14-430: IL-3 may refer to: Interleukin 3 Illinois's 3rd congressional district Illinois Route 3 See also [ edit ] Il Tre , or Il 3 [REDACTED] Topics referred to by the same term This disambiguation page lists articles associated with the same title formed as a letter–number combination. If an internal link led you here, you may wish to change
28-511: Is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide chain. IL-3 is produced as a monomer by activated T cells, monocytes/macrophages and stroma cells. The major function of IL-3 cytokine
42-407: Is capable of stimulating differentiation of immature myelomonocytic cells causing changes to the macrophage and granulocyte populations. IL-3 signaling is able to give rise to widest array of cell lineages which is why it has been independently named “multi-CSF” in some older literature. IL-3 also induces various effector functions in both immature and mature cells that more precisely modulate
56-463: Is ensured by high affinity between cell surface interleukin-3 receptor and IL-3. This high affinity receptor contains α and β subunits. IL-3 shares the β subunit with IL-5 and granulocyte-macrophage colony-stimulating factor ( GM-CSF ). This β subunit sharing explains the biological functional similarities of different hematopoietic growth factors. IL-3 receptors can be found on a variety of cell types including many immature myelomonocytic cells in
70-454: Is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. Activated T cells can either induce their own proliferation and differentiation ( autocrine signaling), or that of other T cells ( paracrine signaling) – both involve IL-2 binding to the IL-2 receptor on T cells (upregulated upon cell activation, under
84-411: Is to regulate the concentrations of various blood-cell types. It induces proliferation and differentiation in both early pluripotent stem cells and committed progenitors . It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype switching . Interleukin 3 is an interleukin , a type of biological signal ( cytokine ) that can improve
98-481: The hemopoietic system such as hemopoietic progenitor cells, as well as certain myeloid progenitors, basophils , and eosinophils . IL-3/Receptor complex induces JAK2/STAT5 cell signalization pathway. It can stimulate transcription factor c‑myc (activation of gene expression) and Ras pathway (suppression of apoptosis). In the early 1960s Ginsberg and Sachs discovered that IL-3 is a potent mast cell growth factor produced from activated T cells . Interleukin 3
112-636: The body's natural response to disease as part of the immune system . In conjunction with other β common chain cytokines GM-CSF and IL-5 , IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell populations via binding at the interleukin-3 receptor . IL-3 is mainly produced by activated T cells with the goal of initiating proliferation of various other immune cell types. However, IL-3 has also been shown to be produced in IgG+ B cells and may be involved in earlier antibody isotype switching. IL-3
126-616: The body’s defense against microbial pathogens. IL-3 is also involved in the reconstruction of platelets via the development of megakaryocytes . Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells . In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage ( granulocytes , monocytes , and dendritic cells ), in conjunction with other cytokines, e.g., Erythropoietin (EPO), Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6 . IL-3
140-505: The induction of macrophage -secreted IL-1 ). The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5 , only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF. IL-3 is a T cell-derived, pluripotent and hematopoietic factor required for survival and proliferation of hematopoietic progenitor cells. The signal transmission
154-528: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=IL-3&oldid=1108838613 " Category : Letter–number combination disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Interleukin 3 1JLI 3562 n/a ENSG00000164399 n/a P08700 n/a NM_000588 n/a NP_000579 n/a Interleukin 3 ( IL-3 )
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#1732873079717168-480: The myelomonocytic leukaemia cell line WEHI-3B. It is thought that this genetic change is the key in development of this leukemia type. Human IL-3 was first cloned in 1986 and since then clinical trials are ongoing. Post-chemotherapy, IL-3 application reduces chemotherapy delays and promotes regeneration of granulocytes and platelets . However, only IL-3 treatment in bone marrow failure disorders such as myelodysplastic syndrome (MDS) and aplastic anemia (AA)
182-400: Was disappointing. It has been shown that combination of IL-3, GM-CSF and stem cell factor enhances peripheral blood stem cells during high-dose chemotherapy. Other studies showed that IL-3 could be a future perspective therapeutic agent in lymphohematopoietic disorders and solid cancers. Interleukin 3 has been shown to interact with IL3RA . Myelomonocyte A myelomonocyte
196-403: Was originally discovered in mice and later isolated from humans. The cytokine was originally discovered via the observation that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3). IL-3 is produced by T cells only after stimulation with antigens or other specific impulses. However, it was observed that IL-3 is present in
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