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Geritol is a United States trademarked name for various dietary supplements, past and present. Geritol is a brand name for several vitamin complexes plus iron or multimineral products in both liquid form and tablets, containing from 9.5 to 18 mg of iron per daily dose. The name conveys a connection with aging, as in " geriatric ". The product has been promoted from almost the beginning of the mass media era as a cure for "iron-poor tired blood".

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127-542: Geritol was introduced as an alcohol-based, iron and B vitamin tonic by Pharmaceuticals, Inc., in August 1950 and primarily marketed as such into the 1970s. Geritol was folded into Pharmaceuticals' 1957 acquisition of J. B. Williams Co., founded in 1885. J. B. Williams Co. was bought by Nabisco in 1971. In 1982, the Geritol product name was acquired by the multinational pharmaceutical firm Beecham (later GlaxoSmithKline ). Geritol

254-680: A brain tumor ; a planned tour of Germany in the autumn of 1980 was subsequently cancelled. The tour was critically lambasted, but surviving recordings of a performance in Johannesburg show Haley in good spirits and good voice. Nonetheless, according to the Haley News fan club newsletter and the Haley biography Sound and Glory , planned concerts (such as a fall 1980 tour of Germany) and proposed recording sessions in New York and Memphis were cancelled, including

381-595: A selective advantage against iron-deficiency anemia. The increase in systemic iron levels becomes pathological in old age, which supports the notion that antagonistic pleiotropy or "hyperfunction" drives human aging. Chronic iron toxicity is usually the result of more chronic iron overload syndromes associated with genetic diseases, repeated transfusions or other causes. In such cases the iron stores of an adult may reach 50 grams (10 times normal total body iron) or more. The most common diseases of iron overload are hereditary hemochromatosis (HH), caused by mutations in

508-406: A Geritol and put your dancin' shoes on." In the 2002 stage musical Hairspray , Edna and Wilbur Turnblad sing to each other of love as they grow old in the song "Timeless to Me". In one line, Edna sings "Pass that Geritol!" Human iron metabolism Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron

635-416: A brain tumor. Haley's British manager, Patrick Malynn, was quoted as saying that "Haley had taken a fit [and] didn't recognize anyone anymore." In addition, a doctor who examined Haley said that the tumor was inoperable. Haley's widow Martha, who was with him in these troubling times, denied he had a brain tumor, as did his close friend Hugh McCallum. Martha and friends related that Haley did not want to go on

762-481: A ceremony also attended by Haley's second wife and youngest daughter. The Comets placed their handprints in cement, leaving a space blank for Haley. More than 100 musicians performed with Bill Haley & His Comets between 1952 and Haley's death in 1981, many becoming fan favorites along the way. Several short-lived Comets reunions were attempted in the 1970s and 1980s, including one contingent (organized by Baltimore -based piano player Joey Welz , who played piano for

889-566: A country-western song, " Jealous Heart ", on which he was backed by a local mariachi band (similar in style to the earlier "Jimmy Martinez"), and a late-60s-style rocker, "Rock on Baby", backed by a group called Superfine Dandelion. Neither recording would be released for 30 years. In 1968, Haley and the Comets recorded a single for the United Artists label, a version of Tom T. Hall 's " That's How I Got to Memphis ", but no long-term association with

1016-540: A false and misleading claim, and heavily penalized with fines totaling $ 812,000 (equivalent to $ 5.57 million in 2023 dollars), the largest FTC fine up to that date (1973). Although subsequent trials and appeals from 1965 to 1973 concluded that some of the FTC demands exceeded its authority, Geritol was already well known and continued to be the largest U.S. company selling iron and B-vitamin supplements through 1979. A 1976 settlement agreement between J.B. Williams & Co. and

1143-501: A fill-in player on live gigs for several years prior to that.) Both these musicians claim trademark ownership of the name "Bill Haley's Comets"; this dates back to Lane and Rappa (during a period when they worked together as one band) winning a trademark infringement lawsuit against the aforementioned Joey Rand group in 1989. Both Rappa's and Lane's bands have, from time to time, recruited other former Comets for their lineups (for example, in 2005, Rappa joined forces with Joey Welz), but for

1270-596: A film short in which she, and Disc Jockey Bill Delzell, played ' Straight Jacket ' and 'Shake Rattle and Roll', which the group are seen playing. In March 1955, the group had four songs in Cash Box magazine's top 50 songs: "Dim, Dim the Lights (I Want Some Atmosphere)"; "Birth of the Boogie"; "Mambo Rock"; and "Shake, Rattle and Roll." Haley's "Shake, Rattle and Roll" never achieved the same level of historical importance as "Rock Around

1397-430: A heightened demand for iron, fueling their transition towards a more invasive mesenchymal state. This iron is necessary for the expression of mesenchymal genes, like those encoding transforming growth factor beta (TGF-β), crucial for EMT. Notably, iron’s unique ability to catalyze protein and DNA demethylation plays a vital role in this gene expression process. Conventional iron uptake pathways, such as those using

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1524-431: A large quantity of iron tablets produced for adult consumption), even more iron can enter the bloodstream and cause a potentially deadly syndrome of iron overload. Large amounts of free iron in the circulation will cause damage to critical cells in the liver, the heart and other metabolically active organs. Iron toxicity results when the amount of circulating iron exceeds the amount of transferrin available to bind it, but

1651-445: A multi-step process known as cellular respiration, more specifically from oxidative phosphorylation at the mitochondrial cristae . Iron is present in the iron–sulfur cluster and heme groups of the electron transport chain proteins that generate a proton gradient that allows ATP synthase to synthesize ATP ( chemiosmosis ). Heme groups are part of hemoglobin , a protein found in red blood cells that serves to transport oxygen from

1778-483: A nearly 20-year career with the Comets. Haley continued to tour for the next year with a succession of new sax players, but his popularity was waning again, and his 1976 performance in London was critically lambasted in the music media, such as Melody Maker . That year, the group also recorded an album, R-O-C-K at Muscle Shoals Sound Studio for Sonet Records. According to one source, "he had conflicted feelings about fame,

1905-568: A performance in Birmingham was videotaped and aired on UK television; it was released on DVD in 2005. During the March tour, Haley recorded several tracks in London for his next album for Sonet, completing the work that summer in Muscle Shoals; the album, Everyone Can Rock & Roll , issued later in 1979, was the last release of new recordings by Haley before his death. On November 26, 1979, Haley and

2032-483: A pony, and holding it over his head – were highlights of the band's live performances during this time. Their music and their act were part of a tradition in jazz and rhythm and blues , but it all came like a thunderclap to most of their audience. In late 1954, Haley and His Comets appeared in a short subject entitled Round Up of Rhythm , performing three songs. This was the earliest known theatrical rock and roll film release. In 1955, Lytle, Richards and Ambrose quit

2159-585: A potential reunion with past members of the Comets. Despite his illness, Haley started compiling notes for possible use as a basis for either a biographical film based on his life, or a published autobiography (accounts differ), and there were plans for him to record an album in Memphis, Tennessee , when the brain tumor began affecting his behavior and he returned to his home in Harlingen, Texas . The October 25, 1980, issue of German tabloid Bild reported that Haley had

2286-578: A recording session. The Comets' association with Orfeon/Dimsa ended later that year. By 1967, as related by Haley in an interview with radio host Red Robinson in that year, the group was "a free agent" without any recording contracts at all, although the band continued to perform regularly in North America and Europe. During this year, Haley—without the Comets—recorded a pair of demos in Phoenix, Arizona :

2413-488: A shorter period of time on average, while high ferroportin expression predicts 90% 10-year survival in breast cancer patients. Similarly, genetic variations in iron transporter genes known to increase serum iron levels also reduce lifespan and the average number of years spent in good health. It has been suggested that mutations that increase iron absorption, such as the ones responsible for hemochromatosis (see below), were selected for during Neolithic times as they provided

2540-471: A succession of bizarre, mostly monologue late-night phone calls to friends and relatives toward the end of his life in which he was semi-coherent. His first wife has been quoted as saying, "He would call you and ramble, dwelling on the past..." The biography also describes Haley painting the windows of his home black, but there is little other information available about his final days. Haley died in his sleep of an apparent heart attack on February 9, 1981, at

2667-399: A systemic bacterial infection, the immune system initiates a process known as " iron withholding ". If bacteria are to survive, then they must obtain iron from their environment. Disease-causing bacteria do this in many ways, including releasing iron-binding molecules called siderophores and then reabsorbing them to recover iron, or scavenging iron from hemoglobin and transferrin . The harder

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2794-465: A transferrin receptor. Transferrin-bound ferric iron is recognized by these transferrin receptors, triggering a conformational change that causes endocytosis. Iron then enters the cytoplasm from the endosome via importer DMT1 after being reduced to its ferrous state by a STEAP family reductase. Alternatively, iron can enter the cell directly via plasma membrane divalent cation importers such as DMT1 and ZIP14 (Zrt-Irt-like protein 14). Again, iron enters

2921-410: A variety of interdependent factors, including total iron stores, the extent to which the bone marrow is producing new red blood cells, the concentration of hemoglobin in the blood, and the oxygen content of the blood. The body also absorbs less iron during times of inflammation , in order to deprive bacteria of iron. Recent discoveries demonstrate that hepcidin regulation of ferroportin is responsible for

3048-478: Is absorbed varies depending on the source. Generally, the best-absorbed forms of iron come from animal products. Absorption of dietary iron in iron salt form (as in most supplements) varies somewhat according to the body's need for iron, and is usually between 10% and 20% of iron intake. Absorption of iron from animal products, and some plant products, is in the form of heme iron, and is more efficient, allowing absorption of from 15% to 35% of intake. Heme iron in animals

3175-463: Is also potentially toxic. Its ability to donate and accept electrons means that it can catalyze the conversion of hydrogen peroxide into free radicals . Free radicals can cause damage to a wide variety of cellular structures, and ultimately kill the cell. Iron bound to proteins or cofactors such as heme is safe. Also, there are virtually no truly free iron ions in the cell, since they readily form complexes with organic molecules. However, some of

3302-465: Is an elegant response to short-term bacterial infection, it can cause problems when it goes on so long that the body is deprived of needed iron for red cell production. Inflammatory cytokines stimulate the liver to produce the iron metabolism regulator protein hepcidin , that reduces available iron. If hepcidin levels increase because of non-bacterial sources of inflammation, like viral infection, cancer, auto-immune diseases or other chronic diseases, then

3429-635: Is an essential bioelement for most forms of life, from bacteria to mammals . Its importance lies in its ability to mediate electron transfer. In the ferrous state (Fe ), iron acts as an electron donor , while in the ferric state (Fe ) it acts as an acceptor . Thus, iron plays a vital role in the catalysis of enzymatic reactions that involve electron transfer (reduction and oxidation, redox ). Proteins can contain iron as part of different cofactors , such as iron–sulfur clusters (Fe-S) and heme groups, both of which are assembled in mitochondria . Human cells require iron in order to obtain energy as ATP from

3556-539: Is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically important part of many aspects of human health and disease. Hematologists have been especially interested in systemic iron metabolism , because iron is essential for red blood cells , where most of the human body's iron is contained. Understanding iron metabolism is also important for understanding diseases of iron overload , such as hereditary hemochromatosis , and iron deficiency , such as iron-deficiency anemia . Iron

3683-566: Is considered an exaggeration. Some sources indicate that the recording—a blend of R&B, western and pop music—is a contender for the title of "first rock'n'roll record" while others state that it was merely "the first rock and roll song to be a hit on the pop charts". It was also said to be the first rock'n'roll recording to be played on national television in the United States (in an episode of Omnibus (American TV program) in 1953). On their last release from Essex, new band member Joey Ambrose

3810-435: Is continuously recycled. Cellular iron levels are controlled differently by different cell types due to the expression of particular iron regulatory and transport proteins. The absorption of dietary iron is a variable and dynamic process. The amount of iron absorbed compared to the amount ingested is typically low, but may range from 5% to as much as 35% depending on circumstances and type of iron. The efficiency with which iron

3937-412: Is devoted to cellular proteins that use iron for important cellular processes like storing oxygen (myoglobin) or performing energy-producing redox reactions ( cytochromes ). A relatively small amount (3–4 mg) circulates through the plasma , bound to transferrin. Because of its toxicity, free soluble iron is kept in low concentration in the body. Iron deficiency first affects the storage of iron in

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4064-409: Is from blood and heme-containing proteins in meat and mitochondria, whereas in plants, heme iron is present in mitochondria in all cells that use oxygen for respiration. Like most mineral nutrients, the majority of the iron absorbed from digested food or supplements is absorbed in the duodenum by enterocytes of the duodenal lining. These cells have special molecules that allow them to move iron into

4191-525: Is heard on the B-side, "Straight Jacket." In the spring of 1954, Haley and His Comets left Essex for New York-based Decca Records , where they were placed under the auspices of veteran producer Milt Gabler , who would produce all of the band's recordings for the label and who had been involved in creating many proto-rock and roll recordings by the likes of the Andrews Sisters and Louis Jordan dating back to

4318-536: Is much larger than the labile iron pool, ranging in concentration from 0.7 mM to 3.6 mM. Iron export occurs in a variety of cell types, including neurons , red blood cells, macrophages and enterocytes. The latter two are especially important since systemic iron levels depend upon them. There is only one known iron exporter, ferroportin . It transports ferrous iron out of the cell, generally aided by ceruloplasmin and/or hephaestin (mostly in enterocytes), which oxidize iron to its ferric state so it can bind ferritin in

4445-735: Is now recognized as a rockabilly style. It sold well and was followed in 1952 by a cover of a 1940s rhythm and blues song called " Rock the Joint " for Holiday's sister company, Essex Records . During those years however, Haley was considered one of the top cowboy yodelers in America. Many Saddlemen recordings were not released until the 1970s and 1980s, and highlights included romantic ballads such as "Rose of My Heart" and western swing tunes such as "Yodel Your Blues Away." The original members of this group were Haley, pianist and accordion player Johnny Grande and steel guitarist Billy Williamson . Al Thompson

4572-428: Is pointless." She took him home, however, fed him and gave him his first dose. As soon as he felt better, he went back out to his room in the pool house, and the downward spiral continued until his death. Media reports immediately following his death indicated that Haley displayed deranged and erratic behavior in the final weeks of his life. According to a biography of Haley by John Swenson, released in 1982, Haley made

4699-444: Is post-translationally repressed by hepcidin , a 25-amino acid peptide hormone. The body regulates iron levels by regulating each of these steps. For instance, enterocytes synthesize more Dcytb, DMT1 and ferroportin in response to iron deficiency anemia. Iron absorption from diet is enhanced in the presence of vitamin C and diminished by excess calcium, zinc, or manganese. The human body's rate of iron absorption appears to respond to

4826-446: Is potentially toxic due to iron's ability to generate reactive oxygen species. Iron from this pool can be taken up by mitochondria via mitoferrin to synthesize Fe-S clusters and heme groups. Iron can be stored in ferritin as ferric iron due to the ferroxidase activity of the ferritin heavy chain. Dysfunctional ferritin may accumulate as hemosiderin , which can be problematic in cases of iron overload. The ferritin storage iron pool

4953-505: The HFE gene, and the more severe disease juvenile hemochromatosis (JH), caused by mutations in either hemojuvelin ( HJV ) or hepcidin ( HAMP ). The exact mechanisms of most of the various forms of adult hemochromatosis, which make up most of the genetic iron overload disorders, remain unsolved. So, while researchers have been able to identify genetic mutations causing several adult variants of hemochromatosis, they now must turn their attention to

5080-815: The CBS television musical variety program The Ed Sullivan Show , or Toast of the Town on Sunday, August 7, 1955, in a broadcast from the Shakespeare Festival Theater in Stratford, Connecticut . They performed a live version of "Rock Around the Clock" featuring Franny Beecher on lead guitar and Dick Richards on drums. The group made a second and final appearance on the Ed Sullivan Show on Sunday, April 28, 1957, performing " Rudy's Rock " and "Forty Cups of Coffee." Bill Haley and

5207-589: The Caterina Valente movie Hier Bin ich Hier Bleib Ich (Here I Am Here I Stay) . Back in the U.S., Haley attempted to start his own record label, Clymax, and establish his own stable of performers, notably Sally Starr (the hostess of a Philadelphia television children's program) and the Matys Brothers . Members of the Comets were commissioned to work as session musicians on many of these recordings, many of which were written or co-written by Haley and members of

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5334-502: The Federal Trade Commission (FTC). In 1965, the FTC ordered the makers of Geritol to disclose that Geritol would relieve symptoms of tiredness only in persons who suffer from iron deficiency anemia , and that the vast majority of people who experience such symptoms do not have such a deficiency. Geritol's claims were discredited in court findings as "conduct amounted to gross negligence and bordered on recklessness," ruled as

5461-565: The Louisiana languor of the original by Bobby Charles , "Don't Knock the Rock", "Rock-a-Beatin' Boogie", "Rudy's Rock" (the first instrumental hit of the rock and roll era), and "Skinny Minnie." Bill Haley and the Comets performed "Rock Around the Clock" in an a cappella and a lip-synched version on the NBC television program Texaco Star Theater hosted by Milton Berle on May 31, 1955. Berle predicted that

5588-409: The anemia of chronic disease may result. In this case, iron withholding actually impairs health by preventing the manufacture of enough hemoglobin-containing red blood cells. Most well-nourished people in industrialized countries have 4 to 5 grams of iron in their bodies (~38 mg iron/kg body weight for women and ~50 mg iron/kg body for men). Of this, about 2.5 g is contained in

5715-439: The gastrointestinal tract . The total amount of loss for healthy people in the developed world amounts to an estimated average of 1 mg a day for men, and 1.5–2 mg a day for women with regular menstrual periods. People with gastrointestinal parasitic infections, more commonly found in developing countries, often lose more. Those who cannot regulate absorption well enough get disorders of iron overload. In these diseases,

5842-466: The lungs to other tissues. Heme groups are also present in myoglobin to store and diffuse oxygen in muscle cells. The human body needs iron for oxygen transport. Oxygen (O 2 ) is required for the functioning and survival of nearly all cell types. Oxygen is transported from the lungs to the rest of the body bound to the heme group of hemoglobin in red blood cells. In muscles cells, iron binds oxygen to myoglobin , which regulates its release. Iron

5969-414: The reticuloendothelial system store iron as part of the process of breaking down and processing hemoglobin from engulfed red blood cells. Iron is also stored as a pigment called hemosiderin , which is an ill-defined deposit of protein and iron, created by macrophages where excess iron is present, either locally or systemically, e.g., among people with iron overload due to frequent blood cell destruction and

6096-451: The 1940s. One of Jordan's records, Saturday Night Fish Fry (1949), is considered to be a contender for the title of "first rock'n' roll record. Gabler later commented that "all the tricks I used with Louis Jordan, I used with Bill Haley". The group's first session, on April 12, 1954, yielded " Rock Around the Clock ", which would become Haley's biggest hit and one of the most important records in rock and roll history. Sales of "Rock Around

6223-634: The British musical charts once again when MCA Records (inheritors of the Decca catalogue) released "Haley's Golden Medley", a hastily compiled edit of the band's best-known hits in the style of the then-popular " Stars on 45 " format. The single reached Number 50 in the UK but was not released in the United States. In 1987, Bill Haley was inducted into the Rock and Roll Hall of Fame . At that time, supporting bands were not also named to

6350-487: The Clock " was the best-selling rock single in the history of the genre and maintained that position for several years. Band leader Bill Haley had previously been a Western swing performer; after recording a rockabilly version of Ike Turner and his Kings of Rhythm 's " Rocket 88 ", one of the first rock and roll recordings, Haley changed his band's musical direction to rock music. They went on to record hit versions of " Crazy Man, Crazy ", " Shake, Rattle & Roll ",

6477-420: The Clock , a memoir by Comets bass player Marshall Lytle. The new name for the group was adopted in the fall of 1952, before the 1953 release of " Crazy Man, Crazy " which had some elements of rock and roll and rockabilly music. Members of the group at that time were Haley, Johnny Grande, Billy Williamson and Marshall Lytle. Grande usually played piano on records but switched to accordion for live shows as it

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6604-408: The Clock" and "Ooh, Look-a There, Ain't She Pretty") and on February 20, 1960 (performing "Rock Around the Clock" and "Tamiami"). In 1956, the group appeared in two of the earliest full-length rock and roll movies with Alan Freed : Rock Around the Clock and Don't Knock the Rock . The Platters were co-stars in the first movie, and Little Richard appeared in the second. Rock Around the Clock

6731-509: The Clock" but it predated it as the first international rock and roll hit. It did not attain the Number 1 position on the American charts, but it became Haley's first gold record. Elvis Presley recorded the song in 1956, combining Haley's arrangement with Turner's original lyrics, but his version was not a substantial hit. Late in 1954, Haley recorded another hit, "Dim, Dim The Lights", which was one of

6858-609: The Clock" started slowly, since it was the B-side of the single, but it performed well enough, that a second Decca session was commissioned. " Shake, Rattle and Roll " followed, a somewhat bowdlerized cover version of the Big Joe Turner recording released earlier in 1954. The single was one of Decca's best-selling records of 1954 and the seventh-best-selling record in November 1954. In 1954, Anita Gordon starred in Round Up of Rhythm ,

6985-404: The Comets appeared on American Bandstand hosted by Dick Clark on ABC television twice in 1957, on the prime-time show on October 28 and on the regular daytime show on November 27. The band also appeared on Dick Clark's Saturday Night Beechnut Show (also known as The Dick Clark Show ), a prime-time TV series from New York on March 22, 1958, during the first season (performing "Rock Around

7112-452: The Comets between gigs and during Haley's retirement. This group rerecorded "Rock Around the Clock" for the television series Happy Days . The Comets , featuring musicians who performed with Haley in 1954–1955, reunited in 1987 and are still touring the world as of 2007, playing showrooms in the United States and Europe. They have also recorded a half-dozen albums for small labels in Europe and

7239-553: The Comets from 1962 to 1965 ) that appeared on The Tomorrow Show , and another run by an Elvis Presley impersonator, Joey Rand (this group later lost a legal action over the right to use the Comets name). Only one group was sent out to perform by Haley himself and his management and production company, consisting of musicians who had played with Haley throughout the 1960s and 1970s—lead guitarist "Nick Masters" (Mathias Nicholas Nastos), bassist Ray Cawley, singer Ray "Pudge" Parsons, and drummer Buddy Dee—and who had continued to perform as

7366-569: The Comets in a salary dispute and formed their own group, the Jodimars . Haley hired several new musicians to take their place: Rudy Pompilli on sax, Al Rex (a former member of the Saddlemen) on double bass, and Ralph Jones on drums. In addition, lead guitarist Franny Beecher , who had been a session musician for Haley since Danny Cedrone 's death in the spring of 1954, became a full-time Comet and Haley's first performing lead guitarist (Cedrone had played

7493-518: The Comets name, all claiming (with varying degrees of authority) to be the continuation of Haley's group. As of the end of 2014, four such groups were still performing in the United States and internationally. In around the mid-1940s, Bill Haley performed with the Down Homers and formed a group called the Four Aces of Western Swing. The group that later became the Comets initially formed as "Bill Haley and

7620-573: The Comets performed for Queen Elizabeth II , a moment Haley considered the proudest of his career. It was also the last time he performed in Europe and the last time most fans saw him perform "Rock Around the Clock". Haley made his final performances in South Africa in May and June 1980. Just before the South African tour commenced, Haley's health was reportedly failing, and he was reportedly diagnosed with

7747-416: The Comets' "Rock the Joint". No one had scored an American Top 20 hit with anything that could really qualify as rock'n'roll before their single "Crazy Man Crazy" in 1953". In 1953, Haley scored his first national success with his original song, "Crazy Man, Crazy", a phrase Haley said he heard from his teenage audience, again released on Essex. Haley later claimed the recording sold a million copies, but this

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7874-435: The Comets. The Clymax experiment only lasted about a year. In 1959, Haley's relationship with Decca collapsed; after a final set of instrumental-only recordings in the fall, Haley announced he was leaving Decca for the new Warner Bros. Records label, which released two more albums in 1960, which were moderately successful. In 1960 Franny Beecher and Rudi Pompilli left the Comets to start their own record label. Replacing Beecher

8001-401: The FTC had the company agreeing to pay $ 125,000 ($ 669,298 in 2023 dollars). Since then, supplemental iron products, including Geritol, have been contraindicated because of concerns over hemochromatosis , and serious questions raised in studies for men, postmenopausal women, and nonanemic patients with liver disease, heart disease, type 2 diabetes, or cancer. In the early days of television ,

8128-654: The George Jones Show), and others) to make a full band. Rappa performed his Upright Bass show before thousands in audiences all over the country. Members of Rappa's "Comets" went on to form the LocoMotion Showband and continued touring the United States without Rappa adding Galen Deig (Drums) and Jimmy Baze (Bass) before eventually disbanding. Esarey went on to graduate from Cedarville University and Luther Rice Theological Seminary. He has since pastored churches and produced his own saxophone instrumental albums. Several of

8255-640: The Hall of Fame. This policy was subsequently changed, and in 2012 a special committee of the Hall of Fame inducted the Comets. Bill Haley and His Comets were also inducted into the Rockabilly Hall of Fame . In June 2005, Bill Haley And His Comets were inducted into the Michigan Rock and Roll Legends Hall of Fame. In July 2005, the surviving members of the 1954–55 Comets (see below) represented Haley when Bill Haley and His Comets were inducted into Hollywood's Rockwalk ,

8382-585: The Orfeon label and its subsidiary, Dimsa. They hosted a television series, Orfeon a Go-Go , and made cameo appearances in several movies, lip-synching some of their old hits. Haley, who was fluent in Spanish, recorded a number of songs in the language, but most of the band's output during these years was instrumental recordings, many utilizing local session musicians playing trumpet. There was also some experimentation with Haley's style during this time; one single for Orfeon

8509-570: The Saddlemen" c.  1949 –1952, and performed mostly country and western songs, though occasionally with a bluesy feel. The group was also the first to record a cover version (in July 1951) of Rocket 88 , originally a jump blues song by Jackie Brenston and his Delta Cats, who were actually Ike Turner and his Kings of Rhythm . He did so for the Philadelphia -based Holiday Records label, in what

8636-437: The United States. This version of the group has also been credited as Bill Haley's Original Comets and, in circumstances in which the use of the Comets name is in dispute, A Tribute to Bill Haley and The Original Band . The basic lineup of this group from 1987 to May 2006 was Marshall Lytle (bass), Joey Ambrose (sax), Johnny Grande (piano), Dick Richards (drums) and Franny Beecher (guitar). British singer Jacko Buddin augmented

8763-418: The aforementioned "Rock Around the Clock", "Dim, Dim the Lights", " Rock-A-Beatin' Boogie ", "Razzle-Dazzle", " See You Later, Alligator ", " The Saints Rock 'N' Roll " and " Rip It Up ". In 1956, the group appeared in two early rock and roll movies with disc jockey Alan Freed : Rock Around the Clock and Don't Knock the Rock . Though the group was considered to be at the forefront of rock and roll during

8890-592: The age of 55, at his home in Harlingen, Texas. He was discovered lying motionless on his bed by a friend who had stopped by to visit him. The friend immediately called the police, and Haley was pronounced dead at the scene. Haley's death certificate gave "natural causes, most likely a heart attack" as the cause of death. Following a small funeral service attended by 75 people, Haley was cremated in Brownsville, Texas . In April 1981, Bill Haley & His Comets returned to

9017-412: The availability of iron needed for hemoglobin synthesis. Although some control exists at the transcriptional level, the regulation of cellular iron levels is ultimately controlled at the translational level by iron-responsive element-binding proteins IRP1 and especially IRP2. When iron levels are low, these proteins are able to bind to iron-responsive elements (IREs). IREs are stem loop structures in

9144-635: The bacteria have to work to get iron, the greater a metabolic price they must pay. That means that iron-deprived bacteria reproduce more slowly. So, control of iron levels appears to be an important defense against many bacterial infections. Certain bacteria species have developed strategies to circumvent that defense, TB causing bacteria can reside within macrophages , which present an iron rich environment and Borrelia burgdorferi uses manganese in place of iron. People with increased amounts of iron, as, for example, in hemochromatosis, are more susceptible to some bacterial infections. Although this mechanism

9271-632: The band was known in Hispanic America) signed with the Orfeón label of Mexico and scored an unexpected hit with "Twist Español", a Spanish-language recording based on the twist dance craze, which was sweeping America at the time. Haley followed up with "Florida Twist" (#3 MEX, according to Billboard Hits Of The World 04.21.62), which was for a time the biggest-selling single in Mexican history. Although Chubby Checker and Hank Ballard were credited with starting

9398-554: The body is able to vigorously regulate its iron uptake. Thus, iron toxicity from ingestion is usually the result of extraordinary circumstances like iron tablet over-consumption rather than variations in diet . The type of acute toxicity from iron ingestion causes severe mucosal damage in the gastrointestinal tract, among other problems. Excess iron has been linked to higher rates of disease and mortality. For example, breast cancer patients with low ferroportin expression (leading to higher concentrations of intracellular iron) survive for

9525-473: The body, and depletion of these stores is thought to be relatively asymptomatic, although some vague and non-specific symptoms have been associated with it. Since iron is primarily required for hemoglobin, iron deficiency anemia is the primary clinical manifestation of iron deficiency. Iron-deficient people will suffer or die from organ damage well before their cells run out of the iron needed for intracellular processes like electron transport. Macrophages of

9652-405: The body. The reserves of iron in industrialized countries tend to be lower in children and women of child-bearing age than in men and in the elderly. Women who must use their stores to compensate for iron lost through menstruation , pregnancy or lactation have lower non-hemoglobin body stores, which may consist of 500 mg , or even less. Of the body's total iron content, about 400 mg

9779-418: The body. To be absorbed, dietary iron can be absorbed as part of a protein such as heme protein or iron must be in its ferrous Fe form. A ferric reductase enzyme on the enterocytes' brush border , duodenal cytochrome B ( Dcytb ), reduces ferric Fe to Fe . A protein called divalent metal transporter 1 ( DMT1 ), which can transport several divalent metals across the plasma membrane, then transports iron across

9906-464: The cytoplasm in the ferrous state after being reduced in the extracellular space by a reductase such as STEAP2, STEAP3 (in red blood cells), Dcytb (in enterocytes) and SDR2. Iron can also enter cells via CD44 in complexes bound to hyaluronic acid during epithelial–mesenchymal transition (EMT). In this process, epithelial cells transform into mesenchymal cells with detachment from the basement membrane , to which they’re normally anchored, paving

10033-405: The enterocyte's cell membrane into the cell. If the iron is bound to heme, it is instead transported across the apical membrane by heme carrier protein 1 (HCP1). Heme is then catabolized by microsomal heme oxygenase into biliverdin , releasing Fe . These intestinal lining cells can then either store the iron as ferritin , which is accomplished by Fe binding to apoferritin (in which case

10160-476: The extracellular medium. Hepcidin causes the internalization of ferroportin, decreasing iron export. Besides, hepcidin seems to downregulate both TFR1 and DMT1 through an unknown mechanism. Another player assisting ferroportin in effecting cellular iron export is GAPDH. A specific post translationally modified isoform of GAPDH is recruited to the surface of iron loaded cells where it recruits apo-transferrin in close proximity to ferroportin so as to rapidly chelate

10287-531: The first R&B songs recorded by a white group to cross over to the R&;B charts. Johnnie Ray had reached Number 1 with " Cry " in 1952. The belated success of "Rock Around the Clock" is attributed to its use in the soundtrack of the film Blackboard Jungle , which was released on March 19, 1955. The song was re-released to coincide with the film and shifted to the single's A-side. Haley's recording became an anthem for rebellious 1950s youth and reached Number 1 on

10414-452: The genre's formative years, the arrival of more risqué acts such as Elvis Presley and Little Richard by 1956 led the more clean-cut Haley and his Comets to decline in popularity. Haley would remain popular in Europe and go on to have a comeback as a nostalgia act in the 1970s, along with many of his contemporaries. Following Haley's death, no fewer than seven different groups have existed under

10541-560: The group on vocals during most of their European tours, with Lytle taking over on vocals for US and Canadian tours beginning in 2000 and full-time in Europe in the mid-2000s. Since they connected with Klaus Kettner's Rock It Concerts (Germany) in 1991, they have played hundreds of shows all over Europe and have appeared on dozens of television shows. In March 2007 they opened the Bill-Haley-Museum in Munich, Germany. Two additional groups claim

10668-432: The guitar solo on the original recording of "Rock Around the Clock" and died shortly after the recording session for "Shake, Rattle and Roll" in the summer of 1954). This version of the band became more popular than the earlier manifestation and appeared in several motion pictures over the next few years. Other hits recorded by the band included " See You Later, Alligator " in which Haley's frantic delivery contrasted with

10795-635: The height of the Women's Liberation Movement , was not appreciated by some women and was lambasted by news and comedy shows. Comedian Robert Klein commented on his 1972 album Child of the Fifties : "Where does he get the nerve?... She has to keep begging him, "Will you keep me one more day?" "All right, one more day: now, get back to the kitchen!" The line was the inspiration for Mary Chapin Carpenter 's 1993 song " He Thinks He'll Keep Her ". In 1992, George Jones used

10922-419: The hemoglobin needed to carry oxygen through the blood (around 0.5 mg of iron per mL of blood), and most of the rest (approximately 2 grams in adult men, and somewhat less in women of childbearing age) is contained in ferritin complexes that are present in all cells, but most common in bone marrow, liver , and spleen . The liver stores of ferritin are the primary physiologic source of reserve iron in

11049-514: The increasingly incongruous Saddlemen name. It soon became apparent that a new name for the group was needed to fit the new musical style. A friend of Haley's, making note of the common mispronunciation of the name Halley's Comet to rhyme with Bailey , suggested that Haley call his band the Comets. This event is cited in the Haley biographies Sound and Glory by John Haley and John von Hoelle; Bill Haley by John Swenson; and in Still Rockin' Around

11176-724: The intracellular iron is bound to low-affinity complexes, and is termed labile iron or "free" iron. Iron in such complexes can cause damage as described above. To prevent that kind of damage, all life forms that use iron bind the iron atoms to proteins . This binding allows cells to benefit from iron while also limiting its ability to do harm. Typical intracellular labile iron concentrations in bacteria are 10-20 micromolar, though they can be 10-fold higher in anaerobic environment, where free radicals and reactive oxygen species are scarcer. In mammalian cells, intracellular labile iron concentrations are typically smaller than 1 micromolar, less than 5 percent of total cellular iron. In response to

11303-430: The iron extruded. The expression of hepcidin, which only occurs in certain cell types such as hepatocytes , is tightly controlled at the transcriptional level and it represents the link between cellular and systemic iron homeostasis due to hepcidin's role as "gatekeeper" of iron release from enterocytes into the rest of the body. Erythroblasts produce erythroferrone , a hormone which inhibits hepcidin and so increases

11430-477: The iron will leave the body when the cell dies and is sloughed off into feces ), or the cell can release it into the body via the only known iron exporter in mammals, ferroportin . Hephaestin , a ferroxidase that can oxidize Fe to Fe and is found mainly in the small intestine, helps ferroportin transfer iron across the basolateral end of the intestine cells. Upon release into the bloodstream, Fe binds transferrin and circulates to tissues. In contrast, ferroportin

11557-585: The label over the next decade. In the United States in 1969, promoter Richard Nader launched a series of rock and roll revival concert tours featuring artists of the 1950s and 1960s. At one of the first of these shows, held at the Felt Forum at Madison Square Garden in New York City, Haley received an eight-and-a-half-minute standing ovation following his performance, as Nader related in his recorded introduction to Haley's live album Bill Haley Scrapbook , which

11684-485: The label resulted. In order to revive his recording career, Haley turned to Europe. By the late 1960s, Haley and the Comets were considered an "oldies" act. The band's popularity never waned in Europe. The group signed a lucrative deal with Sonet Records of Sweden in 1968 and recorded in a new version of "Rock Around the Clock", which hit the European charts that year. The band recorded a mixture of live and studio albums for

11811-411: The line “I don't need your rockin' chair, your Geritol or your Medicare” in his hit song " I Don't Need Your Rockin' Chair ". In 1994, a reunion of members of Bill Haley & His Comets released the album You're Never Too Old to Rock (Hydra Records BCK 27013). One track, "Let's Rock and Roll Some More" features 70-year-old drummer Dick Richards singing "We've been away a while, but we ain't gone/Take

11938-475: The marketing of Geritol was involved in the quiz show scandal , as the sponsor of Twenty-One . For many years after that, Geritol was largely marketed on television programs that appealed primarily to older viewers, such as The Lawrence Welk Show , What's My Line? , The Red Skelton Show , To Tell the Truth , Hee Haw , and Ted Mack's Original Amateur Hour , as well as Arthur Godfrey 's daily show. It

12065-518: The media dubbed the "Second Battle of Waterloo ". The group also toured Australia in 1957, and in 1958 enjoyed a successful (if riot-dominated) tour of the European mainland. Bill Haley & His Comets were the first major American rock and roll act to tour the world in this way. Elvis, who was on military duty in Germany, visited them backstage at some shows. On a free day in Berlin they performed two songs in

12192-473: The members are now active in a very popular Southern Indiana 50's / 60's band called The Duke Boys. In March and July 2005, the members of the 1954–55 group, now billed as simply the Comets after decades of controversy over the use of the name, made several high-profile concert appearances in New York City and Los Angeles organized by Martin Lewis as part of celebrations marking the 50th anniversary of rock and roll,

12319-454: The most part the bandleaders are the only regular members who have worked with Bill Haley directly. Lane died in 2007, but his group continues to perform, led by bandleader Lenny Longo, who has no direct connection with Bill Haley. Rappa incorporated numerous professional musicians from the southern Indiana area (Guitarist Warren Batts, Joe Esarey, Dave Matthews, Joe Denton, saxophonist John Urbina, bassist Jody Hamilton Miley (previous bassist with

12446-415: The name Bill Haley's Comets and have extensively toured in the United States since forming in the 1980s: one originally led by Haley's 1965–68 drummer John "Bam-Bam" Lane, the other run by Al Rappa, who played bass for Haley off and on between late 1959 and early 1969. (The 1959 album "Strictly Instrumental" on Decca was Rappa's first recording session with Bill Haley & His Comets. Haley had used Rappa as

12573-492: The necessary transfusions their condition calls for. If systemic iron overload is corrected, over time the hemosiderin is slowly resorbed by the macrophages. Human iron homeostasis is regulated at two different levels. Systemic iron levels are balanced by the controlled absorption of dietary iron by enterocytes , the cells that line the interior of the intestines , and the uncontrolled loss of iron from epithelial sloughing, sweat, injuries and blood loss. In addition, systemic iron

12700-442: The normal function of these mutated genes. Bill Haley %26 His Comets Bill Haley & His Comets was an American rock and roll band formed in 1947 and continuing until Haley's death in 1981. The band was also known as Bill Haley and the Comets and Bill Haley's Comets . From late 1954 to late 1956, the group recorded nine Top 20 singles, one of which was number one and three that were Top Ten. The single " Rock Around

12827-636: The original). After "Skinny Minnie" hit the charts in 1958, Haley had little further success in the United States, although a spin-off group made up of Comets musicians dubbed The Kingsmen (no relation to the later group of " Louie, Louie " fame) had a hit with an instrumental, "Weekend", that same year. Overseas, however, Haley and his band continued to be popular, touring the United Kingdom in February 1957, when Haley and his crew were mobbed by thousands of fans at Waterloo station in London at an incident which

12954-487: The other would retire. The Comets continued to tour on their own during this period. In 1979, Haley was persuaded to return to performing with the offer of a lucrative contract to tour Europe. An almost completely new group of musicians, mostly British, including saxophonist Pete Thomas , were assembled to perform as the Comets. Haley appeared on numerous television shows and in the movie Blue Suede Shoes , filmed at one of his London concerts in March 1979. A few days later,

13081-402: The pop charts, remaining there for eight weeks, and went to Number 3 on the R&B chart. According to The Guardian , the group was "the first rock'n'roll band" and the song was particularly "important because it was the first rock'n'roll record heard by millions of people worldwide". Ambrose's acrobatic saxophone playing, along with Lytle on the double bass – literally on it, riding it like

13208-713: The release of Blackboard Jungle , the 50th anniversary of "Rock Around the Clock" hitting Number 1, and the 80th birthday of Bill Haley. During a concert at the Viper Room in West Hollywood on July 6, 2005, the Comets were joined on stage for one song by Gina Haley , the youngest daughter of Bill Haley; at a similar appearance in March they were joined by Haley's eldest son, John W. Haley. The 1954–55 Comets were also joined on stage by Bill Haley Jr. during several appearances in 2005 at Bubba Mac's in Somers Point, New Jersey, and at

13335-418: The road anymore and that ticket sales for that planned tour of Germany in the fall of 1980 were slow. McCallum said, "It's my unproven gut feeling that that [the brain tumor] was said to curtail talks about the tour and play the sympathy card." Haley returned to his home in Harlingen, Texas . At this time, Haley's alcoholism appeared to be worsening. According to Martha, by this time, she and Haley fought all

13462-399: The role. During this time (and as late as the fall of 1955), Haley did not have a permanent lead guitar player, choosing to use session musicians on records and either playing lead guitar himself or having Williamson play steel solos. Even before the release of more successful records, the group had achieved greatness in some respects: "No one had blended country and R&B on a single before

13589-423: The song would go to Number 1, calling the band "A group of entertainers who are going right to the top." Berle also sang and danced to the song, which was performed by the entire cast of the show. This was one of the earliest nationally televised performances by a rock and roll band and provided the new musical genre a much wider audience. Bill Haley and the Comets were the first rock and roll performers to appear on

13716-422: The syndrome of anemia of chronic disease. Most of the iron in the body is hoarded and recycled by the reticuloendothelial system, which breaks down aged red blood cells. In contrast to iron uptake and recycling, there is no physiologic regulatory mechanism for excreting iron. People lose a small but steady amount by gastrointestinal blood loss, sweating and by shedding cells of the skin and the mucosal lining of

13843-443: The synthesis of iron importers. Functional or actual iron deficiency can result from a variety of causes. These causes can be grouped into several categories: The body is able to substantially reduce the amount of iron it absorbs across the mucosa. It does not seem to be able to entirely shut down the iron transport process. Also, in situations where excess iron damages the intestinal lining itself (for instance, when children eat

13970-430: The time, and she told him to stop drinking or move out. Eventually, he moved into a room in their pool house. Martha still took care of him and sometimes, he would come in the house to eat, but he ate very little. "There were days we never saw him," said his daughter Martha Maria. In addition to Haley's drinking problems, it was becoming evident that he was also developing serious mental health issues. Martha Maria said, "It

14097-477: The toxicity of iron starts overwhelming the body's ability to bind and store it. Most cell types take up iron primarily through receptor-mediated endocytosis via transferrin receptor 1 (TFR1), transferrin receptor 2 (TFR2) and GAPDH . TFR1 has a 30-fold higher affinity for transferrin-bound iron than TFR2 and thus is the main player in this process. The higher order multifunctional glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) also acts as

14224-637: The traditional TfR1-dependent route. In the cytoplasm, ferrous iron is found in a soluble, chelatable state which constitutes the labile iron pool (~0.001 mM). In this pool, iron is thought to be bound to low-mass compounds such as peptides, carboxylates and phosphates, although some might be in a free, hydrated form ( aqua ions ). Alternatively, iron ions might be bound to specialized proteins known as metallochaperones . Specifically, poly-r(C)-binding proteins PCBP1 and PCBP2 appear to mediate transfer of free iron to ferritin (for storage) and non-heme iron enzymes (for use in catalysis). The labile iron pool

14351-401: The transferrin receptor 1 (TfR1), often prove insufficient to meet these elevated iron demands in cancer cells. As a result, various cytokines and growth factors trigger the upregulation of CD44, a surface molecule capable of internalizing iron bound to the hyaluronan complex. This alternative pathway, relying on CD44-mediated endocytosis, becomes the dominant iron uptake mechanism compared to

14478-574: The twist craze in America, in Mexico and Latin America, Bill Haley and His Comets were proclaimed the Kings of the Twist. Thanks to the success of "Twist Español" and "Florida Twist", among others, the band had continued success in Mexico and Latin America over the next few years, selling many recordings of Spanish and Spanish-flavored material and simulated live performances ( overdubbed audience over studio recordings) on

14605-408: The untranslated regions (UTRs) of mRNA. Both ferritin and ferroportin contain an IRE in their 5' UTRs, so that under iron deficiency their translation is repressed by IRP2, preventing the unnecessary synthesis of storage protein and the detrimental export of iron. In contrast, TFR1 and some DMT1 variants contain 3' UTR IREs, which bind IRP2 under iron deficiency, stabilizing the mRNA, which guarantees

14732-484: The way for the newly differentiated motile mesenchymal cells to begin migration away from the epithelial layer. While EMT plays a crucial role in physiological processes like implantation , where it enables the embryo to invade the endometrium to facilitate placental attachment, its dysregulation can also fuel the malignant spread of tumors empowering them to invade surrounding tissues and establish distant colonies ( metastasis ). Malignant cells often exhibit

14859-533: Was a 20-year-old guitarist, Johnny Kay , from Chester, Pennsylvania. Beecher later returned briefly to play with the Comets, when his record label failed to take off, sharing guitar duties with Kay. Kay left the band in 1966 but returned in the early 1970s for an aborted world tour. He appeared in the Wembley show, which was filmed and released as the London Rock and Roll Show. In 1961–1962, Bill Haley y sus Cometas (as

14986-458: Was a folk ballad, "Jimmy Martinez", which Haley recorded without the Comets. In 1966, the Comets (without Bill Haley) cut an album for Orfeon as session musicians for Big Joe Turner, who had always been an idol to Haley; no joint performance of "Shake, Rattle and Roll" was recorded, however. In a 1974 interview with BBC Radio , Haley said Turner's career was in a slump at this time, so he used his then-considerable influence with Orfeon to get Turner

15113-415: Was acquired by Meda Pharmaceutical in 2011. Meda was acquired by Mylan in 2016. The earlier Geritol liquid formulation was advertised as "twice the iron in a pound of calf's liver," and daily doses contained about 50–100 milligrams of iron as ferric ammonium citrate . The Geritol tonic contained about 12% alcohol and some B vitamins. Geritol was the subject of years of investigation starting in 1959 by

15240-466: Was also kept busy in the studio, recording numerous albums for Sonet and other labels in the 1970s, several with a country music flavor. In 1974, Haley's original Decca recording of "Rock Around the Clock" hit the American sales charts once again, thanks to its use in the film American Graffiti and for two years, on the television program Happy Days . In February 1976, Haley's saxophone player and best friend, Rudy Pompilli , died of cancer after

15367-602: Was also one of the sponsors of the original Star Trek series. Geritol was often used in the 1960s as a punch line for a joke in sitcoms or in comedy routines; comic singer Allan Sherman referenced Geritol on his 1962 album My Son, the Folk Singer , singing "Yasha got a bottle of Geritol" to the tune of " Joshua Fought the Battle of Jericho ". Geritol is famous for a controversial 1972 television commercial tag line, "My wife, I think I'll keep her." This line, brought out during

15494-558: Was extremely private, suffered chronic alcoholism, and troubled relationships". Having admitted to an alcohol problem in a 1974 radio interview for the BBC , Haley continued to battle alcoholism into the 1970s. In early 1977, Haley announced his retirement from performing and settled down at his home in Mexico. According to the John Swenson biography of Haley, the musician was quoted as saying that he and Pompilli had an agreement that if one died,

15621-430: Was like sometimes he was drunk even when he wasn't drinking." After being picked up by the police in Harlingen several times for alleged intoxication, Martha had a judge put Haley in the hospital, where he was seen by a psychiatrist, who said Haley's brain was overproducing a chemical, like adrenaline. The doctor prescribed a medication to stop the overproduction, but said Haley would have to stop drinking. Martha said, "This

15748-410: Was more portable than a piano and easier to deal with during musical numbers that involved a lot of dancing around. Soon after renaming the band Haley hired his first drummer, Earl Famous. Displeased with the lineup, Haley sought out Dick Boccelli (also known as Dick Richards), who turned down the job but recommended a young drummer Charlie Higler. Soon after, Haley asked Richards again, who then accepted

15875-461: Was produced by Sam Katzman (who would produce several Elvis Presley films in the 1960s) and directed by Fred F. Sears. The band's popularity in the United States began to wane in 1956–57 as sexier, wilder acts such as Elvis Presley , Jerry Lee Lewis and Little Richard began to dominate the record charts (although Haley's cover version of Little Richard's " Rip It Up ", released in direct competition with Little Richard's original recording, outsold

16002-594: Was recorded a few weeks later at the Bitter End club in New York. The band appeared in several concert films in the early 1970s, including The London Rock and Roll Show (for which Haley's 1960–66 lead guitarist, John Kay, briefly rejoined the band) and Let the Good Times Roll . After 1974, tax and management problems prevented Haley from performing in the United States, so he performed in Europe almost exclusively, though he also toured South America in 1975. The band

16129-406: Was the group's first bass player, followed by Al Rex and Marshall Lytle . During the group's early years, it recorded under several other names, including Johnny Clifton and His String Band and Reno Browne and Her Buckaroos (although Browne, a female matinee idol of the time, did not actually appear on the record). "Rocket 88", "Rock the Joint", and their immediate follow-ups were released under

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