93-459: A carriage house , also called a remise or coach house , is a term used in North America to describe an outbuilding that was originally built to house horse -drawn carriages and their related tack . Carriage houses were often two stories, with related staff quarters above. In modern usage, the term "carriage house" has taken on several additional, somewhat overlapping meanings: Because of
186-658: A saddle or in a harness between the ages of two and four. They reach full adult development by age five, and have an average lifespan of between 25 and 30 years. Horse breeds are loosely divided into three categories based on general temperament: spirited "hot bloods" with speed and endurance; "cold bloods", such as draft horses and some ponies , suitable for slow, heavy work; and " warmbloods ", developed from crosses between hot bloods and cold bloods, often focusing on creating breeds for specific riding purposes, particularly in Europe. There are more than 300 breeds of horse in
279-412: A selective estrogen receptor modulator (SERM)-like profile of estrogenic activity in studies with monkeys, in which beneficial effects on bone and the cardiovascular system were observed but proliferative responses in breast or endometrium were not seen, although the clinical significance of this is unknown. CEEs consists of the sodium salts of the sulfate esters of equine estrogens in
372-454: A clear hierarchy of rank, led by a dominant individual, usually a mare. They are also social creatures that are able to form companionship attachments to their own species and to other animals, including humans. They communicate in various ways, including vocalizations such as nickering or whinnying, mutual grooming , and body language . Many horses will become difficult to manage if they are isolated, but with training, horses can learn to accept
465-551: A combination of estrogens , or agonists of the estrogen receptors . The major estrogen in CEEs, sodium estrone sulfate , itself is inactive, and rather serves as a prodrug of estrone and then of estradiol . The transformation of estrone sulfate to estrone is catalyzed by steroid sulfatase , and of estrone into estradiol by 17β-hydroxysteroid dehydrogenase . CEEs (as Premarin) and estrone have been found to be equivalent in potency in an animal model of estrogenic activity. On
558-428: A constant eye out for danger. Unlike humans, horses do not sleep in a solid, unbroken period of time, but take many short periods of rest. Horses spend four to fifteen hours a day in standing rest, and from a few minutes to several hours lying down. Total sleep time in a 24-hour period may range from several minutes to a couple of hours, mostly in short intervals of about 15 minutes each. The average sleep time of
651-467: A daily oral dosage of 1.25 mg achieves levels of 120–200 pg/mL and 40–60 pg/mL of estrone and estradiol, respectively. The oral ingestion of 10 mg CEEs, which contains about 4.5 mg sodium estrone sulfate and 2.5 mg sodium equilin sulfate, produces maximal plasma concentrations of estrone and equilin of 1,400 pg/mL and 560 pg/mL within three and five hours, respectively. By 24 hours post-dose of 10 mg,
744-665: A domestic horse is said to be 2.9 hours per day. Horses must lie down to reach REM sleep . They only have to lie down for an hour or two every few days to meet their minimum REM sleep requirements. However, if a horse is never allowed to lie down, after several days it will become sleep-deprived, and in rare cases may suddenly collapse because it slips, involuntarily, into REM sleep while still standing. This condition differs from narcolepsy , although horses may also suffer from that disorder. Premarin Conjugated estrogens ( CEs ), or conjugated equine estrogens ( CEEs ), sold under
837-473: A full 60 calendar months (five years) old. The horse skeleton averages 205 bones. A significant difference between the horse skeleton and that of a human is the lack of a collarbone —the horse's forelimbs are attached to the spinal column by a powerful set of muscles, tendons, and ligaments that attach the shoulder blade to the torso. The horse's four legs and hooves are also unique structures. Their leg bones are proportioned differently from those of
930-478: A good sense of balance and a strong fight-or-flight response . Related to this need to flee from predators in the wild is an unusual trait: horses are able to sleep both standing up and lying down, with younger horses tending to sleep significantly more than adults. Female horses, called mares , carry their young for approximately 11 months and a young horse, called a foal , can stand and run shortly following birth. Most domesticated horses begin training under
1023-630: A high level of intelligence that may or may not be used to cooperate with human handlers. Small size, by itself, is not an exclusive determinant. For example, the Shetland pony which averages 10 hands (40 inches, 102 cm), is considered a pony. Conversely, breeds such as the Falabella and other miniature horses , which can be no taller than 76 centimetres; 7.2 hands (30 in), are classified by their registries as very small horses, not ponies. Horses have 64 chromosomes . The horse genome
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#17328840640691116-439: A higher rate of gastric ulcers than horses listening to music, and racehorses stabled where a radio was played had a higher overall rate of ulceration than horses stabled where there was no radio playing. Horses have a great sense of balance, due partly to their ability to feel their footing and partly to highly developed proprioception —the unconscious sense of where the body and limbs are at all times. A horse's sense of touch
1209-413: A human as a companion, and thus be comfortable away from other horses. However, when confined with insufficient companionship, exercise, or stimulation, individuals may develop stable vices , an assortment of bad habits, mostly stereotypies of psychological origin, that include wood chewing, wall kicking, "weaving" (rocking back and forth), and other problems. Studies have indicated that horses perform
1302-420: A human. For example, the body part that is called a horse's "knee" is actually made up of the carpal bones that correspond to the human wrist . Similarly, the hock contains bones equivalent to those in the human ankle and heel . The lower leg bones of a horse correspond to the bones of the human hand or foot, and the fetlock (incorrectly called the "ankle") is actually the proximal sesamoid bones between
1395-526: A major component of grass, through the process of hindgut fermentation . Cellulose fermentation by symbiotic bacteria and other microbes occurs in the cecum and the large intestine . Horses cannot vomit , so digestion problems can quickly cause colic , a leading cause of death. Although horses do not have a gallbladder , they tolerate high amounts of fat in their diet. The horses' senses are based on their status as prey animals , where they must be aware of their surroundings at all times. The equine eye
1488-797: A number of cognitive tasks on a daily basis, meeting mental challenges that include food procurement and identification of individuals within a social system . They also have good spatial discrimination abilities. They are naturally curious and apt to investigate things they have not seen before. Studies have assessed equine intelligence in areas such as problem solving , speed of learning, and memory . Horses excel at simple learning, but also are able to use more advanced cognitive abilities that involve categorization and concept learning . They can learn using habituation , desensitization , classical conditioning , and operant conditioning , and positive and negative reinforcement . One study has indicated that horses can differentiate between "more or less" if
1581-589: A precocial species, and foals are capable of standing and running within a short time following birth. Foals are usually born in the spring. The estrous cycle of a mare occurs roughly every 19–22 days and occurs from early spring into autumn. Most mares enter an anestrus period during the winter and thus do not cycle in this period. Foals are generally weaned from their mothers between four and six months of age. Horses, particularly colts, are sometimes physically capable of reproduction at about 18 months, but domesticated horses are rarely allowed to breed before
1674-477: A predominantly white hair coat and pink skin, a fairly rare occurrence. Different and unrelated genetic factors can produce white coat colors in horses, including several different alleles of dominant white and the sabino-1 gene . However, there are no " albino " horses, defined as having both pink skin and red eyes. Gestation lasts approximately 340 days, with an average range 320–370 days, and usually results in one foal ; twins are rare. Horses are
1767-482: A progestin may increase the risk of strokes , heart attacks , blood clots , and breast cancer. Following these results, Wyeth experienced a significant decline in its sales of Premarin, Prempro (CEEs and medroxyprogesterone acetate ), and related products, from over $ 2 billion in 2002 to just over $ 1 billion in 2006. This drug has been the subject of litigation; more than 13,000 people have sued Wyeth between 2002 and 2009. Wyeth and Pharmacia & Upjohn prevailed in
1860-753: A significantly greater risk of thromboembolic and cardiovascular complications than oral estradiol ( OR Tooltip Odds ratio = 2.08) and oral esterified estrogens ( OR Tooltip Odds ratio = 1.78). However, in another study, the increase in venous thromboembolism risk with oral CEEs plus medroxyprogesterone acetate and oral estradiol plus norethisterone acetate was found to be equivalent ( RR Tooltip Relative risk = 4.0 and 3.9, respectively). As of present, there are no randomized controlled trials that would allow for unambiguous conclusions. Estrogens, including CEEs, are relatively safe in acute overdose . Inhibitors and inducers of cytochrome P450 enzymes may interact with CEEs. CEEs are
1953-411: A specific and consistent composition (see the table). The major estrogens in CEEs are sodium estrone sulfate and sodium equilin sulfate , which together account for approximately 71.5–92.0% of the total content of CEEs. CEEs are prodrugs of the active forms of the estrogens. Sodium estrone sulfate is a prodrug of estrone , which in turn is a prodrug of estradiol , while sodium equilin sulfate
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#17328840640692046-649: A trial in Philadelphia, was awarded $ 1.5 million in compensatory damages as well as undisclosed punitive damages. As of 2010, Wyeth had won the last four of five cases, most recently in Virginia, finding that they were not responsible for the breast cancer of plaintiff Georgia Torkie-Tork. Wyeth has been quoted as saying "many risk factors associated with breast cancer have been identified, but science cannot establish what role any particular risk factor or combination play in any individual woman's breast cancer." Wyeth's counsel in
2139-451: Is a domesticated , one-toed , hoofed mammal . It belongs to the taxonomic family Equidae and is one of two extant subspecies of Equus ferus . The horse has evolved over the past 45 to 55 million years from a small multi-toed creature, Eohippus , into the large, single-toed animal of today. Humans began domesticating horses around 4000 BCE , and their domestication is believed to have been widespread by 3000 BCE. Horses in
2232-548: Is a prodrug of equilin and then of 17β-dihydroequilin. As such, the major active estrogens with CEEs are estradiol and 17β-dihydroequilin, which have potent estrogenic activity and account for most of the effects of CEEs. The 17α-estrogens in CEEs such as 17α-estradiol and 17α-dihydroequilin have low estrogenicity and are thought to contribute minimally to its effects. There are many different steroids in natural CEE products like Premarin, as many as 230 compounds and including even androgens and progestogens , but only
2325-505: Is adequate healthy food. All horses move naturally with four basic gaits : Besides these basic gaits, some horses perform a two-beat pace , instead of the trot. There also are several four-beat ' ambling ' gaits that are approximately the speed of a trot or pace, though smoother to ride. These include the lateral rack , running walk , and tölt as well as the diagonal fox trot . Ambling gaits are often genetic in some breeds, known collectively as gaited horses . These horses replace
2418-416: Is in the nostrils and nasal cavity, which analyze a wide range of odors. The second, located under the nasal cavity, are the vomeronasal organs , also called Jacobson's organs. These have a separate nerve pathway to the brain and appear to primarily analyze pheromones . A horse's hearing is good, and the pinna of each ear can rotate up to 180°, giving the potential for 360° hearing without having to move
2511-410: Is measured at the highest point of the withers , where the neck meets the back . This point is used because it is a stable point of the anatomy, unlike the head or neck, which move up and down in relation to the body of the horse. In English-speaking countries, the height of horses is often stated in units of hands and inches: one hand is equal to 4 inches (101.6 mm). The height is expressed as
2604-417: Is one of the largest of any land mammal. Horses are lateral-eyed, meaning that their eyes are positioned on the sides of their heads. This means that horses have a range of vision of more than 350°, with approximately 65° of this being binocular vision and the remaining 285° monocular vision . Horses have excellent day and night vision , but they have two-color, or dichromatic vision ; their color vision
2697-426: Is somewhat like red-green color blindness in humans, where certain colors, especially red and related colors, appear as a shade of green. Their sense of smell , while much better than that of humans, is not quite as good as that of a dog. It is believed to play a key role in the social interactions of horses as well as detecting other key scents in the environment. Horses have two olfactory centers. The first system
2790-467: Is summed up by the traditional adage, "no foot, no horse". The horse hoof begins with the distal phalanges , the equivalent of the human fingertip or tip of the toe, surrounded by cartilage and other specialized, blood-rich soft tissues such as the laminae . The exterior hoof wall and horn of the sole is made of keratin , the same material as a human fingernail . The result is that a horse, weighing on average 500 kilograms (1,100 lb), travels on
2883-441: Is the generic name of the drug and its USP Tooltip United States Pharmacopeia and JAN Tooltip Japanese Accepted Name . It is also known as conjugated estrogens or as conjugated equine estrogens . The brand name Premarin is a contraction of " pre gnant mar es' ur in e". CEEs are marketed under a large number of brand names throughout the world. The major brand name of the natural form of CEEs manufactured from
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2976-414: Is unknown. The active forms are metabolized primarily in the liver. There is some enterohepatic recirculation of CEEs. Following a single oral dose of 0.625 CEEs, the biological half-life of estrone was 26.7 hours, of baseline-adjusted estrone was 14.8 hours, and of equilin was 11.4 hours. CEEs are naturally occurring estrane steroids . They are in conjugate form, as
3069-598: Is usually considered to be a horse and one less than 14.2 hands (58 inches, 147 cm) a pony, but there are many exceptions to the traditional standard. In Australia, ponies are considered to be those under 14 hands (56 inches, 142 cm). For competition in the Western division of the United States Equestrian Federation , the cutoff is 14.1 hands (57 inches, 145 cm). The International Federation for Equestrian Sports ,
3162-520: Is well-developed. The most sensitive areas are around the eyes, ears, and nose. Horses are able to sense contact as subtle as an insect landing anywhere on the body. Horses have an advanced sense of taste, which allows them to sort through fodder and choose what they would most like to eat, and their prehensile lips can easily sort even small grains. Horses generally will not eat poisonous plants, however, there are exceptions; horses will occasionally eat toxic amounts of poisonous plants even when there
3255-484: The Morgan horse . Horses are able to sleep both standing up and lying down. In an adaptation from life in the wild, horses are able to enter light sleep by using a " stay apparatus " in their legs, allowing them to doze without collapsing. Horses sleep better when in groups because some animals will sleep while others stand guard to watch for predators. A horse kept alone will not sleep well because its instincts are to keep
3348-472: The Trakehner or Hanoverian , developed when European carriage and war horses were crossed with Arabians or Thoroughbreds, producing a riding horse with more refinement than a draft horse, but greater size and milder temperament than a lighter breed. Certain pony breeds with warmblood characteristics have been developed for smaller riders. Warmbloods are considered a "light horse" or "riding horse". Today,
3441-722: The United Kingdom and Ireland , Premia in Australia and New Zealand , and Premelle in South Africa . Prempak-C is a combination of CEEs and norgestrel which is used in the United Kingdom and Ireland, and Prempak N is a combination of CEEs and medrogestone which is used in South Africa. Many of the aforementioned brand names are also used in other, non-English-speaking countries. CEEs are marketed and available widely throughout
3534-534: The United States and Canada for the treatment of moderate to severe vasomotor symptoms (hot flashes) and vulvovaginal atrophy (atrophic vaginitis, atrophic urethritis) associated with menopause , hypoestrogenism due to hypogonadism , ovariectomy , or primary ovarian failure , abnormal uterine bleeding , the palliative treatment of metastatic breast cancer in women, the palliative treatment of advanced androgen-dependent prostate cancer in men, and
3627-406: The cannon bones (a single equivalent to the human metacarpal or metatarsal bones ) and the proximal phalanges , located where one finds the "knuckles" of a human. A horse also has no muscles in its legs below the knees and hocks, only skin, hair, bone, tendons , ligaments , cartilage , and the assorted specialized tissues that make up the hoof . The critical importance of the feet and legs
3720-460: The gene controlled by the Melanocortin 1 receptor , also known as the "extension gene" or "red factor". Its recessive form is "red" (chestnut) and its dominant form is black. Additional genes control suppression of black color to point coloration that results in a bay , spotting patterns such as pinto or leopard , dilution genes such as palomino or dun , as well as greying , and all
3813-445: The intestines during first-pass metabolism upon oral administration . Following their absorption , they are resulfated mainly in the liver also during the first pass. Following this, they serve as a circulating reservoir and are slowly rehydrolyzed into their unconjugated active forms. Oral CEEs, at a daily dosage of 0.625 mg, achieve estrone and estradiol levels of 150 pg/mL and 30–50 pg/mL, respectively, while
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3906-525: The sodium salts of the C17β sulfate esters . The estrogens in CEEs, in their unconjugated active forms, include bioidentical human estrogens like estradiol and estrone as well as equine-specific estrogens such as equilin and 17β-dihydroequilin . The equine estrogens differ from human estrogens in that they have additional double bonds in the B ring of the steroid nucleus . CEEs contain both 17β-estrogens like estradiol and 17β-dihydroequilin and
3999-577: The "cold-bloods", such as most draft breeds , are quieter and calmer. Sometimes "hot-bloods" are classified as "light horses" or "riding horses", with the "cold-bloods" classified as "draft horses" or "work horses". "Hot blooded" breeds include " oriental horses " such as the Akhal-Teke , Arabian horse , Barb , and now-extinct Turkoman horse , as well as the Thoroughbred , a breed developed in England from
4092-568: The 1962 Kefauver Harris Amendment the FDA had its efficacy reviewed, and in 1972 found it effective for menopausal symptoms and probably effective for osteoporosis. The review also determined that two estrogens – estrone sulfate and equilin sulfate – were primarily responsible for the activity of Premarin, and it laid the groundwork for Abbreviated New Drug Application (ANDA) submissions of generic versions. In 1984 an NIH consensus panel found that estrogens were effective for preventing osteoporosis and 1986
4185-565: The C17α epimers like 17α-estradiol and 17α-dihydroequilin . Conjugated estriol , an extract of the urine of pregnant women and sold under the brand names Progynon and Emmenin in the 1930s, was the predecessor of Premarin. Both of these products contained conjugated estrogens similarly to Premarin, but the estrogens were human estrogens as opposed to equine estrogens and the composition differed. The major active ingredient in Progynon and Emmenin
4278-717: The FDA announced in the Federal Register that Premarin was effective for preventing osteoporosis. This announcement led to a rapid growth in sales, and interest from generic manufacturers to introduce generic versions. Conjugated estrogens was introduced for medical use under the brand name Premarin in Canada in 1941, in the United States in 1942, and in the United Kingdom in 1956. The manufacturer of Premarin secretly paid gynecologist Robert A. Wilson to promote its use by menopausal women in his 1966 book, Feminine Forever , leading to increased sales. Estrogens, conjugated
4371-624: The Southern Hemisphere. The exception is in endurance riding , where the minimum age to compete is based on the animal's actual calendar age. The following terminology is used to describe horses of various ages: In horse racing , these definitions may differ: For example, in the British Isles, Thoroughbred horse racing defines colts and fillies as less than five years old. However, Australian Thoroughbred racing defines colts and fillies as less than four years old. The height of horses
4464-477: The United States, with more than 1 million prescriptions. CEEs are a form of hormone therapy used in women. It is used most commonly in postmenopausal women who have had a hysterectomy to treat hot flashes , and burning, itching, and dryness of the vagina and surrounding areas. It must be used in combination with a progestogen in women who have not had a hysterectomy . For women already taking
4557-473: The United States. However, it has begun to fall out of favor relative to bioidentical estradiol , which is the most widely used form of estrogen in Europe for menopausal hormone therapy. CEEs are available widely throughout the world. An estrogen preparation very similar to CEEs but differing in source and composition is esterified estrogens . In 2020, it was the 283rd most commonly prescribed medication in
4650-456: The age of three, especially females. Horses four years old are considered mature, although the skeleton normally continues to develop until the age of six; maturation also depends on the horse's size, breed, sex, and quality of care. Larger horses have larger bones; therefore, not only do the bones take longer to form bone tissue , but the epiphyseal plates are larger and take longer to convert from cartilage to bone. These plates convert after
4743-442: The brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. It is a mixture of the sodium salts of estrogen conjugates found in horses , such as estrone sulfate and equilin sulfate . CEEs are available in the form of both natural preparations manufactured from the urine of pregnant mares and fully synthetic replications of
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#17328840640694836-727: The calm, patient temperament needed to pull a plow or a heavy carriage full of people. They are sometimes nicknamed "gentle giants". Well-known draft breeds include the Belgian and the Clydesdale . Some, like the Percheron , are lighter and livelier, developed to pull carriages or to plow large fields in drier climates. Others, such as the Shire , are slower and more powerful, bred to plow fields with heavy, clay-based soils. The cold-blooded group also includes some pony breeds. " Warmblood " breeds, such as
4929-531: The case also noted that in the WHI trial, 99.62% of women took the drug and "did not get breast cancer". Animal welfare groups claim that animal husbandry and urine collection methods used in the production of CEEs cause undue stress and suffering to the mares involved. Animal activists have made claims of abuses ranging from inadequate stall size, long periods of confinement, cumbersome urine collection, and continuous breeding cycles. After reaching advanced age, many of
5022-469: The day. Therefore, compared to humans, they have a relatively small stomach but very long intestines to facilitate a steady flow of nutrients. A 450-kilogram (990 lb) horse will eat 7 to 11 kilograms (15 to 24 lb) of food per day and, under normal use, drink 38 to 45 litres (8.4 to 9.9 imp gal; 10 to 12 US gal) of water . Horses are not ruminants , having only one stomach, like humans. But unlike humans, they can digest cellulose ,
5115-471: The effects of CEEs, which may be significantly more potent in comparison to estrone. The pharmacokinetics of vaginal CEEs and of intravenous CEEs have been studied as well. Eoncentrations of equilin that are very high relative to those of other estrogens are produced by typical clinical doses of CEEs. With a dosage of 1.25 mg oral CEEs, equilin levels of 1,082 to 2,465 pg/mL have been observed. The clinical significance of these levels of equilin
5208-635: The estrogens are present in sufficient amounts to produce clinically-relevant effects. A dosage of 0.625 mg/day oral CEEs has been found to increase SHBG levels by 100%. For comparison, 1 mg/day oral estradiol increased SHBG levels by 45%, while 50 μg/day transdermal estradiol increased SHBG levels by 12%. Ethinylestradiol is more potent in its effects on liver protein synthesis than either CEEs or estradiol, with 10 μg/day oral ethinylestradiol having been found to be approximately equivalent to 1.25 mg/day CEEs. A preliminary study of ovulation inhibition in women found that oral CEEs
5301-433: The form of oral tablets (0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, or 1.25 mg) and creams for topical or vaginal administration (0.625 mg/g). Contraindications of CEEs include breast cancer and a history of venous thromboembolism , among others. The most common side effects associated with CEEs are vaginal yeast infections , vaginal spotting or bleeding , painful menses , and cramping of
5394-401: The front of the mouth, adapted to biting off the grass or other vegetation. There are 24 teeth adapted for chewing, the premolars and molars , at the back of the mouth. Stallions and geldings have four additional teeth just behind the incisors, a type of canine teeth called "tushes". Some horses, both male and female, will also develop one to four very small vestigial teeth in front of
5487-504: The head. Noise affects the behavior of horses and certain kinds of noise may contribute to stress—a 2013 study in the UK indicated that stabled horses were calmest in a quiet setting, or if listening to country or classical music, but displayed signs of nervousness when listening to jazz or rock music. This study also recommended keeping music under a volume of 21 decibels . An Australian study found that stabled racehorses listening to talk radio had
5580-437: The incisors show changes as the horse ages; they develop a distinct wear pattern, changes in tooth shape, and changes in the angle at which the chewing surfaces meet. This allows a very rough estimate of a horse's age, although diet and veterinary care can also affect the rate of tooth wear. Horses are herbivores with a digestive system adapted to a forage diet of grasses and other plant material, consumed steadily throughout
5673-437: The legs. While there are some contradictory data, estrogen alone does not appear to increase the risk of coronary heart disease or breast cancer, unlike the case of estrogen in combination with certain progestins such as levonorgestrel or medroxyprogesterone acetate . Only a few clinical studies have assessed differences between oral CEEs and oral estradiol in terms of health parameters. Oral CEEs have been found to possess
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#17328840640695766-494: The levels of estrone and equilin fall to 280 pg/mL and 125 pg/mL, respectively. Oral CEEs 1.25 mg/daily and oral micronized estradiol 1 mg/daily result in similar plasma concentrations of estrone and estradiol (150–300 pg/mL and 30–50 pg/mL for micronized estradiol, respectively) (oral estradiol is extensively metabolized into estrone during hepatic first-pass metabolism ), although this does not account for equilin and other equine estrogens involved in
5859-440: The medication shows relatively increased effects in certain parts of the body like the liver . This results in an increased risk of blood clots and cardiovascular problems with CEEs relative to estradiol. Premarin, the major brand of CEEs in use, is manufactured by Pfizer and was first marketed in 1941 in Canada and in 1942 in the United States . It is the most commonly used form of estrogen in menopausal hormone therapy in
5952-453: The medication, it can be used to treat osteoporosis , although it is not recommended solely for this use. Some lesser known uses are as a means of high-dose estrogen therapy in the treatment of breast cancer in both women and men and in the treatment of prostate cancer in men. It has been used at a dosage of 2.5 mg three times per day (7.5 mg/day total) for prostate cancer. CEEs are specifically approved in countries such as
6045-435: The molars, known as "wolf" teeth, which are generally removed because they can interfere with the bit . There is an empty interdental space between the incisors and the molars where the bit rests directly on the gums, or "bars" of the horse's mouth when the horse is bridled . An estimate of a horse's age can be made from looking at its teeth. The teeth continue to erupt throughout life and are worn down by grazing. Therefore,
6138-447: The natural preparations. They are formulated both alone and in combination with progestins such as medroxyprogesterone acetate . CEEs are usually taken by mouth , but can also be given by application to the skin or vagina as a cream or by injection into a blood vessel or muscle . Side effects of CEEs include breast tenderness and enlargement , headache , fluid retention , and nausea among others. It may increase
6231-1030: The number of full hands, followed by a point , then the number of additional inches, and ending with the abbreviation "h" or "hh" (for "hands high"). Thus, a horse described as "15.2 h" is 15 hands plus 2 inches, for a total of 62 inches (157.5 cm) in height. The size of horses varies by breed, but also is influenced by nutrition . Light-riding horses usually range in height from 14 to 16 hands (56 to 64 inches, 142 to 163 cm) and can weigh from 380 to 550 kilograms (840 to 1,210 lb). Larger-riding horses usually start at about 15.2 hands (62 inches, 157 cm) and often are as tall as 17 hands (68 inches, 173 cm), weighing from 500 to 600 kilograms (1,100 to 1,320 lb). Heavy or draft horses are usually at least 16 hands (64 inches, 163 cm) high and can be as tall as 18 hands (72 inches, 183 cm) high. They can weigh from about 700 to 1,000 kilograms (1,540 to 2,200 lb). The largest horse in recorded history
6324-549: The older oriental breeds. Hot bloods tend to be spirited, bold, and learn quickly. They are bred for agility and speed. They tend to be physically refined—thin-skinned, slim, and long-legged. The original oriental breeds were brought to Europe from the Middle East and North Africa when European breeders wished to infuse these traits into racing and light cavalry horses. Muscular, heavy draft horses are known as "cold bloods." They are bred not only for strength, but also to have
6417-435: The other factors that create the many possible coat colors found in horses. Horses that have a white coat color are often mislabeled; a horse that looks "white" is usually a middle-aged or older gray . Grays are born a darker shade, get lighter as they age, but usually keep black skin underneath their white hair coat (with the exception of pink skin under white markings ). The only horses properly called white are born with
6510-488: The other hand, the active forms of the equine estrogens in CEEs, such as equilin and 17β-dihydroequilin , have greater potency in the liver relative to bioidentical estradiol , similarly to synthetic estrogens like ethinylestradiol and diethylstilbestrol . This results in disproportionate effects on liver protein production compared to estradiol, although to a lesser extent than ethinylestradiol and diethylstilbestrol. In addition, 17β-dihydroequilenin has shown
6603-605: The other parts of the bones, and are crucial to development. Depending on maturity, breed, and work expected, horses are usually put under saddle and trained to be ridden between the ages of two and four. Although Thoroughbred race horses are put on the track as young as the age of two in some countries, horses specifically bred for sports such as dressage are generally not put under saddle until they are three or four years old, because their bones and muscles are not solidly developed. For endurance riding competition, horses are not deemed mature enough to compete until they are
6696-531: The prestigious nature of some large, elaborate carriage houses, the term "carriage house" is commonly used as part of the name of businesses such as antique shops and restaurants. Sometimes these businesses are housed in former carriage houses. Property developers are now including coach houses in their portfolios. The unique architectural features and integrated space for potential car parking make it an attractive offering to many clients. Horse at least 48 published The horse ( Equus ferus caballus )
6789-623: The prevention of postmenopausal osteoporosis . The intravenous formulation of CEEs is specifically used to rapidly limit bleeding in women with hemorrhage due to dysfunctional uterine bleeding . Natural CEEs, as Premarin, are available in the form of oral tablets (0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, or 2.5 mg), creams for topical or vaginal administration (0.625 mg/g), and vials for intravenous or intramuscular injection (25 mg/vial). Synthetic CEEs, such as Cenestin (Synthetic A), Enjuvia (Synthetic B), and generic formulations, are available in
6882-570: The quantity involved is less than four. Domesticated horses may face greater mental challenges than wild horses, because they live in artificial environments that prevent instinctive behavior whilst also learning tasks that are not natural. Horses are animals of habit that respond well to regimentation, and respond best when the same routines and techniques are used consistently. One trainer believes that "intelligent" horses are reflections of intelligent trainers who effectively use response conditioning techniques and positive reinforcement to train in
6975-522: The risk of endometrial hyperplasia and endometrial cancer in women with an intact uterus if it is not taken together with a progestogen like progesterone . The medication may also increase the risk of blood clots , cardiovascular disease , and, when combined with most progestogens, breast cancer . CEEs are estrogens, or agonists of the estrogen receptor , the biological target of estrogens like estradiol . Compared to estradiol, certain estrogens in CEEs are more resistant to metabolism, and
7068-496: The same animals as horses. The distinction between a horse and pony is commonly drawn on the basis of height, especially for competition purposes. However, height alone is not dispositive; the difference between horses and ponies may also include aspects of phenotype , including conformation and temperament. The traditional standard for height of a horse or a pony at maturity is 14.2 hands (58 inches, 147 cm). An animal 14.2 hands (58 inches, 147 cm) or over
7161-507: The same bones as would a human on tiptoe. For the protection of the hoof under certain conditions, some horses have horseshoes placed on their feet by a professional farrier . The hoof continually grows, and in most domesticated horses needs to be trimmed (and horseshoes reset, if used) every five to eight weeks, though the hooves of horses in the wild wear down and regrow at a rate suitable for their terrain. Horses are adapted to grazing . In an adult horse, there are 12 incisors at
7254-472: The same color may be distinguished from one another by white markings , which, along with various spotting patterns, are inherited separately from coat color. Many genes that create horse coat colors and patterns have been identified. Current genetic tests can identify at least 13 different alleles influencing coat color, and research continues to discover new genes linked to specific traits. The basic coat colors of chestnut and black are determined by
7347-470: The style that best fits with an individual animal's natural inclinations. Horses are mammals . As such, they are warm-blooded , or endothermic creatures, as opposed to cold-blooded, or poikilothermic animals. However, these words have developed a separate meaning in the context of equine terminology, used to describe temperament, not body temperature . For example, the " hot-bloods ", such as many race horses , exhibit more sensitivity and energy, while
7440-513: The subspecies caballus are domesticated, although some domesticated populations live in the wild as feral horses . These feral populations are not true wild horses , which are horses that never have been domesticated. There is an extensive, specialized vocabulary used to describe equine-related concepts, covering everything from anatomy to life stages, size, colors , markings , breeds , locomotion , and behavior. Horses are adapted to run , allowing them to quickly escape predators, and possess
7533-544: The term "Warmblood" refers to a specific subset of sport horse breeds that are used for competition in dressage and show jumping . Strictly speaking, the term " warm blood " refers to any cross between cold-blooded and hot-blooded breeds. Examples include breeds such as the Irish Draught or the Cleveland Bay . The term was once used to refer to breeds of light riding horse other than Thoroughbreds or Arabians, such as
7626-788: The trot with one of the ambling gaits. Horses are prey animals with a strong fight-or-flight response . Their first reaction to a threat is to startle and usually flee, although they will stand their ground and defend themselves when flight is impossible or if their young are threatened. They also tend to be curious; when startled, they will often hesitate an instant to ascertain the cause of their fright, and may not always flee from something that they perceive as non-threatening. Most light horse riding breeds were developed for speed, agility, alertness and endurance; natural qualities that extend from their wild ancestors. However, through selective breeding, some breeds of horses are quite docile, particularly certain draft horses. Horses are herd animals , with
7719-401: The urine of pregnant mares . Humans provide domesticated horses with food, water, and shelter, as well as attention from specialists such as veterinarians and farriers . Depending on breed, management and environment, the modern domestic horse has a life expectancy of 25 to 30 years. Uncommonly, a few animals live into their 40s and, occasionally, beyond. The oldest verifiable record
7812-453: The urine of pregnant mares is Premarin. Major brand names of fully synthetic versions of CEEs include Cenestin and Enjuvia in the United States and C.E.S. and Congest in Canada . CEEs are also formulated in combination with progestins. Major brand names of CEEs in combination with medroxyprogesterone acetate include Prempro and Premphase in the United States, Premplus in Canada, Premique in
7905-477: The vast majority of hormone therapy cases previously set for trial through a combination of rulings by judges, verdicts by juries, and dismissals by plaintiffs themselves. Of the company's losses, two of the jury verdicts were reversed post-trial and others are being challenged on appeal. Wyeth also won five summary judgments on Prempro cases and had 15 cases voluntarily dismissed by plaintiffs. The company won dismissals in another 3,000 cases. In 2006, Mary Daniel, in
7998-1085: The world governing body for horse sport, uses metric measurements and defines a pony as being any horse measuring less than 148 centimetres (58.27 in) at the withers without shoes, which is just over 14.2 hands (58 inches, 147 cm), and 149 centimetres (58.66 in; 14. 2 + 1 ⁄ 2 hands), with shoes. Height is not the sole criterion for distinguishing horses from ponies. Breed registries for horses that typically produce individuals both under and over 14.2 hands (58 inches, 147 cm) consider all animals of that breed to be horses regardless of their height. Conversely, some pony breeds may have features in common with horses, and individual animals may occasionally mature at over 14.2 hands (58 inches, 147 cm), but are still considered to be ponies. Ponies often exhibit thicker manes, tails, and overall coat. They also have proportionally shorter legs, wider barrels, heavier bone, shorter and thicker necks, and short heads with broad foreheads. They may have calmer temperaments than horses and also
8091-569: The world today, developed for many different uses. Horses and humans interact in a wide variety of sport competitions and non-competitive recreational pursuits as well as in working activities such as police work , agriculture , entertainment, and therapy . Horses were historically used in warfare, from which a wide variety of riding and driving techniques developed, using many different styles of equipment and methods of control. Many products are derived from horses, including meat , milk , hide , hair , bone, and pharmaceuticals extracted from
8184-699: The world. This includes in all English-speaking countries, throughout the European Union, Latin America, Asia, and elsewhere in the world. Research starting in 1975 showed substantially increased risk of endometrial cancer . Since 1976, the drug has carried a label warning about the risk. As part of the Women's Health Initiative sponsored by the National Institutes of Health , a large-scale clinical trial of menopausal HRT showed that long-term use of estrogen and
8277-461: Was estriol glucuronide . Estrone sulfate was first isolated from the urine of pregnant mares in the late 1930s by researchers in the Department of Biochemistry at University of Toronto . Premarin was first introduced in 1941 by Wyeth Ayerst as a treatment for hot flashes and other symptoms of menopause; at that time, Wyeth Ayerst only had to prove its safety, and not its efficacy. In response to
8370-408: Was sequenced in 2007. It contains 2.7 billion DNA base pairs , which is larger than the dog genome , but smaller than the human genome or the bovine genome . The map is available to researchers. Horses exhibit a diverse array of coat colors and distinctive markings , described by a specialized vocabulary. Often, a horse is classified first by its coat color, before breed or sex. Horses of
8463-531: Was " Old Billy ", a 19th-century horse that lived to the age of 62. In modern times, Sugar Puff, who had been listed in Guinness World Records as the world's oldest living pony, died in 2007 at age 56. Regardless of a horse or pony's actual birth date, for most competition purposes a year is added to its age each January 1 of each year in the Northern Hemisphere and each August 1 in
8556-458: Was 33% effective at 1.25 mg/day and 94% at 3.75 mg/day. A dosage of oral CEEs of 2.5 mg three times daily (7.5 mg/day total) has been found to suppress total testosterone levels in men to an equivalent extent as 3 mg/day oral diethylstilbestrol , which is the minimum dosage of diethylstilbestrol required to consistently suppress total testosterone levels into the castrate range (<50 ng/dL). CEEs are hydrolyzed in
8649-451: Was probably a Shire horse named Mammoth , who was born in 1848. He stood 21.2 ⁄ 4 hands (86.25 inches, 219 cm) high and his peak weight was estimated at 1,524 kilograms (3,360 lb). The record holder for the smallest horse ever is Thumbelina , a fully mature miniature horse affected by dwarfism . She was 43 centimetres; 4.1 hands (17 in) tall and weighed 26 kg (57 lb). Ponies are taxonomically
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