7-570: Crk may refer to: Adapter molecule crk CRK (disambiguation) Creek (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Crk . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Crk&oldid=1188128065 " Category : Disambiguation pages Hidden categories: Short description
14-520: Is a protein that in humans is encoded by the CRK gene . The CRK protein participates in the Reelin signaling cascade downstream of DAB1 . Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in
21-502: Is different from Wikidata All article disambiguation pages All disambiguation pages Adapter molecule crk 1JU5 , 2DVJ , 2EYV , 2EYW , 2EYX , 2EYY , 2EYZ , 2MS4 1398 12928 ENSG00000167193 ENSMUSG00000017776 P46108 Q64010 NM_016823 NM_005206 NM_001277219 NM_001277221 NM_133656 NP_005197 NP_058431 NP_001264148 NP_001264150 NP_598417 Adapter molecule crk also known as proto-oncogene c-Crk
28-590: Is encoded by the CRKL gene . v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with Crk participates in
35-423: Is involved in some of the same signaling pathways but is a protein tyrosine-kinase. CRK (gene) has been shown to interact with: CRKL 2BZX , 2BZY , 2EO3 , 2LQN , 2LQW 1399 12929 ENSG00000099942 ENSMUSG00000006134 P46109 P47941 NM_005207 NM_001277231 NM_007764 NP_005198 NP_001264160 NP_031790 Crk-like protein is a protein that in humans
42-551: The Reelin signaling cascade downstream of DAB1 . v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk. The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells. Crk should not be confused with Src , which also has cellular (c-Src) and viral (v-Src) forms and
49-470: The vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. Crk together with CrkL participates in
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