Misplaced Pages

#745254

83-513: Discovery science is a scientific methodology. Discovery Science may also refer to: Discovery science Discovery science places an emphasis on 'basic' discovery, which can fundamentally change the status quo. For example, in the early years of water resources research, the use of discovery science was demonstrated by seeking to elucidate phenomena that was, until that point, unexplained. It did not matter how unusual these ideas may have been perceived to be. In this sense, discovery science

166-491: A herbicide ), reduction of spoilage, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents , biofuels , and other industrially useful goods, as well as for bioremediation . Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 to 1,600,000 square kilometers (4,200,000 to 395,400,000 acres). 10% of

249-474: A plasmid vector inserted into the bacterium Escherichia coli . Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas of abattoir animals (cattle or pigs). The genetically engineered bacteria are able to produce large quantities of synthetic human insulin at relatively low cost. Biotechnology has also enabled emerging therapeutics like gene therapy . The application of biotechnology to basic science (for example through

332-793: A 'pipeline' for leading-edge medical development. According to the AACR Cancer Progress Report 2021 , discovery science has the potential to drive clinical breakthroughs. Since discovery science underlies key discoveries and development of new therapies for medicine, it remains important for advancing critical care. Numerous discoveries have increased life span and productivity, and decreased health-related costs, thereby revolutionising medical care. Resultantly, return on investment for discovery science has proven to be high. For example, its combination of computational methods with knowledge on inflammatory and genomic pathways has resulted in optimised clinical trials . Ultimately, discovery science

415-668: A Unified Database System) database is intended to help companies, interested private users and competent authorities to find precise information on the presence, detection and identification of GMOs used in the European Union . The information is provided in English. In 1988, after prompting from the United States Congress , the National Institute of General Medical Sciences ( National Institutes of Health ) (NIGMS) instituted

498-455: A bacterium (of the genus Pseudomonas ) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of the Pseudomonas bacterium). The MOSFET invented at Bell Labs between 1955 and 1960, Two years later, Leland C. Clark and Champ Lyons invented

581-534: A challenge, which can lead to drug and biomarker discovery and development, commercial challenges and genomics-informed clinical trials. Importantly, these key scientific challenges are interdependent with each other. Directed and streamlined approaches are sought to be developed for a rapid generation of biological discoveries, which can allow for cancer genomic discoveries to translate to the clinic. Delivering personalised cancer medicine benefits from traditional, unconstrained and non-directed academic exploration, with

664-438: A child's parentage (genetic mother and father) or in general a person's ancestry . In addition to studying chromosomes to the level of individual genes, genetic testing in a broader sense includes biochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes in chromosomes , genes, or proteins. Most of

747-413: A consortium could be used as industrial microbes to produce precursors of the chemotherapeutic agent paclitaxel by applying the metabolic engineering in a co-culture approach to exploit the benefits from the two microbes. Another example of synthetic biology applications in industrial biotechnology is the re-engineering of the metabolic pathways of E. coli by CRISPR and CRISPRi systems toward

830-502: A decline in progress due to a change from discovery-based field work to the gathering of data for modal parameterisation. In field hydrology, models are not any more useful than an understanding of how systems work, and discovery science allows for this understanding. Several important examples of field-based inquiry and discovery have taken place in field hydrology. These include: identifying spatial patterns of soil moisture and how they relate to topography ; interrogating such data through

913-422: A drug's efficacy or toxicity . The purpose of pharmacogenomics is to develop rational means to optimize drug therapy, with respect to the patients' genotype , to ensure maximum efficacy with minimal adverse effects . Such approaches promise the advent of " personalized medicine "; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Biotechnology has contributed to

SECTION 10

#1732868798746

996-407: A failure to discover and develop new therapies, which could have an impact on the critically ill. Within critical care, there is an aim to renew emphasis on basic, translational science through platforms such as medical journals and conferences, as well as the critical care medical curricula. Advances in discovery-based science thereby underlie key discoveries and development in medicine, constituting

1079-410: A food source into another form. Before the time of Charles Darwin 's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection. For thousands of years, humans have used selective breeding to improve

1162-417: A funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed. Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support are provided for two or three years during

1245-568: A general trend of increasing use of computers and computational theory in all fields of science, and newer methods of data mining employ specialised machine learning algorithms for automated hypothesis forming and automated theorem proving . While computational methods are gaining interest, there is a decline in efforts to support critical care through basic and translational science, i.e., forms of discovery science which are essential for advancing understanding of pathophysiology . A loss of interest in basic and translational science may lead to

1328-536: A harmful microbe are examples of environmental implications of biotechnology. Many cities have installed CityTrees , which use biotechnology to filter pollutants from urban atmospheres. The regulation of genetic engineering concerns approaches taken by governments to assess and manage the risks associated with the use of genetic engineering technology, and the development and release of genetically modified organisms (GMO), including genetically modified crops and genetically modified fish . There are differences in

1411-415: A notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies. Krimsky, Sheldon (2015). "An Illusory Consensus behind GMO Health Assessment". Science, Technology, & Human Values . 40 (6): 883–914. doi : 10.1177/0162243915598381 . S2CID   40855100 . I began this article with the testimonials from respected scientists that there

1494-513: A number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm. The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken

1577-434: A number of ecological benefits, if not used in excess. Insect-resistant crops have proven to lower pesticide usage, therefore reducing the environmental impact of pesticides as a whole. However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by

1660-594: A promising method to combat malnutrition in India and other countries. Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, including industrial fermentation . It includes the practice of using cells such as microorganisms , or components of cells like enzymes , to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels . In

1743-471: A pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum , to produce acetone , which the United Kingdom desperately needed to manufacture explosives during World War I . Biotechnology has also led to the development of antibiotics. In 1928, Alexander Fleming discovered the mold Penicillium . His work led to the purification of

SECTION 20

#1732868798746

1826-531: A significant impact on many areas of society, from medicine to agriculture to environmental science . One of the key techniques used in biotechnology is genetic engineering , which allows scientists to modify the genetic makeup of organisms to achieve desired outcomes. This can involve inserting genes from one organism into another, and consequently, create new traits or modifying existing ones. Other important techniques used in biotechnology include tissue culture, which allows researchers to grow cells and tissues in

1909-705: A wealth of knowledge which has been gathered by a broad range of research and decades of work. Biological insights are required to inform drug discovery and to set a clear clinical path for development. Historically, acquisition of such knowledge through functional and mechanistic studies has been uncoordinated, random, and inefficient. The process of moving from cancer genomic discoveries to personalised medicine involves some major scientific, logistical and regulatory hurdles. This includes patient consent, sample acquisition, clinical annotation and study design, all of which can lead to data generation and computational analyses. Additionally, functional and mechanistic studies remain

1992-414: A wide range of procedures for modifying living organisms for human purposes, going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization . Modern usage also includes genetic engineering, as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as

2075-420: Is a big challenge for discovery-based science. Although it is possible for results to be statistically validated by independent datasets, tests of functionality affect ultimate validation. Collaborative efforts are therefore critical for success. Biotechnology Biotechnology is a multidisciplinary field that involves the integration of natural sciences and engineering sciences in order to achieve

2158-507: Is a rapidly evolving field with significant potential to address pressing global challenges and improve the quality of life for people around the world; however, despite its numerous benefits, it also poses ethical and societal challenges, such as questions around genetic modification and intellectual property rights . As a result, there is ongoing debate and regulation surrounding the use and application of biotechnology in various industries and fields. The concept of biotechnology encompasses

2241-635: Is based on the basic biological sciences (e.g., molecular biology , biochemistry , cell biology , embryology , genetics , microbiology ) and conversely provides methods to support and perform basic research in biology. Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation, and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis , for example), forecasted, formulated, developed, manufactured, and marketed for

2324-560: Is based on the attitude that ‘‘we must not allow our concepts of the earth, in so far as they transcend the reach of observation, to root themselves so deeply and so firmly in our minds that the process of uprooting them causes mental discomfort" (as stated by Davis in 1926). For discovery science to be utilised, there is a need to revert to creating and testing genuine hypotheses, rather than focusing on praising concepts that are already familiar. While researchers commonly feel that new hypotheses will naturally emerge inductively from curiosity in

2407-557: Is complex and heterogenous, as it is collected from multiple sources (e.g., labs and institutions) and uses different kinds of standards. On the other hand, deep data is collected at multiple levels, e.g., from genes to molecules, cells, circuits, behaviours, and symptoms. Broad data allows for population level inferences to be made; deep data is required for personalised medicine. However, combining broad and deep data and storing them in large-scale databases makes it practically impossible to rely on traditional statistical approaches. Instead,

2490-638: Is considered one of the essential cornerstones in industrial biotechnology due to its financial and sustainable contribution to the manufacturing sector. Jointly biotechnology and synthetic biology play a crucial role in generating cost-effective products with nature-friendly features by using bio-based production instead of fossil-based. Synthetic biology can be used to engineer model microorganisms , such as Escherichia coli , by genome editing tools to enhance their ability to produce bio-based products, such as bioproduction of medicines and biofuels . For instance, E. coli and Saccharomyces cerevisiae in

2573-618: Is currently enabling a transition to the era of personalised medicine for treating complex syndromes, e.g., sepsis and ARDS. With a robust infrastructure, discovery science can resultantly revolutionise medical care and biological research. Discovery science has converged with clinical medicine and cancer genomics, and this convergence has been accelerated by recent advances in genome technologies and genomic information. The effect of cancer genomics has been noticeable in every area of cancer research. The majority of successful applications of genomic knowledge in today's clinical medicine involves

Discovery Science - Misplaced Pages Continue

2656-460: Is discovery-based. Normally, discovery-based approaches for research are initially hypothesis-free, however, hypothesis testing can be elevated to a new level that effectively supports traditional hypothesis-driven studies. Researchers hope that combining integrative analyses of data from a range of different levels can result in new classification approaches to enable personalised interventions. Some biologists, such as Leroy Hood, have suggested that

2739-859: Is expected to be good news for the biotechnology sector, with the Department of Energy estimating ethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans—the main inputs into biofuels—by developing genetically modified seeds that resist pests and drought. By increasing farm productivity, biotechnology boosts biofuel production. Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non-food (industrial) uses of crops and other products (e.g., biodegradable plastics , vegetable oil , biofuels ), and environmental uses. For example, one application of biotechnology

2822-435: Is expected to have disappointing results as a fundamental part of discovery science. In particular, this may apply to medicine for the critically ill, where disease syndromes may be complex and multi-factorial. In psychiatry, studying complex relationships between brain and behaviour requires a large-scale science. This calls for a need to conceptually switch from hypothesis-driven studies to hypothesis-generating research which

2905-565: Is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story. And contrast: Panchin, Alexander Y.; Tuzhikov, Alexander I. (January 14, 2016). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology . 37 (2): 213–217. doi : 10.3109/07388551.2015.1130684 . ISSN   0738-8551 . PMID   26767435 . S2CID   11786594 . Here, we show that

2988-474: Is no overland flow visible. Therefore, there is a need for discovery science in field hydrology, despite any unusual hydrological hypotheses that are formed. An example of discovery science being enhanced for human brain function can be seen in the 1000 Functional Connectomes Project (FCP) . This project was launched in 2009 as a way of generating and collecting functional magnetic resonance imaging (fMRI) data from over 1,000 individuals. Similarly to decoding

3071-673: Is the application of the principles of engineering and natural sciences to tissues, cells, and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals. Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical or chemical engineering such as tissue engineering , biopharmaceutical engineering , and genetic engineering . Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit

3154-708: Is the directed use of microorganisms for the manufacture of organic products (examples include beer and milk products). Another example is using naturally present bacteria by the mining industry in bioleaching . Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities ( bioremediation ), and also to produce biological weapons . A series of derived terms have been coined to identify several branches of biotechnology, for example: In medicine, modern biotechnology has many applications in areas such as pharmaceutical drug discoveries and production, pharmacogenomics , and genetic testing (or genetic screening ). In 2021, nearly 40% of

3237-488: Is widely used in biomedical applications, such as the detection of DNA hybridization , biomarker detection from blood , antibody detection, glucose measurement, pH sensing, and genetic technology . By the mid-1980s, other BioFETs had been developed, including the gas sensor FET (GASFET), pressure sensor FET (PRESSFET), chemical field-effect transistor (ChemFET), reference ISFET (REFET), enzyme-modified FET (ENFET) and immunologically modified FET (IMFET). By

3320-631: The DNA of which has been modified with genetic engineering techniques. In most cases, the main aim is to introduce a new trait that does not occur naturally in the species. Biotechnology firms can contribute to future food security by improving the nutrition and viability of urban agriculture. Furthermore, the protection of intellectual property rights encourages private sector investment in agrobiotechnology. Examples in food crops include resistance to certain pests, diseases, stressful environmental conditions, resistance to chemical treatments (e.g. resistance to

3403-461: The Human Genome Project ) has also dramatically improved our understanding of biology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well. Genetic testing allows the genetic diagnosis of vulnerabilities to inherited diseases , and can also be used to determine

Discovery Science - Misplaced Pages Continue

3486-484: The phenomenological world more closely than the senses alone (even augmented senses, e.g. via microscopes , telescopes , bifocals etc.) opens a new source of knowledge for hypothesis formation. This process is also known as inductive reasoning or the use of specific observations to make generalisations. Discovery science is usually a complex process, and consequently does not follow a simple linear cause and effect pattern. This means that outcomes are uncertain, and it

3569-455: The EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing. The cultivation of GMOs has triggered a debate about the coexistence of GM and non-GM crops. Depending on the coexistence regulations, incentives for the cultivation of GM crops differ. The EUginius (European GMO Initiative for

3652-518: The antibiotic compound formed by the mold by Howard Florey , Ernst Boris Chain and Norman Heatley – to form what we today know as penicillin . In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced

3735-502: The application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms, such as pharmaceuticals, crops, and livestock . As per the European Federation of Biotechnology , biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services. Biotechnology

3818-442: The application of organisms and parts thereof for products and services. The term biotechnology was first used by Károly Ereky in 1919 to refer to the production of products from raw materials with the aid of living organisms. The core principle of biotechnology involves harnessing biological systems and organisms, such as bacteria, yeast , and plants, to perform specific tasks or produce valuable substances. Biotechnology had

3901-462: The broad definition of "utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise. Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution . Through early biotechnology, the earliest farmers selected and bred the best-suited crops (e.g., those with

3984-436: The broad population is essential for successfully implementing discovery-based science in the context of human brain function. Discovery-based methodologies are often viewed in contrast to traditional scientific practice, where hypotheses are formed before close examination of experimental data. However, from a philosophical perspective where all or most of the observable " low-hanging fruit " has already been plucked, examining

4067-509: The course of their PhD thesis work. Nineteen institutions offer NIGMS supported BTPs. Biotechnology training is also offered at the undergraduate level and in community colleges. But see also: Domingo, José L.; Bordonaba, Jordi Giné (2011). "A literature review on the safety assessment of genetically modified plants" (PDF) . Environment International . 37 (4): 734–742. Bibcode : 2011EnInt..37..734D . doi : 10.1016/j.envint.2011.01.003 . PMID   21296423 . Archived (PDF) from

4150-445: The current decades, significant progress has been done in creating genetically modified organisms (GMOs) that enhance the diversity of applications and economical viability of industrial biotechnology. By using renewable raw materials to produce a variety of chemicals and fuels, industrial biotechnology is actively advancing towards lowering greenhouse gas emissions and moving away from a petrochemical-based economy. Synthetic biology

4233-488: The difference between beneficial biotechnology (e.g., bioremediation is to clean up an oil spill or hazard chemical leak) versus the adverse effects stemming from biotechnological enterprises (e.g., flow of genetic material from transgenic organisms into wild strains) can be seen as applications and implications, respectively. Cleaning up environmental wastes is an example of an application of environmental biotechnology ; whereas loss of biodiversity or loss of containment of

SECTION 50

#1732868798746

4316-458: The discovery and manufacturing of traditional small molecule pharmaceutical drugs as well as drugs that are the product of biotechnology – biopharmaceutics . Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978 Genentech developed synthetic humanized insulin by joining its gene with

4399-562: The discovery of biochemical pathways which can identify targets for therapies, 2) developing new processes for manufacturing biological materials, 3) monitoring manufacturing processes for the purpose of quality control, and 4) developing diagnostic tests and efficacious treatment strategies for clinical diseases. In the context of proteomics, current life-science research remains technology-limited, however, recent available tools have assisted in evolving such research from being hypothesis-driven to discovery-driven. Field hydrology has experienced

4482-402: The early 2000s, BioFETs such as the DNA field-effect transistor (DNAFET), gene-modified FET (GenFET) and cell-potential BioFET (CPFET) had been developed. A factor influencing the biotechnology sector's success is improved intellectual property rights legislation—and enforcement—worldwide, as well as strengthened demand for medical and pharmaceutical products. Rising demand for biofuels

4565-607: The fact these organisms are subject to intellectual property law. Biotechnology has several applications in the realm of food security. Crops like Golden rice are engineered to have higher nutritional content, and there is potential for food products with longer shelf lives. Though not a form of agricultural biotechnology, vaccines can help prevent diseases found in animal agriculture. Additionally, agricultural biotechnology can expedite breeding processes in order to yield faster results and provide greater quantities of food. Transgenic biofortification in cereals has been considered as

4648-443: The field of biology . However, some of these required tools are limited in the sense that they are inaccessible or too costly because the related technology is still being developed. Data mining is the most common tool used in discovery science, and is applied to data from diverse fields of study such as DNA analysis , climate modelling , nuclear reaction modelling , and others. The use of data mining in discovery science follows

4731-468: The first biosensor in 1962. Biosensor MOSFETs were later developed, and they have since been widely used to measure physical , chemical , biological and environmental parameters. The first BioFET was the ion-sensitive field-effect transistor (ISFET), invented by Piet Bergveld in 1970. It is a special type of MOSFET, where the metal gate is replaced by an ion -sensitive membrane , electrolyte solution and reference electrode . The ISFET

4814-416: The first forms of biotechnology. These processes also were included in early fermentation of beer . These processes were introduced in early Mesopotamia , Egypt , China and India , and still use the same basic biological methods. In brewing , malted grains (containing enzymes ) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in

4897-428: The form of resting-state functional MRI (R-fMRI) . The potential of discovery science remains vast, e.g. 1) helping with decision-making and guiding clinical diagnoses by developing objective measures of brain functional integrity, 2) assessing the level of efficacy of treatment interventions, and 3) tracking responses to treatment. Among the scientific community, recruiting participation and achieving collaboration from

4980-417: The goal of directing scientific inquiry to convert genomic discovery to diagnostic and therapeutic targets. Another example of discovery science is proteomics, a technology-driven and technology limited discovery science. Technologies for proteomic analysis provide information that is useful in discovery science. Proteome analysis as a discovery science is applicable in biotechnology , e.g., it assists in 1)

5063-416: The grains broke down into alcohols, such as ethanol. Later, other cultures produced the process of lactic acid fermentation , which produced other preserved foods, such as soy sauce . Fermentation was also used in this time period to produce leavened bread . Although the process of fermentation was not fully understood until Louis Pasteur 's work in 1857, it is still the first use of biotechnology to convert

SECTION 60

#1732868798746

5146-478: The highest yields) to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize , restore nitrogen , and control pests . Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants — one of

5229-419: The human genome, the mapping of human brain function presents challenges to the functional neuroimaging community. For the first phase of discovery science, it is necessary to accumulate and share large-scale datasets for data mining. Traditionally, the neuroimaging community within psychology has focused on task-based and hypothesis-driven approaches, however, a powerful tool for discovery science has emerged in

5312-511: The lab for research and medical purposes, and fermentation , which is used to produce a wide range of products such as beer, wine, and cheese. The applications of biotechnology are diverse and have led to the development of essential products like life-saving drugs, biofuels , genetically modified crops, and innovative materials. It has also been used to address environmental challenges, such as developing biodegradable plastics and using microorganisms to clean up contaminated sites. Biotechnology

5395-715: The market, but in 2015 the FDA approved the first GM salmon for commercial production and consumption. There is a scientific consensus that currently available food derived from GM crops poses no greater risk to human health than conventional food, but that each GM food needs to be tested on a case-by-case basis before introduction. Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe. The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation. GM crops also provide

5478-810: The methods of genetic engineering . These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such as selective breeding and mutation breeding . Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed ripening tomato. To date most genetic modification of foods have primarily focused on cash crops in high demand by farmers such as soybean , corn , canola , and cotton seed oil . These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed; in November 2013 none were available on

5561-630: The model of ‘discovery science’ is a model which certain research fields are heading towards. For example, it is believed that more information about gene function can be discovered, through the evolution of data-mining tools. Discovery-based approaches are often referred to as “ big data ” approaches, because of the large-scale datasets that they involve analyses of. Big data includes large-scale homogenous study designs and highly variant datasets, and can be further divided into different kinds of datasets. For example, in neuropsychiatric studies, big data can be categorised as ‘broad’ or ‘deep’ data. Broad data

5644-531: The new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the United States Supreme Court ruled that a genetically modified microorganism could be patented in the case of Diamond v. Chakrabarty . Indian-born Ananda Chakrabarty , working for General Electric , had modified

5727-404: The original on October 9, 2022. In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as

5810-457: The production of a chemical known as 1,4-butanediol , which is used in fiber manufacturing. In order to produce 1,4-butanediol, the authors alter the metabolic regulation of the Escherichia coli by CRISPR to induce point mutation in the glt A gene, knockout of the sad gene, and knock-in six genes ( cat 1, suc D, 4hbd , cat 2, bld , and bdh ). Whereas CRISPRi system used to knockdown

5893-460: The production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops. In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917, Chaim Weizmann first used

5976-441: The products). The utilization of biological processes, organisms or systems to produce products that are anticipated to improve human lives is termed biotechnology. By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly ) for interfacing with and utilizing living things. Bioengineering

6059-422: The purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using

6142-467: The regulation of GMOs between countries, with some of the most marked differences occurring between the US and Europe. Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety. The European Union differentiates between approval for cultivation within

6225-518: The relevant field, it should be acknowledged that hypotheses can be generated by models . Additionally, deductive testing must involve field observation, so that imperfect answers can be substituted with questions that are more clearly defined. Hypothesis-driven studies can be transformed into discovery-driven studies with the help of newly available tools and technology-driven life science research. These tools have allowed for new questions to be asked, and new paradigms to be considered, particularly in

6308-404: The respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents

6391-534: The three competing genes ( gab D, ybg C, and tes B) that affect the biosynthesis pathway of 1,4-butanediol. Consequently, the yield of 1,4-butanediol significantly increased from 0.9 to 1.8 g/L. Environmental biotechnology includes various disciplines that play an essential role in reducing environmental waste and providing environmentally safe processes, such as biofiltration and biodegradation . The environment can be affected by biotechnologies, both positively and adversely. Vallero and others have argued that

6474-542: The time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder . As of 2011 several hundred genetic tests were in use. Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied by genetic counseling . Genetically modified crops ("GM crops", or "biotech crops") are plants used in agriculture ,

6557-530: The topic of concern, the success of these approaches depends on integrated analyses of the various types of relevant data, and the resultant insight provided. For example, when researching psychiatric dysfunction, it is important to integrate vast and complex data such as brain imaging, genomic data and behavioural data, to uncover any brain-behaviour connections that are relevant to psychiatric dysfunction. Therefore, there are challenges to integrating data and developing mining tools. Furthermore, validation of results

6640-565: The total company value of pharmaceutical biotech companies worldwide were active in Oncology with Neurology and Rare Diseases being the other two big applications. Pharmacogenomics (a combination of pharmacology and genomics ) is the technology that analyses how genetic makeup affects an individual's response to drugs. Researchers in the field investigate the influence of genetic variation on drug responses in patients by correlating gene expression or single-nucleotide polymorphisms with

6723-464: The use of geostatistics ; and discovering the importance of macropore flow and hydrological connectivity. Some discovery-based questions that have been asked in field hydrology include 1) determining which parts of the watershed are most important in determining water delivery to the channel, 2) how the presence of 'old' water can be explained by groundwater travelling into the stream, and 3) how there can be an explanation for flashy hydrographs when there

6806-409: The use of discovery-based big data approaches can allow for the generation of hypotheses and offer an analytical tool with high-throughput for pattern recognition and data mining. It is in this way that discovery-based approaches can provide insight into causes and mechanisms of the area of study. Although discovery-based and data-driven big data approaches can inform understanding of mechanisms behind

6889-507: The world's crop lands were planted with GM crops in 2010. As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the US, Brazil , Argentina , India , Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain. Genetically modified foods are foods produced from organisms that have had specific changes introduced into their DNA with

#745254