N-acetylglucosamine-1-phosphate transferase ( GlcNAc-1-phosphotransferase ) is a transferase enzyme.
5-632: It is made up of two alpha (α), two betas (β), and two gammas (γ) subunits. GNPTAB produces the alpha and beta subunits, GNPTG produces the gamma subunit. GlcNAc-1-phosphotransferase functions to prepare newly made enzymes for lysosome transportation (lysosomal hydrolases to the lysosome). Lysosomes , a part of an animal cell, helps break down large molecules into smaller ones that can be reused. GlcNAc-1-phosphotransferase phosphorylates carbon 6 of one or more mannosyl residues of N linked glycoproteins being processed in Golgi Apparatus . UDP-GLcNAc provides
10-528: Is a gene in the human body. It is one of three genes that were found to correlate with stuttering . The GNPTG gene codes instructions for making the gamma subunit of an enzyme called GlcNAc-1-phosphotransferase (also called N-acetylglucosamine-1-phosphate transferase ). This enzyme is made up of two alpha (α), two beta (β), and two gamma (γ) subunits . GNPTAB produces the alpha and beta subunits. GlcNAc-1-phosphotransferase functions to prepare newly made enzymes for lysosome transportation (lysosomal hydrolases to
15-556: The Lysosomal Enzyme–Targeting Pathway and Persistent Stuttering. New England Journal of Medicine 362, 677–685. This enzyme -related article is a stub . You can help Misplaced Pages by expanding it . GNPTG 84572 214505 ENSG00000090581 ENSMUSG00000035521 Q9UJJ9 Q6S5C2 NM_032520 NM_172529 NM_001346737 NP_115909 NP_001333666 NP_766117 GNPTG (“N-acetylglucosamine-1-phosphate transferase, gamma subunit.”)
20-431: The lysosome). Lysosomes , a part of an animal cells, helps break down large molecules into smaller ones that can be reused. GlcNAc-1-phosphotransferase catalyzes the N -linked glycosylation of asparagine residues with a molecule called mannose-6-phosphate (M6P). M6P acts as indicator whether a hydrolase should be transported to the lysosome or not. Once a hydrolase has the indication from an M6P, it can be transported to
25-546: The phosphate in a reaction catalysed by this enzyme. M6P acts as an indicator of whether a hydrolase should be transported to the lysosome or not. Once a hydrolase indicates an M6P, it can be transported to a lysosome. Surprisingly some lysosomal enzymes are only tagged at a rate of 5% or lower. It is associated with the following conditions: In melanocytic cells, GNPTG gene expression may be regulated by MITF . Kang, C., Riazuddin, S., Mundorff, J., Krasnewich, D., Friedman, P., Mullikin, J.C., and Drayna, D. (2010). Mutations in
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