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137-490: The film tells the story of two men (Marshall and Gargan) and two women (Colbert and Boland), who leave from a plague -ridden ship and reach the Malayan jungle. The relationships between the four people before they enter the jungle are examined and are transformed as they interact with natural phenomena and the natives who populate the jungle. The film also relates how each of the four people carried on in life after they emerged from

274-465: A plague outbreak in five Indian states caused an estimated 700 infections (including 52 deaths) and triggered a large migration of Indians within India as they tried to avoid the disease. It was during the 1894 Hong Kong plague outbreak that Alexandre Yersin isolated the bacterium responsible ( Yersinia pestis ), a few days after Japanese bacteriologist Kitasato Shibasaburō had isolated it. However,

411-456: A sensational victory against Bulgaria and the Kievan Rus' in 971. John in particular was an astute administrator who reformed military structures and implemented effective fiscal policies. After John's death, Constantine VII's grandsons Basil II and Constantine VIII ruled jointly for half a century, although the latter exercised no real power before Basil's death in 1025. Their early reign

548-463: A combination of external threats and internal instabilities caused the Roman state to splinter as regional armies acclaimed their generals as "soldier-emperors". One of these, Diocletian ( r.  284–305 ), seeing that the state was too big to be ruled by one man, attempted to fix the problem by instituting a Tetrarchy , or rule of four, and dividing the empire into eastern and western halves. Although

685-626: A considerable increase in the size of urban settlements, together with a notable upsurge in new towns. Trade was also flourishing; the Venetians, the Genoese and others opened up the ports of the Aegean to commerce, shipping goods from the Crusader states and Fatimid Egypt to the west and trading with the empire via Constantinople. Manuel's death on 24 September 1180 left his 11-year-old son Alexios II Komnenos on

822-460: A contested legacy to Roman identity and to associate negative connotations from ancient Latin literature. The adjective "Byzantine", which derived from Byzantion (Latinised as Byzantium ), the name of the Greek settlement Constantinople was established on, was only used to describe the inhabitants of that city; it did not refer to the empire, which they called Romanía —"Romanland". After

959-532: A distinction between the earlier Roman Empire and the later Byzantine Empire . During the earlier Pax Romana period, the western parts of the empire became increasingly Latinised , while the eastern parts largely retained their preexisting Hellenistic culture . This created a dichotomy between the Greek East and Latin West . These cultural spheres continued to diverge after Constantine I ( r.  324–337 ) moved

1096-664: A human case of bubonic plague was reported. Officials responded by activating a city-wide plague-prevention system for the remainder of the year. Also in July 2020, in Mongolia, a teenager died from bubonic plague after consuming infected marmot meat. Yersinia pestis has been discovered in archaeological finds from the Late Bronze Age (~3800 BP ). The bacteria is identified by ancient DNA in human teeth from Asia and Europe dating from 2,800 to 5,000 years ago. Some authors have suggested that

1233-577: A large number in Venice. According to chronicler Niketas Choniates , a prostitute was even set up on the patriarchal throne. When order had been restored, the crusaders and the Venetians proceeded to implement their agreement; Baldwin of Flanders was elected emperor of a new Latin Empire , and the Venetian Thomas Morosini was chosen as patriarch. The lands divided up among the leaders included most of

1370-496: A large population of rats, the animals can harbor low levels of the plague infection without causing human outbreaks. With no new rat inputs being added to the population from other areas, the infection only spread to humans in very rare cases of overcrowding. After being transmitted via the bite of an infected flea, the Y. pestis bacteria become localized in an inflamed lymph node , where they begin to colonize and reproduce. Infected lymph nodes develop hemorrhages, which result in

1507-504: A lengthy conflict against Sasanid Persia and ended in 363 with the death of his son-in-law Julian . The short Valentinianic dynasty , occupied with wars against barbarians , religious debates, and anti-corruption campaigns, ended in the East with the death of Valens at the Battle of Adrianople in 378. Valens's successor, Theodosius I ( r.  379–395 ), restored political stability in

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1644-632: A line through the Adriatic Sea and south to Cyrene, Libya . This encompassed most of the Balkans , all of modern Greece, Turkey, Syria , Palestine ; North Africa, primarily with modern Egypt and Libya ; the Aegean islands along with Crete , Cyprus and Sicily , and a small settlement in Crimea . The landscape of the Empire was defined by the fertile fields of Anatolia , long mountain ranges and rivers such as

1781-467: A role in controlling the 2003 Oran outbreak of the bubonic plague. Another means of prevention in large European cities was a city-wide quarantine to not only limit interaction with people who were infected, but also to limit the interaction with the infected rats. Several classes of antibiotic are effective in treating bubonic plague. These include aminoglycosides such as streptomycin and gentamicin , tetracyclines (especially doxycycline ), and

1918-506: A role in increasing the transmission effectiveness of the plague. The plague resurfaced for a third time in the mid-19th century; this is also known as "the modern pandemic". Like the two previous outbreaks, this one also originated in Eastern Asia , most likely in Yunnan , a province of China, where there are several natural plague foci . The initial outbreaks occurred in the second half of

2055-450: A small fleet of 100 ships to defend the capital, but other than that he was indifferent to the populace. He was finally overthrown when Isaac II Angelos , surviving an imperial assassination attempt, seized power with the aid of the people and had Andronikos killed. The reign of Isaac II, and more so that of his brother Alexios III , saw the collapse of what remained of the centralised machinery of Byzantine government and defence. Although

2192-417: A speedy and marked improvement. Gradually, however, Andronikos's reign deteriorated. The aristocrats were infuriated against him, and to make matters worse, Andronikos seemed to have become increasingly unbalanced; executions and violence became increasingly common, and his reign turned into a reign of terror. Andronikos seemed almost to seek the extermination of the aristocracy as a whole. The struggle against

2329-510: A two-month siege on 29 May 1453. The final Byzantine emperor, Constantine XI Palaiologos , was last seen casting off his imperial regalia and throwing himself into hand-to-hand combat after the walls of the city were taken. The Empire was centred in what is now Greece and Turkey with Constantinople as its capital. In the 5th century, it controlled the eastern basis of the Mediterranean running east from Singidunum (modern Belgrade ) in

2466-595: A vector to jump from animals to humans. The mortality rate is highest in the summer and early fall. The successful control of rat populations in dense urban areas is essential to outbreak prevention. One example is the use of a machine called the Sulfurozador , used to deliver sulphur dioxide to eradicate the pest that spread the bubonic plague in Buenos Aires, Argentina during the early 18th century. Targeted chemoprophylaxis , sanitation , and vector control also played

2603-531: Is evidence that some Komnenian heirs had set up a semi-independent state in Trebizond before 1204. According to the historian Alexander Vasiliev , "the dynasty of the Angeloi, Greek in its origin, ... accelerated the ruin of the Empire, already weakened without and disunited within." In 1198, Pope Innocent III broached the subject of a new crusade through legates and encyclical letters. The stated intent of

2740-532: Is impossible to precisely date the foundation of the Byzantine Empire. In a series of conflicts between the third and first centuries   BC, the Roman Republic gradually established hegemony over the eastern Mediterranean , while its government ultimately transformed into the one-person rule of an emperor . The Roman Empire enjoyed a period of relative stability until the third century AD , when

2877-449: Is no consensus on a "foundation date" for the Byzantine Empire, if there was one at all. The growth of the study of "late antiquity" has led to some historians setting a start date in the seventh or eighth centuries. Others believe a "new empire" began during changes in c.  300   AD. Still others hold that these starting points are too early or too late, and instead begin c.  500 . Geoffrey Greatrex believes that it

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3014-514: Is one of three types of plague caused by the bacterium Yersinia pestis . One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever , headaches , and vomiting , as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. Acral necrosis , the dark discoloration of skin, is another symptom. Occasionally, swollen lymph nodes, known as " buboes ", may break open. The three types of plague are

3151-421: Is one or more infected, enlarged, and painful lymph nodes, known as buboes . Buboes associated with the bubonic plague are commonly found in the armpits, upper femoral area, groin, and neck region. These buboes will grow and become more painful over time, often to the point of bursting. Symptoms include heavy breathing, continuous vomiting of blood ( hematemesis ), aching limbs, coughing, and extreme pain caused by

3288-692: The Tactica , a military treatise; and the Book of the Eparch , which codified Constantinople's trading regulations. In non-literary contexts Leo was less successful: the empire lost in Sicily and against the Bulgarians , while he provoked theological scandal by marrying four times in an attempt to father a legitimate heir. The early reign of that heir, Constantine VII , was tumultuous, as his mother Zoe , his uncle Alexander ,

3425-524: The Catalan Company ravaging the countryside and increasing resentment towards Constantinople. The situation became worse for Byzantium during the civil wars after Andronikos III died. A six-year-long civil war devastated the empire, allowing the Serbian ruler Stefan Dušan to overrun most of the empire's remaining territory and establish a Serbian Empire . In 1354, an earthquake at Gallipoli devastated

3562-681: The Council of Clermont and urged all those present to take up arms under the sign of the Cross and launch an armed pilgrimage to recover Jerusalem and the East from the Muslims. The response in Western Europe was overwhelming. Alexios was able to recover a number of important cities, islands and much of western Asia Minor. The Crusaders agreed to become Alexios' vassals under the Treaty of Devol in 1108, which marked

3699-608: The Council of Piacenza in 1095, envoys from Alexios spoke to Pope Urban II about the suffering of the Christians of the East and underscored that without help from the West, they would continue to suffer under Muslim rule. Urban saw Alexios' request as a dual opportunity to cement Western Europe and reunite the Eastern Orthodox Church with the Roman Catholic Church under his rule. On 27 November 1095, Urban called

3836-471: The Danube , he pushed his troops too far in 602—they mutinied, proclaimed an officer named Phocas as emperor, and executed Maurice. The Sasanians seized their moment and reopened hostilities ; Phocas was unable to cope and soon faced a major rebellion led by Heraclius . Phocas lost Constantinople in 610 and was soon executed, but the destructive civil war accelerated the empire's decline. Under Khosrow II ,

3973-717: The Danube . In the north and west were the Balkans, the corridors between the mountain ranges of Pindos , the Dinaric Alps , the Rhodopes and the Balkans . In the south and east were Anatolia, the Pontic Mountains and the Taurus - Anti-Taurus range, which served as passages for armies, while the Caucasus mountains lay between the Empire and its eastern neighbours. Roman roads connected

4110-685: The Eastern Roman Empire , was the continuation of the Roman Empire centred in Constantinople during late antiquity and the Middle Ages . The eastern half of the Empire survived the conditions that caused the fall of the West in the 5th century AD, and continued to exist until the fall of Constantinople to the Ottoman Empire in 1453. During most of its existence, the empire remained

4247-617: The Empire of Trebizond , was created after Alexios I of Trebizond , commanding the Georgian expedition in Chaldia a few weeks before the sack of Constantinople, found himself de facto emperor and established himself in Trebizond. Of the three successor states, Epirus and Nicaea stood the best chance of reclaiming Constantinople. The Nicaean Empire struggled to survive the next few decades, however, and by

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4384-501: The Great Plague of London in 1665–66. Later works, such as Albert Camus 's novel The Plague or Ingmar Bergman 's film The Seventh Seal have used bubonic plague in settings, such as quarantined cities in either medieval or modern times, as a backdrop to explore themes including the breakdown of society, institutions, and individuals during the plague; the cultural and psychological existential confrontation with mortality; and

4521-621: The Komnenian restoration , and Constantinople would remain the largest and wealthiest city in Europe until the 13th century. The empire was largely dismantled in 1204, following the Sack of Constantinople by Latin armies at the end of the Fourth Crusade ; its former territories were then divided into competing Greek rump states and Latin realms . Despite the eventual recovery of Constantinople in 1261,

4658-663: The Normans who arrived in Italy at the beginning of the 11th century. During a period of strife between Constantinople and Rome culminating in the East-West Schism of 1054 , the Normans advanced gradually into Byzantine Italy . Reggio , the capital of the tagma of Calabria, was captured in 1060 by Robert Guiscard , followed by Otranto in 1068. Bari , the main Byzantine stronghold in Apulia ,

4795-565: The Pechenegs , who were caught by surprise and annihilated at the Battle of Levounion on 28 April 1091. Having achieved stability in the West, Alexios could turn his attention to the severe economic difficulties and the disintegration of the empire's traditional defences. However, he still did not have enough manpower to recover the lost territories in Asia Minor and to the advance by the Seljuks. At

4932-617: The Renaissance . The fall of Constantinople is sometimes used to mark the dividing line between the Middle Ages and the early modern period . The inhabitants of the empire, now generally termed Byzantines, thought of themselves as Romans ( Romaioi ). Their Islamic neighbours similarly called their empire the "land of the Romans" ( Bilād al-Rūm ), but the people of medieval Western Europe preferred to call them "Greeks" ( Graeci ), due to having

5069-454: The Roman papacy . In 780, Empress Irene assumed power on behalf of her son Constantine VI . Although she was a capable administrator who temporarily resolved the iconoclasm controversy, the empire was destabilized by her feud with her son. The Bulgars and Abbasids meanwhile inflicted numerous defeats on the Byzantine armies, and the papacy crowned Charlemagne as Roman emperor in 800. In 802,

5206-652: The Umayyad Caliphate , but the empire subsequently stabilised under the Isaurian dynasty. The empire was able to expand once more under the Macedonian dynasty , experiencing a two-century-long renaissance . This came to an end in 1071, with the defeat by the Seljuk Turks at the Battle of Manzikert . Thereafter, periods of civil war and Seljuk incursion resulted in the loss of most of Asia Minor . The empire recovered during

5343-537: The Western canon . The Decameron , by Boccaccio, is notable for its use of a frame story involving individuals who have fled Florence for a secluded villa to escape the Black Death. First-person, sometimes sensationalized or fictionalized, accounts of living through plague years have also been popular across centuries and cultures. For example, Samuel Pepys 's diary makes several references to his first-hand experiences of

5480-479: The World Health Organization recommends that only high-risk groups, such as certain laboratory personnel and health care workers, get inoculated. Several antibiotics are effective for treatment, including streptomycin , gentamicin , and doxycycline . Without treatment, plague results in the death of 30% to 90% of those infected. Death, if it occurs, is typically within 10 days. With treatment,

5617-556: The Yunnan Province in 1855. The term bubonic is derived from the Greek word βουβών , meaning ' groin ' . The bubonic plague is an infection of the lymphatic system , usually resulting from the bite of an infected flea, Xenopsylla cheopis (the Oriental rat flea ). Several flea species carried the bubonic plague, such as Pulex irritans (the human flea ), Xenopsylla cheopis , and Ceratophyllus fasciatus . Xenopsylla cheopis

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5754-506: The besiegers and from them penetrated the town. The Mongol forces catapulted plague-infested corpses into Caffa as a form of attack, one of the first known instances of biological warfare . When spring arrived, the Italian merchants fled on their ships, unknowingly carrying the Black Death. Carried by the fleas on rats, the plague initially spread to humans near the Black Sea and then outwards to

5891-516: The fluoroquinolone ciprofloxacin . Mortality associated with treated cases of bubonic plague is about 1–15%, compared to a mortality of 40–60% in untreated cases. People potentially infected with the plague need immediate treatment and should be given antibiotics within 24 hours of the first symptoms to prevent death. Other treatments include oxygen, intravenous fluids, and respiratory support. People who have had contact with anyone infected by pneumonic plague are given prophylactic antibiotics. Using

6028-508: The sea walls of Constantinople , overhaul provincial governance, and wage inconclusive campaigns against the Abbasids. After his death, his empress Theodora , ruling on behalf of her son Michael III , permanently extinguished the iconoclastic movement; the empire prospered under their sometimes-fraught rule. However, Michael was posthumously vilified by historians loyal to the dynasty of his successor Basil I , who assassinated him in 867 and who

6165-541: The 18th century. The disease remained localized in Southwest China for several years before spreading. In the city of Canton , beginning in January 1894, the disease had killed 80,000 people by June. Daily water traffic with the nearby city of Hong Kong rapidly spread the plague there, killing over 2,400 within two months during the 1894 Hong Kong plague . The third pandemic spread the disease to port cities throughout

6302-626: The 532 Nika revolt he rebuilt much of Constantinople, including the original Hagia Sophia . Justinian took advantage of political instability in Italy to attempt the reconquest of lost western territories. The Vandal Kingdom in North Africa was subjugated in 534 by the general Belisarius , who then invaded Italy ; the Ostrogothic Kingdom was destroyed in 554. In the 540s, however, Justinian began to suffer reversals on multiple fronts. Taking advantage of Constantinople's preoccupation with

6439-468: The 8th century. Because the infectious disease spread inland by the transferring of merchandise through Justinian's efforts in acquiring luxurious goods of the time and exporting supplies, his capital became the leading exporter of the bubonic plague. Procopius, in his work Secret History , declared that Justinian was a demon of an emperor who either created the plague himself or was being punished for his sinfulness. Medieval society's increasing population

6576-504: The Arab efforts to capture Constantinople in the 670s , but suffered a reversal against the Bulgars , who soon established an empire in the northern Balkans . Nevertheless, he and Constans had done enough to secure the empire's position, especially as the Umayyad Caliphate was undergoing another civil war . Justinian II sought to build on the stability secured by his father Constantine but

6713-408: The Byzantine administration's policy of heavy taxation and abolishing of the levy. The weakening of Georgia and Armenia played a significant role in the Byzantine defeat at Manzikert in 1071. Basil II is considered among the most capable Byzantine emperors and his reign as the apex of the empire in the Middle Ages . By 1025, the date of Basil II's death, the Byzantine Empire stretched from Armenia in

6850-675: The Democratic Republic of the Congo had the most plague cases, with over 1,100 cases in the Democratic Republic of the Congo alone. From 1,000 to 2,000 cases are conservatively reported per year to the WHO . From 2012 to 2017, reflecting political unrest and poor hygienic conditions, Madagascar began to host regular epidemics. Between 1900 and 2015, the United States had 1,036 human plague cases, with an average of 9 cases per year. In 2015, 16 people in

6987-415: The Empire by land, with the Via Egnatia running from Constantinople to the Albanian coast through Macedonia and the Via Traiana to Adrianople (modern Edirne ), Serdica (modern Sofia ) and Singidunum. By water, Crete, Cyprus and Sicily were key naval points and the main ports connecting Constantinople were Alexandria, Gaza, Caesarea and Antioch. The Aegean sea was considered an internal lake within

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7124-432: The Empire. The emperor was the centre of the whole administration of the Empire, who the legal historian Kaius Tuori has said was "above the law, within the law, and the law itself"; with a power that is difficult to define and which does not align with our modern understanding of the separation of powers. The proclamations of the crowds of Constantinople, and the inaugurations of the patriarch from 457, would legitimise

7261-453: The European population. Because the plague killed so many of the working population, wages rose due to the demand for labor. Some historians see this as a turning point in European economic development . The disease is also considered to have been responsible for the Plague of Justinian , originating in the Eastern Roman Empire in the 6th century CE, as well as the third epidemic , affecting China , Mongolia , and India , originating in

7398-411: The Mongol invasion also gave Nicaea a temporary respite from Seljuk attacks, allowing it to concentrate on the Latin Empire to its north. The Empire of Nicaea, founded by the Laskarid dynasty , managed to recapture Constantinople in 1261 and defeat Epirus . This led to a short-lived revival of Byzantine fortunes under Michael VIII Palaiologos , but the war-ravaged empire was ill-equipped to deal with

7535-405: The Normans were driven out of Greece, in 1186 the Vlachs and Bulgars began a rebellion that led to the formation of the Second Bulgarian Empire . The internal policy of the Angeloi was characterised by the squandering of the public treasure and fiscal maladministration. Imperial authority was severely weakened, and the growing power vacuum at the centre of the empire encouraged fragmentation. There

7672-401: The Sassanids occupied the Levant and Egypt and pushed into Asia Minor, while Byzantine control of Italy slipped and the Avars and Slavs ran riot in the Balkans. Although Heraclius repelled a siege of Constantinople in 626 and defeated the Sassanids in 627, this was a pyrrhic victory . The early Muslim conquests soon saw the conquest of the Levant , Egypt , and the Sassanid Empire by

7809-413: The Tetrarchy system quickly failed, the division of the empire proved an enduring concept. Constantine I ( r.  306–337 ) secured sole power in 324. Over the following six years, he rebuilt the city of Byzantium as a capital city , which was renamed Constantinople . Rome , the previous capital, was further from the important eastern provinces and in a less strategically important location; it

7946-426: The Turkish invaders at the Battle of Hyelion and Leimocheir , brought troops from the capital and was able to gather an army along the way, a sign that the Byzantine army remained strong and that the defensive program of western Asia Minor was still successful. John and Manuel pursued active military policies, and both deployed considerable resources on sieges and city defences; aggressive fortification policies were at

8083-402: The Wars , of his personal encounter with the plague and the effect it had on the rising empire. In the spring of 542, the plague arrived in Constantinople, working its way from port city to port city and spreading around the Mediterranean Sea , later migrating inland eastward into Asia Minor and west into Greece and Italy. The Plague of Justinian is said to have been "completed" in the middle of

8220-486: The West, Khosrow I of the Sasanian Empire invaded Byzantine territory and sacked Antioch in 540. Meanwhile, the emperor's internal reforms and policies began to falter, not helped by a devastating plague that killed a large proportion of the population and severely weakened the empire's social and financial stability. The most difficult period of the Ostrogothic war, against their king Totila , came during this decade, while divisions among Justinian's advisors undercut

8357-401: The West. Zeno ( r.  474–491 ) convinced the problematic Ostrogoth king Theodoric to take control of Italy from Odoacer, which he did; dying with the empire at peace, Zeno was succeeded by Anastasius I ( r.  491–518 ). Although his Monophysitism brought occasional issues, Anastasius was a capable administrator and instituted several successful financial reforms including

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8494-429: The Western provinces to achieve an economic revival that continued until the close of the century. It has been argued that Byzantium under the Komnenian rule was more prosperous than at any time since the Persian invasions of the 7th century. During the 12th century, population levels rose and extensive tracts of new agricultural land were brought into production. Archaeological evidence from both Europe and Asia Minor shows

8631-522: The abolition of the chrysargyron tax . He was the first emperor to die with no serious problems affecting his empire since Diocletian. The reign of Justinian I was a watershed in Byzantine history. Following his accession in 527, the law-code was rewritten as the influential Corpus Juris Civilis and Justinian produced extensive legislation on provincial administration; he reasserted imperial control over religion and morality through purges of non-Christians and "deviants"; and having ruthlessly subdued

8768-401: The administration's response. He also did not fully heal the divisions in Chalcedonian Christianity , as the Second Council of Constantinople failed to make a real difference. Justinian died in 565; his reign saw more success than that of any other Byzantine emperor, yet he left his empire under massive strain. Financially and territorially overextended, Justin II ( r.  565–578 )

8905-568: The aristocracy turned into wholesale slaughter, while the emperor resorted to ever more ruthless measures to shore up his regime. Despite his military background, Andronikos failed to deal with Isaac Komnenos of Cyprus, Béla III of Hungary who reincorporated Croatian territories into Hungary, and Stephen Nemanja of Serbia who declared his independence from the Byzantine Empire. Yet, none of these troubles compared to William II of Sicily 's invasion force of 300 ships and 80,000 men, arriving in 1185 and sacking Thessalonica . Andronikos mobilised

9042-402: The bacteria enter through the skin through a flea bite and travel via the lymphatic vessels to a lymph node , causing it to swell. Diagnosis is made by finding the bacteria in the blood, sputum , or fluid from lymph nodes. Prevention is through public health measures such as not handling dead animals in areas where plague is common. While vaccines against the plague have been developed,

9179-661: The bacterium reproduces in the person's blood and lungs respectively. Laboratory testing is required in order to diagnose and confirm plague. Ideally, confirmation is through the identification of Y. pestis culture from a patient sample. Confirmation of infection can be done by examining serum taken during the early and late stages of infection . To quickly screen for the Y. pestis antigen in patients, rapid dipstick tests have been developed for field use. Samples taken for testing include: Bubonic plague outbreaks are controlled by pest control and modern sanitation techniques. This disease uses fleas commonly found on rats as

9316-438: The broad-based antibiotic streptomycin has proven to be dramatically successful against the bubonic plague within 12 hours of infection. Globally between 2010 and 2015, there were 3,248 documented cases, which resulted in 584 deaths. The countries with the greatest number of cases are the Democratic Republic of the Congo , Madagascar , and Peru . For over a decade since 2001, Zambia, India, Malawi, Algeria, China, Peru, and

9453-403: The capital to Constantinople and legalised Christianity . Under Theodosius I ( r. 379–395 ), Christianity became the state religion , and other religious practices were proscribed . Greek gradually replaced Latin for official use as Latin fell into disuse. The empire experienced several cycles of decline and recovery throughout its history, reaching its greatest extent after the fall of

9590-432: The capital, and Alexios Angelos was elevated to the throne as Alexios IV along with his blind father Isaac. Alexios IV and Isaac II were unable to keep their promises and were deposed by Alexios V . The crusaders again took the city on 13 April 1204 , and Constantinople was subjected to pillage and massacre by the rank and file for three days. Many priceless icons, relics and other objects later turned up in Western Europe ,

9727-413: The city had collapsed so severely that it was now little more than a cluster of villages separated by fields. On 2 April 1453, Sultan Mehmed 's army of 80,000 men and large numbers of irregulars laid siege to the city. Despite a desperate last-ditch defence of the city by the massively outnumbered Christian forces (c. 7,000 men, 2,000 of whom were foreign), Constantinople finally fell to the Ottomans after

9864-635: The country. Unusually, most of the cases were pneumonic rather than bubonic. In June 2018, a child was confirmed to be the first person in Idaho to be infected by bubonic plague in nearly 30 years. A couple died in May 2019, in Mongolia, while hunting marmots . Another two people in the province of Inner Mongolia, China, were treated in November 2019 for the disease. In July 2020, in Bayannur , Inner Mongolia of China,

10001-589: The crusade was to conquer Egypt , the centre of Muslim power in the Levant. The Crusader army arrived at Venice in the summer of 1202 and hired the Venetian fleet to transport them to Egypt. As a payment to the Venetians, they captured the (Christian) port of Zara in Dalmatia , which was a vassal city of Venice, it had rebelled and placed itself under Hungary's protection in 1186. Shortly afterward, Alexios IV Angelos , son of

10138-512: The death of tissue. Y. pestis bacilli can resist phagocytosis and even reproduce inside phagocytes and kill them. As the disease progresses, the lymph nodes can hemorrhage and become swollen and necrotic . Bubonic plague can progress to lethal septicemic plague in some cases. The plague is also known to spread to the lungs and become the disease known as the pneumonic plague . Symptoms appear two to seven days after getting bitten and they include: The best-known symptom of bubonic plague

10275-437: The decay or decomposition of the skin while the person is still alive. Additional symptoms include extreme fatigue, gastrointestinal problems, spleen inflammation, lenticulae (black dots scattered throughout the body), delirium, coma , organ failure, and death. Organ failure is a result of the bacteria infecting organs through the bloodstream. Other forms of the disease include septicemic plague and pneumonic plague , in which

10412-499: The deposed and blinded Emperor Isaac II, made contact with the Crusaders. Alexios offered to reunite the Byzantine church with Rome, pay the Crusaders 200,000 silver marks, join the crusade, and provide all the supplies they needed to reach Egypt. The crusaders arrived at Constantinople in the summer of 1203 and quickly attacked , starting a major fire that damaged large parts of the city, and briefly seized control. Alexios III fled from

10549-471: The east by allowing the Goths to settle in Roman territory; he also twice intervened in the western half, defeating the usurpers Magnus Maximus and Eugenius in 388 and 394 respectively. He actively condemned paganism , confirmed the primacy of Nicene Christianity over Arianism , and established Christianity as the Roman state religion . He was the last emperor to rule both the western and eastern halves of

10686-433: The east to Calabria in southern Italy in the west. Many successes had been achieved, ranging from the conquest of Bulgaria to the annexation of parts of Georgia and Armenia, and the reconquests of Crete , Cyprus , and the important city of Antioch . These were not temporary tactical gains but long-term reconquests. At the same time, Byzantium was faced with new enemies. Its provinces in southern Italy were threatened by

10823-527: The emperor's role as the leader of the Christian world, John marched into the Holy Land at the head of the combined forces of the empire and the Crusader states; yet despite his efforts in leading the campaign, his hopes were disappointed by the treachery of his Crusader allies. In 1142, John returned to press his claims to Antioch, but he died in the spring of 1143 following a hunting accident. John's chosen heir

10960-523: The empire's eastern defences. The emergency lent weight to the military aristocracy in Anatolia, who in 1068 secured the election of one of their own, Romanos Diogenes , as emperor. In the summer of 1071, Romanos undertook a massive eastern campaign to draw the Seljuks into a general engagement with the Byzantine army. At the Battle of Manzikert , Romanos suffered a surprise defeat against Sultan Alp Arslan and

11097-492: The empire's fall, early modern scholars referred to the empire by many names, including the "Empire of Constantinople", the "Empire of the Greeks", the "Eastern Empire", the "Late Empire", the "Low Empire", and the "Roman Empire". The increasing use of "Byzantine" and "Byzantine Empire" likely started with the 15th-century historian Laonikos Chalkokondyles , whose works were widely propagated, including by Hieronymus Wolf . "Byzantine"

11234-544: The empire, gaining only short-term success. To avoid another sacking of the capital by the Latins, he forced the Church to submit to Rome, again a temporary solution for which the peasantry hated Michael and Constantinople. The efforts of Andronikos II and later his grandson Andronikos III marked Byzantium's last genuine attempts to restoring the glory of the empire. However, the use of mercenaries by Andronikos II often backfired, with

11371-460: The empire; after his death, the West would be destabilised by a succession of "soldier-emperors", unlike the East, where administrators would continue to hold power. Theodosius II ( r.  408–450 ) largely left the rule of the east to officials such as Anthemius , who constructed the Theodosian Walls to defend Constantinople, now firmly entrenched as Rome's capital. Theodosius' reign

11508-514: The end of the Norman threat during Alexios' reign. Alexios's son John II Komnenos succeeded him in 1118 and ruled until 1143. John was a pious and dedicated emperor who was determined to undo the damage to the empire suffered at the Battle of Manzikert half a century earlier. Famed for his piety and his remarkably mild and just reign, John was an exceptional example of a moral ruler at a time when cruelty

11645-606: The enemies that surrounded it. To maintain his campaigns against the Latins, Michael pulled troops from Asia Minor and levied crippling taxes on the peasantry, causing much resentment. Massive construction projects were completed in Constantinople to repair the damage of the Fourth Crusade, but none of these initiatives were of any comfort to the farmers in Asia Minor suffering raids from Muslim ghazis. Rather than holding on to his possessions in Asia Minor, Michael chose to expand

11782-569: The former Byzantine possessions. Although Venice was more interested in commerce than conquering territory, it took key areas of Constantinople, and the Doge took the title of " Lord of a Quarter and Half a Quarter of the Roman Empire ". After the sack of Constantinople in 1204 by Latin crusaders, two Byzantine successor states were established: the Empire of Nicaea and the Despotate of Epirus . A third,

11919-595: The fort, allowing the Ottomans (who were hired as mercenaries during the civil war by John VI Kantakouzenos ) to establish themselves in Europe. By the time the Byzantine civil wars had ended, the Ottomans had defeated the Serbians and subjugated them as vassals. Following the Battle of Kosovo , much of the Balkans became dominated by the Ottomans. Constantinople by this stage was underpopulated and dilapidated. The population of

12056-411: The gut of infected fleas, and this results in the flea regurgitating ingested blood, which is now infected, into the bite site of a rodent or human host. Once established, the bacteria rapidly spread to the lymph nodes of the host and multiply. The fleas that transmit the disease only directly infect humans when the rat population in the area is wiped out from a mass infection. Furthermore, in areas with

12193-483: The heart of their imperial military policies. Despite the defeat at Myriokephalon, the policies of Alexios, John and Manuel resulted in vast territorial gains, increased frontier stability in Asia Minor, and secured the stabilisation of the empire's European frontiers. From c.  1081 to c.  1180 , the Komnenian army assured the empire's security, enabling Byzantine civilisation to flourish. This allowed

12330-465: The jungle. The film was a box office disappointment for Paramount. This film, along with The Sign of the Cross , Cleopatra , The Crusades and Union Pacific , was released on DVD in 2006 by Universal Studios as part of The Cecil B. DeMille Collection . This article about an adventure film is a stub . You can help Misplaced Pages by expanding it . Bubonic plague Bubonic plague

12467-708: The later part of his reign, John focused his activities on the East, personally leading numerous campaigns against the Turks in Asia Minor. His campaigns fundamentally altered the balance of power in the East, forcing the Turks onto the defensive, while retaking many towns, fortresses, and cities across the peninsula for the Byzantines. He defeated the Danishmend Emirate of Melitene and reconquered all of Cilicia , while forcing Raymond of Poitiers , Prince of Antioch, to recognise Byzantine suzerainty. In an effort to demonstrate

12604-533: The latter's description was imprecise and also expressed doubts of its relation to the disease, and thus the bacterium is today only named after Yersin. The scale of death and social upheaval associated with plague outbreaks has made the topic prominent in many historical and fictional accounts since the disease was first recognized. The Black Death in particular is described and referenced in numerous contemporary sources , some of which, including works by Chaucer , Boccaccio , and Petrarch , are considered part of

12741-564: The mass mortality rate cheapened life and thus increased warfare, crime, popular revolt, waves of flagellants , and persecution. The Black Death originated in Central Asia and spread from Italy and then throughout other European countries. Arab historians Ibn Al-Wardni and Almaqrizi believed the Black Death originated in Mongolia. Chinese records also show a huge outbreak in Mongolia in the early 1330s. In 2022, researchers presented evidence that

12878-418: The measures he took to reform the government of the empire have been praised by historians. According to the historian George Ostrogorsky , Andronikos was determined to root out corruption: under his rule, the sale of offices ceased; selection was based on merit, rather than favouritism; and officials were paid an adequate salary to reduce the temptation of bribery. In the provinces, Andronikos's reforms produced

13015-579: The mid-13th century it had lost much of southern Anatolia. The weakening of the Sultanate of Rûm following the Mongol invasion in 1242–1243 allowed many beyliks and ghazis to set up their own principalities in Anatolia, weakening the Byzantine hold on Asia Minor. Two centuries later, one of the Beys of these beyliks, Osman I , would establish the Ottoman Empire that would eventually conquer Constantinople. However,

13152-542: The most capable Byzantine emperors, withstood continued Arab attacks, civil unrest, and natural disasters, and reestablished the state as a major regional power. Leo's reign produced the Ecloga , a new code of law to succeed that of Justinian II, and continued to reform the "theme system" in order to lead offensive campaigns against the Muslims, culminating in a decisive victory in 740 . Constantine overcame an early civil war against his brother-in-law Artabasdos , made peace with

13289-489: The most powerful economic, cultural, and military force in the Mediterranean world . The term "Byzantine Empire" was only coined following the empire's demise; its citizens referred to the polity as the "Roman Empire" and to themselves as "Romans". Due to the imperial seat's move from Rome to Byzantium , the adoption of state Christianity , and the predominance of Greek instead of Latin , modern historians continue to make

13426-567: The new Abbasid Caliphate , campaigned successfully against the Bulgars, and continued to make administrative and military reforms. However, due to both emperors' support for the Byzantine Iconoclasm , which opposed the use of religious icons , they were later vilified by Byzantine historians; Constantine's reign also saw the loss of Ravenna to the Lombards , and the beginning of a split with

13563-466: The newly-formed Arabic Rashidun Caliphate . By Heraclius' death in 641, the empire had been severely reduced economically as well as territorially—the loss of the wealthy eastern provinces had deprived Constantinople of three-quarters of its revenue. The next seventy-five years are poorly documented. Arab raids into Asia Minor began almost immediately, and the Byzantines resorted to holding fortified centres and avoiding battle at all costs; although it

13700-483: The origin of the plague and how it traveled through the continent. Mitochondrial DNA of modern rats in Western Europe indicated that these rats came from two different areas, one being Africa and the other unclear. The research regarding this pandemic has greatly increased with technology. Through archaeo-molecular investigation, researchers have discovered the DNA of plague bacillus in the dental core of those that fell ill to

13837-555: The outset of his reign, Alexios faced a formidable attack from the Normans under Guiscard and his son Bohemund of Taranto , who captured Dyrrhachium and Corfu and laid siege to Larissa in Thessaly . Guiscard's death in 1085 temporarily eased the Norman problem. The following year, the Seljuq sultan died, and the sultanate was split due to internal rivalries. By his own efforts, Alexios defeated

13974-521: The patriarch Nicholas , the powerful Simeon I of Bulgaria , and other influential figures jockeyed for power. In 920, the admiral Romanos I used his fleet to secure power, crowning himself and demoting Constantine to the position of junior co-emperor. His reign, which brought peace with Bulgaria and successes in the east under the general John Kourkouas , was ended in 944 by the machinations of his sons, whom Constantine soon usurped in turn. Constantine's ineffectual sole rule has often been construed as

14111-406: The plague as an allegory raising contemporary moral or spiritual questions. Some of the earliest instances of biological warfare were said to have been products of the plague, as armies of the 14th century were recorded catapulting diseased corpses over the walls of towns and villages to spread the pestilence. This was done by Jani Beg when he attacked the city of Kaffa in 1343. Later, plague

14248-552: The plague originated near Lake Issyk-Kul in Kyrgyzstan . The Mongols had cut the trade route (the Silk Road ) between China and Europe, which halted the spread of the Black Death from eastern Russia to Western Europe. The European epidemic may have begun with the siege of Caffa , an attack that Mongols launched on the Italian merchants' last trading station in the region, Caffa , in the Crimea . In late 1346, plague broke out among

14385-743: The plague was responsible for the Neolithic decline . The first recorded epidemic affected the Sasanian Empire and their arch-rivals, the Eastern Roman Empire (Byzantine Empire) and was named the Plague of Justinian (541–549 AD) after emperor Justinian I , who was infected but survived through extensive treatment. The pandemic resulted in the deaths of an estimated 25 million (6th century outbreak) to 50 million people (two centuries of recurrence). The historian Procopius wrote, in Volume II of History of

14522-528: The plague. Analysis of teeth of the deceased allows researchers to further understand both the demographics and mortuary patterns of the disease. For example, in 2013 in England, archeologists uncovered a burial mound to reveal 17 bodies, mainly children, who had died of the Bubonic plague. They analyzed these burial remains using radiocarbon dating to determine they were from the 1530s, and dental core analysis revealed

14659-410: The pope and Western Christian kingdoms, and he successfully handled the passage of the crusaders through his empire. In the East, Manuel suffered a major defeat in 1176 at the Battle of Myriokephalon against the Turks. These losses were quickly recovered, and in the following year Manuel's forces inflicted a defeat upon a force of "picked Turks". The Byzantine commander John Vatatzes , who destroyed

14796-590: The ports of southern Italy, he sent an expedition to Italy in 1155, but disputes within the coalition led to the eventual failure of the campaign. Despite this military setback, Manuel's armies successfully invaded the southern parts of the Kingdom of Hungary in 1167, defeating the Hungarians at the Battle of Sirmium . By 1168, nearly the whole of the eastern Adriatic coast lay in Manuel's hands. Manuel made several alliances with

14933-508: The presence of Yersinia pestis. Other evidence for rats that are currently still being researched consists of gnaw marks on bones, predator pellets and rat remains that were preserved in situ . This research allows individuals to trace early rat remains to track the path traveled and in turn connect the impact of the Bubonic Plague to specific breeds of rats. Burial sites, known as plague pits, offer archaeologists an opportunity to study

15070-441: The reconstituted empire would wield only regional power during its final two centuries of existence. Its remaining territories were progressively annexed by the Ottomans in perennial wars fought throughout the 14th and 15th centuries. The fall of Constantinople to the Ottomans in 1453 ultimately brought the empire to an end. Many refugees who had fled the city after its capture settled in Italy and throughout Europe, helping to ignite

15207-402: The remains of people who died from the plague. Another research study indicates that these separate pandemics were all interconnected. A current computer model indicates that the disease did not go away in between these pandemics. It rather lurked within the rat population for years without causing human epidemics. Eastern Roman Empire The Byzantine Empire , also referred to as

15344-481: The rest of Europe as a result of people fleeing from one area to another. Rats migrated with humans, traveling among grain bags, clothing, ships, wagons, and grain husks. Continued research indicates that black rats , those that primarily transmitted the disease, prefer grain as a primary meal. Due to this, the major bulk grain fleets that transported major city's food shipments from Africa and Alexandria to heavily populated areas, and were then unloaded by hand, played

15481-425: The result of the route of infection: bubonic plague, septicemic plague , and pneumonic plague . Bubonic plague is mainly spread by infected fleas from small animals . It may also result from exposure to the body fluids from a dead plague-infected animal. Mammals such as rabbits , hares , and some cat species are susceptible to bubonic plague, and typically die upon contraction. In the bubonic form of plague,

15618-569: The risk of death is around 10%. Globally between 2010 and 2015 there were 3,248 documented cases, which resulted in 584 deaths. The countries with the greatest number of cases are the Democratic Republic of the Congo , Madagascar , and Peru . The plague is considered the likely cause of the Black Death that swept through Asia, Europe, and Africa in the 14th century and killed an estimated 50 million people, including about 25% to 60% of

15755-543: The throne. Alexios was highly incompetent in the office, and with his mother Maria of Antioch 's Frankish background, his regency was unpopular. Eventually, Andronikos I Komnenos , a grandson of Alexios I, overthrew Alexios II in a violent coup d'état . After eliminating his potential rivals, he had himself crowned as co-emperor in September 1183. He eliminated Alexios II and took his 12-year-old wife Agnes of France for himself. Andronikos began his reign well; in particular,

15892-442: The unpopular Irene was overthrown by Nikephoros I ; he reformed the empire's administration but died in battle against the Bulgars in 811. Military defeats and societal disorder, especially the resurgence of iconoclasm, characterised the next eighteen years. Stability was somewhat restored during the reign of Theophilos ( r.  829–842 ), who exploited economic growth to complete construction programs, including rebuilding

16029-466: The west during the reign of Justinian I ( r. 527–565 ), who briefly reconquered much of Italy and the western Mediterranean coast . The appearance of plague and a devastating war with Persia exhausted the empire's resources; the early Muslim conquests that followed saw the loss of the empire's richest provinces— Egypt and Syria —to the Rashidun Caliphate . In 698, Africa was lost to

16166-458: The west, the warlord Odoacer deposed Romulus Augustulus in 476, killed his titular successor Julius Nepos in 480, and the office of western emperor was formally abolished. Through a combination of luck, cultural factors, and political decisions, the Eastern empire never suffered from rebellious barbarian vassals and was never ruled by barbarian warlords—the problems which ensured the downfall of

16303-584: The western United States developed plague, including 2 cases in Yosemite National Park . These US cases usually occur in rural northern New Mexico, northern Arizona, southern Colorado, California, southern Oregon, and far western Nevada. In November 2017, the Madagascar Ministry of Health reported an outbreak to the WHO (World Health Organization) with more cases and deaths than any recent outbreak in

16440-662: The world in the second half of the 19th century and the early 20th century via shipping routes. The plague infected people in Chinatown in San Francisco from 1900 to 1904, and in the nearby locales of Oakland and the East Bay again from 1907 to 1909. During the former outbreak, in 1902, authorities made permanent the Chinese Exclusion Act , a law originally signed into existence by President Chester A. Arthur in 1882. The Act

16577-422: The zenith of Byzantine learning , but while several works were compiled, they were largely intended to legitimise and glorify the emperor's Macedonian dynasty . His son and successor died young; under two soldier-emperors, Nikephoros II ( r.  963–969 ) and John I Tzimiskes ( r.  969–976 ), the Roman army claimed numerous military successes, including the conquest of Cilicia and Antioch , and

16714-592: Was besieged in August 1068 and fell in April 1071 . About 1053, Constantine IX disbanded what the historian John Skylitzes calls the "Iberian Army", which consisted of 50,000 men, and it was turned into a contemporary Drungary of the Watch . Two other knowledgeable contemporaries, the former officials Michael Attaleiates and Kekaumenos , agree with Skylitzes that by demobilising these soldiers, Constantine did catastrophic harm to

16851-560: Was captured. Alp Arslan treated him with respect and imposed no harsh terms on the Byzantines. In Constantinople a coup put in power Michael Doukas , who soon faced the opposition of Nikephoros Bryennios and Nikephoros III Botaneiates . By 1081, the Seljuks had expanded their rule over virtually the entire Anatolian plateau from Armenia in the east to Bithynia in the west, and had established their capital at Nicaea , just 90 kilometres (56 miles) from Constantinople. The Komnenian dynasty attained full power under Alexios I in 1081. From

16988-550: Was given credit for his predecessor's achievements. Basil I ( r.  867–886 ) continued Michael's policies. His armies campaigned with mixed results in Italy but defeated the Paulicians of Tephrike . His successor Leo VI ( r.  886–912 ) compiled and propagated a huge number of written works. These included the Basilika , a Greek translation of Justinian I's law-code which included over 100 new laws of Leo's devising;

17125-573: Was his fourth son, Manuel I Komnenos , who campaigned aggressively against his neighbours both in the west and east. In Palestine, Manuel allied with the Crusader Kingdom of Jerusalem and sent a large fleet to participate in a combined invasion of Fatimid Egypt . Manuel reinforced his position as overlord of the Crusader states, with his hegemony over Antioch and Jerusalem secured by agreement with Raynald , Prince of Antioch, and Amalric of Jerusalem . In an effort to restore Byzantine control over

17262-540: Was invaded annually, Anatolia avoided permanent Arab occupation. The outbreak of the First Fitna in 656 gave Byzantium breathing space, which it used wisely: some order was restored in the Balkans by Constans II ( r.  641–668 ), who began the administrative reorganisation known as the " theme system ", in which troops were allocated to defend specific provinces. With the help of the recently rediscovered Greek fire , Constantine IV ( r.  668–685 ) repelled

17399-556: Was marked by the theological dispute over Nestorianism , which was eventually deemed heretical , and by the formulation of the Codex Theodosianus law code. It also saw the arrival of Attila 's Huns , who ravaged the Balkans and exacted a massive tribute from the empire; Attila however switched his attention to the rapidly-deteriorating western empire , and his people fractured after his death in 453. After Leo I ( r.  457–474 ) failed in his 468 attempt to reconquer

17536-406: Was not esteemed by the "soldier-emperors" who ruled from the frontiers or by the empire's population who, having been granted citizenship , considered themselves "Roman". Constantine extensively reformed the empire's military and civil administration and instituted the gold solidus as a stable currency. He favoured Christianity , which he had converted to in 312. Constantine's dynasty fought

17673-506: Was occupied by conflicts against two prominent generals, Bardas Skleros and Bardas Phokas , which ended in 989 with the former's death and the latter's submission. Between 1021 and 1022, following years of tensions, Basil II led a series of victorious campaigns against the Kingdom of Georgia , resulting in the annexation of several Georgian provinces to the empire. Basil's successors also annexed Bagratid Armenia in 1045. Importantly, both Georgia and Armenia were significantly weakened by

17810-490: Was overthrown in 695 after attempting to exact too much from his subjects; over the next twenty-two years, six more rebellions followed in an era of political instability . The reconstituted caliphate sought to break Byzantium by taking Constantinople, but the newly crowned Leo III managed to repel the 717–718 siege , the first major setback of the Muslim conquests. Leo and his son Constantine V ( r.  741–775 ), two of

17947-608: Was put to deadly halt when, in the Late Middle Ages , Europe experienced the deadliest disease outbreak in history. They called it the Great Dying or The Great Pestilence, later coined The Black Death. Lasting in potency for roughly six years, 1346–1352, the Black Death claimed one-third of the European human population, with mortality rates as high as 70%–80%. Some historians believe that society subsequently became more violent as

18084-515: Was soon at war on many fronts. The Lombards , fearing the aggressive Avars , conquered much of northern Italy by 572. The Sasanian wars restarted that year, and continued until the emperor Maurice finally emerged victorious in 591; by that time, the Avars and Slavs had repeatedly invaded the Balkans , causing great instability. Maurice campaigned extensively in the region during the 590s, but although he managed to re-establish Byzantine control up to

18221-565: Was supposed to last for 10 years, but was renewed in 1892 with the Geary Act , then followed by the 1902 decision. The last major outbreak in the United States occurred in Los Angeles in 1924, though the disease is still present in wild rodents and can be passed to humans who come in contact with them. According to the World Health Organization , the pandemic was considered active until 1959, when worldwide casualties dropped to 200 per year. In 1994,

18358-402: Was the most effective flea species for transmission. The flea is parasitic on house and field rats and seeks out other prey when its rodent host dies. Rats were an amplifying factor to bubonic plague due to their common association with humans as well as the nature of their blood. The rat's blood allows the rat to withstand a major concentration of the plague. The bacteria form aggregates in

18495-726: Was the norm. For this reason, he has been called the Byzantine Marcus Aurelius . During his twenty-five-year reign, John made alliances with the Holy Roman Empire in the West and decisively defeated the Pechenegs at the Battle of Beroia . He thwarted Hungarian and Serbian threats during the 1120s, and in 1130 he allied himself with Lothair III , the German Emperor against the Norman King Roger II of Sicily . In

18632-415: Was used adjectivally alongside terms such as "Empire of the Greeks" until the 19th century. It is now the primary term, used to refer to all aspects of the empire; some modern historians believe that, as an originally prejudicial and inaccurate term, it should not be used. As the historiographical periodizations of " Roman history ", " late antiquity ", and "Byzantine history" significantly overlap, there

18769-924: Was used during the Second Sino-Japanese War as a bacteriological weapon by the Imperial Japanese Army . These weapons were provided by Shirō Ishii 's units and used in experiments on humans before being used in the field. For example, in 1940, the Imperial Japanese Army Air Service bombed Ningbo with fleas carrying the bubonic plague. During the Khabarovsk War Crime Trials , the accused, such as Major General Kiyoshi Kawashima, testified that, in 1941, 40 members of Unit 731 air-dropped plague -contaminated fleas on Changde . These operations caused epidemic plague outbreaks. Substantial research has been done regarding

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