127-471: The Dynamic Graphics Project (commonly referred to as dgp ) is an interdisciplinary research laboratory at the University of Toronto devoted to projects involving Computer Graphics , Computer Vision , Human Computer Interaction , and Visualization . The lab began as the computer graphics research group of Computer Science Professor Leslie Mezei [ fr ] in 1967. Mezei invited Bill Buxton ,
254-583: A Jesuit seminary, entered federation with the university in 1979. In contrast with the constituent colleges, the colleges of Knox, Massey, Regis, St. Michael's, Trinity, Victoria and Wycliffe continue to exist as legally distinct entities, each possessing a separate financial endowment . While St. Michael's, Trinity and Victoria continue to recognize their religious affiliations and heritage, they have since adopted secular policies of enrolment and teaching in non-divinity subjects. Some colleges have, or once had, collegiate structures of their own: Emmanuel College
381-527: A low church seminary, both encouraged their students to study for non-divinity degrees at University College. In 1885, they entered a formal affiliation with the University of Toronto, and became federated schools in 1890. The idea of federation initially met strong opposition at Victoria University , a Methodist school in Cobourg , but a financial incentive in 1890 convinced the school to join. Decades after
508-468: A molecular mass of 5808 Da . The molecular formula of human insulin is C 257 H 383 N 65 O 77 S 6 . It is a combination of two peptide chains ( dimer ) named an A-chain and a B-chain, which are linked together by two disulfide bonds . The A-chain is composed of 21 amino acids, while the B-chain consists of 30 residues. The linking (interchain) disulfide bonds are formed at cysteine residues between
635-869: A pioneer of human–computer interaction to join. In 1972, Ronald Baecker , another HCI pioneer joined dgp, establishing dgp as the first Canadian university group focused on computer graphics and human-computer interaction. According to csrankings.org, for the combined subfields of computer graphics , HCI , and visualization the dgp is the number one research institution in the world. Since then, dgp has hosted many well known faculty and students in computer graphics, computer vision and HCI (e.g., Alain Fournier , Bill Reeves , Jos Stam , Demetri Terzopoulos , Marilyn Tremaine ). dgp also occasionally hosts artists in residence (e.g., Oscar -winner Chris Landreth ). Many past and current researchers at Autodesk (and before that Alias Wavefront ) graduated after working at dgp. dgp
762-408: A 110 amino acid-long protein called "preproinsulin". Preproinsulin is translated directly into the rough endoplasmic reticulum (RER), where its signal peptide is removed by signal peptidase to form "proinsulin". As the proinsulin folds , opposite ends of the protein, called the "A-chain" and the "B-chain", are fused together with three disulfide bonds . Folded proinsulin then transits through
889-719: A basic health system . Insulin may have originated more than a billion years ago. The molecular origins of insulin go at least as far back as the simplest unicellular eukaryotes . Apart from animals, insulin-like proteins are also known to exist in fungi and protists . Insulin is produced by beta cells of the pancreatic islets in most vertebrates and by the Brockmann body in some teleost fish . Cone snails : Conus geographus and Conus tulipa , venomous sea snails that hunt small fish, use modified forms of insulin in their venom cocktails. The insulin toxin, closer in structure to fishes' than to snails' native insulin, slows down
1016-535: A college be established in York. On March 15, 1827, a royal charter was formally issued by King George IV , proclaiming "from this time one College, with the style and privileges of a University ... for the education of youth in the principles of the Christian Religion , and for their instruction in the various branches of Science and Literature ... to continue for ever, to be called King's College." The granting of
1143-600: A dramatic renaissance after the 2003 SARS crisis, and it is now Canada's largest public health school, with more than 750 faculty, 800 students, and research and training partnerships with institutions throughout Toronto and the world. With more than $ 39 million in research funding per year, the School supports discovery in global health, tobacco impacts on health , occupational disease and disability, air pollution, inner city health, circumpolar health, and many other pressing issues in population health. The Temerty Faculty of Medicine
1270-417: A glucose load (75 or 100 g of glucose), followed by a slow drop over the next 100 minutes, to remain above 120 mg/100 mL after two hours after the start of the test. In a normal person the blood glucose level is corrected (and may even be slightly over-corrected) by the end of the test. An insulin spike is a 'first response' to blood glucose increase, this response is individual and dose specific although it
1397-464: A model that resembles those of the University of Cambridge and the University of Oxford in Britain. The colleges hold substantial autonomy over admissions, scholarships, programs and other academic and financial affairs, in addition to the housing and social duties of typical residential colleges . The system emerged in the 19th century, as ecclesiastical colleges considered various forms of union with
SECTION 10
#17330935293661524-755: A range of services and facilities, including a library, restaurants, barbershops, an art gallery, a theatre, concerts, debates, study spaces, and a swimming pool. The confluence of assorted functions is the result of an effort to create a holistic educational experience, a goal summarized in the Founders' Prayer. The Hart House model was influential in the planning of student centres at other universities, notably Cornell University 's Willard Straight Hall . Hart House resembles some traditional aspects of student representation through its financial support of student clubs, and its standing committees and board of stewards that are composed mostly of undergraduate students. However,
1651-445: A transcription factor for MafA in an unknown manner and MafA is transported out of the cell. MafA is then translocated back into the nucleus where it binds the C1 element of the insulin promoter. These transcription factors work synergistically and in a complex arrangement. Increased blood glucose can after a while destroy the binding capacities of these proteins, and therefore reduce
1778-416: Is strongly conserved and varies only slightly between species. Bovine insulin differs from human in only three amino acid residues, and porcine insulin in one. Even insulin from some species of fish is similar enough to human to be clinically effective in humans. Insulin in some invertebrates is quite similar in sequence to human insulin, and has similar physiological effects. The strong homology seen in
1905-399: Is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin ( INS) gene . It is the main anabolic hormone of the body. It regulates the metabolism of carbohydrates , fats , and protein by promoting the absorption of glucose from the blood into cells of the liver , fat , and skeletal muscles . In these tissues the absorbed glucose
2032-512: Is a ceremonial boulevard and arterial thoroughfare that runs through downtown between Queen's Park and Front Street . The Spadina , St. George , Museum , Queen's Park , and St. Patrick stations of the Toronto subway system are nearby. The architecture is epitomized by a combination of Romanesque and Gothic Revival buildings spread across the eastern and central portions of campus, most dating between 1858 and 1929. The traditional heart of
2159-564: Is a college of Victoria and St. Hilda's College is part of Trinity; St. Joseph's College had existed as a college within St. Michael's until it was dissolved in 2006. Ewart College existed as an affiliated college until 1991, when it was merged into Knox College. Postgraduate theology degrees are conferred by the colleges of Knox, Regis and Wycliffe, along with the divinity faculties within Emmanuel, St. Michael's and Trinity, including joint degrees with
2286-408: Is affiliated with a network of ten teaching hospitals , providing medical treatment, research and advisory services to patients and clients from Canada and abroad. A core member of the network is University Health Network , itself a specialized federation of Toronto General Hospital , Princess Margaret Cancer Centre , Toronto Western Hospital , and Toronto Rehabilitation Institute . Physicians in
2413-546: Is also regulated by glucose: high glucose promotes insulin production while low glucose levels lead to lower production. Insulin enhances glucose uptake and metabolism in the cells, thereby reducing blood sugar. Their neighboring alpha cells , by taking their cues from the beta cells, secrete glucagon into the blood in the opposite manner: increased secretion when blood glucose is low, and decreased secretion when glucose concentrations are high. Glucagon increases blood glucose by stimulating glycogenolysis and gluconeogenesis in
2540-676: Is an early example of the North American student centre , simultaneously serving cultural, intellectual, and recreational interests within its large Gothic-revival complex. University of Toronto alumni include five Prime Ministers of Canada (including William Lyon Mackenzie King and Lester B. Pearson ), three Governors General of Canada , nine foreign leaders, and 17 justices of the Supreme Court of Canada . As of 2024 , 13 Nobel laureates , six Turing Award winners, 100 Rhodes Scholars , and one Fields Medalist have been affiliated with
2667-486: Is as follows: This is the primary mechanism for release of insulin. Other substances known to stimulate insulin release include the amino acids arginine and leucine, parasympathetic release of acetylcholine (acting via the phospholipase C pathway), sulfonylurea , cholecystokinin (CCK, also via phospholipase C), and the gastrointestinally derived incretins , such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Release of insulin
SECTION 20
#17330935293662794-699: Is characterized by increased glucagon secretion which is unaffected by, and unresponsive to the concentration of blood glucose. But insulin is still secreted into the blood in response to the blood glucose. As a result, glucose accumulates in the blood. The human insulin protein is composed of 51 amino acids , and has a molecular mass of 5808 Da . It is a hetero dimer of an A-chain and a B-chain, which are linked together by disulfide bonds . Insulin's structure varies slightly between species of animals. Insulin from non-human animal sources differs somewhat in effectiveness (in carbohydrate metabolism effects) from human insulin because of these variations. Porcine insulin
2921-404: Is converted into either glycogen , via glycogenesis , or fats ( triglycerides ), via lipogenesis ; in the liver, glucose is converted into both. Glucose production and secretion by the liver are strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is thus an anabolic hormone, promoting
3048-446: Is especially close to the human version, and was widely used to treat type 1 diabetics before human insulin could be produced in large quantities by recombinant DNA technologies. Insulin was the first peptide hormone discovered. Frederick Banting and Charles Best , working in the laboratory of John Macleod at the University of Toronto , were the first to isolate insulin from dog pancreas in 1921. Frederick Sanger sequenced
3175-492: Is far more stable than the monomer, which is desirable for practical reasons; however, the monomer is a much faster-reacting drug because diffusion rate is inversely related to particle size. A fast-reacting drug means insulin injections do not have to precede mealtimes by hours, which in turn gives people with diabetes more flexibility in their daily schedules. Insulin can aggregate and form fibrillar interdigitated beta-sheets . This can cause injection amyloidosis , and prevents
3302-420: Is hosting the annual convocation ceremonies, the building is a venue for academic and social events throughout the year. The sandstone buildings of Knox College epitomizes the North American collegiate Gothic design, with its characteristic cloisters surrounding a secluded courtyard. A lawn at the northeast is anchored by Hart House , a Gothic-revival student centre complex. Among its many common rooms,
3429-399: Is inhibition due to dominance of the α-adrenergic receptors. When the glucose level comes down to the usual physiologic value, insulin release from the β-cells slows or stops. If the blood glucose level drops lower than this, especially to dangerously low levels, release of hyperglycemic hormones (most prominently glucagon from islet of Langerhans alpha cells) forces release of glucose into
3556-415: Is known as a homodimer. Insulin binds to the α-subunits of the homodimer, which faces the extracellular side of the cells. The β subunits have tyrosine kinase enzyme activity which is triggered by the insulin binding. This activity provokes the autophosphorylation of the β subunits and subsequently the phosphorylation of proteins inside the cell known as insulin receptor substrates (IRS). The phosphorylation of
3683-635: Is located in the St. George Campus of University of Toronto in the Bahen Centre for Information Technology . dgp researchers regularly publish at ACM SIGGRAPH , ACM SIGCHI and ICCV . dgp hosts the Toronto User Experience (TUX) Speaker Series and the Sanders Series Lectures. University of Toronto The University of Toronto ( UToronto or U of T ) is a public research university in Toronto , Ontario , Canada, located on
3810-450: Is located in the nuclear periphery as a result of interaction with HDAC1 and 2 , which results in downregulation of insulin secretion. An increase in blood glucose levels causes phosphorylation of PDX1 , which leads it to undergo nuclear translocation and bind the A3 element within the insulin promoter. Upon translocation it interacts with coactivators HAT p300 and SETD7 . PDX1 affects
3937-460: Is missing an intron ( Ins1 ). Transcription of the insulin gene increases in response to elevated blood glucose. This is primarily controlled by transcription factors that bind enhancer sequences in the ~400 base pairs before the gene's transcription start site. The major transcription factors influencing insulin secretion are PDX1 , NeuroD1 , and MafA . During a low-glucose state, PDX1 (pancreatic and duodenal homeobox protein 1)
Dynamic Graphics Project - Misplaced Pages Continue
4064-533: Is packaged inside mature granules waiting for metabolic signals (such as leucine, arginine, glucose and mannose) and vagal nerve stimulation to be exocytosed from the cell into the circulation. Insulin and its related proteins have been shown to be produced inside the brain, and reduced levels of these proteins are linked to Alzheimer's disease. Insulin release is stimulated also by beta-2 receptor stimulation and inhibited by alpha-1 receptor stimulation. In addition, cortisol, glucagon and growth hormone antagonize
4191-494: Is strongly inhibited by norepinephrine (noradrenaline), which leads to increased blood glucose levels during stress. It appears that release of catecholamines by the sympathetic nervous system has conflicting influences on insulin release by beta cells, because insulin release is inhibited by α 2 -adrenergic receptors and stimulated by β 2 -adrenergic receptors. The net effect of norepinephrine from sympathetic nerves and epinephrine from adrenal glands on insulin release
4318-502: Is the massive Robarts Library complex, built in 1972 and opened a year later in 1973. It features raised podia, extensive use of triangular geometric designs and a towering 14-storey concrete structure that cantilevers above a field of open space and mature trees. Sidney Smith Hall is the home to the Faculty of Arts and Science, as well as a few departments within the faculty. The Leslie L. Dan Pharmacy Building , completed in 2006, exhibits
4445-418: Is the presence of zinc atoms (Zn ) on the axis of symmetry, which are surrounded by three water molecules and three histidine residues at position B10. The hexamer is an inactive form with long-term stability, which serves as a way to keep the highly reactive insulin protected, yet readily available. The hexamer-monomer conversion is one of the central aspects of insulin formulations for injection. The hexamer
4572-603: The Canadian Institutes of Health Research , the Natural Sciences and Engineering Research Council and the Social Sciences and Humanities Research Council amounting to about one-third of the research budget. About eight per cent of research funding came from corporations, mostly in the healthcare industry . The first practical electron microscope was built by the physics department in 1938. During World War II,
4699-554: The Faculty of Medicine from Toronto-based philanthropists James and Louise Temerty . This broke the previous record for the school set in 2019 when Gerry Schwartz and Heather Reisman jointly donated $ 100 million for the creation of a 70,000-square-metre (750,000 sq ft) innovation and artificial intelligence centre. The Faculty of Medicine has been renamed the Temerty Faculty of Medicine in their honour. In December 2021,
4826-556: The Golgi apparatus and is packaged into specialized secretory vesicles . In the granule, proinsulin is cleaved by proprotein convertase 1/3 and proprotein convertase 2 , removing the middle part of the protein, called the " C-peptide ". Finally, carboxypeptidase E removes two pairs of amino acids from the protein's ends, resulting in active insulin – the insulin A- and B- chains, now connected with two disulfide bonds. The resulting mature insulin
4953-690: The Greco-Roman period, and the painting Adam and Eve by Lucas Cranach the Elder , dated from 1538. The University of Toronto Collection features Canadian contemporary art , while the University College Art Collection holds significant works by the Group of Seven and 19th century landscape artists . In the 2022 Academic Ranking of World Universities (also known as the Shanghai Ranking),
5080-700: The Group of Twenty , and the Citizen Lab , which conducts research on Internet censorship as a joint founder of the OpenNet Initiative . The university operates international offices in Berlin, Hong Kong and Siena . The Dalla Lana School of Public Health is a Faculty of the University of Toronto that began as one of the Schools of Hygiene begun by the Rockefeller Foundation in 1927. The School went through
5207-735: The Hart House Debates were suspended, although exhibition and interfaculty games were still held. The David Dunlap Observatory in Richmond Hill opened in 1935, followed by the University of Toronto Institute for Aerospace Studies in 1949. By the 1961–62 academic year, the university had a total enrolment of 14,302 students, including 1,531 graduate students. The university opened suburban campuses in Scarborough in 1964 and in Mississauga in 1967. The university's former affiliated schools at
Dynamic Graphics Project - Misplaced Pages Continue
5334-512: The Ontario Agricultural College and Glendon Hall became fully independent of the University of Toronto and became part of University of Guelph in 1964 and York University in 1965, respectively. Beginning in the 1980s, reductions in government funding prompted more rigorous fundraising efforts. In 2000, geophysicist Kin-Yip Chun was reinstated as a professor of the university, after he launched an unsuccessful lawsuit against
5461-517: The Rotman School of Management . The Faculty of Applied Science and Engineering is the other major direct-entry undergraduate faculty. The University of Toronto is the birthplace of an influential school of thought on communication theory and literary criticism known as the Toronto School . Described as "the theory of the primacy of communication in the structuring of human cultures and
5588-653: The Spanish Civil War , the history of science and medicine , Canadiana and the history of books . The Cheng Yu Tung East Asian Library has a rare 40,000-volume Chinese collection from the Song Dynasty (960–1279) to the Qing Dynasty (1644–1911) that was originally held by scholar Mu Xuexun (1880–1929). The Richard Charles Lee Canada-Hong Kong Library has the largest research collection for Hong Kong and Canada–Hong Kong studies outside of Hong Kong. The rest of
5715-444: The high-tech architectural style of glass and steel by British architect Norman Foster . The University of Toronto has traditionally been a decentralized institution, with governing authority shared among its central administration, academic faculties and colleges. The Governing Council is the unicameral legislative organ of the central administration, overseeing general academic, business and institutional affairs. Before 1971,
5842-457: The histone modifications through acetylation and deacetylation as well as methylation . It is also said to suppress glucagon . NeuroD1 , also known as β2, regulates insulin exocytosis in pancreatic β cells by directly inducing the expression of genes involved in exocytosis. It is localized in the cytosol , but in response to high glucose it becomes glycosylated by OGT and/or phosphorylated by ERK , which causes translocation to
5969-599: The British colonial elite, known as the Family Compact . Reformist politicians opposed the clergy's control over colonial institutions and fought to have the college secularized . In 1849, after a lengthy and heated debate, the newly elected responsible government of the Province of Canada voted to rename King's College as the University of Toronto and severed the school's ties with the church. Having anticipated this decision,
6096-661: The British use of wit . Smaller debating societies at Trinity, University and Victoria College have served as initial training grounds for debaters who later progress to Hart House. The club won the World Universities Debating Championship in 1981 and 2006. The North American Model United Nations (NAMUN) hosts an annual Model United Nations conference on campus, while the United Nations Society participates in various North American and international conferences. The Toronto chess team has captured
6223-530: The IRS activates a signal transduction cascade that leads to the activation of other kinases as well as transcription factors that mediate the intracellular effects of insulin. The cascade that leads to the insertion of GLUT4 glucose transporters into the cell membranes of muscle and fat cells, and to the synthesis of glycogen in liver and muscle tissue, as well as the conversion of glucose into triglycerides in liver, adipose, and lactating mammary gland tissue, operates via
6350-525: The Niagara border in 1866. The Corps was part of the Reserve Militia led by professor Henry Croft . Established in 1878, the School of Practical Science was the precursor to the Faculty of Applied Science and Engineering , which has been nicknamed Skule since its earliest days. While the Faculty of Medicine opened in 1843, medical teaching was conducted by proprietary schools from 1853 until 1887 when
6477-502: The United States, alongside McGill University . Academically, the University of Toronto is noted for influential movements and curricula in literary criticism and communication theory , known collectively as the Toronto School . The university was the birthplace of insulin , stem cell research, the first artificial cardiac pacemaker , and the site of the first successful lung transplant and nerve transplant. The university
SECTION 50
#17330935293666604-809: The University of Toronto announced the launch of the Defy Gravity campaign, the largest fundraising campaign in Canadian history, with a goal of raising $ 4 billion for the university. The university grounds lie about 2 kilometres (1.2 mi) north of the Financial District in Downtown Toronto , immediately north of Chinatown and the Discovery District , and immediately south of the neighbourhoods of Yorkville and The Annex . The site encompasses 55.8 hectares (138 acres) bounded mostly by Bay Street to
6731-457: The University of Toronto in 1921 is considered among the most significant events in the history of medicine . The stem cell was discovered at the university in 1963, forming the basis for bone marrow transplantation and all subsequent research on adult and embryonic stem cells . This was the first of many findings at Toronto relating to stem cells, including the identification of pancreatic and retinal stem cells. The cancer stem cell
6858-430: The University of Toronto is Hart House , a neo-Gothic student activity centre that was initiated and financed by alumnus-benefactor Vincent Massey and named for his grandfather Hart . Opened in 1919, the complex aimed to establish a communitarian student culture in the university and its students, who at the time kept largely within their own colleges under the decentralized collegiate system. The Hart House offers
6985-399: The University of Toronto to ensure their viability. The desire to preserve religious traditions in a secular institution resulted in the federative collegiate model that came to characterize the university. University College was the founding nondenominational college, created in 1853 after the university was secularized. Knox College , a Presbyterian institution, and Wycliffe College ,
7112-483: The University of Toronto was named the top research university in Canada by Research Infosource, with a sponsored research income (external sources of funding) of $ 1,234.278 million in 2020. In the same year, the university's faculty averaged a sponsored research income of $ 446,600, while graduate students averaged a sponsored research income of $ 61,000. The federal government was the largest source of funding, with grants from
7239-404: The actions of insulin during times of stress. Insulin also inhibits fatty acid release by hormone-sensitive lipase in adipose tissue. Contrary to an initial belief that hormones would be generally small chemical molecules, as the first peptide hormone known of its structure, insulin was found to be quite large. A single protein (monomer) of human insulin is composed of 51 amino acids , and has
7366-483: The activation, by IRS-1, of phosphoinositol 3 kinase ( PI3K ). This enzyme converts a phospholipid in the cell membrane by the name of phosphatidylinositol 4,5-bisphosphate (PIP2), into phosphatidylinositol 3,4,5-triphosphate (PIP3), which, in turn, activates protein kinase B (PKB). Activated PKB facilitates the fusion of GLUT4 containing endosomes with the cell membrane, resulting in an increase in GLUT4 transporters in
7493-459: The acute thermoregulatory and glucoregulatory response to food intake, suggesting that central nervous insulin contributes to the co-ordination of a wide variety of homeostatic or regulatory processes in the human body. Insulin also has stimulatory effects on gonadotropin-releasing hormone from the hypothalamus , thus favoring fertility . Once an insulin molecule has docked onto the receptor and effected its action, it may be released back into
7620-455: The amino acid structure in 1951, which made insulin the first protein to be fully sequenced. The crystal structure of insulin in the solid state was determined by Dorothy Hodgkin in 1969. Insulin is also the first protein to be chemically synthesised and produced by DNA recombinant technology . It is on the WHO Model List of Essential Medicines , the most important medications needed in
7747-403: The amount of insulin secreted, causing diabetes . The decreased binding activities can be mediated by glucose induced oxidative stress and antioxidants are said to prevent the decreased insulin secretion in glucotoxic pancreatic β cells . Stress signalling molecules and reactive oxygen species inhibits the insulin gene by interfering with the cofactors binding the transcription factors and
SECTION 60
#17330935293667874-415: The blood from the liver glycogen stores, supplemented by gluconeogenesis if the glycogen stores become depleted. By increasing blood glucose, the hyperglycemic hormones prevent or correct life-threatening hypoglycemia. Evidence of impaired first-phase insulin release can be seen in the glucose tolerance test , demonstrated by a substantially elevated blood glucose level at 30 minutes after the ingestion of
8001-517: The blood. In type 2 diabetes , the destruction of beta cells is less pronounced than in type 1, and is not due to an autoimmune process. Instead, there is an accumulation of amyloid in the pancreatic islets, which likely disrupts their anatomy and physiology. The pathogenesis of type 2 diabetes is not well understood but reduced population of islet beta-cells, reduced secretory function of islet beta-cells that survive, and peripheral tissue insulin resistance are known to be involved. Type 2 diabetes
8128-518: The building's Great Hall is noted for large stained-glass windows and a long quotation from John Milton 's Areopagitica inscribed around the walls. The adjacent Soldiers' Tower stands 143 feet (44 m) tall as the most prominent structure in the vicinity, its stone arches etched with the names of university members lost to the battlefields of the two World Wars. The tower houses a 51-bell carillon played on special occasions such as Remembrance Day and convocation. North of University College,
8255-552: The buried Taddle Creek , linking with Trinity College, Varsity Arena and the Faculty of Law . Victoria College is on the eastern side of Queen's Park, centred on a Romanesque main building made of contrasting red sandstone and grey limestone. Developed after the Second World War , the western section of the campus consists mainly of modernist and internationalist structures that house laboratories and faculty offices. The most significant example of Brutalist architecture
8382-468: The charter was largely the result of intense lobbying by John Strachan , the influential future first Anglican Bishop of Toronto who took office as the college's first president. The original three-storey Greek Revival school building was built on the present site of Queen's Park . Under Strachan's stewardship, King's College was a religious institution closely aligned with the Church of England and
8509-417: The conversion of small molecules in the blood into large molecules in the cells. Low insulin in the blood has the opposite effect, promoting widespread catabolism , especially of reserve body fat . Beta cells are sensitive to blood sugar levels so that they secrete insulin into the blood in response to high level of glucose, and inhibit secretion of insulin when glucose levels are low. Insulin production
8636-502: The country's legal education system away from the apprenticeship model that prevailed until the mid-20th century. The Ontario Institute for Studies in Education is the teachers college of the university, affiliated with its two laboratory schools , the Institute of Child Study and the University of Toronto Schools (a private high school run by the university). Autonomous institutes at
8763-511: The creation of New College in 1962, Innis College in 1964 and Woodsworth College in 1974, all of them nondenominational. Along with University College, they comprise the university's constituent colleges, which are established and funded by the central administration and are therefore financially dependent. Massey College was established in 1963 by the Massey Foundation as a college exclusively for graduate students. Regis College ,
8890-755: The death of John Strachan, the Anglican seminary Trinity College entered federation in 1904, followed in 1910 by St. Michael's College , a Roman Catholic college founded by the Basilian Fathers . Among the institutions that had considered federation but ultimately remained independent were McMaster University , a Baptist school that later moved to Hamilton , and Queen's College, a Presbyterian school in Kingston that later became Queen's University . Constituent colleges Theological colleges Federated colleges Postgraduate college The post-war era saw
9017-488: The east, Bloor Street to the north, Spadina Avenue to the west and College Street to the south. An enclave surrounded by university grounds, Queen's Park , contains the Ontario Legislative Building and several historic monuments. With its green spaces and many interlocking courtyards, the university forms a distinct region of urban parkland in the city's downtown core. The namesake University Avenue
9144-582: The enraged Strachan had resigned a year earlier to open Trinity College as a private Anglican seminary. University College was created as the nondenominational teaching branch of the University of Toronto. During the American Civil War , the threat of Union blockade on British North America prompted the creation of the University Rifle Corps , which saw battle in resisting the Fenian raids on
9271-429: The enzymes controlling the rate of glycolysis leading to the synthesis of fats via malonyl-CoA in the tissues that can generate triglycerides , and also the enzymes that control the rate of gluconeogenesis in the liver. The overall effect of these final enzyme dephosphorylations is that, in the tissues that can carry out these reactions, glycogen and fat synthesis from glucose are stimulated, and glucose production by
9398-456: The extracellular environment, or it may be degraded by the cell. The two primary sites for insulin clearance are the liver and the kidney. It is broken down by the enzyme, protein-disulfide reductase (glutathione) , which breaks the disulphide bonds between the A and B chains. The liver clears most insulin during first-pass transit, whereas the kidney clears most of the insulin in systemic circulation. Degradation normally involves endocytosis of
9525-575: The faculty absorbed the Toronto School of Medicine. Meanwhile, the university continued to set examinations and confer medical degrees. The university opened the Faculty of Law in 1887, followed by the Faculty of Dentistry in 1888 when the Royal College of Dental Surgeons became an affiliate. Women were first admitted to the university in 1884. A devastating fire in 1890 gutted the interior of University College and destroyed 33,000 volumes from
9652-430: The first phase of insulin exocytosis, most of the granules predispose for exocytosis are released after the calcium internalization. This pool is known as Readily Releasable Pool (RRP). The RRP granules represent 0.3-0.7% of the total insulin-containing granule population, and they are found immediately adjacent to the plasma membrane. During the second phase of exocytosis, insulin granules require mobilization of granules to
9779-408: The global human metabolism level include: The actions of insulin (indirect and direct) on cells include: Insulin also influences other body functions, such as vascular compliance and cognition . Once insulin enters the human brain, it enhances learning and memory and benefits verbal memory in particular. Enhancing brain insulin signaling by means of intranasal insulin administration also enhances
9906-575: The grounds that surround Queen's Park . It was founded by royal charter in 1827 as King's College , the first institution of higher learning in Upper Canada . Originally controlled by the Church of England , the university assumed its present name in 1850 upon becoming a secular institution. As a collegiate university , it comprises 11 colleges each with substantial autonomy on financial and institutional affairs and significant differences in character and history. The university maintains three campuses,
10033-518: The insulin sequence of diverse species suggests that it has been conserved across much of animal evolutionary history. The C-peptide of proinsulin , however, differs much more among species; it is also a hormone, but a secondary one. Insulin is produced and stored in the body as a hexamer (a unit of six insulin molecules), while the active form is the monomer. The hexamer is about 36000 Da in size. The six molecules are linked together as three dimeric units to form symmetrical molecule. An important feature
10160-567: The largest ever research grant in Canada, a $ 200 million grant from the Government of Canada in 2023. The Varsity Blues are the athletic teams that represent the university in intercollegiate league matches, primarily within U Sports , with ties to gridiron football , rowing and ice hockey. The earliest recorded instance of gridiron football occurred at University of Toronto's University College in November 1861. The university's Hart House
10287-464: The libraries, Robarts Library , holds about five million bound volumes that form the main collection for humanities and social sciences . The Thomas Fisher Rare Book Library constitutes one of the largest repositories of publicly accessible rare books and manuscripts . Its collections range from ancient Egyptian papyri to incunabula and libretti ; the subjects of focus include British, Western and Canadian literature , Aristotle , Darwin ,
10414-687: The library collections are dispersed at departmental and faculty libraries in addition to about 1.3 million bound volumes the colleges hold. The university has collaborated with the Internet Archive since 2005 to digitize some of its library holdings. Housed within University College, the University of Toronto Art Centre contains three major art collections. The Malcove Collection is primarily represented by Early Christian and Byzantine sculptures, bronzeware, furniture, icons and liturgical items. It also includes glassware and stone reliefs from
10541-566: The library, but the university restored the building and replenished its library within two years. Over the next two decades, a collegiate system took shape as the university arranged federation with several ecclesiastical colleges, including Strachan's Trinity College in 1904. The university operated the Royal Conservatory of Music from 1896 to 1991 and the Royal Ontario Museum from 1912 to 1968; both still retain close ties with
10668-428: The liver in extracting insulin from the blood. This oscillation is important to consider when administering insulin-stimulating medication, since it is the oscillating blood concentration of insulin release, which should, ideally, be achieved, not a constant high concentration. This may be achieved by delivering insulin rhythmically to the portal vein , by light activated delivery, or by islet cell transplantation to
10795-413: The liver through glycogenolysis and gluconeogenesis are inhibited. The breakdown of triglycerides by adipose tissue into free fatty acids and glycerol is also inhibited. After the intracellular signal that resulted from the binding of insulin to its receptor has been produced, termination of signaling is then needed. As mentioned below in the section on degradation, endocytosis and degradation of
10922-465: The liver. The blood insulin level can be measured in international units , such as μIU/mL or in molar concentration , such as pmol/L, where 1 μIU/mL equals 6.945 pmol/L. A typical blood level between meals is 8–11 μIU/mL (57–79 pmol/L). The effects of insulin are initiated by its binding to a receptor, the insulin receptor (IR) , present in the cell membrane. The receptor molecule contains an α- and β subunits. Two molecules are joined to form what
11049-464: The liver. The secretion of insulin and glucagon into the blood in response to the blood glucose concentration is the primary mechanism of glucose homeostasis . Decreased or absent insulin activity results in diabetes , a condition of high blood sugar level ( hyperglycaemia ). There are two types of the disease. In type 1 diabetes , the beta cells are destroyed by an autoimmune reaction so that insulin can no longer be synthesized or be secreted into
11176-521: The main students' unions on administrative and policy issues are the University of Toronto Students' Union , Association of Part-time Undergraduate Students and the Graduate Students' Union. Student representative bodies also exist at the various colleges, academic faculties and departments. The Hart House Debating Club employs a debating style that combines the American emphasis on analysis and
11303-477: The main building of Trinity College displays Jacobethan Tudor architecture , while its chapel was built in the Perpendicular Gothic style of Giles Gilbert Scott . The chapel features exterior walls of sandstone and interiors of Indiana Limestone and was built by Italian stonemasons using ancient building methods. Philosopher's Walk is a scenic footpath that follows a meandering, wooded ravine ,
11430-433: The medical institutes have cross-appointments to faculty and supervisory positions in university departments. The Rotman School of Management developed the discipline and methodology of integrative thinking , upon which the school used to base its curriculum. Founded in 1887, the Faculty of Law 's emphasis on formal teachings of liberal arts and legal theory was then considered unconventional, but gradually helped shift
11557-468: The nucleus. In the nucleus β2 heterodimerizes with E47 , binds to the E1 element of the insulin promoter and recruits co-activator p300 which acetylates β2. It is able to interact with other transcription factors as well in activation of the insulin gene. MafA is degraded by proteasomes upon low blood glucose levels. Increased levels of glucose make an unknown protein glycosylated . This protein works as
11684-484: The oldest of which is St. George, located in downtown Toronto . The other two satellite campuses are located in Scarborough and Mississauga . The University of Toronto offers over 700 undergraduate and 200 graduate programs. The university receives the most annual scientific research funding and endowment of any Canadian university. It is also one of two members of the Association of American Universities outside
11811-610: The plasma membrane and a previous preparation to undergo their release. Thus, the second phase of insulin release is governed by the rate at which granules get ready for release. This pool is known as a Reserve Pool (RP). The RP is released slower than the RRP (RRP: 18 granules/min; RP: 6 granules/min). Reduced first-phase insulin release may be the earliest detectable beta cell defect predicting onset of type 2 diabetes . First-phase release and insulin sensitivity are independent predictors of diabetes. The description of first phase release
11938-402: The plasma membrane. PKB also phosphorylates glycogen synthase kinase (GSK), thereby inactivating this enzyme. This means that its substrate, glycogen synthase (GS), cannot be phosphorylated, and remains dephosphorylated, and therefore active. The active enzyme, glycogen synthase (GS), catalyzes the rate limiting step in the synthesis of glycogen from glucose. Similar dephosphorylations affect
12065-492: The positions A7-B7 and A20-B19. There is an additional (intrachain) disulfide bond within the A-chain between cysteine residues at positions A6 and A11. The A-chain exhibits two α-helical regions at A1-A8 and A12-A19 which are antiparallel; while the B chain has a central α -helix (covering residues B9-B19) flanked by the disulfide bond on either sides and two β-sheets (covering B7-B10 and B20-B23). The amino acid sequence of insulin
12192-530: The prey fishes by lowering their blood glucose levels. Insulin is produced exclusively in the beta cells of the pancreatic islets in mammals, and the Brockmann body in some fish. Human insulin is produced from the INS gene , located on chromosome 11. Rodents have two functional insulin genes; one is the homolog of most mammalian genes ( Ins2 ), and the other is a retroposed copy that includes promoter sequence but that
12319-472: The publication of the first observational evidence proving the existence of black holes . Toronto astronomers have also discovered the Uranian moons of Caliban and Sycorax , the dwarf galaxies of Andromeda I , II and III , and the supernova SN 1987A . A pioneer in computing technology, the university designed and built UTEC , one of the world's first operational computers, and later purchased Ferut ,
12446-463: The publication placed the university 19th in the world. In the 2024–25 U.S. News & World Report Best Global University Ranking , the university ranked 17th in the world, and first in Canada. The Canadian-based Maclean's magazine ranked the University of Toronto second in their 2022–2023 Medical Doctoral university category. Maclean's 2023 university rankings also ranked the University of Toronto first in its reputation survey. The university
12573-461: The receptor bound to insulin is a main mechanism to end signaling. In addition, the signaling pathway is also terminated by dephosphorylation of the tyrosine residues in the various signaling pathways by tyrosine phosphatases. Serine/Threonine kinases are also known to reduce the activity of insulin. The structure of the insulin– insulin receptor complex has been determined using the techniques of X-ray crystallography . The actions of insulin on
12700-531: The second commercial computer after UNIVAC I . Multi-touch technology was developed at Toronto, with applications ranging from handheld devices to high-end drawing monitors to collaboration walls . The AeroVelo Atlas , which won the Igor I. Sikorsky Human Powered Helicopter Competition in 2013, was developed by the university's team of students and graduates and was tested in Vaughan . The discovery of insulin at
12827-496: The storage of insulin for long periods. Beta cells in the islets of Langerhans release insulin in two phases. The first-phase release is rapidly triggered in response to increased blood glucose levels, and lasts about 10 minutes. The second phase is a sustained, slow release of newly formed vesicles triggered independently of sugar, peaking in 2 to 3 hours. The two phases of the insulin release suggest that insulin granules are present in diverse stated populations or "pools". During
12954-543: The structuring of the human mind", the school is rooted in the works of Eric A. Havelock and Harold Innis and the subsequent contributions of Edmund Snow Carpenter , Northrop Frye and Marshall McLuhan . Since 1963, the McLuhan Program in Culture and Technology of the Faculty of Information has carried the mandate for teaching and advancing the Toronto School. Several notable works in arts and humanities are based at
13081-455: The time: "Until I reached Toronto," remarked Lord Dufferin during his visit in 1872, "I confess I was not aware that so magnificent a specimen of architecture existed upon the American continent ." The building was declared a National Historic Site of Canada in 1968. Built in 1907, Convocation Hall is recognizable for its domed roof and Ionic -pillared rotunda. Although its foremost function
13208-2685: The top title six times at the Pan American Intercollegiate Team Chess Championship . The Formula SAE Racing Team won the Formula Student European Championships in 2003, 2005 and 2006. Insulin 1A7F , 1AI0 , 1AIY , 1B9E , 1BEN , 1EV3 , 1EV6 , 1EVR , 1FU2 , 1FUB , 1G7A , 1G7B , 1GUJ , 1HIQ , 1HIS , 1HIT , 1HLS , 1HTV , 1HUI , 1IOG , 1IOH , 1J73 , 1JCA , 1JCO , 1K3M , 1KMF , 1LKQ , 1LPH , 1MHI , 1MHJ , 1MSO , 1OS3 , 1OS4 , 1Q4V , 1QIY , 1QIZ , 1QJ0 , 1RWE , 1SF1 , 1T1K , 1T1P , 1T1Q , 1TRZ , 1TYL , 1TYM , 1UZ9 , 1VKT , 1W8P , 1XDA , 1XGL , 1XW7 , 1ZEG , 1ZEH , 1ZNJ , 2AIY , 2C8Q , 2C8R , 2CEU , 2H67 , 2HH4 , 2HHO , 2HIU , 2JMN , 2JUM , 2JUU , 2JUV , 2JV1 , 2JZQ , 2K91 , 2K9R , 2KJJ , 2KJU , 2KQQ , 2KXK , 2L1Y , 2L1Z , 2LGB , 2M1D , 2M1E , 2M2M , 2M2N , 2M2O , 2M2P , 2OLY , 2OLZ , 2OM0 , 2OM1 , 2OMG , 2OMH , 2OMI , 2QIU , 2R34 , 2R35 , 2R36 , 2RN5 , 2VJZ , 2VK0 , 2W44 , 2WBY , 2WC0 , 2WRU , 2WRV , 2WRW , 2WRX , 2WS0 , 2WS1 , 2WS4 , 2WS6 , 2WS7 , 3AIY , 3BXQ , 3E7Y , 3E7Z , 3EXX , 3FQ9 , 3I3Z , 3I40 , 3ILG , 3INC , 3IR0 , 3Q6E , 3ROV , 3TT8 , 3U4N , 3UTQ , 3UTS , 3UTT , 3V19 , 3V1G , 3W11 , 3W12 , 3W13 , 3W7Y , 3W7Z , 3W80 , 3ZI3 , 3ZQR , 3ZS2 , 3ZU1 , 4AIY , 4AJX , 4AJZ , 4AK0 , 4AKJ , 4EFX , 4EWW , 4EWX , 4EWZ , 4EX0 , 4EX1 , 4EXX , 4EY1 , 4EY9 , 4EYD , 4EYN , 4EYP , 4F0N , 4F0O , 4F1A , 4F1B , 4F1C , 4F1D , 4F1F , 4F1G , 4F4T , 4F4V , 4F51 , 4F8F , 4FG3 , 4FKA , 4GBC , 4GBI , 4GBK , 4GBL , 4GBN , 4IUZ , 5AIY , 2LWZ , 3JSD , 3KQ6 , 3P2X , 3P33 , 1JK8 , 2MLI , 2MPG , 2MPI , 2MVC , 2MVD , 4CXL , 4CXN , 4CY7 , 4NIB , 4OGA , 4P65 , 4Q5Z , 4RXW , 4UNE , 4UNG , 4UNH , 4XC4 , 4WDI , 4Z76 , 4Z77 , 4Z78 , 2N2W , 5CO6 , 5ENA , 4Y19 , 5BQQ , 5BOQ , 2N2V , 5CNY , 5CO9 , 5EN9 , 4Y1A , 2N2X , 5BPO , 5CO2 , 5BTS , 5HYJ , 5C0D ,%%s 1EFE , 1SJT , 1SJU , 2KQP ,%%s 1T0C ,%%s 2G54 , 2G56 , 3HYD , 2OMQ 3630 16334 ENSG00000254647 ENSMUSG00000000215 P01308 P01326 NM_000207 NM_001185097 NM_001185098 NM_001291897 NM_001185083 NM_001185084 NM_008387 NP_001172026.1 NP_001172027.1 NP_001278826.1 NP_000198 NP_000198 NP_000198 NP_000198 NP_001172012 NP_001172013 NP_032413 Insulin ( / ˈ ɪ n . sj ʊ . l ɪ n / , from Latin insula , 'island')
13335-458: The transcription factors itself. Several regulatory sequences in the promoter region of the human insulin gene bind to transcription factors . In general, the A-boxes bind to Pdx1 factors, E-boxes bind to NeuroD , C-boxes bind to MafA , and cAMP response elements to CREB . There are also silencers that inhibit transcription. Insulin is synthesized as an inactive precursor molecule,
13462-457: The university alleging racial discrimination. In 2017, a human rights application was filed against the University by one of its students for allegedly delaying the investigation of sexual assault and being dismissive of their concerns. In 2018, the university cleared one of its professors of allegations of discrimination and antisemitism in an internal investigation, after a complaint was filed by one of its students. The University of Toronto
13589-559: The university as independent institutions. The University of Toronto Press was founded in 1901 as Canada's first academic publishing house . The Faculty of Forestry, founded in 1907 with Bernhard Fernow as dean, was Canada's first university faculty devoted to forest science. In 1910, the Faculty of Education opened its laboratory school , the University of Toronto Schools . The First and Second World Wars curtailed some university activities as undergraduate and graduate men eagerly enlisted. Intercollegiate athletic competitions and
13716-552: The university developed the G-suit , a life-saving garment worn by Allied fighter plane pilots, later adopted for use by astronauts. Development of the infrared chemiluminescence technique improved analyses of energy behaviours in chemical reactions. In 1963, the asteroid 2104 Toronto is discovered in the David Dunlap Observatory in Richmond Hill and is named after the university. In 1972, studies on Cygnus X-1 led to
13843-483: The university fourth in the world, and first in Canada. The University Ranking by Academic Performance 2019–2020 rankings placed the university second in the world, and first in Canada. Along with academic and research-based rankings, the university has also been ranked by publications that evaluate the employment prospects of its graduates. In the Times Higher Education's 2022 global employability ranking,
13970-531: The university grounds in Toronto's Discovery District , conducting $ 1 billion of medical research annually. MaRS Discovery District is a research park that serves commercial enterprises and the university's technology transfer ventures. In 2008, the university disclosed 159 inventions and had 114 active start-up companies. Its SciNet Consortium operates the most powerful supercomputer in Canada. A notable hub for social, cultural and recreational activities at
14097-907: The university include the Canadian Institute for Theoretical Astrophysics , the Pontifical Institute of Mediaeval Studies and the Fields Institute . Within the Faculty of Arts and Science, notable departments include the Department of Mathematics . The University of Toronto Libraries is the third-largest academic library system in North America, following those of Harvard and Yale , measured by number of volumes held. Its collections include more than 12 million print books, 1.9 million digital books, over 160,000 journal titles, and close to 30,000 metres of archival materials. The largest of
14224-538: The university operated the Connaught Medical Research Laboratories , now part of the pharmaceutical corporation Sanofi-Aventis . Among the research conducted at the laboratory was the development of gel electrophoresis . The University of Toronto is the primary research presence that supports one of the world's largest concentrations of biotechnology firms. More than 5,000 principal investigators reside within 2 kilometres (1.2 mi) from
14351-463: The university ranked 11th in the world, and first in Canada. In QS's 2022 graduate employability ranking, the university ranked 21st in the world, and first in Canada. In a 2013 employment survey conducted by the New York Times , the University of Toronto was ranked 14th in the world. In 2018, the University of Toronto Entrepreneurship was ranked the fourth best university-based incubator in
14478-483: The university ranked 22nd in the world and first in Canada. The 2023 QS World University Rankings ranked the university 21st in the world, and first in Canada. In 2019, it ranked 11th among the universities around the world by SCImago Institutions Rankings . The 2023 Times Higher Education World University Rankings ranked the university 18th in the world, and first in Canada. In the Times' 2020 reputational ranking,
14605-787: The university through the Toronto School of Theology . The Faculty of Arts and Science is the university's main undergraduate faculty, and administers most of the courses in the college system. While the colleges are not entirely responsible for teaching duties, most of them house specialized academic programs and lecture series. Among other subjects, Trinity College is associated with programs in international relations , as are University College with Canadian studies , Victoria College with Renaissance studies , Innis College with film studies and urban studies , New College with gender studies , Woodsworth College with industrial relations and St. Michael's College with Medieval studies . The faculty teaches undergraduate commerce in collaboration with
14732-428: The university was governed under a bicameral system composed of the board of governors and the university senate. The chancellor, usually a former governor general , lieutenant governor , premier or diplomat, is the ceremonial head of the university. The president is appointed by the council as the chief executive. Unlike most North American institutions, the University of Toronto is a collegiate university with
14859-590: The university's various programs and curricula in international affairs, foreign policy, and public policy . As the Cold War heightened, Toronto's Slavic studies program evolved into an important institution on Soviet politics and economics, financed by the Rockefeller , Ford and Mellon foundations. The Munk School is also home to the G20 Research Group , which conducts independent monitoring and analysis on
14986-672: The university, including the Dictionary of Canadian Biography since 1959 and the Collected Works of Erasmus since 1969. The Records of Early English Drama collects and edits the surviving documentary evidence of dramatic arts in pre- Puritan England, while the Dictionary of Old English compiles the early vocabulary of the English language from the Anglo-Saxon period. The Munk School of Global Affairs and Public Policy encompasses
15113-408: The university, known as Front Campus, is near the campus centre in an oval lawn enclosed by King's College Circle. The centrepiece is the main building of University College , built in 1857 with an eclectic blend of Richardsonian Romanesque and Norman architectural elements. The dramatic effect of this blended design by architect Frederick William Cumberland drew praise from European visitors of
15240-582: The university. The founding of a colonial college had long been the desire of John Graves Simcoe , the first Lieutenant-Governor of Upper Canada and founder of York , the colonial capital. As an Oxford -educated military commander who had fought in the American Revolutionary War , Simcoe believed a college was needed to counter the spread of republicanism from the United States . The Upper Canada Executive Committee recommended in 1798 that
15367-441: The world by UBI Global in the "World Top Business Incubator – Managed by a University" category. Since 1926, the University of Toronto has been a member of the Association of American Universities , a consortium of the leading North American research universities. The university manages by far the largest annual research budget of any university in Canada with sponsored direct-cost expenditures of $ 878 million in 2010. In 2021,
15494-427: Was also home to the first electron microscope , the development of deep learning , neural network , multi-touch technology, the identification of the first black hole Cygnus X-1 , and the development of the theory of NP-completeness . The University of Toronto is the recipient of both the single largest philanthropic gift in Canadian history, a $ 250 million donation from James and Louise Temerty in 2020, and
15621-456: Was always previously assumed to be food type specific only. Even during digestion, in general, one or two hours following a meal, insulin release from the pancreas is not continuous, but oscillates with a period of 3–6 minutes, changing from generating a blood insulin concentration more than about 800 p mol /l to less than 100 pmol/L (in rats). This is thought to avoid downregulation of insulin receptors in target cells, and to assist
15748-409: Was first identified in 1997 by Toronto researchers, who have since found stem cell associations in leukemia , brain tumours and colorectal cancer . Medical inventions developed at Toronto include the glycaemic index , the infant cereal Pablum , the use of protective hypothermia in open heart surgery and the first artificial cardiac pacemaker . The first successful single-lung transplant
15875-546: Was performed at Toronto in 1981, followed by the first nerve transplant in 1988, and the first double-lung transplant in 1989. Researchers identified the maturation promoting factor that regulates cell division , and discovered the T-cell receptor , which triggers responses of the immune system. The university is credited with isolating the genes that cause Fanconi anemia , cystic fibrosis and early-onset Alzheimer's disease , among numerous other diseases. Between 1914 and 1972,
16002-596: Was ranked in spite of having opted out—along with several other universities in Canada—of participating in Maclean's graduate survey since 2006. The university's research performance has been noted in several bibliometric university rankings, which use citation analysis to evaluate the impact a university has on academic publications. In 2019, the Performance Ranking of Scientific Papers for World Universities ranked
16129-470: Was the first Canadian university to amass a financial endowment greater than one billion dollars in 2007. From 2011 to 2018, the university embarked on the Boundless fundraising campaign, which concluded in 2018 at $ 2.641 billion raised, setting a new all-time fundraising record in Canada. On September 24, 2020, the university announced the single largest donation in Canadian history, a $ 250 million gift to
#365634