132-632: The Gila monster ( Heloderma suspectum , / ˈ h iː l ə / HEE -lə ) is a species of venomous lizard native to the Southwestern United States and the northwestern Mexican state of Sonora . It is a heavy, slow-moving reptile, up to 56 centimetres (22 in) long, and it is the only venomous lizard native to the United States. Its venomous close relatives, the four beaded lizards (all former subspecies of Heloderma horridum ) inhabit Mexico and Guatemala . The Gila monster
264-504: A compartment syndrome . Four potentially lethal toxins have been isolated from the Gila monster's venom, which cause hemorrhage in internal organs and exophthalmos (bulging of the eyes), and helothermine , which causes lethargy , partial paralysis of the limbs, and hypothermia in rats . Some are similar in action of the vasoactive intestinal peptide (VIP), which relaxes smooth muscle and regulates water and electrolyte secretion between
396-468: A Caliph) on their way to Guerrero, Mexico where they played a future role in the wars of independence . Sebastián Vizcaíno explored and mapped the coast of California in 1602 for New Spain , putting ashore in Monterey . Despite the on-the-ground explorations of California in the 16th century, Rodríguez's idea of California as an island persisted. Such depictions appeared on many European maps well into
528-516: A Gila monster as an Old West outlaw named Bad Bill, voiced by Ray Winstone . The Gila monster has also seen usage as a mascot and state symbol . The official mascot of Eastern Arizona College located in Thatcher, Arizona , is Gila Hank, a gun-toting, cowboy hat-wearing Gila monster. In 2017, the Vegas Golden Knights selected a Gila monster named Chance as their official mascot. In 2019,
660-407: A Gila monster is normally not fatal to healthy adult humans. One fatality has been confirmed since 1930, on February 16, 2024, and the rare fatalities recorded before 1930 occurred in adults who were intoxicated by alcohol or had mismanaged the treatment of the bite. The Gila monster can bite quickly and may not release the victim without intervention. If bitten, the victim may attempt to fully submerge
792-510: A Gila monster. He tied it to his saddle and it bit the middle finger of his right hand and would not let go. A ranch hand pried open the lizard's mouth with a pocket knife, cut open his finger to stimulate bleeding, and then tied saddle strings around his finger and wrist. They summoned Dr. John C. Handy of Tucson, who took Vail back to Tucson for treatment, but Vail experienced swollen and bleeding glands in his throat for sometime afterward. Dr. Handy's friend, Dr. George Goodfellow of Tombstone,
924-459: A Spanish navigator." The name most likely derived from the mythical island of California in the fictional story of Queen Calafia , as recorded in a 1510 work The Adventures of Esplandián by Garci Rodríguez de Montalvo . Queen Calafia's kingdom was said to be a remote land rich in gold and pearls, inhabited by beautiful Black women who wore gold armor and lived like Amazons , as well as griffins and other strange beasts. Abbreviations of
1056-467: A case of Gila monster bite, and I don't want to be. I think a man who is fool enough to get bitten by a Gila monster ought to die. The creature is so sluggish and slow of movement that the victim of its bite is compelled to help largely in order to get bitten." —Dr. Ward, Arizona Graphic , September 23, 1899 In the Old West , the pioneers believed a number of myths about the Gila monster, including that
1188-428: A chemical arms race. Predator/prey pairs are expected to coevolve over long periods of time. As the predator capitalizes on susceptible individuals, the surviving individuals are limited to those able to evade predation. Resistance typically increases over time as the predator becomes increasingly unable to subdue resistant prey. The cost of developing venom resistance is high for both predator and prey. The payoff for
1320-519: A commodity until the 1849 California Gold Rush . From the 1820s, trappers and settlers from the United States and Canada began to arrive in Northern California. These new arrivals used the Siskiyou Trail , California Trail , Oregon Trail and Old Spanish Trail to cross the rugged mountains and harsh deserts in and surrounding California. The early government of the newly independent Mexico
1452-414: A determinate "wavelike" sequence. They change/replace their teeth during their entire life. The Gila monster's bright colors might be suitable to teach predators not to bother this "painful" creature. Because the Gila monster's prey consists mainly of eggs, small animals, and otherwise "helpless" prey, the Gila monster's venom is thought to have evolved for defensive rather than for hunting use. The venom of
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#17329054649441584-644: A dry environment is a slow metabolism, allowing them to use less than half the amount of energy expected for lizards of their size. Gila monsters, and possibly also the Mexican beaded lizard , store water in their urinary bladder and reabsorb it across the bladder epithelium. Their tail is used for energy storage in the form of fat. The Gila monster's diet consists of a variety of food items – small mammals (such as young rabbits , hares , mice , ground squirrels , and other rodents ), small birds , snakes , lizards, frogs , insects , other invertebrates , carrion , and
1716-568: A favorable microclimate and adequate humidity. Gila monsters rely heavily on the use of shelters and spend much of their time dwelling there. Often times these shelters are in rocky areas in Navajo Sandstone and basaltic lava flows. Gila monsters depend on water resources and can be observed in puddles of water after a summer rain. They avoid living in open areas, such as flats and open grasslands. Gila monsters spend 90% of their lifetime underground in burrows or rocky shelters. They are active in
1848-560: A free state, the "loitering or orphaned Indians", were de facto enslaved by their new Anglo-American masters under the 1850 Act for the Government and Protection of Indians . One of these de facto slave auctions was approved by the Los Angeles City Council and occurred for nearly twenty years. There were many massacres in which hundreds of indigenous people were killed by settlers for their land. Between 1850 and 1860,
1980-457: A half hours. There is only a single record of attempted mating outside of a shelter. The female lays eggs at the end of May into June. A clutch may consist of up to eight (rarely more than six) eggs. The incubation in captivity lasts about 5 months, depending on the incubation temperature. The hatchlings are about 16 cm (6.3 in) long and can bite and inject venom as soon as they are hatched. The egg development and hatching time of young in
2112-624: A modest home which in the 1960s cost $ 25,000 would cost half a million dollars or more in urban areas by 2005. More people commuted longer hours to afford a home in more rural areas while earning larger salaries in the urban areas. Speculators bought houses, expecting to make a huge profit in months, then rolling it over by buying more properties. Mortgage companies were compliant, as people assumed prices would keep rising. The bubble burst in 2007–8 as prices began to crash. Hundreds of billions in property values vanished and foreclosures soared, as financial institutions and investors were badly hurt. In
2244-463: A part of Mexico. In 1846, the total settler population of the western part of the old Alta California had been estimated to be no more than 8,000, plus about 100,000 Native Americans, down from about 300,000 before Hispanic settlement in 1769. In 1848, only one week before the official American annexation of the area, gold was discovered in California, this being an event which was to forever alter both
2376-560: A protective mucus that acts as a chemical camouflage or macromolecular mimicry preventing "not self" recognition by the sea anemone and nematocyst discharge. Clownfish may acclimate their mucus to resemble that of a specific species of sea anemone. California California is a state in the Western United States , lying on the American Pacific Coast . It borders Oregon to the north, Nevada and Arizona to
2508-721: A short break in 1862 when legislative sessions were held in San Francisco due to flooding in Sacramento . Once the state's Constitutional Convention had finalized its state constitution, it applied to the U.S. Congress for admission to statehood . On September 9, 1850, as part of the Compromise of 1850 , California became a free state and September 9 a state holiday . During the American Civil War (1861–1865), California sent gold shipments eastward to Washington in support of
2640-401: A sophisticated injection formula with sustained release of the drug, the lizard protein remains effective much longer than the human hormone. This helps diabetics keep their blood glucose levels under control for a week by a single injection. Exenatide also slows the emptying of the stomach and causes a decrease in appetite, contributing to weight loss. The antidiabetic exenatide (Byetta) from
2772-596: A state Constitutional Convention was first held in Monterey. Among the first tasks of the convention was a decision on a location for the new state capital. The first full legislative sessions were held in San Jose (1850–1851). Subsequent locations included Vallejo (1852–1853), and nearby Benicia (1853–1854); these locations eventually proved to be inadequate as well. The capital has been located in Sacramento since 1854 with only
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#17329054649442904-464: A sting. In bees and wasps , the stinger is a modified ovipositor (egg-laying device). In Polistes fuscatus , the female continuously releases a venom that contains a sex pheromone that induces copulatory behavior in males. In wasps such as Polistes exclamans , venom is used as an alarm pheromone, coordinating a response from the nest and attracting nearby wasps to attack the predator. In some species, such as Parischnogaster striatula , venom
3036-531: A stout snout, massive head, and "little"-appearing eyes, which can be protected by a nictitating membrane . The Gila monster has four close living relatives, all of which are beaded lizards. There are three species in Mexico: Heloderma exasperatum , Heloderma horridum and Heloderma alvarezi , as well as another species in Guatemala: Heloderma charlesbogerti . The evolutionary history of
3168-446: A uniform, simple, and less colorful pattern. This drastically changes within the first 6 months of their lives. Hatchlings from the northern area of the species' distribution have a tendency to retain most of their juvenile pattern. It has also been seen that Gila monsters in areas with darker rocks and substrate will have darker colorations. The heads of males are very often larger and more triangular-shaped than in females. The length of
3300-470: A wide range of diseases, explored in over 5,000 scientific papers. In medicine, snake venom proteins are used to treat conditions including thrombosis , arthritis , and some cancers . Gila monster venom contains exenatide , used to treat type 2 diabetes . Solenopsins extracted from fire ant venom has demonstrated biomedical applications, ranging from cancer treatment to psoriasis . A branch of science, venomics , has been established to study
3432-422: A wide range of medical conditions including thrombosis , arthritis , and some cancers . Studies in venomics are investigating the potential use of venom toxins for many other conditions. The use of venom across a wide variety of taxa is an example of convergent evolution . It is difficult to conclude exactly how this trait came to be so intensely widespread and diversified. The multigene families that encode
3564-600: Is Sacramento . The state's diverse geography ranges from the Pacific Coast and metropolitan areas in the west to the Sierra Nevada mountains in the east, and from the redwood and Douglas fir forests in the northwest to the Mojave Desert in the southeast. Two-thirds of the nation's earthquake risk lies in California. The Central Valley , a fertile agricultural area, dominates the state's center. The large size of
3696-401: Is actively delivered through a wound by means of a bite, sting, or similar action. The toxin is delivered through a specially evolved venom apparatus , such as fangs or a stinger , in a process called envenomation . Venom is often distinguished from poison , which is a toxin that is passively delivered by being ingested, inhaled, or absorbed through the skin, and toxungen , which
3828-695: Is actively transferred to the external surface of another animal via a physical delivery mechanism. Venom has evolved in terrestrial and marine environments and in a wide variety of animals: both predators and prey, and both vertebrates and invertebrates . Venoms kill through the action of at least four major classes of toxin, namely necrotoxins and cytotoxins , which kill cells; neurotoxins , which affect nervous systems; myotoxins , which damage muscles; and haemotoxins , which disrupt blood clotting . Venomous animals cause tens of thousands of human deaths per year. Venoms are often complex mixtures of toxins of differing types. Toxins from venom are used to treat
3960-534: Is applied all over the body as an antimicrobial protection. Many caterpillars have defensive venom glands associated with specialized bristles on the body called urticating hairs . These are usually merely irritating, but those of the Lonomia moth can be fatal to humans. Bees synthesize and employ an acidic venom ( apitoxin ) to defend their hives and food stores, whereas wasps use a chemically different venom to paralyse prey, so their prey remains alive to provision
4092-476: Is found in a few other reptiles such as the Mexican beaded lizard , the gila monster , and some monitor lizards, including the Komodo dragon . Mass spectrometry showed that the mixture of proteins present in their venom is as complex as the mixture of proteins found in snake venom. Some lizards possess a venom gland; they form a hypothetical clade, Toxicofera , containing the suborders Serpentes and Iguania and
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4224-454: Is higher. Rattlesnakes have responded locally by increasing the effectiveness of their venom. The kingsnakes of the Americas are constrictors that prey on many venomous snakes. They have evolved resistance which does not vary with age or exposure. They are immune to the venom of snakes in their immediate environment, like copperheads, cottonmouths, and North American rattlesnakes, but not to
4356-487: Is known about the social behavior of Gila monster, but it has been observed engaging in male to male combat, in which the dominant male lies on top of the subordinate one and pins it with its front and hind limbs. While fighting, both lizards arch their bodies, pushing against each other and twisting around in an effort to gain the dominant position. A "wrestling match" ends when the pressure exerts their forces, although bouts may be repeated. These bouts are typically observed in
4488-655: Is pigmented in black-blue colors, picks up scent molecules to be transferred to the opening of the Jacobson organ around the middle of the upper mouth cavern. Prey may be crushed to death if large, or eaten alive, most of the time head first, and helped down by muscular contractions and neck flexing. After food has been swallowed, the Gila monster may immediately resume tongue flicking and search behavior for identifying more prey such as eggs or young in nests. Gila monsters are able to climb trees, cacti , and even fairly straight, rough-surfaced walls. "I have never been called to attend
4620-460: Is proven that reptile and platypus venom have independently evolved, it is thought that there are certain protein structures that are favored to evolve into toxic molecules. This provides more evidence of why venom has become a homoplastic trait and why very different animals have convergently evolved. Envenomation resulted in 57,000 human deaths in 2013, down from 76,000 deaths in 1990. Venoms, found in over 173,000 species, have potential to treat
4752-515: Is sluggish in nature, so it is not generally dangerous and very rarely poses a real threat to humans. However, it has a fearsome reputation and is sometimes killed despite the species being protected by state law in Arizona . The name "Gila" refers to the Gila River Basin in the U.S. states of Arizona and New Mexico , where the Gila monster was once plentiful. Heloderma means "studded skin", from
4884-466: Is still very questionable. A more successful strategy would be, for example, if the new "settlers" were offered intensive education about this species (e.g., limited toxicity, lifestyle) with the aim of tolerating the reptile or even being proud of having this unique "roommate" in one's own neighborhood. In 1963, the San Diego Zoo became the first zoo to successfully breed Gila monsters in captivity. In
5016-517: Is the home of Hollywood , the oldest and one of the largest film industries in the world, profoundly influencing global entertainment. The San Francisco Bay and the Greater Los Angeles areas are seen as the centers of the global technology and U.S. film industries, respectively. The Spaniards gave the name Las Californias to the peninsula of Baja California (in modern-day Mexico). As Spanish explorers and settlers moved north and inland,
5148-422: Is true for animals relocated to appropriate habitats. Besides this, they also become more exposed to predators. Therefore, the process of simple relocation is "naïve" and potentially dangerous for both the relocated animals and existing populations and for the inhabitants of the region where the resettlement is taking place. If relocating the lizards further away, they might be totally disoriented, thus their survival
5280-523: The Ancient Greek words helos ( ἧλος ), "the head of a nail or stud", and derma ( δέρμα ), "skin". The species epithet suspectum comes from the describer, paleontologist Edward Drinker Cope . At first, this new specimen of Heloderma was misidentified and considered to be a northern variation of the beaded lizard already known to live in Mexico. He suspected that the lizard might be venomous due to
5412-500: The Battle of Providencia near Los Angeles, he convinced each side that they had no reason to be fighting each other. As a result of Marsh's actions, they abandoned the fight, Micheltorena was defeated, and California-born Pio Pico was returned to the governorship. This paved the way to California's ultimate acquisition by the United States. In 1846, a group of American settlers in and around Sonoma rebelled against Mexican rule during
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5544-631: The Bear Flag Revolt . Afterward, rebels raised the Bear Flag (featuring a bear, a star, a red stripe and the words "California Republic") at Sonoma. The Republic's only president was William B. Ide , who played a pivotal role during the Bear Flag Revolt. This revolt by American settlers served as a prelude to the later American military invasion of California and was closely coordinated with nearby American military commanders. The California Republic
5676-695: The California Master Plan for Higher Education in 1960 to develop an efficient system of public education. Meanwhile, attracted to the mild Mediterranean climate, cheap land, and the state's variety of geography, filmmakers established the studio system in Hollywood in the 1920s. California manufactured 9% of US armaments produced during World War II , ranking third behind New York and Michigan . California easily ranked first in production of military ships at drydock facilities in San Diego, Los Angeles, and
5808-985: The Cnidaria , sea urchins among the Echinodermata , and cone snails and cephalopods , including octopuses , among the Molluscs . Venom is found in some 200 cartilaginous fishes, including stingrays , sharks , and chimaeras ; the catfishes (about 1000 venomous species); and 11 clades of spiny-rayed fishes ( Acanthomorpha ), containing the scorpionfishes (over 300 species), stonefishes (over 80 species), gurnard perches , blennies , rabbitfishes , surgeonfishes , some velvetfishes , some toadfishes , coral crouchers , red velvetfishes , scats , rockfishes , deepwater scorpionfishes , waspfishes , weevers , and stargazers . Some salamanders can extrude sharp venom-tipped ribs. Two frog species in Brazil have tiny spines around
5940-554: The Graham Affair , which was resolved in part with the intercession of Royal Navy officials. One of the largest ranchers in California was John Marsh . After failing to obtain justice against squatters on his land from the Mexican courts, he determined that California should become part of the United States. Marsh conducted a letter-writing campaign espousing the California climate, the soil, and other reasons to settle there, as well as
6072-467: The IUCN . They are listed as "Apparently Secure" by NatureServe . In 1952, the Gila monster became the first venomous animal to be given legal protection. They are now protected in all states of their distribution. International trade in the species is regulated under Appendix II of CITES . "Possibly the greatest threat to the continued existence of helodermatids is the man-made destruction of their habitat as
6204-541: The Indigenous people of California had not yet developed a natural immunity. Under its new American administration, California's first governor Peter Hardeman Burnett instituted policies that have been described as a state-sanctioned policy of elimination of California's indigenous people. Burnett announced in 1851 in his Second Annual Message to the Legislature: "That a war of extermination will continue to be waged between
6336-602: The Presidio of San Diego , the first religious and military settlements founded by the Spanish in California. By the end of the expedition in 1770, they would establish the Presidio of Monterey and Mission San Carlos Borromeo de Carmelo on Monterey Bay. After the Portolà expedition, Spanish missionaries led by Father-President Serra set out to establish 21 Spanish missions of California along El Camino Real ("The Royal Road") and along
6468-745: The Route 66 . From 1900 to 1965, the population grew from fewer than one million to the greatest in the Union. In 1940, the Census Bureau reported California's population as 6% Hispanic, 2.4% Asian, and 90% non-Hispanic white. To meet the population's needs, engineering feats like the California and Los Angeles Aqueducts ; the Oroville and Shasta Dams ; and the Bay and Golden Gate Bridges were built. The state government adopted
6600-518: The Treaty of Guadalupe Hidalgo (February 2, 1848) that ended the war, the westernmost portion of the annexed Mexican territory of Alta California soon became the American state of California, and the remainder of the old territory was then subdivided into the new American Territories of Arizona, Nevada, Colorado and Utah . The even more lightly populated and arid lower region of old Baja California remained as
6732-653: The coast of California were the members of a Spanish maritime expedition led by Portuguese captain Juan Rodríguez Cabrillo in 1542. Cabrillo was commissioned by Antonio de Mendoza , the Viceroy of New Spain , to lead an expedition up the Pacific coast in search of trade opportunities; they entered San Diego Bay on September 28, 1542, and reached at least as far north as San Miguel Island . Privateer and explorer Francis Drake explored and claimed an undefined portion of
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#17329054649446864-556: The eggs of birds, lizards, snakes, and tortoises . Three to four extensive meals in spring are claimed to give them enough energy for a whole season. They can store fat in their tails and therefore do not need to eat often. Nevertheless, they feed whenever they come across suitable prey. Young Gila monsters can swallow up to 50% of their body weight in a single meal. Adults may eat up to one third of their body weight in one meal. The Gila monster uses its extremely acute sense of smell to locate prey. The strong, two-ended tipped tongue, which
6996-439: The phosphodiester bonds of DNA ; and neurotoxins, which disrupt signalling in the nervous system. Snake venom causes symptoms including pain, swelling, tissue necrosis, low blood pressure, convulsions, haemorrhage (varying by species of snake), respiratory paralysis, kidney failure, coma, and death. Snake venom may have originated with duplication of genes that had been expressed in the salivary glands of ancestors. Venom
7128-449: The small and large intestines . These bioactive peptides are able to bind to VIP receptors in many different human tissues. One of these, helodermin, has been shown to inhibit the growth of lung cancer . In February 2024, a Colorado man died after sustaining a 4 minute long bite from a pet Gila Monster. Autopsy reports determined cause of death to come from the animal bite/venom. The constituents of H. suspectum venom that have received
7260-537: The 16th and 17th centuries led to the colonization by the Spanish Empire . The area became a part of Mexico in 1821, following its successful war for independence , but was ceded to the United States in 1848 after the Mexican–American War . The California gold rush started in 1848 and led to social and demographic changes, including depopulation of Indigenous tribes. The western portion of Alta California
7392-513: The 18th century. The Portolá expedition of 1769–70 was a pivotal event in the Spanish colonization of California, resulting in the establishment of numerous missions, presidios , and pueblos . The military and civil contingent of the expedition was led by Gaspar de Portolá , who traveled over land from Sonora into California, while the religious component was headed by Junípero Serra , who came by sea from Baja California . In 1769, Portolá and Serra established Mission San Diego de Alcalá and
7524-482: The 1992 Rodney King riots. California was the hub of the Black Panther Party , known for arming African Americans to defend against racial injustice. Mexican, Filipino, and other migrant farm workers rallied in the state around Cesar Chavez for better pay in the 1960s and 70s. During the 20th century, two great disasters happened: the 1906 San Francisco earthquake and 1928 St. Francis Dam flood remain
7656-403: The 21st century, droughts and frequent wildfires attributed to climate change have occurred. From 2011 to 2017, a persistent drought was the worst in its recorded history. The 2018 wildfire season was the state's deadliest and most destructive. One of the first confirmed COVID-19 cases in the United States occurred in California on January 26, 2020. A state of emergency was declared in
7788-513: The California coast in 1579, landing north of the future city of San Francisco . The first Asians to set foot on what would be the United States occurred in 1587, when Filipino sailors arrived in Spanish ships at Morro Bay . Coincidentally the descendants of the Muslim Caliph Hasan ibn Ali in formerly Islamic Manila and had converted, then mixed Christianity with Islam, upon Spanish conquest, transited through California (Named after
7920-522: The California coast, 16 sites of which having been chosen during the Portolá expedition. Numerous major cities in California grew out of missions, including San Francisco ( Mission San Francisco de Asís ), San Diego ( Mission San Diego de Alcalá ), Ventura ( Mission San Buenaventura ), or Santa Barbara ( Mission Santa Barbara ), among others. Juan Bautista de Anza led a similarly important expedition throughout California in 1775–76, which would extend deeper into
8052-529: The California government in 2022. These groups were also diverse in their political organization, with bands, tribes, villages, and, on the resource-rich coasts, large chiefdoms , such as the Chumash , Pomo and Salinan . Trade, intermarriage, craft specialists, and military alliances fostered social and economic relationships between many groups. Although nations would sometimes war, most armed conflicts were between groups of men for vengeance . Acquiring territory
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#17329054649448184-443: The California state government paid around 1.5 million dollars (some 250,000 of which was reimbursed by the federal government) to hire militias with the stated purpose of protecting settlers, however these militias perpetrated numerous massacres of indigenous people. Indigenous people were also forcibly moved to reservations and rancherias, which were often small and isolated and without enough natural resources or funding from
8316-405: The Gila monster came to an abrupt and unexpected end on October 28, 2016, when a backhoe was digging at the outer walls of a house in a suburb of northern Tucson . The backhoe extracted a nest of a female Gila monster with five eggs in the process of hatching. The Gila monster is now known to hatch near the end of October and immediately proceed into hibernation without surfacing. They then appear on
8448-596: The Gila monster has a varied reputation. The Apache believed its breath could kill a man, and the Tohono O'Odham and the Pima believed it possessed a spiritual power that could cause sickness. In contrast, the Seri and the Yaqui believed the Gila monster's hide had healing properties. The Navajo/Dine believe the Gila monster was the first medicine man. The Gila monster starred as a monster in
8580-434: The Gila monster include that the animal's breath is toxic enough to kill humans, that it can spit venom like a spitting cobra , that it can leap several feet in the air to attack, and that the Gila monster did not have an anus and therefore expelled waste from its mouth, the source of its venom and "fetid breath" (perhaps stemming from the fact that its venom in fact has an intense, specific smell). Among Native American tribes,
8712-621: The Helodermatidae may be traced back to the Cretaceous period (145 to 166 million years ago), when Gobiderma pulchrum and Estesia mongolensis were present. The genus Heloderma has existed since the Miocene , when H. texana lived. Fragments of osteoderms from the Gila monster have been found in Late Pleistocene (10,000 to 8,000 years ago) deposits near Las Vegas , Nevada . Because
8844-609: The San Francisco Bay Area. Due to the hiring opportunities California offered during the conflict, the population multiplied from the immigration it received due to the work in its war factories, military bases, and training facilities. After World War II, California's economy expanded due to strong aerospace and defense industries, whose size decreased following the end of the Cold War . Stanford University began encouraging faculty and graduates to stay instead of leaving
8976-490: The U.S. Army. In the 20th century, thousands of Japanese people migrated to California. The state in 1913 passed the Alien Land Act , excluding Asian immigrants from owning land. During World War II, Japanese Americans in California were interned in concentration camps; in 2020, California apologized. Migration to California accelerated during the early 20th century with the completion of transcontinental highways like
9108-454: The Union . However, due to the existence of a large contingent of pro-South sympathizers within the state, the state was not able to muster any full military regiments to send eastwards to officially serve in the Union war effort. Still, several smaller military units within the Union army, such as the "California 100 Company" , were unofficially associated with the state of California due to a majority of their members being from California. At
9240-463: The beaded lizards from further south. The scales of the belly are free from osteoderms. Female Gila monsters go through a total shed lasting about 2 weeks before depositing their eggs. The dorsal part is often shed in one large piece. Adult males normally shed in smaller segments in August. The young seem to be in constant shed. Adults have more or less yellow to pink colors on a black surface. Hatchlings have
9372-454: The best land in the state, were secularized by 1834 and became the property of the Mexican government. The governor granted many square leagues of land to others with political influence. These huge ranchos or cattle ranches emerged as the dominant institutions of Mexican California. The ranchos developed under ownership by Californios (Hispanics native of California) who traded cowhides and tallow with Boston merchants. Beef did not become
9504-464: The best route to follow, which became known as "Marsh's route". His letters were read, reread, passed around, and printed in newspapers throughout the country, and started the first wagon trains rolling to California. After ushering in the period of organized emigration to California, Marsh became involved in a military battle between the much-hated Mexican general, Manuel Micheltorena and the California governor he had replaced, Juan Bautista Alvarado. At
9636-746: The cloaca. One study investigating a population of Gila monsters in southwestern Utah noted that the lizard's activity peaked from late April to mid June. The average distance traveled during their bouts of activity was 210 metres (690 ft), but on occasion some lizards would travel distances greater than 1 kilometre (0.62 mi). During the Gila monster's active season of approximately 90 days, only ten days were spent active. Gila monsters are slow sprinters, but they have relatively high endurance and maximal aerobic capacity ( VO 2 max ) compared to other lizards. They are preyed upon by coyotes , badgers and raptors . Hatchlings are preyed on by snakes, such as kingsnakes ( Lampropeltis sp.). Among adaptations to
9768-536: The conquest include the Battle of San Pasqual and the Battle of Dominguez Rancho in Southern California, as well as the Battle of Olómpali and the Battle of Santa Clara in Northern California. After a series of defensive battles in the south, the Treaty of Cahuenga was signed by the Californios on January 13, 1847, securing a censure and establishing de facto American control in California. Following
9900-465: The cost of physiological resistance is an increased chance of survival for prey, but it allows predators to expand into underutilised trophic niches. The California ground squirrel has varying degrees of resistance to the venom of the Northern Pacific rattlesnake . The resistance involves toxin scavenging and depends on the population. Where rattlesnake populations are denser, squirrel resistance
10032-406: The crown of their skulls which, on impact, deliver venom into their targets. Some 450 species of snake are venomous. Snake venom is produced by glands below the eye (the mandibular glands ) and delivered to the target through tubular or channeled fangs. Snake venoms contain a variety of peptide toxins, including proteases , which hydrolyze protein peptide bonds; nucleases , which hydrolyze
10164-535: The deadliest in U.S. history. Although air pollution has been reduced, health problems associated with pollution continue. Brown haze known as " smog " has been substantially abated after federal and state restrictions on automobile exhaust. An energy crisis in 2001 led to rolling blackouts , soaring power rates, and the importation of electricity from neighboring states. Southern California Edison and Pacific Gas and Electric Company came under heavy criticism. Housing prices in urban areas continued to increase;
10296-557: The east, and shares an international border with the Mexican state of Baja California to the south. With nearly 39 million residents across an area of 163,696 square miles (423,970 km ), it is the most populous U.S. state, the third-largest by area, and most populated subnational entity in North America . Prior to European colonization , California was one of the most culturally and linguistically diverse areas in pre-Columbian North America . European exploration in
10428-552: The end of its lower jaws, unlike snakes, whose venom is produced in glands behind the eyes. The Gila monster lacks strong musculature in glands above the eyes; instead, in Heloderma , the venom is propelled from the gland via a tubing to the base of the lower teeth and then by capillary forces into two grooves of the tooth and then chewed into the victim. The teeth are tightly anchored to the jaw ( pleurodont ). Broken and regular replacement teeth have to wait every time to go into position in
10560-533: The families Varanidae , Anguidae , and Helodermatidae . Euchambersia , an extinct genus of therocephalians , is hypothesized to have had venom glands attached to its canine teeth. A few species of living mammals are venomous, including solenodons , shrews , the European mole , vampire bats , male platypuses , and slow lorises . Shrews have venomous saliva and most likely evolved their trait similarly to snakes. The presence of tarsal spurs akin to those of
10692-471: The film The Giant Gila Monster (though the titular monster was actually portrayed by a Mexican beaded lizard). It played a minor role in the motion picture The Treasure of the Sierra Madre . In Brock Brower 's 1971 novel The Late Great Creature , fictional horror movie star Simon Moro is presented as famous for playing the reptilian werewolf -like Gila Man. The 2011 animated film Rango featured
10824-515: The food chambers of their young. The use of venom is much more widespread than just these examples; many other insects, such as true bugs and many ants , also produce venom. The ant species Polyrhachis dives uses venom topically for the sterilisation of pathogens. There are venomous invertebrates in several phyla , including jellyfish such as the dangerous box jellyfish , the Portuguese man-of-war (a siphonophore) and sea anemones among
10956-618: The government to adequately sustain the populations living on them. As a result, settler colonialism was a calamity for indigenous people. Several scholars and Native American activists, including Benjamin Madley and Ed Castillo , have described the actions of the California government as a genocide , as well as the 40th governor of California Gavin Newsom . Benjamin Madley estimates that from 1846 to 1873, between 9,492 and 16,092 indigenous people were killed, including between 1,680 and 3,741 killed by
11088-468: The grooves in the teeth. The Gila monster is the largest extant lizard species native to North America north of the Mexican border. Its snout-to-vent length ranges from 26 to 36 cm (10 to 14 in). The tail is about 20% of the body size, and the largest specimens may reach 51 to 56 cm (20 to 22 in) in total length. Body mass is typically in the range of 550 to 800 g (1.21 to 1.76 lb). They appear strong in their body structure with
11220-475: The helodermatids have remained relatively unchanged morphologically, they are occasionally regarded as living fossils . Although the Gila monster appears closely related to the monitor lizards (varanids) of Africa, Asia, and Australia, their wide geographical separation and distinct features indicate that Heloderma is better placed in a separate family. The scales of the head, back, and tail contain little pearl-shaped bones (osteoderms) similar to those found in
11352-456: The highest output of any U.S. state, and is led by its dairy , almonds , and grapes . With the busiest port in the country ( Los Angeles ), California plays a pivotal role in the global supply chain, hauling in about 40% of goods imported to the US. Notable contributions to popular culture , ranging from entertainment , sports , music , and fashion , have their origins in California. California
11484-410: The indigenous peoples developed complex forms of ecosystem management, including forest gardening to ensure the regular availability of food and medicinal plants . This was a form of sustainable agriculture . To mitigate destructive large wildfires from ravaging the natural environment, indigenous peoples developed a practice of controlled burning . This practice was recognized for its benefits by
11616-556: The interior and north of California. The Anza expedition selected numerous sites for missions, presidios, and pueblos, which subsequently would be established by settlers. Gabriel Moraga , a member of the expedition, would also christen many of California's prominent rivers with their names in 1775–1776, such as the Sacramento River and the San Joaquin River . After the expedition, Gabriel's son, José Joaquín Moraga , would found
11748-407: The land is developed for construction or to create more cultivable land." Gila monsters found in these situations and relocated – with best intentions – up to 1.2 km (0.75 mi) away, return to where they were found within 2 months and at great effort. This is up to five times the normal energy use than if they had not been removed, which uses up their energy stores unnecessarily. The same
11880-524: The largest dam removal and river restoration project in US history was announced for the Klamath River , as a win for California tribes. Covering an area of 163,696 sq mi (423,970 km ), California is the third-largest state in the United States in area, after Alaska and Texas . California is one of the most geographically diverse states in the union and is often geographically bisected into two regions, Southern California , comprising
12012-403: The last two decades, experienced breeders have shared their knowledge and expertise to give advice to other herpetologists on overcoming the difficulties in Heloderma reproduction under human care. Though the Gila monster is venomous, it poses little threat to humans due to its sluggish nature. Nevertheless, it has a fearsome reputation and is often killed by humans. Myths that have formed about
12144-469: The lizard had foul or toxic breath and that its bite was fatal. The Tombstone Epitaph of Tombstone, Arizona , wrote about a Gila monster that a local person caught on May 14, 1881: This is a monster, and no baby at that, it being probably the largest specimen ever captured in Arizona. It is 27 inches long and weighs 35 lb. It was caught by H. C. Hiatt on the road between Tombstone and Grand Central Mill, and
12276-460: The lizard in water, pry the jaws open with a knife or stick, or physically yank the lizard free. While pulling the lizard directly increases risk of severe lacerations from the lizard's sharp teeth, it may also mitigate envenomation. Symptoms of the bite include excruciating pain, edema, and weakness associated with a rapid drop in blood pressure. YouTuber Coyote Peterson described the bite as "like hot lava coursing through your veins" and claimed it
12408-448: The management of type 2 diabetes. It is a synthetic blueprint of the protein exendin-4, isolated from the Gila monster's venom. In a 3-year study with people with type 2 diabetes, exenatide showed healthy sustained glucose levels. The effectiveness is because the lizard protein is 53% identical to glucagon-like peptide-1 analog (GLP-1), a hormone released from the human digestive tract that helps to regulate insulin and glucagon . Using
12540-637: The many toxins that they contain; some venoms are complex mixtures of toxins of differing types. Major classes of toxin in venoms include: Venom is widely distributed taxonomically, being found in both invertebrates and vertebrates, in aquatic and terrestrial animals, and among both predators and prey. The major groups of venomous animals are described below. Venomous arthropods include spiders , which use fangs on their chelicerae to inject venom , and centipedes , which use forcipules — modified legs — to deliver venom, while scorpions and stinging insects inject venom with
12672-474: The mating season. Males with greater strength and endurance are thought to enjoy greater reproductive success. Although the Gila monster has a low metabolism and one of the lowest lizard sprint speeds, it has one of the highest aerobic scope values (the increase in oxygen consumption from rest to maximum metabolic exertion) among lizards, allowing it to engage in intense aerobic activity for a sustained period of time. Gila monsters are listed as near threatened by
12804-788: The middle of the state lies the California Central Valley , bounded by the Sierra Nevada in the east, the coastal mountain ranges in the west, the Cascade Range to the north and by the Tehachapi Mountains in the south. The Central Valley is California's productive agricultural heartland. Divided in two by the Sacramento-San Joaquin River Delta , the northern portion, the Sacramento Valley serves as
12936-526: The morning during the dry season (spring and early summer). The lizards move to different shelters every 4–5 days up to the beginning of the summer season. By doing so, they optimize for a suitable microhabitat. Later in the summer, they may be active on warm nights or after a thunderstorm . They maintain a surface body temperature of about 30 °C (86 °F). Close to 37 °C (99 °F), they are able to decrease their body temperature by up to 2 °C (3.6 °F) by an activated, limited evaporation via
13068-402: The most attention from researchers are the bioactive peptides, including helodermin, helospectin, exendin-3, and exendin-4. Exendin-4, which is specific for H. suspectum , has formed the basis of a class of medications for the treatment of type 2 diabetes , known as GLP-1 receptor agonists . In 2005, the U.S. Food and Drug Administration approved the drug exenatide (marketed as Byetta) for
13200-400: The next five days in bed, but he completely recovered. When Scientific American ran another ill-founded report on the lizard's ability to kill people, he wrote in reply and described his own studies and personal experience. He wrote that he knew several people who had been bitten by Gila monsters, but had not died from the bite. The Gila monster produces venom in modified salivary glands at
13332-443: The platypus in many non- therian Mammaliaformes groups suggests that venom was an ancestral characteristic among mammals. Extensive research on platypuses shows that their toxin was initially formed from gene duplication, but data provides evidence that the further evolution of platypus venom does not rely as much on gene duplication as was once thought. Modified sweat glands are what evolved into platypus venom glands. Although it
13464-414: The population of San Francisco increased from 500 to 150,000. The seat of government for California under Spanish and later Mexican rule had been located in Monterey from 1777 until 1845. Pio Pico, the last Mexican governor of Alta California, had briefly moved the capital to Los Angeles in 1845. The United States consulate had also been located in Monterey, under consul Thomas O. Larkin . In 1849,
13596-414: The proteins associated with venom and how individual components of venom can be used for pharmaceutical means. Venom is used as a trophic weapon by many predator species. The coevolution between predators and prey is the driving force of venom resistance, which has evolved multiple times throughout the animal kingdom. The coevolution between venomous predators and venom-resistant prey has been described as
13728-710: The pueblo of San Jose in 1777, making it the first civilian-established city in California. During this same period, sailors from the Russian Empire explored along the northern coast of California. In 1812, the Russian-American Company established a trading post and small fortification at Fort Ross on the North Coast . Fort Ross was primarily used to supply Russia's Alaskan colonies with food supplies. The settlement did not meet much success, failing to attract settlers or establish long term trade viability, and
13860-465: The races until the Indian race becomes extinct must be expected. While we cannot anticipate the result with but painful regret, the inevitable destiny of the race is beyond the power and wisdom of man to avert." As in other American states, indigenous peoples were forcibly removed from their lands by American settlers , like miners, ranchers, and farmers. Although California had entered the American union as
13992-403: The region known as California , or Las Californias , grew. Eventually it included lands north of the peninsula, Alta California , part of which became the present-day U.S. state of California. A 2017 state legislative document states, "Numerous theories exist as to the origin and meaning of the word 'California, ' " and that all anyone knows is the name was added to a map by 1541 "presumably by
14124-644: The state as part of the Gold Rush or to seek work. Even though the Chinese proved indispensable in building the transcontinental railroad from California to Utah, perceived job competition with the Chinese led to anti-Chinese riots in the state, and eventually the US ended migration from China partially as a response to pressure from California with the 1882 Chinese Exclusion Act . Under earlier Spanish and Mexican rule, California's original native population had precipitously declined, above all, from Eurasian diseases to which
14256-485: The state of Utah made the Gila monster its official state reptile . In 2023, Australian band King Gizzard and the Lizard Wizard released a single titled " Gila Monster " from their album PetroDragonic Apocalypse , with the album's artwork featuring a Gila monster on its cover art and heavily within the album's concept narrative. Venom Venom or zootoxin is a type of toxin produced by an animal that
14388-511: The state on March 4, 2020, and remained in effect until Governor Gavin Newsom ended it in February 2023. A mandatory statewide stay-at-home order was issued on March 19, 2020, which was ended in January 2021. Cultural and language revitalization efforts among indigenous Californians have progressed among tribes as of 2022. Some land returns to indigenous stewardship have occurred. In 2022,
14520-430: The state results in climates that vary from moist temperate rainforest in the north to arid desert in the interior, as well as snowy alpine in the mountains . Droughts and wildfires are an ongoing issue. California's economy is the largest of any U.S. state, with a $ 4.0 trillion gross state product as of 2024 . It is the largest sub-national economy in the world. California's agricultural industry has
14652-515: The state's demographics and its finances. Soon afterward, a massive influx of immigration into the area resulted, as prospectors and miners arrived by the thousands. The population burgeoned with United States citizens, Europeans, Middle Easterns, Chinese and other immigrants during the great California gold rush . By the time of California's application for statehood in 1850, the settler population of California had multiplied to 100,000. By 1854, more than 300,000 settlers had come. Between 1847 and 1870,
14784-522: The state's name include CA, Cal., Calif., Califas , and US-CA . California was one of the most culturally and linguistically diverse areas in pre-Columbian North America . Historians generally agree that there were at least 300,000 people living in California prior to European colonization. The Indigenous peoples of California included more than 70 distinct ethnic groups , inhabiting environments ranging from mountains and deserts to islands and redwood forests. Living in these diverse geographic areas,
14916-614: The state, and develop a high-tech region, now known as Silicon Valley . As a result of this, California is a world center of the entertainment and music industries, of technology, engineering, and the aerospace industry, and as the US center of agricultural production. Just before the Dot Com Bust , California had the fifth-largest economy in the world. In the mid and late twentieth century, race-related incidents occurred. Tensions between police and African Americans, combined with unemployment and poverty in inner cities, led to riots, such as
15048-535: The surface from May through June the following year when prey should be abundant. In summer, Gila monsters gradually spend less time on the surface to avoid the hottest part of the season; occasionally, they may be active at night. Females that have laid eggs are exhausted and thin, fighting for survival, and have to spend extra effort to "reconstitute". The brumation of Gila monsters begins in October. Gila monsters can live up to 40 years in captivity, though rarely. Little
15180-618: The tail of the two sexes is statistically very similar, so it does not help in differentiation of the sexes. Individuals with stout tail ends occur in both nature and under human breeding. The Gila monster is found in the Southwestern United States and Mexico, across a range including Sonora, Arizona, and parts of California , Nevada, Utah , and New Mexico. No records have been given from Baja California . They inhabit scrubland , succulent desert, and oak woodland, seeking shelter in burrows, thickets, and under rocks in locations with
15312-504: The ten southernmost counties, and Northern California , comprising the 48 northernmost counties. It is bordered by Oregon to the north, Nevada to the east and northeast, Arizona to the southeast, the Pacific Ocean to the west and shares an international border with the Mexican state of Baja California to the south (with which it makes up part of The Californias region of North America , alongside Baja California Sur ). In
15444-527: The tentacles of venomous sea anemones (an obligatory symbiosis for the fish), and are resistant to their venom. Only 10 known species of anemones are hosts to clownfish and only certain pairs of anemones and clownfish are compatible. All sea anemones produce venoms delivered through discharging nematocysts and mucous secretions. The toxins are composed of peptides and proteins. They are used to acquire prey and to deter predators by causing pain, loss of muscular coordination, and tissue damage. Clownfish have
15576-407: The time of California's admission into the Union, travel between California and the rest of the continental United States had been a time-consuming and dangerous feat. Nineteen years later, and seven years after it was greenlighted by President Lincoln, the first transcontinental railroad was completed in 1869. California was then reachable from the eastern States in a week's time. Much of the state
15708-403: The toxins of venomous animals are actively selected , creating more diverse toxins with specific functions. Venoms adapt to their environment and victims, evolving to become maximally efficient on a predator 's particular prey (particularly the precise ion channels within the prey). Consequently, venoms become specialized to an animal's standard diet. Venoms cause their biological effects via
15840-557: The transition from Spanish colonial rule to independent Mexican rule. In 1821, the Mexican War of Independence gave the Mexican Empire (which included California) independence from Spain. For the next 25 years, Alta California remained a remote, sparsely populated, northwestern administrative district of the newly independent country of Mexico, which shortly after independence became a republic. The missions , which controlled most of
15972-433: The venom of, for example, king cobras or black mambas. Among marine animals, eels are resistant to sea snake venoms, which contain complex mixtures of neurotoxins, myotoxins, and nephrotoxins, varying according to species. Eels are especially resistant to the venom of sea snakes that specialise in feeding on them, implying coevolution; non-prey fishes have little resistance to sea snake venom. Clownfish always live among
16104-568: The venomous Gila monster is also an example of a medical value of venom peptides, targeting G protein-coupled receptors (GPCRs). The Gila monster emerges from brumation in early March. Gila monsters sexually mature at 4–5 years old. It mates in April and May. The male initiates courtship by flicking his tongue to search for the female's scent. If the female rejects his advances, she will bite him and chase him away. When successful, copulation has been observed in captivity to last from 15 minutes to two and
16236-402: The wild has been a subject of ongoing speculation. The first model stated that youngsters hatch in fall and stay underground. The second theory postulated a nearly developed embryo remains inside the egg over winter and hatches in spring. Hatchlings (weight about 35 g (1.2 oz)) are observed at the end of April to early June. Discussions of the exact egg development and hatching cycle of
16368-409: Was "the worst pain [he] had ever experienced". It is generally regarded as the most painful venom produced by any vertebrate. More than a dozen peptides and other substances have been isolated from the Gila monster's venom, including hyaluronidase , serotonin , phospholipase A 2 , and several kallikrein -like glycoproteins responsible for the pain and edema caused by a bite, without producing
16500-541: Was abandoned by 1841. During the War of Mexican Independence , Alta California was largely unaffected and uninvolved in the revolution, though many Californios supported independence from Spain , which many believed had neglected California and limited its development. Spain's trade monopoly on California had limited local trade prospects. Following Mexican independence, California ports were freely able to trade with foreign merchants. Governor Pablo Vicente de Solá presided over
16632-641: Was among the first to research the actual effects of Gila monster venom. Scientific American reported in 1890, "The breath is very fetid, and its odor can be detected at some little distance from the lizard. It is supposed that this is one way in which the monster catches the insects and small animals which form a part of its food supply – the foul gas overcoming them." Goodfellow offered to pay local residents $ 5.00 for Gila monster specimens. He bought several and collected more on his own. In 1891, he purposely provoked one of his captive lizards into biting him on his finger. The bite made him ill and he spent
16764-536: Was extremely well suited to fruit cultivation and agriculture in general. Vast expanses of wheat, other cereal crops, vegetable crops, cotton, and nut and fruit trees were grown (including oranges in Southern California), and the foundation was laid for the state's prodigious agricultural production in the Central Valley and elsewhere. In the nineteenth century, a large number of migrants from China traveled to
16896-607: Was highly unstable, and in a reflection of this, from 1831 onwards, California also experienced a series of armed disputes, both internal and with the central Mexican government. During this tumultuous political period Juan Bautista Alvarado was able to secure the governorship during 1836–1842. The military action which first brought Alvarado to power had momentarily declared California to be an independent state, and had been aided by Anglo-American residents of California, including Isaac Graham . In 1840, one hundred of those residents who did not have passports were arrested, leading to
17028-714: Was not usually the purpose of these small-scale battles. Men and women generally had different roles in society. Women were often responsible for weaving, harvesting, processing, and preparing food, while men for hunting and other forms of physical labor. Most societies also had roles for people whom the Spanish referred to as joyas , who they saw as "men who dressed as women". Joyas were responsible for death , burial , and mourning rituals , and they performed women's social roles. Indigenous societies had terms such as two-spirit to refer to them. The Chumash referred to them as 'aqi. The early Spanish settlers detested and sought to eliminate them. The first Europeans to explore
17160-493: Was purchased by Messrs. Ed Baker and Charles Eastman, who now have it on exhibition at Kelley's Wine House, next door above Grand Hotel, Allen Street. Eastern people who have never seen one of these monsters should not fail to inspect his Aztecship, for they might accidentally stumble upon one some fine day and get badly frightened, except they know what it is. On May 8, 1890, southeast of Tucson , Arizona Territory , Empire Ranch owner Walter Vail captured and thought he had killed
17292-494: Was short-lived; the same year marked the outbreak of the Mexican–American War (1846–1848). Commodore John D. Sloat of the United States Navy sailed into Monterey Bay in 1846 and began the U.S. military invasion of California , with Northern California capitulating in less than a month to the United States forces. In Southern California, Californios continued to resist American forces. Notable military engagements of
17424-399: Was then organized and admitted as the 31st state in 1850 , as a free state , following the Compromise of 1850 . The Greater Los Angeles and San Francisco Bay areas are the nation's second- and fifth-most populous urban regions , with 19 million and 10 million residents respectively. Los Angeles is the state's most populous city and the nation's second-most ; California's capital
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