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George Eliava Institute

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The George Eliava Institute of Bacteriophage, Microbiology and Virology (aka Tbilisi Institute) has been active since the 1930s in the field of phage therapy , which is used to combat microbial infection (cf. antibiotic-resistant strains).

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95-773: The institute was opened in Tbilisi , Georgia in 1923, and was a bacteriology laboratory. Its founder, Prof. George Eliava , was not aware of bacteriophages until 1919–1921. In those years he met Felix d'Herelle during a visit to the Pasteur Institute in Paris . There, Eliava was enthusiastic about the potential of phages in the curing of bacterial disease, and invited d'Herelle to visit his laboratory in Georgia. D'Herelle visited Tbilisi twice in 1933–34, and agreed to work with Prof. Eliava. It has been suggested that d'Herelle became enamored of

190-451: A vigesimal numeric system like Basque and (partially) French . Numbers greater than 20 and less than 100 are described as the sum of the greatest possible multiple of 20 plus the remainder. For example, "93" literally translates as 'four times twenty plus thirteen' ( ოთხმოცდაცამეტი , otkhmotsdatsamet’i ). One of the most important Georgian dictionaries is the Explanatory dictionary of

285-526: A European-style plan by Russian authorities (Sololaki, Rustaveli Avenue, Vera, etc.) have a Western appearance, with a mix of styles popular in Europe at the time: Beaux Arts, Orientalist, and various period revival styles. Tbilisi is most notable for its abundance of Art Nouveau buildings and details (common in Sololaki and Chughureti), which flourished from the mid-1890s to through the end of Russian rule. Art Nouveau

380-552: A Roman grammarian from the 2nd century AD. The first direct attestations of the language are inscriptions and palimpsests dating to the 5th century, and the oldest surviving literary work is the 5th century Martyrdom of the Holy Queen Shushanik by Iakob Tsurtaveli . The emergence of Georgian as a written language appears to have been the result of the Christianization of Georgia in the mid-4th century, which led to

475-665: A capital-like effect called Mtavruli for titles and inscriptions. Georgian is an agglutinative language with a complex verb structure that can include up to eight morphemes , exhibiting polypersonalism . The language has seven noun cases and employs a left-branching structure with adjectives preceding nouns and postpositions instead of prepositions. Georgian lacks grammatical gender and articles, with definite meanings established through context. Georgian's rich derivation system allows for extensive noun and verb formation from roots, with many words featuring initial consonant clusters. The Georgian writing system has evolved from ancient scripts to

570-506: A form of "semi-independence" and did not lose its statehood, but Tbilisi would be strongly influenced by the Mongols for the next century, both politically and culturally. In the 1320s, the Mongols retreated from Georgia, and Tbilisi became the capital of an independent Georgian state, once again. However, an outbreak of the Black Death struck the city in 1366. Between the late 14th century and

665-584: A form similar to or the same as their names for the country of Georgia ( Гуьржех Gürƶex ) as does the historical Kabardian name ( Курджы Kwrdžə ), while Abkhaz Қарҭ ( Ķarţ ) is from the Mingrelian ქართი ( Karti ). Archaeologists discovered evidence of continuous habitation of the Tbilisi suburb of Dighomi since the early Bronze Age, and stone artifacts dating to the Paleolithic age. During

760-463: A housing crisis after World War II. Entire neighborhoods (Saburtalo, Dighomi) appeared on the outskirts of the city in a matter of decades, built with advances in mass-production technology. Georgian architects produced some of the Soviet Union's most interesting architectural achievements, including Tbilisi's 1975 Ministry of Roads and the 1984 Wedding Palace . Since the collapse of the Soviet Union,

855-471: A kind of hierarchy, because most of them have lost their distinctive topographic limits. The natural first level of subdivision of the city is into the right and left banks of the Mtkvari river. The names of the oldest neighborhoods go back to the early Middle Ages and sometimes pose a great linguistic interest. The newest whole-built developments bear chiefly residential marketing names. In 19th-century Tbilisi,

950-507: A limited scope of affairs. This subdivision was established under Soviet rule in the 1930s, following the general subdivision of the Soviet Union . After Georgia regained independence, the raion system was modified and reshuffled. According to the latest revision, Tbilisi raions include: Most of the raions are named after historic quarters of the city. The citizens of Tbilisi widely recognize an informal system of smaller historic neighborhoods. Such neighborhoods are several, however, constituting

1045-563: A location of the Transcaucasus interim government which established, in the spring of 1918, the short-lived independent Transcaucasian Federation with the capital in Tbilisi. At this time, Tbilisi had roughly the same number of Armenians as Georgians, with Russians being the third largest ethnic group. It was in the former Viceroy of the Caucasus's palace where the independence of three Transcaucasus nations – Georgia, Armenia and Azerbaijan –

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1140-490: A ri means 'friend'; megobrebi ( megob Ø rebi ) means 'friends', with the loss of a in the last syllable of the word stem. Georgian has seven noun cases: nominative , ergative , dative , genitive , instrumental , adverbial and vocative . An interesting feature of Georgian is that, while the subject of a sentence is generally in the nominative case and the object is in the accusative case (or dative), one can find this reversed in many situations (this depends mainly on

1235-399: A row, as may be seen in words like გვფრცქვნ ი gvprtskvni 'you peel us' and მწვრთნ ელი mts’vrtneli 'trainer'. Vicenik has observed that Georgian vowels following ejective stops have creaky voice and suggests this may be one cue distinguishing ejectives from their aspirated and voiced counterparts. Georgian has been written in a variety of scripts over its history. Currently

1330-540: A typical year. The absolute minimum recorded temperature is −24.4 °C (−11.9 °F) in January 1883 and the absolute maximum is 42.0 °C (107.6 °F) on 17 July 1882. Average annual precipitation is 511.5 mm (20.1 in). May is the wettest month (averaging 84.0 mm (3.3 in) of precipitation) while January is the driest (averaging 16.4 mm (0.6 in) of precipitation). Snow falls on average 15–25 days per year. The surrounding mountains often trap

1425-454: A variation of Tiflis . On 20 September 2006, the Georgian parliament held a ceremony celebrating the 70th anniversary of the renaming. Some of the traditional names of Tbilisi in other languages of the region have different roots. The Ossetian name Калак ( Kalak ) derives from the Georgian word ქალაქი ( kalaki ) meaning simply city. Chechen and Ingush names for the city use

1520-589: A word. Georgian vowels in non-initial syllables are pronounced with a shorter duration compared to vowels in initial syllables. long polysyllabic words may have a secondary stress on their third or fourth syllable. Georgian contains many "harmonic clusters" involving two consonants of a similar type (voiced, aspirated, or ejective) that are pronounced with only a single release; e.g. ბგ ერა bgera 'sound', ცხ ოვრება tskhovreba 'life', and წყ ალი ts’q’ali 'water'. There are also frequent consonant clusters , sometimes involving more than six consonants in

1615-516: Is a present director of the Eliava Institute. The Institute includes the following laboratories: Laboratory of Physiology of Microorganisms, Laboratory of Biochemistry, Laboratory of Morphology of Bacteriophages, Laboratory of Immunology (includes the group of Virology), Laboratory of Standardization and Deposing of Bacteriophages (includes the group of Brucella and Anaerobic Bacteriophages), Laboratory of Biotechnology and Gene Engineering (includes

1710-512: Is most closely related to the Zan languages ( Megrelian and Laz ) and more distantly to Svan . Georgian has various dialects , with standard Georgian based on the Kartlian dialect, and all dialects are mutually intelligible. The history of Georgian spans from Early Old Georgian in the 5th century, to Modern Georgian today. Its development as a written language began with the Christianization of Georgia in

1805-947: Is rather light, and in fact Georgian transliterates the tenuis stops in foreign words and names with the ejectives. The coronal occlusives ( /tʰ tʼ d n/ , not necessarily affricates) are variously described as apical dental, laminal alveolar, and "dental". Per Canepari, the main realizations of the vowels are [ i ], [ e̞ ], [ ä ], [ o̞ ], [ u ]. Aronson describes their realizations as [ i̞ ], [ e̞ ], [ ä ] (but "slightly fronted"), [ o̞ ], [ u̞ ]. Shosted transcribed one speaker's pronunciation more-or-less consistently with [ i ], [ ɛ ], [ ɑ ], [ ɔ ], [ u ]. Allophonically, [ ə ] may be inserted to break up consonant clusters, as in /dɡas/ [dəɡäs] . In casual speech, /iV, Vi/ sequences can be realized phonetically as [jV~i̯V, Vj~Vi̯]. Phrase-final unstressed vowels may sometimes be partially reduced. Prosody in Georgian involves stress, intonation, and rhythm. Stress

1900-486: Is reflected in its architecture, which is a mix of medieval , neoclassical , Beaux Arts , Art Nouveau , Stalinist , and Modern structures. Historically, Tbilisi has been home to people of multiple cultural, ethnic, and religious backgrounds, though its population is overwhelmingly Eastern Orthodox Christian . Notable tourist destinations include cathedrals Sameba and Sioni , Freedom Square , Rustaveli Avenue and Agmashenebeli Avenue , medieval Narikala Fortress ,

1995-406: Is replaced with either a hawk or other small birds of prey in the legend). The king's falcon allegedly caught or injured a pheasant during the hunt, after which both birds fell into a nearby hot spring and died from burns. King Vakhtang became so impressed with the hot springs that he decided to clear the forest and build a city on the location. King Dachi of Iberia ( r.  522–534 ),

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2090-849: Is the Dinamo Arena (55,000 seats) and the second-largest is the Mikheil Meskhi Stadium (24,680 seats). The Sports Palace , which usually hosts basketball games with high attendance and tennis tournaments, can seat about 11,000 people. Vere Basketball Hall is a smaller indoor sports arena with a seating capacity of 2,500. Football is the most popular sport in Tbilisi, followed by rugby and basketball . Other popular sports include wrestling , tennis , swimming , and water polo . It has several professional football and rugby teams, as well as wrestling clubs. U.S. National Basketball Association players Zaza Pachulia and Nikoloz Tskitishvili are Tbilisi natives. Outside of professional sports,

2185-519: Is the capital and largest city of Georgia , lying on the banks of the Kura River with around 1.2 million inhabitants, which is about a third of the country's population. Tbilisi was founded in the fifth century AD by Vakhtang I of Iberia . Since then, the city has served as the capital of various Georgian kingdoms and republics. Between 1801 and 1917, then part of the Russian Empire , Tiflis

2280-649: Is the Russian Quarter, the seat of the officials and of the larger business firms. This is adjoined on the south by the Armenian and Persian Bazaars. Tbilisi is located in the South Caucasus at 41° 43' North and 44° 47' East. The city lies in Eastern Georgia on both banks of the Kura River (locally known as Mtkvari). The elevation of the city ranges from 380–770 metres above sea level (1,250–2,530 ft) and has

2375-415: Is the most widely spoken Kartvelian language ; it serves as the literary language or lingua franca for speakers of related languages. It is the official language of Georgia and the native or primary language of 88% of its population. Its speakers today amount to approximately 3.8 million. Georgian is written with its own unique Georgian scripts , alphabetical systems of unclear origin. Georgian

2470-401: Is very weak, and linguists disagree as to where stress occurs in words. Jun, Vicenik, and Lofstedt have proposed that Georgian stress and intonation are the result of pitch accents on the first syllable of a word and near the end of a phrase. According to Borise, Georgian has fixed initial word-level stress cued primarily by greater syllable duration and intensity of the initial syllable of

2565-452: The Dittionario giorgiano e italiano . These were meant to help western Catholic missionaries learn Georgian for evangelical purposes. On the left are IPA symbols, and on the right are the corresponding letters of the modern Georgian alphabet, which is essentially phonemic. Former /qʰ/ ( ჴ ) has merged with /x/ ( ხ ), leaving only the latter. The glottalization of the ejectives

2660-494: The Mkhedruli script is almost completely dominant; the others are used mostly in religious documents and architecture. Mkhedruli has 33 letters in common use; a half dozen more are obsolete in Georgian, though still used in other alphabets, like Mingrelian, Laz, and Svan. The letters of Mkhedruli correspond closely to the phonemes of the Georgian language. According to the traditional account written down by Leonti Mroveli in

2755-563: The Ak Koyunlu tribesmen of Uzun Hassan . As early as the 1510s, Tbilisi (and the kingdoms of Kartli and Kakheti ) were made vassal territories of Safavid Iran . In 1522, Tbilisi was garrisoned for the first time by a large Safavid force. Following the death of king ( shah ) Ismail I (r. 1501–1524), king David X of Kartli expelled the Iranians. During this period, many parts of Tbilisi were reconstructed and rebuilt. The four campaigns of

2850-589: The Armenian Apostolic Church have significant followings as well. A minority of the population (around 1.5%) practises Islam (mainly Shia Islam ), while about 0.1% of Tbilisi's population practises Judaism . Also, a Roman Catholic church and the Yazidi Sultan Ezid Temple can be found in the city. Until the beginning of the 19th century, sports such as horse-riding ( polo in particular), wrestling , boxing , and marksmanship were

2945-561: The Avchala District to River Lochini. The part of the city which lies on the right side of the river, though, is built along the foothills of the Trialeti Range , the slopes of which in many cases descend all the way to the edges of the river. The mountains, therefore, are a significant barrier to urban development on its right bank. This type of a geographic environment creates pockets of very densely developed areas, while other parts of

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3040-944: The Eastern Orthodox world of the time. During Queen Tamar 's reign, Shota Rustaveli worked in Tbilisi while writing his legendary epic poem The Knight in the Panther's Skin . This period is often referred to as "Georgia's Golden Age" or the Georgian Renaissance . Tbilisi's "Golden Age" did not last for more than a century. In 1226, Tbilisi was captured by the Khwarezmian Empire under Shah Jalal al-Din , who massacred tens of thousands of Christians. The Khwarezmian occupation left Tbilisi's defenses severely devastated and prone to further attacks by Mongol armies. In 1236, after suffering crushing Mongol defeats , Georgia submitted to Mongol domination . The nation itself maintained

3135-571: The EuroBasket 2022 at the new 10,000-seat Tbilisi Arena (next to the Olympic Palace ), as one of the tournament co-hosts alongside Czech Republic (Prague), Germany (Berlin, Cologne), and Italy (Milan). The large majority of Georgia's media companies (including television, newspaper, and radio) are headquartered in Tbilisi. The city is home to the popular television channels Rustavi 2 , Imedi , TV Pirveli , Mtavari Arkhi , Formula , Maestro , and

3230-506: The Georgian Orthodox Church and together are called Khutsuri 'priest alphabet'. In Mkhedruli , there is no case. Sometimes, however, a capital-like effect, called Mtavruli ('title' or 'heading'), is achieved by modifying the letters so that their vertical sizes are identical and they rest on the baseline with no descenders. These capital-like letters are often used in page headings, chapter titles, monumental inscriptions, and

3325-452: The Kartlian dialect. Over the centuries, it has exerted a strong influence on the other dialects. As a result, they are all, generally, mutually intelligible with standard Georgian, and with one another. The history of the Georgian language is conventionally divided into the following phases: The earliest extant references to Georgian are found in the writings of Marcus Cornelius Fronto ,

3420-731: The Law on Georgia's Capital – Tbilisi (20 February 1998). Tbilisi is governed by the Tbilisi City Assembly (Sakrebulo) and the Tbilisi City Hall (Meria). The City Assembly and mayor are elected once every four years by direct elections. The Mayor of Tbilisi is Kakha Kaladze and the Chairman of the Tbilisi city Assembly is Giorgi Alibegashvili. Administratively, the city is divided into raions (districts), which have their own units of central and local government with jurisdiction over

3515-607: The Romanov family and others. The main new artery built under Russian administration was Golovin Avenue (present-day Rustaveli Avenue ), on which the Viceroys of the Caucasus established their residence. For much of the early 19th century, Tbilisi's largest ethnic group was Armenian, at some point forming 74.3% of the population. After the Russian Revolution of 1917 , the city served as

3610-648: The Seljuks , the troops of King David IV of Georgia besieged Tbilisi, taking it in 1122. David moved his residence from Kutaisi to Tbilisi, making it the capital of a unified Georgian State , thus inaugurating the Georgian Golden Age . From the 12–13th centuries, Tbilisi became a regional power with a thriving economy and astonishing cultural output. By the end of the 12th century, the population of Tbilisi had reached 100,000. The city also became an important literary and cultural center, not only for Georgia, but also for

3705-553: The pseudo-Moorish Opera Theater , and the Georgian National Museum . The climate in Tbilisi mostly ranges from 20 to 32 °C (68 to 90 °F) in summer and −1 to 7 °C (30 to 45 °F) in winter. The name "Tbilisi" derives from Old Georgian Tbilisi ( Asomtavruli : ႧႡႨႪႨႱႨ , Mkhedruli : თბილისი ), and further from tpili ( Modern Georgian : თბილი , warm, itself from Old Georgian: ႲႴႨႪႨ ṭpili ). The name Tbilisi (the place of warmth)

3800-452: The 11th century, the first Georgian script was created by the first ruler of the Kingdom of Iberia , Pharnavaz , in the 3rd century BC. The first examples of a Georgian script date from the 5th century AD. There are now three Georgian scripts, called Asomtavruli 'capitals', Nuskhuri 'small letters', and Mkhedruli . The first two are used together as upper and lower case in the writings of

3895-730: The 1783 Treaty of Georgievsk . Despite this agreement, the city was captured and devastated in 1795 by the Iranian Qajar ruler Agha Mohammad Khan , who sought to re-establish Iran's traditional sovereignty over the region. In 1801, the Russian Empire annexed the Georgian Kingdom of Kartli-Kakheti (of which Tbilisi was the capital), later cementing its rule with the Treaty of Gulistan of 1813, which ended Iranian control of Georgia. Within Tsarist Russia, Tbilisi (known then as Tiflis)

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3990-415: The 1850s, Tbilisi once again emerged as a major trade and cultural center. The likes of Ilia Chavchavadze , Akaki Tsereteli , Mirza Fatali Akhundzade , Iakob Gogebashvili , Alexander Griboyedov and many other statesmen, poets and artists all found their home in Tbilisi. The city was visited on numerous occasions by and was the object of affection of Alexander Pushkin , Leo Tolstoy , Mikhail Lermontov ,

4085-548: The 4th century. Georgian phonology features a rich consonant system, including aspirated, voiced, and ejective stops , affricates , and fricatives . Its vowel system consists of five vowels with varying realizations. Georgian prosody involves weak stress, with disagreements among linguists on its placement. The language's phonotactics include complex consonant clusters and harmonic clusters. The Mkhedruli script , dominant in modern usage, corresponds closely to Georgian phonemes and has no case distinction, though it employs

4180-508: The Eliava Institute continued to deteriorate until it was on the verge of closure. However, in 1997, a report on the institute was broadcast by the BBC , sparking a flurry of media interest in the West . The headlines drew doctors and scientists to Tbilisi - and also, most importantly, energetic entrepreneurs from around the world who were determined to help save the institute and its stocks and fully explore

4275-502: The English-language daily The Messenger , weekly FINANCIAL, Georgia Today , and the English-language weekly The Georgian Times . Out of the city's radio stations Imedi Radio (105.9 FM ), Fortuna, and Radio 105 are some of the most influential competitors with large national audiences. Radio stations in Tbilisi include 5 Lines Radio (93.8 FM), Europe +Tbilisi (99.6 FM), and Georgian Patriarchy Radio (105.4 FM). The architecture in

4370-568: The Georgian language ( ქართული ენის განმარტებითი ლექსიკონი ). It consists of eight volumes and about 115,000 words. It was produced between 1950 and 1964, by a team of linguists under the direction of Arnold Chikobava . Georgian has a word derivation system, which allows the derivation of nouns from verb roots both with prefixes and suffixes, for example: It is also possible to derive verbs from nouns: Likewise, verbs can be derived from adjectives, for example: In Georgian many nouns and adjectives begin with two or more contiguous consonants. This

4465-505: The Georgian quarter was confined to the southeastern part of the city; Baedeker describes the layout succinctly: In the north part of the town, on the left bank of the Kurá and to the south of the railway station, stretches the clean German Quarter, formerly occupied by German immigrants from Württemberg (1818). To the south is the Gruzinian or Georgian Quarter (Avlabár). On the right bank of the Kurá

4560-664: The High Commissioner to Armenia, Colonel William N. Haskell . Under the national government, Tbilisi turned into the first Caucasian University City after the Tbilisi State University was founded in 1918. On 25 February 1921, the Bolshevist Russian 11th Red Army invaded Tbilisi and after bitter fighting at the outskirts of the city, declared Soviet rule. In 1921, the Democratic Republic of Georgia

4655-566: The Institute of Microbiology & Epidemiology (founded separately in 1936) merged, and the Institute of Microbiology, Epidemiology and Bacteriophage was formed. It existed until 1951 and was authorized by the People's Commissary of Health of Georgia. After 1951, it came under the auspices of the All-Union Ministry of Health and was renamed The Institute of Vaccine and Sera. Since its inception,

4750-686: The Persians ruled the city until 627, when Tbilisi was sacked by the Byzantine / Khazar armies and later, in 736–738, Arab armies entered the town under Marwan II . After this point, the Arabs established an emirate centered in Tbilisi. Arabic dirhams were brought to Georgia following the Arab conquest in the seventh century, and a mint was founded in Tbilisi that produced coins with inscriptions in both Arabic and Georgian. In 764, Tbilisi – still under Arab control –

4845-536: The Public Broadcasting Channel, among others. Tbilisi's television market has experienced notable changes since 2019, when changes in the ownership of Rustavi 2 prompted many of its employees to leave and partake in the creation of new television channels, namely Mtavari Arkhi and TV Formula. Tbilisi has a number of newspaper publishing houses. Some of the most noteworthy newspapers include the daily 24 Saati ("24 Hours"), Rezonansi ("Resonance"), Alia ,

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4940-449: The Soviet Union. In 1980, the city hosted the first state-sanctioned rock festival in the USSR. As a major tourist destination for both Soviet citizens and foreign visitors, Tbilisi's "Old Town" (the neighborhoods within the original city walls) was reconstructed in the 1970s and 1980s. Tbilisi witnessed mass anti-Russian demonstrations during 1956 in the 9 March Massacre , in protest against

5035-488: The above-mentioned groups, Tbilisi is home to other ethnic groups including Ossetians , Abkhazians , Ukrainians , Greeks , Jews , Assyrians , Yazidis , and others. More than 95% of the residents of Tbilisi practise some form of Christianity (the most predominant of which is the Georgian Orthodox Church ). The Russian Orthodox Church , which is in full communion with the Georgian Orthodox Church, and

5130-496: The anti-Stalin policies of Nikita Khrushchev . Peaceful protests occurred in 1978, and in 1989 the April 9 tragedy was a peaceful protest that turned violent. Since the break-up of the Soviet Union , Tbilisi has experienced periods of significant instability and turmoil. After a brief civil war, which the city endured for two weeks from December 1991 to January 1992 (when pro- Gamsakhurdia and Opposition forces clashed), Tbilisi became

5225-403: The character of the verb). This is called the dative construction . In the past tense of the transitive verbs, and in the present tense of the verb "to know", the subject is in the ergative case. Georgian has a rich word-derivation system. By using a root, and adding some definite prefixes and suffixes, one can derive many nouns and adjectives from the root. For example, from the root - kart -,

5320-529: The city are left undeveloped due to the complex topographic relief. To the north of the city, a large reservoir (commonly known as the Tbilisi Sea) is fed by irrigation canals. Tbilisi has a humid temperate climate ( Köppen : Cfa , Trewartha : Do ) with considerable continental and semi-arid influences. The city experiences hot, humid summers and moderately cold dry winters. Like other regions of Georgia, Tbilisi receives significant rainfall throughout

5415-578: The city has a number of intercollegiate and amateur sports teams and clubs. Tbilisi's signature football club, Dinamo Tbilisi , has not won a major European championship since the 1980–1981 season, when it won the European UEFA Cup Winners' Cup and became the easternmost team in Europe to achieve the feat. The basketball club Dinamo Tbilisi won the Euroleague in 1962 , but also never repeated any such feat. Tbilisi hosted Group A matches for

5510-600: The city is a mixture of local (Georgian) and Byzantine , Neoclassical , Art Nouveau , Beaux-Arts , Middle Eastern, and Soviet modern styles. Very few buildings survived the destruction of the city in 1795, so most historical buildings in Tbilisi date to the Russian Imperial period (1801–1917). The oldest parts of the city (Kala, Abanotubani, Avlabari) were largely rebuilt on their medieval street plans, and some old houses were even rebuilt on much older foundations. The areas of downtown Tbilisi which were developed according to

5605-550: The clouds within and around the city, mainly during the Spring and Autumn months, resulting in prolonged rainy and/or cloudy weather. Northwesterly winds dominate in most parts of Tbilisi throughout the year. Southeasterly winds are common as well. As a multiethnic city, Tbilisi is home to more than 100 ethnic groups. Around 90% of the population consists of ethnic Georgians , with significant populations of other ethnic groups such as Armenians , Russians , and Azerbaijanis . Along with

5700-477: The communist idea. In 1934, Joseph Stalin invited d'Herelle to the institute in Tbilisi; he accepted and worked there for about 18 months. D'Herelle dedicated one of his books to Stalin, The Bacteriophage and the Phenomenon of Cure , written and published in Tbilisi in 1935. However, the collaboration between the two scientists was not to be. Around the time d'Herelle was to take up residence, in 1937 George Eliava

5795-452: The current Mkhedruli, used for most purposes. The language has a robust grammatical framework with unique features such as syncope in morphophonology and a left-branching syntax. Georgian's vocabulary is highly derivational, allowing for diverse word formations, while its numeric system is vigesimal. No claimed genetic links between the Kartvelian languages and any other language family in

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5890-511: The drain. Thousands of bacteriophage samples identified over the years and catalogued in huge, refrigerated "libraries" suffered irreversible damage due to frequent electrical outages. Apparently, the Russians transferred some of the equipment to their territory and built plants for the production of bacteriophages in other locations. Clearly, they recognized the importance of the research and also that of continued bacteriophage therapy. The situation at

5985-498: The following words can be derived: Kart veli ('a Georgian person'), Kart uli ('the Georgian language') and Sa kart velo ('the country of Georgia'). Most Georgian surnames end in - dze 'son' (Western Georgia), - shvili 'child' (Eastern Georgia), - ia (Western Georgia, Samegrelo ), - ani (Western Georgia, Svaneti ), - uri (Eastern Georgia), etc. The ending - eli is a particle of nobility, comparable to French de , Dutch van , German von or Polish - ski . Georgian has

6080-690: The group of Selection and Taxonomy of Bacteriophages), Laboratory of Microbial Ecology, and Laboratory for Genetics of Microorganisms and Bacteriophages. 41°44′03″N 44°46′19″E  /  41.73417°N 44.77194°E  / 41.73417; 44.77194 Tbilisi Tbilisi ( English: / t ə b ɪ ˈ l iː s i , t ə ˈ b ɪ l ɪ s i / tə-bil- EE -see, tə- BIL -iss-ee ; Georgian : თბილისი , pronounced [ˈtʰbilisi] ), in some languages still known by its pre-1936 name Tiflis ( / ˈ t ɪ f l ɪ s / TIF -liss ), ( Georgian : ტფილისი , romanized : t'pilisi )

6175-621: The heart of the Caucasus between Europe and Asia, Tbilisi became an object of rivalry among the region's various powers such as the Roman Empire , Parthia , Sassanid Persia , Muslim Arabs , the Byzantine Empire , and the Seljuk Turks . The cultural development of the city was somewhat dependent on who ruled the city at various times, although Tbilisi was fairly cosmopolitan. From 570 to 580,

6270-703: The institute was composed of a combination of industrial and scientific (research) departments. In 1988 the institute was rearranged again and emerged as the Scientific Industrial Union "Bacteriophage" (SIU "Bacteriophage"). Around that time, its scientific portion was renamed the George Eliava Research Institute of Bacteriophage. Based on the original intentions of D'Herelle and Eliava, the Bacteriophage Institute retained its leadership among other institutes of similar profile over

6365-520: The intrusion of cold air masses from Russia, Tbilisi has a relatively mild microclimate compared to other cities that possess a similar climate along the same latitudes. The average annual temperature in Tbilisi is 13.8 °C (56.8 °F). January is the coldest month with an average temperature of 2.7 °C (36.9 °F). July is the hottest month with an average temperature of 25.4 °C (77.7 °F). Daytime high temperatures reach or exceed 32 °C (90 °F) on an average of 22 days during

6460-455: The king Tahmasp I (r. 1524–1576) resulted in the reoccupation of Kartli and Kakheti, and a Safavid force was permanently stationed in Tbilisi from 1551 onwards. With the 1555 Treaty of Amasya , and more firmly from 1614 to 1747, with brief intermissions, Tbilisi was an important city under Iranian rule, and it functioned as a seat of the Iranian vassal kings of Kartli whom the shah conferred with

6555-456: The late 18th century, Tbilisi would again be under the rule of various foreign powers. On several occasions, the city would even be completely burned and razed to the ground. In 1386, Tbilisi was invaded and sacked several times by the armies of Tamerlane . In 1440, the city was invaded and destroyed by Jahan Shah (the Shah of the town of Tabriz , Persia ). From 1477 to 1478, the city was held by

6650-407: The late Bronze Age to early Iron Age, it was the largest settlement in the Caucasus. According to legend, the present-day territory of Tbilisi was covered by forests as late as 458. One widely accepted variant of the Tbilisi foundation myth states that King Vakhtang I of Iberia ( r.  c. 447/49 – 502/22 ) went hunting in the heavily wooded region with a falcon (sometimes the falcon

6745-498: The like. This is the Georgian standard keyboard layout. The standard Windows keyboard is essentially that of manual typewriters . Georgian is an agglutinative language . Certain prefixes and suffixes can be joined in order to build a verb. In some cases, one verb can have up to eight different morphemes in it at the same time. An example is ageshenebinat ('you [all] should've built [it]'). The verb can be broken down to parts: a-g-e-shen-eb-in-a-t . Each morpheme here contributes to

6840-555: The local language. In addition, the Georgian-language form Ṭpilisi was modernized on the basis of a proposal by Georgian linguists; the ancient Georgian component ტფილი ( ṭpili , 'warm') was replaced by the newer თბილი ( tbili ). That form was the basis for the new official Russian name ( Тбилиси Tbilisi ). Most other languages have subsequently adopted the new name form, but some languages, such as Turkish, Persian, Greek , Spanish , and German , have retained

6935-472: The meaning of the verb tense or the person who has performed the verb. The verb conjugation also exhibits polypersonalism ; a verb may potentially include morphemes representing both the subject and the object. In Georgian morphophonology , syncope is a common phenomenon. When a suffix (especially the plural suffix - eb -) is attached to a word that has either of the vowels a or e in the last syllable, this vowel is, in most words, lost. For example, megob

7030-792: The most popular city sports. Influence from the Russian Empire brought more Western sports and activities (billiards, fencing) to Tbilisi. The Soviet period brought an increased popularization of sports that were common in Europe and, to a certain extent, the United States. At the same time, Tbilisi developed the necessary infrastructure for professional sports. By 1978, the city had around 250 large and small sports facilities, including, among others, four indoor and six outdoor Olympic-sized pools, 185 basketball courts and halls, 192 volleyball facilities, 82 handball arenas, 19 tennis courts, 31 football fields, and five stadiums. The largest stadium in Tbilisi

7125-546: The nation in general). Mass protests took place in November 2003 after falsified parliamentary elections forced more than 100,000 people into the streets and concluded with the Rose Revolution . Since 2003, Tbilisi has experienced considerably more stability with decreasing crime rates, an improved economy, and a real estate boom. During the 2008 South Ossetia war , the Tbilisi area was hit by multiple Russian air attacks. After

7220-535: The potential of this "new" and highly effective therapy. Georgian scientists whose names were connected in some way to the institute saw great opportunity, and some of them emigrated to the West to be part of joint projects. Some of the institute's projects with the rest of the world can be seen on the website of the Georgian Academy of Sciences, the umbrella entity which now includes the Eliava Institute. Mzia Kutateladze

7315-567: The replacement of Aramaic as the literary language . By the 11th century, Old Georgian had developed into Middle Georgian. The most famous work of this period is the epic poem The Knight in the Panther's Skin , written by Shota Rustaveli in the 12th century. In 1629, a certain Nikoloz Cholokashvili authored the first printed books written (partially) in Georgian, the Alphabetum Ibericum sive Georgianum cum Oratione and

7410-467: The scene of frequent armed confrontations among various mafia clans and illegal business operators. During the Shevardnadze Era (1992–2003), crime and corruption were rampant. Many segments of society became impoverished because of unemployment caused by the crumbling economy. Average citizens of Tbilisi started to become increasingly disillusioned with the existing quality of life in the city (and in

7505-567: The shape of an amphitheatre surrounded by mountains on three sides. To the north, Tbilisi is bounded by the Saguramo Range , to the east and south-east by the Iori Plain , to the south and west by various endings (subranges) of the Trialeti Range . The relief of Tbilisi is complex. The part of the city which lies on the left bank of the Kura River extends for more than 30 km (19 mi) from

7600-589: The skin, and pills, drops, and rinses consisting of phages were sold and are still sold at pharmacies throughout Eastern Europe at low prices. After the Republic of Georgia declined to join the Russian Federation and the Georgian Civil War broke out in 1991, the Tbilisi facility was essentially ruined. The Eliava Institute's facilities were damaged and decades of research on bacteriophage nearly went down

7695-449: The successor of Vakhtang I, moved the capital of Iberia from Mtskheta to Tbilisi and began construction of the fortress wall that lined the city's new boundaries. From the sixth century, Tbilisi grew at a steady pace due to the region's strategic location along with important trade and travel routes between Europe and Asia. Tbilisi's favorable trade location, however, did not necessarily bode well for its survival. Located strategically in

7790-651: The title of vali . In 1718, the Venetian senate implored the Safavid emperor Soltan Hoseyn to protect the Catholic Armenians and Capuchin missionaries in Tbilisi from the Gregorian Armenians. Under the later rules of Teimuraz II and Heraclius II , Tbilisi became a vibrant political and cultural center free of foreign rule—but, fearful of the constant threat of invasion, Georgia's rulers sought Russian protection in

7885-643: The urban landscape is largely characterized by unregulated construction. New towers occupy formerly public spaces and overcrowded apartment buildings sprout "kamikaze loggia" overnight. Since 2004, the city government has taken initiatives to curb uncontrolled construction projects with mixed success. Tbilisi now has several skyscraper complexes, such as the Axis Towers , Hilton Garden Inn Tbilisi Chavchavadze , Holiday Inn Tbilisi , and King David Residences . Georgian language Georgian ( ქართული ენა , kartuli ena , pronounced [ˈkʰartʰuli ˈena] )

7980-470: The war, several large-scale projects were started, including a streetcar system, a railway bypass and a relocation of the central station , and new urban highways. In June 2015, a flood killed at least twenty people and caused animals from the city's zoo to be released into the streets. The status of Tbilisi, as the nation's capital, is defined by Article 10 of the Constitution of Georgia (1995) and

8075-399: The world are accepted in mainstream linguistics. Among the Kartvelian languages, Georgian is most closely related to the so-called Zan languages ( Megrelian and Laz ); glottochronological studies indicate that it split from the latter approximately 2700 years ago. Svan is a more distant relative that split off much earlier, perhaps 4000 years ago. Standard Georgian is largely based on

8170-489: The year with no distinct dry period. The city's climate is influenced both by dry (Central Asian/Siberian) air masses from the east and oceanic (Atlantic/Black Sea) air masses from the west. Because the city is bounded on most sides by mountain ranges, the close proximity to large bodies of water (Black and Caspian Seas ) and the fact that the Greater Caucasus Mountains Range (further to the north) blocks

8265-561: The years. Teimuraz Chanishvili was the leader of the scientific part of the institute for over 30 years, until his death in August 2007. The institute in Tbilisi became a general Soviet institute for the development and production of bacteriophage drugs. Patients with serious infectious diseases came from all over the Soviet Union to receive treatments there. Bacteriophages became a routine part of treatment in clinics and hospitals. Ointments for

8360-660: Was occupied by the Soviet Bolshevik forces from Russia, and until 1936, Tbilisi functioned first as the capital city of the Transcaucasian SFSR (which included Armenia, Azerbaijan , and Georgia), and afterward until 1991 as the capital of the Georgian Soviet Socialist Republic . During Soviet rule, Tbilisi's population grew significantly, the city became more industrialized, and it also came to be an important political, social, and cultural centre of

8455-615: Was declared by their respective national councils on 26 to 28 May 1918. After this, Tbilisi functioned as the capital of the Democratic Republic of Georgia until 25 February 1921. From 1918 to 1919, the city also consecutively served as the headquarters of the country's German garrison and later the British 27th Division ; Tbilisi was also the main office of the British Chief Commissioner in Transcaucasia, Oliver Wardrop and

8550-521: Was decreed as bourgeois by communist authorities, who introduced experimental modern architecture. The more conservative and historically inflected Stalinist architecture in Georgia is embodied by the 1938 Marx-Engels-Lenin Institute building ("Imeli"), now housing the Biltmore Hotel Tbilisi . Tbilisi's postwar architecture is similar to the brand of midcentury modernism found across the Soviet Union. The city expanded dramatically in response to

8645-460: Was executed and denounced as an enemy of the people . D'Herelle returned to France. He never was allowed to come back to Georgia by the Soviets. D'Herelle's book was also banned from distribution. In spite of this development, the institute did not change its practical specialization, and continued its activity in the field of bacteriophage research. In 1938, the Institute of Bacteriophage Research and

8740-602: Was included within the Tiflis Uyezd county in 1801, and became the administrative center of the Tiflis Governorate ( Gubernia ) following the latter's establishment in 1846. Russian Imperial administrators implemented a new European-style city plan and commissioned new buildings in Western styles. Roads and railroads were built to connect Tbilisi to other important cities in the Russian Empire , such as Batumi and Poti . By

8835-572: Was once again sacked by the Khazars. In 853, the armies of Arab leader Bugha Al-Turki invaded Tbilisi in order to enforce its return to Abbasid allegiance. The Arab domination of Tbilisi continued until about 1050. In 1065, the Seljuk Sultan Alp Arslan campaigned against the Kingdom of Georgia , subjugated Tbilisi, and built a mosque in the city. In 1121, after the Battle of Didgori against

8930-519: Was the seat of the Caucasus Viceroyalty , governing both the northern and the southern parts of the Caucasus . Because of its location at the crossroads between Europe and Asia, and its proximity to the lucrative Silk Road , throughout history, Tbilisi has been a point of contention among various global powers. To this day, the city's location ensures its position as an important transit route for energy and trade projects. Tbilisi's history

9025-600: Was therefore given to the city because of the area's numerous sulfuric hot springs . Until 1936, the name of the city in English and most other languages followed the Persian pronunciation Tiflis , while the Georgian name was ტფილისი ( Ṭpilisi ). On 17 August 1936, by order of the Soviet leadership, the official Russian names of various cities were changed to more closely match

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