84-609: The Lagos–Kano Standard Gauge Railway is a 1,343 kilometres (835 miles)-long standard gauge railway under construction in Nigeria . Once complete, the railway will connect the Atlantic Ocean port city of Lagos to Kano , near the border with Niger , passing through the national capital of Abuja . The railway replaces the Cape gauge Western Line built by the British in 1896–1927, which has
168-625: A healthy diet are also recommended. Supportive care in severe cases includes treatment to relieve symptoms , fluid therapy , oxygen support and prone positioning , and medications or devices to support other affected vital organs. More severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address
252-602: A standard gauge line desirable. In 2006, the Nigerian government awarded a $ 8.3 billion contract to the China Civil Engineering Construction Corporation to construct a standard gauge railway from Lagos to Kano. Due to an inability to secure funding for the whole project, the Nigerian government decided to build the standard gauge line in segments and rehabilitate the narrow-gauge line in the meantime. The 187 km segment from Abuja to Kaduna
336-615: A variant of concern (VoC) or a variant of interest (VoI). Many of these variants have shared the more infectious D614G . As of May 2023, the WHO had downgraded all variants of concern to previously circulating as these were no longer detected in new infections. Sub-lineages of the Omicron variant (BA.1 – BA.5) were considered separate VoCs by the WHO until they were downgraded in March 2023 as no longer widely circulating. As of 24 September 2024 ,
420-493: A comprehensive international study. Such deaths include deaths due to healthcare capacity constraints and priorities, as well as reluctance to seek care (to avoid possible infection). Further research may help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with
504-628: A country (for example, 1,440 mm or 4 ft 8 + 11 ⁄ 16 in to 1,445 mm or 4 ft 8 + 7 ⁄ 8 in in France). The first tracks in Austria and in the Netherlands had other gauges ( 1,000 mm or 3 ft 3 + 3 ⁄ 8 in in Austria for the Donau Moldau line and 1,945 mm or 6 ft 4 + 9 ⁄ 16 in in
588-464: A frequent passenger on the train, calling it "a very impressive work in progress considering the difficulty of really executing anything in this country." The railway was officially inaugurated by President Muhammadu Buhari on 10 June 2021. On 15 May 2018, the Nigerian Minister of Transportation signed a $ 6.68 billion contract with the China Civil Engineering Construction Corporation to complete
672-590: A large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged. The end of a pandemic or other epidemic only rarely involves the total disappearance of a disease, and historically, much less attention has been given to defining the ends of epidemics than their beginnings. The ends of particular epidemics have been defined in a variety of ways, differing according to academic field, and differently based on location and social group. An epidemic's end can be considered
756-530: A lower design capacity and is in a deteriorated condition. Two segments of the railway have been completed and begun passenger trains. The segment between Abuja and Kaduna officially opened in July 2016. The segment between Lagos and Ibadan was flagged off in June 2021. After Nigeria became independent from Great Britain , the colonial-era railways progressively fell into a state of disrepair. Passenger traffic on
840-448: A median range of 0.24% to 1.49%. IFRs rise as a function of age (from 0.002% at age 10 and 0.01% at age 25, to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85). These rates vary by a factor of ≈10,000 across the age groups. For comparison, the IFR for middle-aged adults is two orders of magnitude higher than the annualised risk of a fatal automobile accident and much higher than
924-815: A random sample have consistently found that total infections considerably exceed the reported case counts. Many countries, early on, had official policies to not test those with only mild symptoms. The strongest risk factors for severe illness are obesity, complications of diabetes , anxiety disorders, and the total number of conditions. During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested. A retrospective cohort study in China found that children and adults were just as likely to be infected. Among more thorough studies, preliminary results from 9 April 2020 found that in Gangelt ,
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#17328846096731008-457: A social phenomenon, not just a biological one. Time reported in March 2024 that expert opinions differ on whether or not COVID-19 is considered endemic or pandemic, and that the WHO continued to call the disease a pandemic on its website. During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus", "the coronavirus outbreak" and
1092-505: A standard gauge of 4 ft 8 + 1 ⁄ 2 in ( 1,435 mm ), and those in Ireland to a new standard gauge of 5 ft 3 in ( 1,600 mm ). In Great Britain, Stephenson's gauge was chosen on the grounds that existing lines of this gauge were eight times longer than those of the rival 7 ft or 2,134 mm (later 7 ft 1 ⁄ 4 in or 2,140 mm ) gauge adopted principally by
1176-451: A test. Conversely, deaths of people who died from underlying conditions following a positive test may be included. Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts. Official death counts have been claimed to underreport the actual death toll, because excess mortality (the number of deaths in a period compared to a long-term average) data show an increase in deaths that
1260-423: A time-consuming and expensive process. The result was the adoption throughout a large part of the world of a "standard gauge" of 1,435 mm ( 4 ft 8 + 1 ⁄ 2 in ), allowing interconnectivity and interoperability. A popular legend that has circulated since at least 1937 traces the origin of the 1,435 mm ( 4 ft 8 + 1 ⁄ 2 in ) gauge even further back than
1344-518: Is associated with COVID-19 and is reported in as many as 88% of cases. The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol ) that infected people exhale as they breathe, talk, cough, sneeze, or sing. Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors. SARS‑CoV‑2 belongs to
1428-745: Is currently operated by the Ghana Railway Company Limited . Kojokrom-Sekondi Railway Line (The Kojokrom-Sekondi line is a branch line that joins the Western Railway Line at Kojokrom ) Indian nationwide rail system ( Indian Railways ) uses 1,676 mm ( 5 ft 6 in ) broad gauge. 96% of the broad gauge network is electrified. The railway tracks of Java and Sumatra use 1,067 mm ( 3 ft 6 in ). Planned and under construction high-speed railways to use 1,668 mm ( 5 ft 5 + 21 ⁄ 32 in ) to maintain interoperability with
1512-480: Is defined in U.S. customary / Imperial units as exactly "four feet eight and one half inches", which is equivalent to 1,435.1 mm. As railways developed and expanded, one of the key issues was the track gauge (the distance, or width, between the inner sides of the rails) to be used. Different railways used different gauges, and where rails of different gauge met – a " gauge break " – loads had to be unloaded from one set of rail cars and reloaded onto another,
1596-600: Is discouraged altogether by the World Health Organization (WHO), due to limited evidence of its efficacy. The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold . In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalisation. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died,
1680-439: Is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID-19 ). Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated
1764-485: Is not explained by COVID-19 deaths alone. Using such data, estimates of the true number of deaths from COVID-19 worldwide have included a range from 18.2 to 33.5 million (≈27.4 million) by 18 November 2023 by The Economist , as well as over 18.5 million by 1 April 2023 by the Institute for Health Metrics and Evaluation and ≈18.2 million (earlier) deaths between 1 January 2020, and 31 December 2021, by
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#17328846096731848-556: Is the most widely used track gauge around the world, with about 55% of the lines in the world using it. All high-speed rail lines use standard gauge except those in Russia , Finland , Uzbekistan , and some line sections in Spain . The distance between the inside edges of the rails is defined to be 1,435 mm except in the United States, Canada, and on some heritage British lines, where it
1932-452: Is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals. Based on Johns Hopkins University statistics, the global CFR was 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023. The number varies by region and has generally declined over time. Several variants have been named by WHO and labelled as
2016-406: Is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and the original SARS-CoV . The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test , which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." The test
2100-614: Is typically done on respiratory samples obtained by a nasopharyngeal swab ; however, a nasal swab or sputum sample may also be used. The WHO has published several testing protocols for the disease. Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching
2184-452: The Exim Bank of China and the balance coming from the Nigerian government. The China Civil Engineering Construction Corporation (CCECC) began construction of the railway on 20 February 2011, and it began laying track in 2013. However, various difficulties delayed the completion of the route. Railway supplies were being stolen by miscreants, forcing CCECC to build a corridor fence to secure
2268-501: The Huanan Seafood Wholesale Market there, but it is possible that human-to-human transmission began earlier. Molecular clock analysis suggests that the first cases were likely to have been between October and November 2019. The scientific consensus is that the virus is most likely of a zoonotic origin, from bats or another closely related mammal. While other explanations such as speculations that SARS-CoV-2
2352-407: The Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions. One measure that public health officials and policymakers have used to monitor the pandemic and guide decision-making is the test positivity rate ("percent positive"). According to Johns Hopkins in 2020, one benchmark for a "too high" per cent positive is 5%, which was used by
2436-598: The Liverpool and Manchester Railway , authorised in 1826 and opened 30 September 1830. The extra half inch was not regarded at first as very significant, and some early trains ran on both gauges daily without compromising safety. The success of this project led to Stephenson and his son Robert being employed to engineer several other larger railway projects. Thus the 4 ft 8 + 1 ⁄ 2 in ( 1,435 mm ) gauge became widespread and dominant in Britain. Robert
2520-597: The basic reproduction number (R 0 ) for COVID-19 in January 2020 were between 1.4 and 2.5, but a subsequent analysis claimed that it may be about 5.7 (with a 95 per cent confidence interval of 3.8 to 8.9). In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28 December, 282,790,822 individuals worldwide had been confirmed as infected. As of 14 April 2022 , over 500 million cases were confirmed globally. Most cases are unconfirmed, with
2604-474: The variants of interest as specified by the World Health Organization are BA.2.86 and JN.1, and the variants under monitoring are JN.1.7, KP.2, KP.3, KP.3.1.1, JN.1.18, LB.1, and XEC. Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste , nasal congestion and runny nose , cough, muscle pain , sore throat , fever, diarrhoea , and breathing difficulties . People with
Lagos–Kano Standard Gauge Railway - Misplaced Pages Continue
2688-429: The "Wuhan coronavirus outbreak", with the disease sometimes called "Wuhan pneumonia ". In January 2020, the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma . WHO finalised
2772-700: The Abuja–Kaduna line in 2016 came at a critical time for ground transport in the region. Starting in 2009, the Abuja–Kaduna Expressway fell into a state of lawlessness as it was besieged by armed robbers and kidnappers. Many of the victims were prominent government officials, including Sierra Leone's High Commissioner to Nigeria. Fearing for their safety, travelers flocked to the train. Daily patronage increased 270% to 3,700, and railway officials were accused of and arrested for ticket racketeering . Senator Mohammed Ali Ndume reported that he had to stand on
2856-589: The Abuja–Kaduna line opened. CCECC took over construction on the line and, on 29 September 2020, it was officially inaugurated by President Muhammadu Buhari in a virtual ceremony. In October 2019, the government signed a $ 3.9 billion contract with the China Railway Construction Corporation Limited to extend the railway from Warri to Abuja, connecting it to the Lagos–Kanos Standard Gauge Railway. The completion of
2940-889: The Great Western Railway. It allowed the broad-gauge companies in Great Britain to continue with their tracks and expand their networks within the "Limits of Deviation" and the exceptions defined in the Act. After an intervening period of mixed-gauge operation (tracks were laid with three rails), the Great Western Railway finally completed the conversion of its network to standard gauge in 1892. In North East England, some early lines in colliery ( coal mining ) areas were 4 ft 8 in ( 1,422 mm ), while in Scotland some early lines were 4 ft 6 in ( 1,372 mm ). The British gauges converged starting from 1846 as
3024-631: The Netherlands for the Hollandsche IJzeren Spoorweg-Maatschappij ), but for interoperability reasons (the first rail service between Paris and Berlin began in 1849, first Chaix timetable) Germany adopted standard gauges, as did most other European countries. The modern method of measuring rail gauge was agreed in the first Berne rail convention of 1886. Several lines were initially built as standard gauge but were later converted to another gauge for cost or for compatibility reasons. 2,295 km (1,426 mi) Victoria built
3108-565: The Nigerian government had to deploy soldiers to protect the railway workers from hoodlums and armed robbers. Construction was further delayed by the 2019 Nigerian general election , when CCECC evacuated its Chinese employees as a precaution. Progress was slowed in 2020 by the social distancing needed to fight the COVID-19 pandemic , as only 20 workers were present on construction sites that once held 200. Passenger trains began trial operations on 7 December 2020. Nobel laureate Wole Soyinka became
3192-430: The Nigerian railways fell from 11 million in 1964 to 1.6 million in 2003. Freight traffic almost collapsed, falling from 3 million tonnes in 1964 to less than 100,000 tonnes in 2000. In early 2013, it took 31 hours for passenger trains to travel between Lagos and Kano , at an average speed of just 45 km/h. Although projects have begun to rehabilitate the Cape gauge railways, economic growth in Nigeria has made
3276-728: The UK to Mexico in 2023. On 28 March 2022, a passenger train on the Abuja-Kaduna line was attacked by bandits . At least 8 people were killed and 65 were kidnapped. Standard gauge A standard-gauge railway is a railway with a track gauge of 1,435 mm ( 4 ft 8 + 1 ⁄ 2 in ). The standard gauge is also called Stephenson gauge (after George Stephenson ), international gauge , UIC gauge , uniform gauge , normal gauge in Europe, and SGR in East Africa. It
3360-636: The WHO in the past. As of 10 March 2023, more than 6.88 million deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020. These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, time since the initial outbreak, and population characteristics, such as age, sex, and overall health. Multiple measures are used to quantify mortality. Official death counts typically include people who died after testing positive. Such counts exclude deaths without
3444-419: The WHO, US, European Union, and Australia. On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines. On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics , in
Lagos–Kano Standard Gauge Railway - Misplaced Pages Continue
3528-534: The advantages of equipment interchange became increasingly apparent. By the 1890s, the entire network was converted to standard gauge. The Royal Commission made no comment about small lines narrower than standard gauge (to be called "narrow gauge"), such as the Ffestiniog Railway . Thus it permitted a future multiplicity of narrow gauges in the UK. It also made no comments about future gauges in British colonies, which allowed various gauges to be adopted across
3612-448: The broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ≈34%). SARS-CoV-2
3696-576: The centre of a major infection cluster in Germany, 15 per cent of a population sample tested positive for antibodies . Screening for COVID-19 in pregnant women in New York City , and blood donors in the Netherlands, found rates of positive antibody tests that indicated more infections than reported. Seroprevalence -based estimates are conservative as some studies show that persons with mild symptoms do not have detectable antibodies. Initial estimates of
3780-746: The city of Shanghai, China. For the first two years of the pandemic, no specific and effective treatment or cure was available. In 2021, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor , Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir ), to treat adult patients. FDA later gave it an EUA. Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), adequate intake of oral fluids and rest. Good personal hygiene and
3864-476: The coal mines of County Durham . He favoured 4 ft 8 in ( 1,422 mm ) for wagonways in Northumberland and Durham , and used it on his Killingworth line. The Hetton and Springwell wagonways also used this gauge. Stephenson's Stockton and Darlington railway (S&DR) was built primarily to transport coal from mines near Shildon to the port at Stockton-on-Tees . Opening in 1825,
3948-487: The coalfields of northern England, pointing to the evidence of rutted roads marked by chariot wheels dating from the Roman Empire . Snopes categorised this legend as "false", but commented that it "is perhaps more fairly labeled as 'Partly true, but for trivial and unremarkable reasons. ' " The historical tendency to place the wheels of horse-drawn vehicles around 5 ft ( 1,524 mm ) apart probably derives from
4032-525: The colonies. Parts of the United States, mainly in the Northeast, adopted the same gauge, because some early trains were purchased from Britain. The American gauges converged, as the advantages of equipment interchange became increasingly apparent. Notably, all the 5 ft ( 1,524 mm ) broad gauge track in the South was converted to "almost standard" gauge 4 ft 9 in ( 1,448 mm ) over
4116-459: The course of two days beginning on 31 May 1886. See Track gauge in the United States . In continental Europe, France and Belgium adopted a 1,500 mm ( 4 ft 11 + 1 ⁄ 16 in ) gauge (measured between the midpoints of each rail's profile ) for their early railways. The gauge between the interior edges of the rails (the measurement adopted from 1844) differed slightly between countries, and even between networks within
4200-480: The cumulative number of infected individuals (including asymptomatic and undiagnosed infections and excluding vaccinated infected individuals). It is expressed in percentage points. Other studies refer to this metric as the infection fatality risk . In November 2020, a review article in Nature reported estimates of population-weighted IFRs for various countries, excluding deaths in elderly care facilities, and found
4284-441: The development of various vaccine platforms during early 2020. The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic and severe illness. The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. As of March 2023, more than 5.5 billion people had received one or more doses (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine
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#17328846096734368-513: The eyes, nose, or mouth with unwashed hands. Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items. A COVID-19 vaccine
4452-735: The first railways to the 5 ft 3 in ( 1,600 mm ) Irish broad gauge. New South Wales then built to the standard gauge, so trains had to stop on the border and passengers transferred, which was only rectified in the 1960s. Queensland still runs on a narrow gauge but there is a standard gauge line from NSW to Brisbane. NMBS/SNCB 3,619 km (2,249 mi) Brussels Metro 40 km (25 mi) Trams in Brussels 140 km (87 mi) 1,032 km (641 mi) The Toronto Transit Commission uses 4 ft 10 + 7 ⁄ 8 in ( 1,495 mm ) gauge on its streetcar and subway lines. Takoradi to Sekondi Route,
4536-525: The general public beginning in December 2020, made available through government and international programs such as COVAX , aiming to provide vaccine equity . Treatments include novel antiviral drugs and symptom control. Common mitigation measures during the public health emergency included travel restrictions , lockdowns , business restrictions and closures, workplace hazard controls , mask mandates , quarantines, testing systems, and contact tracing of
4620-657: The infected. The pandemic caused severe social and economic disruption around the world, including the largest global recession since the Great Depression . Widespread supply shortages , including food shortages , were caused by supply chain disruptions and panic buying . Reduced human activity led to an unprecedented temporary decrease in pollution . Educational institutions and public areas were partially or fully closed in many jurisdictions, and many events were cancelled or postponed during 2020 and 2021. Telework became much more common for white-collar workers as
4704-429: The initial gauge of 4 ft 8 in ( 1,422 mm ) was set to accommodate the existing gauge of hundreds of horse-drawn chaldron wagons that were already in use on the wagonways in the mines. The railway used this gauge for 15 years before a change was made, debuting around 1850, to the 1,435 mm ( 4 ft 8 + 1 ⁄ 2 in ) gauge. The historic Mount Washington Cog Railway ,
4788-484: The issue of respiratory failure. Existing drugs such as hydroxychloroquine , lopinavir/ritonavir , and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect. The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and
4872-576: The majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services . A December 2022 WHO study estimated excess deaths from the pandemic during 2020 and 2021, again concluding ≈14.8 million excess early deaths occurred, reaffirming and detailing their prior calculations from May as well as updating them, addressing criticisms. These numbers do not include measures like years of potential life lost and may make
4956-495: The official names COVID-19 and SARS-CoV-2 on 11 February 2020. Tedros Adhanom Ghebreyesus explained: CO for corona , VI for virus , D for disease and 19 for when the outbreak was first identified (31 December 2019). WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications. WHO named variants of concern and variants of interest using Greek letters . The initial practice of naming them according to where
5040-591: The old 4 ft ( 1,219 mm ) plateway was relaid to 5 ft ( 1,524 mm ) so that Blenkinsop's engine could be used. Others were 4 ft 4 in ( 1,321 mm ) (in Beamish ) or 4 ft 7 + 1 ⁄ 2 in ( 1,410 mm ) (in Bigges Main (in Wallsend ), Kenton , and Coxlodge ). English railway pioneer George Stephenson spent much of his early engineering career working for
5124-534: The outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat , nocturnal cough , and fatigue. Transmission of the virus is often through airborne particles . Mutations have produced many strains (variants) with varying degrees of infectivity and virulence . COVID-19 vaccines were developed rapidly and deployed to
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#17328846096735208-407: The pandemic 2021's leading cause of death . The time between symptom onset and death ranges from 6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. The infection fatality ratio (IFR) is the cumulative number of deaths attributed to the disease divided by
5292-491: The pandemic evolved. Misinformation circulated through social media and mass media , and political tensions intensified . The pandemic raised issues of racial and geographic discrimination , health equity , and the balance between public health imperatives and individual rights . The WHO ended the PHEIC for COVID-19 on 5 May 2023. The disease has continued to circulate, but as of 2024, experts were uncertain as to whether it
5376-415: The population's age structure and the age-specific pattern of infections. There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV. For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19. Another metric in assessing death rate is the case fatality ratio (CFR), which
5460-436: The rails is better, thus the minimum distance between the wheels (and, by extension, the inside faces of the rail heads ) was the important one. A standard gauge for horse railways never existed, but rough groupings were used; in the north of England none was less than 4 ft ( 1,219 mm ). Wylam colliery's system, built before 1763, was 5 ft ( 1,524 mm ), as was John Blenkinsop 's Middleton Railway ;
5544-548: The remaining segments of the Lagos–Kano Standard Gauge Railway. Construction is expected to take 2–3 years from the availability of funds. In 1987, the Nigerian government awarded a contract to build the country's first standard gauge railway, linking the mines at Itakpe to the Ajaokuta Steel Mill and onwards to the port city of Warri . However, the project stagnated and was still not finished when
5628-411: The rest of the network. All other railways use 1,668 mm ( 5 ft 5 + 21 ⁄ 32 in ) ( broad gauge ) and/or 1,000 mm ( 3 ft 3 + 3 ⁄ 8 in ) metre gauge . BLS , Rigi Railways (rack railway) 449 km Several states in the United States had laws requiring road vehicles to have a consistent gauge to allow them to follow ruts in
5712-458: The risk of dying from seasonal influenza . In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in
5796-448: The road. Those gauges were similar to railway standard gauge. COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic ), caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), began with an outbreak of COVID-19 in Wuhan , China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared
5880-496: The same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum , shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhoea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell
5964-485: The term "narrow gauge" for gauges less than standard did not arise for many years, until the first such locomotive-hauled passenger railway, the Ffestiniog Railway , was built. In 1845, in the United Kingdom of Great Britain and Ireland , a Royal Commission on Railway Gauges reported in favour of a standard gauge. The subsequent Gauge Act ruled that new passenger-carrying railways in Great Britain should be built to
6048-411: The time from symptom onset to death has ranged from two to eight weeks. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to intensive care units (ICU). Between 5% and 50% of COVID-19 patients experience long COVID , a condition characterised by long-term consequences persisting after
6132-566: The tracks. The decline in the value of the Nigerian naira led to a shortfall in government funding for the project. Delays arose in the acquisition of land required for the railway through compulsory purchase . Although CCECC had marked the Daughters of Charity hospital in Abuja for demolition in 2014, the government did not pay compensation to the hospital until April 2016. The railway was officially inaugurated on 26 July 2016. A $ 1.53 billion contract
6216-468: The train for the whole trip, and Senator James Manager said, "It is one who wants to commit suicide that will take the road." In September 2023 Angel Trains, who lease trains to UK operators, were reported to be negotiating with Nigeria to sell redundant Great Western Railway High Speed Train sets with Class 43 high speed locomotives for operation in Nigeria. Other trains of this type have been exported from
6300-694: The typical convalescence period of the disease. The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise , headaches, shortness of breath , loss of smell, muscle weakness , low fever and cognitive dysfunction . Many countries attempted to slow or stop the spread of COVID-19 by recommending, mandating or prohibiting behaviour changes, while others relied primarily on providing information. Measures ranged from public advisories to stringent lockdowns. Outbreak control strategies are divided into elimination and mitigation. Experts differentiate between elimination strategies (known as " zero-COVID ") that aim to completely stop
6384-543: The variants were identified (e.g. Delta began as the " Indian variant") is no longer common. A more systematic naming scheme reflects the variant's PANGO lineage (e.g., Omicron 's lineage is B.1.1.529) and is used for other variants. SARS-CoV-2 is a virus closely related to bat coronaviruses , pangolin coronaviruses, and SARS-CoV . The first known outbreak (the 2019–2020 COVID-19 outbreak in mainland China ) started in Wuhan , Hubei, China, in December 2019. Many early cases were linked to people who had visited
6468-479: The width needed to fit a carthorse in between the shafts. Research, however, has been undertaken to support the hypothesis that "the origin of the standard gauge of the railway might result from an interval of wheel ruts of prehistoric ancient carriages". In addition, while road-travelling vehicles are typically measured from the outermost portions of the wheel rims, it became apparent that for vehicles travelling on rails, having main wheel flanges that fit inside
6552-426: The world's first mountain -climbing rack railway , is still in operation in the 21st century, and has used the earlier 4 ft 8 in ( 1,422 mm ) gauge since its inauguration in 1868. George Stephenson introduced the 1,435 mm ( 4 ft 8 + 1 ⁄ 2 in ) gauge (including a belated extra 1 ⁄ 2 in (13 mm) of free movement to reduce binding on curves ) for
6636-443: Was accidentally released from a laboratory have been proposed, as of 2021 these were not supported by evidence. Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease. Due to the effect of sampling bias , studies which obtain a more accurate number by extrapolating from
6720-511: Was awarded in 2012 to the China Civil Engineering Construction Corporation for construction of the Lagos–Ibadan segment (156 km) of the standard gauge railway by 2016. However, the project has also faced delays. A ground-breaking ceremony finally took place on 7 March 2017, and the railway was scheduled for completion in December 2018. Construction was delayed by heavy rains in Spring 2018, and
6804-589: Was reported to have said that if he had had a second chance to choose a gauge, he would have chosen one wider than 4 ft 8 + 1 ⁄ 2 in ( 1,435 mm ). "I would take a few inches more, but a very few". During the " gauge war " with the Great Western Railway , standard gauge was called " narrow gauge ", in contrast to the Great Western's 7 ft 1 ⁄ 4 in ( 2,140 mm ) broad gauge . The modern use of
6888-457: Was still a pandemic. Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 24 November 2024, COVID-19 has caused 7,075,455 confirmed deaths. The COVID-19 pandemic ranks as the fifth- deadliest pandemic or epidemic in history . In epidemiology , a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting
6972-598: Was the first to be built. Abuja was not on the national railway network , as it was purpose-built as a capital city after Nigeria became independent from Great Britain. Kaduna is an important junction point on the existing Cape gauge railway network, where a branch line departs the Lagos–Nguru line for Kafanchan, on the Port Harcourt–Maiduguri Railway. The construction of the Abuja–Kaduna segment cost $ 876 million, consisting of $ 500 million in loans from
7056-502: Was the most widely used. According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021. On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster Nuvaxovid ) was authorised for use in adults in the United Kingdom. It has subsequently received endorsement/authorisation from
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