A monograph is generally a work on one (usually scholarly) subject, or one aspect of a subject, often created by a single author or artist. Traditionally it is in written form and published as a book, but it may be an artwork, audiovisual work, or exhibition made up of visual artworks . In library cataloguing , the word has a specific and broader meaning, while in the United States, the Food and Drug Administration uses the term to mean a set of published standards.
68-631: The European Pharmacopoeia ( Pharmacopoeia Europaea , Ph. Eur. ) is a major regional pharmacopoeia which provides common quality standards throughout the pharmaceutical industry in Europe to control the quality of medicines , and the substances used to manufacture them. It is a published collection of monographs which describe both the individual and general quality standards for ingredients, dosage forms , and methods of analysis for medicines. These standards apply to medicines for both human and veterinary use. The European Pharmacopoeia has
136-578: A legally binding character. It is used as an official reference to serve public health , and is part of the regulatory requirements for obtaining a Marketing Authorisation (MA) for a medicinal (human or veterinary) product. The quality standards of the European Pharmacopoeia apply throughout the entire life-cycle of a product, and become legally binding and mandatory on the same date in all thirty-nine (39) signatory states, which include all European Union member states. Several legal texts make
204-555: A basis on which a globally international pharmacopoeia could be prepared, but regulatory complexity and regional variation in conditions of pharmacy are hurdles to fully harmonizing across all countries (that is, defining thousands of details that can all be known to work successfully in all places). Nonetheless, some progress has been made under the banner of the International Council on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH),
272-450: A broader meaning: a non-serial publication complete in one volume (book) or a definite number of books. Thus it differs from a serial or periodical publication such as a magazine , academic journal , or newspaper . In this context only, books such as novels are considered monographs. In biological taxonomy , a monograph is a comprehensive treatment of a taxon in written form. Monographs typically review all known species within
340-457: A commercial standard of purity as distinct from a medicinal one is needed, since the preparations used in medicine should be of the highest possible degree of purity obtainable, and this standard would be too high and too expensive for ordinary purposes. The use of trade synonyms in the Pharmacopoeia, such as saltpetre for purified potassium nitrate , and milk of sulphur for precipitated sulphur,
408-513: A common monograph that provides a common set of tests and specifications for a specific material. This is a slow process. The World Health Organization has produced the International Pharmacopoeia (Ph.Int.), which does not replace a national pharmacopoeia but rather provides a model or template for one and also can be invoked by legislation within a country to serve as that country's regulation. Though formerly printed there has been
476-465: A compound of "medicine, drug, poison" ( Ancient Greek : φάρμακον , romanized : pharmakon ), with the verb "to make" ( Ancient Greek : ποιεῖν , romanized : poiein ), and the abstract noun suffix -ία -ia . In early modern editions of Latin texts, the Greek diphthong οι ( oi ) is latinized to its Latin equivalent oe which is in turn written with the ligature œ , giving
544-482: A corrected impression of the same was issued. Subsequent editions were published in 1824, 1836, and 1851. The first Edinburgh Pharmacopoeia was published in 1699 and the last in 1841; the first Dublin Pharmacopoeia in 1807 and the last in 1850. The preparations contained in these three pharmacopoeias were not all uniform in strength, a source of much inconvenience and danger to the public, when powerful preparations such as dilute hydrocyanic acid were ordered in
612-684: A directorate of the Council of Europe , provides scientific and administrative support for the European Pharmacopoeia , the governing body is the European Pharmacopoeia Commission. The European Pharmacopoeia Commission determines the general principles applicable to the elaboration of the European Pharmacopoeia. It also decides the work programme, sets up and appoints experts to the specialised groups responsible for preparing monographs, adopts these monographs, and recommends dates for
680-498: A group, add any newly discovered species, and collect and synthesize available information on the ecological associations, geographic distributions, and morphological variations within the group. The first-ever monograph of a plant taxon was Robert Morison 's 1672 Plantarum Umbelliferarum Distributio Nova , a treatment of the Apiaceae . Book publishers use the term "artist monograph" or "art monograph" to indicate books dealing with
748-540: A legal standard for the drugs and preparations contained in it. The Pharmacopoeia is defined in the preface as only "intended to afford to the members of the medical profession and those engaged in the preparation of medicines throughout the British Empire one uniform standard and guide whereby the nature and composition of, substances to be used in medicine may be ascertained and determined". It cannot be an encyclopaedia of substances used in medicine, and can be used only as
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#1733086040696816-400: A pharmacopoeia. De Villeneuve, fellow student of Vesalius and the best galenist of Paris according to Johann Winter von Andernach , published the anonymous " Dispensarium or Enquiridion " in 1543, at Lyon , France, with Jean Frellon as editor. This work contains 224 original recipes by De Villeneuve and others by Lespleigney and Chappuis. As usual when it comes to pharmacopoeias, this work
884-494: A separate charter, and it was enacted that no grocer should keep an apothecary's shop. The preparation of physicians' prescriptions was thus confined to the apothecaries, upon whom pressure was brought to bear to make them dispense accurately, by the issue of a pharmacopoeia in May 1618 by the College of Physicians , and by the power which the wardens of the apothecaries received in common with
952-420: A single artist, as opposed to broader surveys of art subjects. The term monograph is also used for audiovisual or film documentary-type representations of a subject, often creatively expressed. The term "monographic film" has also been used for short fiction or animated films. Video or film essays on a single topic are also referred to as monographs. IndyVinyl , by Scottish film academic Ian Garwood,
1020-571: A standard for the substances and preparations contained in it, and for no others. It has been held in the Divisional Courts (Dickins v. Randerson) that the Pharmacopoeia is a standard for official preparations asked for under their pharmacopoeial name. But there are many substances in the Pharmacopoeia which are not only employed in medicine, but have other uses, such as sulphur , gum benzoin , tragacanth , gum arabic , ammonium carbonate , beeswax , oil of turpentine , linseed oil , and for these
1088-643: A transition to a situation where pharmaceutical information is available as printed volumes and on the internet . The rapid increase in knowledge renders necessary frequent new editions, to furnish definite formulae for preparations that have already come into extensive use in medical practice, so as to ensure uniformity of strength, and to give the characters and tests by which their purity and potency may be determined. However each new edition requires several years to carry out numerous experiments for devising suitable formulae, so that current pharmacopoeia are never quite up to date. This difficulty has hitherto been met by
1156-686: A tri-regional organisation that represents the drug regulatory authorities of the European Union , Japan , and the United States . Representatives from the Pharmacopoeias of these three regions have met twice yearly since 1990 in the Pharmacopoeial Discussion Group to try to work towards "compendial harmonisation". Specific monographs are proposed, and if accepted, proceed through stages of review and consultation leading to adoption of
1224-454: Is a book containing directions for the identification of compound medicines , and published by the authority of a government or a medical or pharmaceutical society. Descriptions of preparations are called monographs . In a broader sense it is a reference work for pharmaceutical drug specifications . The term derives from Ancient Greek : φαρμακοποιία , romanized : pharmakopoiia "making of (healing) medicine, drug-making",
1292-564: Is a monographic research project focused on "vinyl records in American independent cinema between 1987 and 2018". It includes an 8,000-word peer-reviewed academic book chapter; video compilations; "critical montages "; and a series of social media posts, all curated on a website. Garwood has written that his project is "an attempt to produce a research output equivalent to an academic monograph, but incorporating video-based forms of criticism that have been popularised through online film culture". In
1360-466: Is common. Monograph The English term monograph is derived from modern Latin monographia , which has its root in Greek . In the English word, mono- means ' single ' and -graph means ' something written ' . Unlike a textbook , which surveys the state of knowledge in a field, the main purpose of a monograph is to present primary research and original scholarship. This research
1428-610: Is no standard of purity that can be used under the Adulteration of Food and Drugs Act, and for these, as well as for the commercial quality of those drugs and essential oils which are also in the Pharmacopoeia, a legal standard of commercial purity is much needed. This subject formed the basis of discussion at several meetings of the Pharmaceutical Society, and the results have been embodied in a work called Suggested Standards for Foods and Drugs by C. G. Moor, which indicates
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#17330860406961496-411: Is partly answerable for this difficulty, and has proved to be a mistake, since it affords ground for legal prosecution if a chemist sells a drug of ordinary commercial purity for trade purposes, instead of the purified preparation which is official in the Pharmacopoeia for medicinal use. This would not be the case if the trade synonym were omitted. For many drugs and chemicals not in the Pharmacopoeia there
1564-483: Is presented at length, distinguishing a monograph from an article. For these reasons, publication of a monograph is commonly regarded as vital for career progression in many academic disciplines. Intended for other researchers and bought primarily by libraries, monographs are generally published as individual volumes in a short print run . In Britain and the U.S., what differentiates a scholarly monograph from an academic trade title varies by publisher, though generally it
1632-426: Is the assumption that the readership has not only specialised or sophisticated knowledge but also professional interest in the subject of the work. A written monograph is usually a specialist book on one topic, although its meaning has been broadened to include any works which are not reference works and which may be written by one or more authors, or an edited collection. In library cataloguing , monograph has
1700-573: The Shennong Ben Cao Jing was compiled between 200-250 AD. It contains descriptions of 365 medications. The earliest known officially sponsored pharmacopoeia was compiled in 659 AD by a team of 23 pharmaceutical scientists led by Su jing during the Tang dynasty (618-907 AD) and was called the Xinxiu bencao (Newly Revised Canon of Material Medical). The work consists of 20 volumes with one dedicated to
1768-597: The British Empire . As regards the purely pharmaceutical part of the work a committee of reference in pharmacy, nominated by the pharmaceutical societies of Great Britain and Ireland (as they were then), was appointed to report to the Pharmacopoeia Committee of the Medical Council. Some difficulty has arisen since the passing of the Adulteration of Food and Drugs Act concerning the use of the Pharmacopoeia as
1836-577: The European Pharmacopoeia mandatory in Europe. The Convention on the Elaboration of a European Pharmacopoeia (ETS No. 50) which was adopted by the Council of Europe in 1964, laid the groundwork for the development of the European Pharmacopoeia . In 1994, a Protocol (ETS No. 134) was adopted, amending the convention to prepare for the accession of the European Union (EU), and defining the respective powers of
1904-739: The European Union are signatories to the Convention on the Elaboration of a European Pharmacopoeia. There are 30 observers in all: five European countries, 23 non-European countries, the World Health Organization (WHO) and the Taiwan Food and Drug Administration (TFDA) of the Ministry of Health and Welfare. While the European Directorate for the Quality of Medicines & HealthCare (EDQM),
1972-563: The 12th century (and printed in 1491), and Ibn Baytar in the 14th century. The Shen-nung pen ts'ao ching (Divine Husbandman's Materia Medica) is the earliest known Chinese pharmacopoeia. The text describes 365 medicines derived from plants, animals, and minerals; according to legend it was written by the Chinese god Shennong . Pharmacopeial synopsis were recorded in the Timbuktu manuscripts of Mali . The earliest extant Chinese pharmacopoeia,
2040-640: The British Pharmacopoeia in 1898. A committee of the Royal Pharmaceutical Society of Great Britain was appointed at the request of the General Medical Council to advise on pharmaceutical matters. A census of prescriptions was taken to ascertain the relative frequency with which different preparations and drugs were used in prescriptions, and suggestions and criticisms were sought from various medical and pharmaceutical bodies across
2108-511: The EU is prepared by a governmental organization, and has a specified role in law in the EU. In the U.S., the USP-NF (United States Pharmacopeia – National Formulary) has been issued by a private non-profit organization since 1820 under the authority of a Convention that meets periodically that is largely constituted by physicians, pharmacists, and other public health professionals, setting standards published in
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2176-547: The European Union and its member states within the European Pharmacopoeia Commission. European Union Directive 2001/82/EC and Directive 2001/83/EC , (as amended) state the legally binding character of European Pharmacopoeia texts for Marketing Authorisation Applications (MAA). All manufacturers of medicines or substances for pharmaceutical use therefore must apply the European Pharmacopoeia quality standards in order to be able to market and use these products in Europe. As of February 2020, thirty-nine (39) member states and
2244-454: The Pharmacopoeia is shown by the fact that they are even more largely used than the Pharmacopoeia itself, the first issued in 18 editions and the second in 13 editions at comparatively short intervals. In the UK, the task of elaborating a new Pharmacopoeia is entrusted to a body of a purely medical character, and legally the pharmacist does not, contrary to the practice in other countries, have a voice in
2312-493: The Union of Soviet Socialist Republics (USSRP), although the de facto nature of the nationality of republics within that state differed from the de jure nature. The European Union has a supranational pharmacopoeia, the European Pharmacopoeia ; it has not replaced the national pharmacopoeias of EU member states but rather helps to harmonize them. Attempts have been made by international pharmaceutical and medical conferences to settle
2380-531: The average degree of purity of many drugs and chemicals used in the arts, as well as the highest degree of purity obtainable in commerce of those used in medicine. An important step has also been taken in this direction by the publication under the authority of the Council of the Pharmaceutical Society of Great Britain of the British Pharmaceutical Codex (BPC), in which the characters of and tests for
2448-449: The censors of the College of Physicians of examining the shops of apothecaries within 7 m. of London and destroying all the compounds which they found unfaithfully prepared. This, the first authorized London Pharmacopoeia, was selected chiefly from the works of Mezue and Nicolaus de Salerno, but it was found to be so full of errors that the whole edition was cancelled, and a fresh edition
2516-401: The commercial grade of purity of those in the Pharmacopoeia which are used for non-medical purposes. Another legal difficulty connected with modern pharmacopoeias is the inclusion in some of them of synthetic chemical remedies, the processes for preparing which have been patented, whilst the substances are sold under trade-mark names. The scientific chemical name is often long and unwieldy, and
2584-512: The compendia through various Expert Committees. In the U.S. when there is an applicable USP-NF quality monograph, drugs and drug ingredients must conform to the compendial requirements (such as for strength, quality or purity) or be deemed adulterated or misbranded under the Federal food and drug laws. The Soviet Union had a nominally supranational pharmacopoeia, the State Pharmacopoeia of
2652-634: The context of Food and Drug Administration regulation, monographs represent published standards by which the use of one or more substances is automatically authorized. For example, the following is an excerpt from the Federal Register : "The Food and Drug Administration (FDA) is issuing a final rule in the form of a final monograph establishing conditions under which over-the-counter (OTC) sunscreen drug products are generally recognized as safe and effective and not misbranded as part of FDA's ongoing review of OTC drug products." Such usage has given rise to
2720-465: The excrements of human beings, dogs, mice, geese, and other animals, calculi , human skull, and moss growing on it, blind puppies, earthworms , etc. Although other editions of the London Pharmacopoeia were issued in 1621, 1632, 1639, and 1677, it was not until the edition of 1721, published under the auspices of Sir Hans Sloane , that any important alterations were made. In this issue many of
2788-504: The first pharmacopoeia of Amsterdam named Pharmacopoea Amstelredamensis in 1636. This was a combined effort to improve public health after an outbreak of the bubonic plague , and also to limit the number of quack apothecary shops in Amsterdam. Until 1617, such drugs and medicines as were in common use were sold in England by the apothecaries and grocers. In that year the apothecaries obtained
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2856-531: The implementation of its decisions within the territories of the contracting parties. This Commission meets in Strasbourg , France, three times a year, to adopt texts proposed by its groups of experts, and to decide on its programme of work and general policies. Items are added to the work programme in response to requests received by the European Directorate for the Quality of Medicines & HealthCare from
2924-400: The issue of impurities in medicinal products, which do not offer any therapeutic benefit for the patient and sometimes are potentially toxic. Impurities are present at every stage of the manufacture of medicines: in starting materials, active pharmaceutical ingredients (APIs), reagents, intermediates, excipients and primary packaging materials. But Ph. Eur. texts’ section on impurities is perhaps
2992-430: The kind of preparations required for the method of their manufacture. The necessity for this element in the construction of a pharmacopoeia is now fully recognized in other countries, in most of which pharmaceutical chemists are represented on the committee for the preparation of the legally recognized manuals. There are national and international pharmacopoeias, like the EU and the U.S. pharmacopoeias. The pharmacopeia in
3060-603: The latter, several of the compounds described in the large edition were omitted and the formulae given on a smaller scale. Also Vesalius claimed he had written some " dispensariums " and " manuals " on the works of Galenus . Apparently he burnt them. According to recent research communicated at the congresses of the International Society for the History of Medicine by the scholar Francisco Javier González Echeverría, Michel De Villeneuve ( Michael Servetus ) also published
3128-414: The matter. This is notwithstanding the fact that, although the medical practitioner is naturally the best judge of the drug or preparations that will afford the best therapeutic result, they are not as competent as the pharmacist to say how that preparation can be produced in the most effective and satisfactory manner, nor how the purity of drugs can be tested. The change occurred with the fourth edition of
3196-462: The member states and their national authorities, industry or experts from around the world, based on current scientific and health issues. Each national delegation has one vote. In all technical questions, the decisions of the commission are taken by a unanimous vote of the national delegations that cast a vote. Member states' representatives mostly come from health authorities , national pharmacopoeia authorities and universities ; and are appointed by
3264-442: The member states themselves. For example, a German version is jointly published by Austria, Germany and Switzerland. In the future, the former three-year cycle comprising one edition and eight supplements will be replaced by an annual edition made up of three issues, numbered .1 to .3 (for example, the 12th Edition will consist of issues 12.1, 12.2 and 12.3). Each of these issues will contain the new and revised texts adopted at one of
3332-418: The most essential part of a quality standard of an active substance. A new edition of the European Pharmacopoeia is published every three years: in both English and French, by the Council of Europe . It is made available in print and electronic (online and downloadable) versions; the online version is also accessible from smartphones and tablet computers . Translations into other languages are published by
3400-455: The national authorities on the basis of their expertise. Representatives of the thirty (30) observers are invited to attend the sessions, but cannot vote. The current chair of the commission is Prof. Salvador Cañigueral, elected in March 2022. The term of the chair is three years, and runs in parallel with other members of the commission's Presidium. The first edition of the European Pharmacopoeia
3468-613: The one country and dispensed according to the national pharmacopoeia in another. As a result, the Medical Act of 1858 ordained that the General Medical Council should publish a book containing a list of medicines and compounds, to be called the British Pharmacopoeia , which would be a substitute throughout Great Britain and Ireland for the separate pharmacopoeias. Hitherto these had been published in Latin. The first British Pharmacopoeia
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#17330860406963536-568: The patentee for infringement of patent rights. Hence the only solution is for the physician to use the chemical name (which cannot be patented) as given in the Pharmacopoeia, or, for those synthetic remedies not included in the Pharmacopoeia, the scientific and chemical name given in the British Pharmaceutical Codex . In most of the Neo-Latin names, Pharmacopoea is the more common spelling, although for several of them, Pharmacopoeia
3604-408: The physician prefers when writing a prescription to use the shorter name under which it is sold by the patentees . In this case the pharmacist is compelled to use the more expensive patented article, which may lead to complaints from the patient. If the physician were to use the same article under its pharmacopoeial name when the patented article is prescribed, they would become open to prosecution by
3672-477: The publication of such non-official formularies as Squire's Companion to the Pharmacopoeia and Martindale: The complete drug reference (formerly Martindale's: the extra pharmacopoeia ), in which all new remedies and their preparations, uses and doses are recorded, and in the former the varying strengths of the same preparations in the different pharmacopoeias are also compared (Squire's was incorporated into Martindale in 1952). The need of such works to supplement
3740-413: The purity of many unofficial drugs and preparations are given as well as the character of many glandular preparations and antitoxins that have come into use in medicine, but have not yet been introduced into the Pharmacopoeia. This work may also possibly serve as a standard under the Adulteration of Food and Drugs Act for the purity and strength of drugs not included in the Pharmacopoeia and as a standard for
3808-530: The remedies previously in use were omitted, although a good number were still retained, such as dogs' excrement, earthworms, and moss from the human skull; the botanical names of herbal remedies were for the first time added to the official ones; the simple distilled waters were ordered of a uniform strength; sweetened spirits, cordials and ratafias were omitted as well as several compounds no longer used in London, although still in vogue elsewhere. A great improvement
3876-731: The spelling pharmacopœia ; in modern UK English , œ is written as oe , giving the spelling pharmacopoeia , while in American English oe becomes e , giving us pharmacopeia . Although older writings exist which deal with herbal medicine , the major initial work in the field is considered to be the Edwin Smith Papyrus in Egypt , Pliny 's pharmacopoeia. A number of early pharmacopoeia books were written by Persian and Arab physicians . These included The Canon of Medicine of Avicenna in 1025 AD, and works by Ibn Zuhr (Avenzoar) in
3944-515: The table of contents, and 25 volumes of pictures with one volume dedicated to the table of contents. A third part consisting of seven volumes contained illustrated descriptions. The text contains descriptions of 850 medicines with 114 new ones. The work was used throughout China for the next 400 years. A dated work appeared in Nuremberg in 1542; a passing student Valerius Cordus showed a collection of medical prescriptions, which he had selected from
4012-457: The tendency to simplify was carried out to a much greater extent, and the extremely compound medicines which had formed the principal remedies of physicians for 2,000 years were discarded, while a few powerful drugs which had been considered too dangerous to be included in the Pharmacopoeia of 1765 were restored to their previous position. In 1809 the French chemical nomenclature was adopted, and in 1815
4080-411: The three European Pharmacopoeia Commission (EPC) sessions held annually. What will not change is the implementation schedule, which remains January, April and July, respectively, of the year following publication of a text [1] " Pharmacopoeia A pharmacopoeia , pharmacopeia , or pharmacopoea (from the obsolete typography pharmacopœia , meaning "drug-making"), in its modern technical sense,
4148-686: The treatises on simples (basic medicinal ingredients) by Avicenna and Serapion ; the De synonymis and Quid pro quo of Simon Januensis ; the Liber servitoris of Bulchasim Ben Aberazerim , which described preparations made from plants, animals, and minerals, and was the type of the chemical portion of modern pharmacopoeias; and the Antidotarium of Nicolaus de Salerno , containing Galenic formulations arranged alphabetically. Of this last work, there were two editions in use — Nicolaus magnus and Nicolaus parvus: in
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#17330860406964216-544: The writings of the most eminent medical authorities, to the physicians of the town, who urged him to print it for the benefit of the apothecaries , and obtained the sanction of the senatus for his work. A work known as the Antidotarium Florentinum , was published under the authority of the college of medicine of Florence in the 16th century. In 1511, the Concordie Apothecariorum Barchinone
4284-519: Was complementary to a previous Materia Medica that De Villeneuve published that same year. This finding was communicated by the same scholar in the International Society for the History of Medicine , with agreement of John M. Riddle , one of the foremost experts on Materia Medica - Dioscorides works. Nicolaes Tulp , mayor of Amsterdam and respected surgeon general, gathered all of his doctor and chemist friends together and they wrote
4352-407: Was effected in the edition published in 1746, in which only those preparations were retained which had received the approval of the majority of the pharmacopoeia committee; to these was added a list of those drugs only which were supposed to be the most efficacious. An attempt was made to simplify further the older formulae by the rejection of superfluous ingredients. In the edition published in 1788
4420-564: Was published by the Society of Apothecaries of Barcelona and kept in the School of Pharmacy of the University of Barcelona . The term Pharmacopoeia first appears as a distinct title in a work published at Basel , Switzerland, in 1561 by A. Foes, but does not appear to have come into general use until the beginning of the 17th century. Before 1542, the works principally used by apothecaries were
4488-537: Was published in 1969, and consisted of 120 texts. The 11th edition, currently applicable, was published in July 2022. The Ph. Eur. is applicable in 39 European countries and used in over 130 countries worldwide. Nowadays it contains over 3000 texts (the monographs ), covering all therapeutic areas and consisting of: Ph. Eur. texts contain detailed analytical methods to identify the substance or product and control its quality and quantitative strength. Ph. Eur. texts also address
4556-486: Was published in the English language in 1864, but gave such general dissatisfaction both to the medical profession and to chemists and druggists that the General Medical Council brought out a new and amended edition in 1867. This dissatisfaction was probably owing partly to the fact that the majority of the compilers of the work were not engaged in the practice of pharmacy, and therefore not competent to decide upon
4624-550: Was published in the following December. At this period the compounds employed in medicine were often heterogeneous mixtures, some of which contained from 20 to 70, or more, ingredients, while a large number of simples were used in consequence of the same substance being supposed to possess different qualities according to the source from which it was derived. Thus crabs' eyes (i.e., gastroliths ), pearls, oyster shells, and coral were supposed to have different properties. Among other ingredients entering into some of these formulae were
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