von Baeyer . This
15510-411: The new substance by amalgamating Barbara with urea . Another story holds that Baeyer synthesized the substance from the collected urine of a Munich waitress named Barbara. No substance of medical value was discovered, however, until 1903 when two German scientists working at Bayer , Emil Fischer and Joseph von Mering , discovered that barbital was very effective in putting dogs to sleep. Barbital
15651-763: The patients name, and have to contain the name and initials, address, city and telephone number of the licensed prescriber issuing the prescriptions, as well as the name and initials, address and city of the person the prescription is issued to). Among that group of drugs are the barbiturates amobarbital , butalbital , cyclobarbital , and pentobarbital . In the United States, the Controlled Substances Act of 1970 classified most barbiturates as controlled substances—and they remain so as of August 2023 . Barbital , methylphenobarbital (also known as mephobarbital ), and phenobarbital are designated schedule IV drugs, and "Any substance which contains any quantity of
15792-740: The plasma-bound concentrations of the drug. Users who consume alcohol or other sedatives after the drug's effects have worn off, but before it has cleared the system, may experience a greatly exaggerated effect from the other sedatives which can be incapacitating or even fatal. Barbiturates induce a number of hepatic CYP enzymes (most notably CYP2C9 , CYP2C19 , and CYP3A4 ), leading to exaggerated effects from many prodrugs and decreased effects from drugs which are metabolized by these enzymes to inactive metabolites. This can result in fatal overdoses from drugs such as codeine , tramadol , and carisoprodol , which become considerably more potent after being metabolized by CYP enzymes. Although all known members of
15933-480: The population of Nebraska was 1,961,504 on April 1, 2020, a 7.4% increase since the 2010 United States census . The center of population of Nebraska is in Polk County , in the city of Shelby . According to HUD 's 2022 Annual Homeless Assessment Report , there were an estimated 2,246 homeless people in Nebraska . The table below shows the racial composition of Nebraska's population as of 2022. According to
16074-514: The purpose of the injection being death. The several explanations include: cannulae are sterilized and have their quality heavily controlled during manufacture, so using sterile ones is a routine medical procedure. Secondly, the prisoner could receive a stay of execution after the cannulae have been inserted, as happened in the case of James Autry in October 1983 (he was eventually executed on March 14, 1984). Third, use of unsterilized equipment would be
16215-487: The readoption of shootings. The first prisoner in Vietnam to be executed by lethal injection, on August 6, 2013, was 27-year-old Nguyen Anh Tuan, arrested for murder and robbery. Between 2013 and 2016, 429 prisoners were executed by this method in the country. Typically, three drugs are used in lethal injection. Pancuronium bromide (Pavulon) is used to cause muscle paralysis and respiratory arrest, potassium chloride to stop
16356-406: The region of present-day Nebraska for thousands of years before European colonization . The historic tribes in the state included the Omaha , Missouria , Ponca , Pawnee , Otoe , and various branches of the Lakota ( Sioux ), some of which migrated from eastern areas into the region. When European exploration, trade, and settlement began, both Spain and France sought to control the region. In
16497-478: The reliability of all information obtained through such methods into question. Nonetheless, it is still employed in certain circumstances by defense and law enforcement agencies as a "humane" alternative to torture interrogation when the subject is believed to have information critical to the security of the state or agency employing the tactic. In 1988, the synthesis and binding studies of an artificial receptor binding barbiturates by six complementary hydrogen bonds
16638-576: The resting membrane potential of the heart muscle cells, particularly impacting the heart's pacemaker cells. However, potassium's effect on membrane potential is concentration dependent and ultimately occurs in two phases. Given the reference range for serum potassium is 3.5-5.5 mEq/L, concentrations up to 8 mEq/L shorten action potential duration and the refractory period due to an allosteric effect of potassium ions on potassium channels, leading to increased conduction velocity and subsequently quicker potassium efflux which contributes to quicker repolarization and
16779-881: The risks associated with such use. Barbiturates have largely been replaced by benzodiazepines and nonbenzodiazepines ("Z-drugs") in routine medical practice, particularly in the treatment of anxiety disorders and insomnia , because of the significantly lower risk of overdose, and the lack of an antidote for barbiturate overdose . Despite this, barbiturates are still in use for various purposes: in general anesthesia , epilepsy , treatment of acute migraines or cluster headaches , acute tension headaches , euthanasia , capital punishment , and assisted suicide . Barbiturates, such as phenobarbital , were long used as anxiolytics and hypnotics . Intermediate-acting barbiturates reduce time to fall asleep, increase total sleep time, and reduce REM sleep time. Today they have been largely replaced by benzodiazepines for these purposes because
16920-415: The same is true for Nigeria. Lethal injection was also used in the Philippines until the country re-abolished the death penalty in 2006. Although primarily introduced as a more "humane" method of execution, lethal injection has been subject to criticism, being described by some as cruel and unusual . Opponents in particular critique the operation of lethal injections by untrained corrections officers and
17061-421: The same time, Wyoming and Utah were considering the use of execution by firing squad in addition to other existing execution methods. In 2016, Pfizer joined over 20 American and European pharmaceutical manufacturers that had previously blocked the sale of their drugs for use in lethal injections, effectively closing the open market for FDA -approved manufacturers for any potential lethal execution drug. In
17202-519: The scheduling of barbiturates as controlled drugs. In the Netherlands, the Opium Law classifies all barbiturates as List II drugs, with the exception of secobarbital , which is on List I . There is a small group of List II drugs for which physicians have to write the prescriptions according to the same, tougher guidelines as those for List I drugs (writing the prescription in full in letters, listing
17343-406: The shooting execution began earlier, in 2006, after concerns of the mental state of the firing squad members after executions. The drugs used consist of pancuronium bromide (paralytic), potassium chloride (cardiotoxin), and sodium thiopental (anesthetic). The production of these substances, however, is low in Vietnam. This led to drug shortages and to considering using other domestic poisons or
17484-399: The site of the IV line, as well as along the punctured vein; it interrupts the electrical activity of the heart muscle and causes it to stop beating, bringing about the death of the person being executed. The intravenous tubing leads to a room next to the execution chamber, usually separated from the condemned by a curtain or wall. Typically, a prison employee trained in venipuncture inserts
17625-524: The southeast corner of the state to about 13.8 inches (350 mm) in the Panhandle. Humidity also decreases significantly from east to west. Snowfall across the state is fairly even, with most of Nebraska receiving between 25 and 35 inches (0.64 and 0.89 m) of snow each year. Nebraska's highest-recorded temperature was 118 °F (48 °C) in Minden on July 24, 1936. The state's lowest-recorded temperature
17766-634: The southwest of this region may be classed as a humid subtropical climate ( Cfa ) using the −3 °C or 26.6 °F near the Kansas state line, analogous to the predominantly humid subtropical climate of Kansas and Oklahoma . Western Nebraska, including The Panhandle and adjacent areas bordering Colorado have a semi-arid climate (Köppen BSk ). The entire state experiences wide seasonal variations in both temperature and precipitation. Average temperatures are fairly uniform across Nebraska, with hot summers and generally cold winters. However, chinook winds from
17907-623: The southwest; and Wyoming to the west. The state has 93 counties and is split between two time zones , with the majority of the state observing Central Time and the Panhandle and surrounding counties observing Mountain Time . Three rivers cross the state from west to east. The Platte River , formed by the confluence of the North Platte and the South Platte , runs through the state's central portion,
18048-418: The state tax, some Nebraska cities assess a city sales and use tax, in 0.5% increments, up to a maximum of 1.5%. Dakota County levies an additional 0.5% county sales tax. Food and ingredients that are generally for home preparation and consumption are not taxable. All real property within the state of Nebraska is taxable unless specifically exempted by statute. Since 1992, only depreciable personal property
18189-573: Was abolished. Five additional states ( Arkansas , Kentucky , Louisiana , North Carolina , and Tennessee ) announced that they would switch to a single-drug protocol but, as of April 2014, had not executed anyone since switching protocols. After sodium thiopental began being used in executions, Hospira , the only American company that made the drug, stopped manufacturing it due to its use in executions. The subsequent nationwide shortage of sodium thiopental led states to seek other drugs to use in executions. Pentobarbital, often used for animal euthanasia ,
18330-686: Was attacked and destroyed near present-day Columbus by a large force of Pawnee and Otoe, both allied with the French. The massacre ended Spanish exploration of the area for the remainder of the 18th century. In 1762, during the Seven Years' War , France ceded the Louisiana territory to Spain. This left Britain and Spain competing for dominance along the Mississippi River; by 1773, the British were trading with
18471-404: Was done by condensing urea with diethyl malonate . There are several stories about how the substance got its name. The most likely story is that Baeyer and his colleagues went to celebrate their discovery in a tavern where the town's artillery garrison were also celebrating the feast of Saint Barbara – the patron saint of artillerymen. An artillery officer is said to have christened
18612-603: Was founded in Nebraska City by territorial governor J. Sterling Morton . The National Arbor Day Foundation is still headquartered in Nebraska City , with some offices in Lincoln. In the late 19th century, African Americans migrated from the South to Nebraska as part of the Great Migration . Eventually, they lived primarily to Omaha which offered working-class jobs in meat packing , the railroads and other industries. Omaha has
18753-509: Was introduced at the end of 2010 due to a shortage of sodium thiopental, and has since become the primary sedative in lethal injections in the United States. Barbiturates are the same class of drug used in medically assisted suicide. In euthanasia protocols, the typical dose of thiopental is 1.5 grams; the Dutch Euthanasia protocol indicates 1-1.5 grams or 2 grams in case of high barbiturate tolerance. The dose used for capital punishment
18894-430: Was published. Since this first article, different kind of receptors were designed, as well as different barbiturates and cyanurates , not for their efficiencies as drugs but for applications in supramolecular chemistry , in the conception of materials and molecular devices. The preferred IUPAC name of the base compound, barbituric acid, is 1,3-diazinane-2,4,6-trione. Different barbiturates have different substituents in
19035-693: Was scoured by Ice Age glaciers ; the Dissected Till Plains were left after the glaciers retreated. The Dissected Till Plains is a region of gently rolling hills; Omaha and Lincoln are in this region. The Great Plains occupy most of western Nebraska, with the region consisting of several smaller, diverse land regions, including the Sandhills , the Pine Ridge , the Rainwater Basin , the High Plains and
19176-597: Was signed in Vienna . Designed to regulate amphetamines , barbiturates, and other synthetics, the 34th version of the treaty , as of 25 January 2014 , regulates secobarbital as schedule II, amobarbital, butalbital, cyclobarbital, and pentobarbital as schedule III, and allobarbital , barbital , butobarbital , mephobarbital , phenobarbital , butabarbital , and vinylbital as schedule IV on its "Green List". The combination medication Fioricet , consisting of butalbital, caffeine, and paracetamol (acetaminophen), however,
19317-473: Was that the vast prairie land was perfect for cattle grazing. This helped settlers to learn the unfamiliar geography of the area. The second factor was the invention of several farming technologies. New agricultural innovations such as barbed wire, windmills, and the steel plow, combined with fair weather, enabled settlers to transform Nebraska into prime farming land. By the 1880s, Nebraska's population had soared to more than 450,000 people. The Arbor Day holiday
19458-453: Was the case with the execution of Christopher Newton on May 24, 2007. According to state law, if a physician 's participation in the execution is prohibited for reasons of medical ethics , then the death ruling can be made by the state medical examiner 's office. After confirmation that death has occurred, a coroner signs the condemned's death certificate. Missouri and, before the abolition of capital punishment, Delaware , uses or used
19599-506: Was then marketed by Bayer under the trade name Veronal . It is said that Mering proposed this name because the most peaceful place he knew was the Italian city of Verona . In 1912, Bayer introduced another barbituric acid derivative, phenobarbital , under the trade name Luminal, as a sedative – hypnotic . It was not until the 1950s that the behavioral disturbances and physical dependence potential of barbiturates became recognized. Since
19740-673: Was used as part of a three-drug cocktail for the first time on December 16, 2010, when John David Duty was executed in Oklahoma . It was then used as the drug in a single-drug execution for the first time on March 10, 2011, when Johnnie Baston was executed in Ohio. Lethal injection has also been used in cases of euthanasia to facilitate voluntary death in patients with terminal or chronically painful conditions. Euthanasia can be accomplished either through oral, intravenous, or intramuscular administration of drugs. In individuals who are incapable of swallowing lethal doses of medication, an intravenous route
19881-667: Was −47 °F (−44 °C) in Camp Clarke on February 12, 1899. Nebraska is located in Tornado Alley . Thunderstorms are common during both the spring and the summer. Violent thunderstorms and tornadoes happen primarily during those two seasons, although they also can occur occasionally during the autumn. Eighty-nine percent of the cities in Nebraska have fewer than 3,000 people. Nebraska shares this characteristic with five other Midwestern states: Kansas , Oklahoma , North Dakota and South Dakota , and Iowa . Hundreds of towns have
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