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70-427: Étienne-Jules Marey ( French: [etjɛn ʒyl maʁɛ] ; 5 March 1830, Beaune , Côte-d'Or – 15 May 1904, Paris) was a French scientist, physiologist and chronophotographer . His work was significant in the development of cardiology , physical instrumentation, aviation, cinematography and the science of laboratory photography. He is widely considered to be a pioneer of photography and an influential pioneer of

140-484: A Progressive Party member and, later, a Republican Party member of the U.S. House of Representatives from the State of New York . Beaune is twinned with: Blood pressure Blood pressure is one of the vital signs —together with respiratory rate , heart rate , oxygen saturation , and body temperature —that healthcare professionals use in evaluating a patient's health. Normal resting blood pressure in an adult

210-491: A hypertensive emergency when blood pressure is more than 180/120 mmHg. Levels of arterial pressure put mechanical stress on the arterial walls. Higher pressures increase heart workload and progression of unhealthy tissue growth ( atheroma ) that develops within the walls of arteries. The higher the pressure, the more stress that is present and the more atheroma tend to progress and the heart muscle tends to thicken, enlarge and become weaker over time. Persistent hypertension

280-542: A standard deviation of less than 8 mm Hg. Most of these semi-automated methods measure blood pressure using oscillometry (measurement by a pressure transducer in the cuff of the device of small oscillations of intra-cuff pressure accompanying heartbeat-induced changes in the volume of each pulse). Blood pressure is influenced by cardiac output , systemic vascular resistance , blood volume and arterial stiffness , and varies depending on person's situation, emotional state, activity and relative health or disease state. In

350-762: A 10 mmHg increase in pulse pressure was associated with a 20% increased risk of cardiovascular mortality, and a 13% increase in risk for all coronary end points. The study authors also noted that, while risks of cardiovascular end points do increase with higher systolic pressures, at any given systolic blood pressure the risk of major cardiovascular end points increases, rather than decreases, with lower diastolic levels. This suggests that interventions that lower diastolic pressure without also lowering systolic pressure (and thus lowering pulse pressure) could actually be counterproductive. There are no drugs currently approved to lower pulse pressure, although some antihypertensive drugs may modestly lower pulse pressure, while in some cases

420-549: A 24-hour period). The risk of cardiovascular disease increases progressively above 90 mmHg, especially among women. Observational studies demonstrate that people who maintain arterial pressures at the low end of these pressure ranges have much better long-term cardiovascular health. There is an ongoing medical debate over what is the optimal level of blood pressure to target when using drugs to lower blood pressure with hypertension, particularly in older people. Blood pressure fluctuates from minute to minute and normally shows

490-750: A circadian rhythm over a 24-hour period, with highest readings in the early morning and evenings and lowest readings at night. Loss of the normal fall in blood pressure at night is associated with a greater future risk of cardiovascular disease and there is evidence that night-time blood pressure is a stronger predictor of cardiovascular events than day-time blood pressure. Blood pressure varies over longer time periods (months to years) and this variability predicts adverse outcomes. Blood pressure also changes in response to temperature, noise, emotional stress , consumption of food or liquid, dietary factors, physical activity, changes in posture (such as standing-up ), drugs , and disease. The variability in blood pressure and

560-469: A decrease in excessive diastolic pressure can actually increase risk, probably due to the increased difference between systolic and diastolic pressures (ie. widened pulse pressure). If systolic blood pressure is elevated (>140 mmHg) with a normal diastolic blood pressure (<90 mmHg), it is called isolated systolic hypertension and may present a health concern. According to the 2017 American Heart Association blood pressure guidelines state that

630-414: A drug that lowers overall blood pressure may actually have the counterproductive side effect of raising pulse pressure. Pulse pressure can both widen or narrow in people with sepsis depending on the degree of hemodynamic compromise. A pulse pressure of over 70 mmHg in sepsis is correlated with an increased chance of survival and a more positive response to IV fluids . Mean arterial pressure (MAP)

700-464: A gold foil to an insect wing and shone light on it to study the flapping of the wing. He also used a soot covered glass-fibre introduced along the path of the insect wing to determine if it crossed with the wing in the upper stroke or lower stroke by examining the side on which the soot was cleared. Then he became fascinated by movements of air and started to study bigger flying animals, like birds. He adopted and further developed animated photography into

770-898: A health-care worker measured blood pressure non-invasively by auscultation (listening) through a stethoscope for sounds in one arm's artery as the artery is squeezed, closer to the heart, by an aneroid gauge or a mercury-tube sphygmomanometer . Auscultation is still generally considered to be the gold standard of accuracy for non-invasive blood pressure readings in clinic. However, semi-automated methods have become common, largely due to concerns about potential mercury toxicity, although cost, ease of use and applicability to ambulatory blood pressure or home blood pressure measurements have also influenced this trend. Early automated alternatives to mercury-tube sphygmomanometers were often seriously inaccurate, but modern devices validated to international standards achieve an average difference between two standardized reading methods of 5 mm Hg or less, and

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840-658: A horse trotting and galloping, first in the flesh and then as a skeleton. The presence and activity of Marey in Naples is well documented, in particular thanks to the documentation preserved in the historical archive of the Stazione Zoologica Anton Dohrn . Marey began to travel to Naples presumably because of his relation with madame Vilbort, wife of Joseph Vilbort , the director of the French journal Le Globe . Madame Vilbort moved to Naples to cure her illness, thanks to

910-552: A law that stated that an increase in blood pressure caused a lowering of the heart rate and vice versa. He also invented "Marey's tambour" for physiological experiments. Marey's chronophotographic gun was first made in 1882. This instrument was capable of taking 12 consecutive frames a second, with all the frames recorded on the same picture. Using these pictures he studied horses, birds, dogs, sheep, donkeys, elephants, fish, microscopic creatures, molluscs, insects, reptiles, etc. Some call it Marey's "animated zoo". Marey also conducted

980-681: A separate field of chronophotography in the 1880s. His revolutionary idea was to record several phases of movement on one photographic surface. In 1890 he published a substantial volume entitled Le Vol des Oiseaux ( The Flight of Birds ), richly illustrated with photographs, drawings, and diagrams. He also created stunningly precise sculptures of various flying birds. Marey studied other animals too. He published La Machine animale in 1873 (translated as "Animal Mechanism"). The English photographer Eadweard Muybridge carried out his "Photographic Investigation" in Palo Alto, California , to prove that Marey

1050-464: A significant margin of error. Certain researchers have argued for physicians to begin using aortic pressure, as opposed to peripheral blood pressure, as a guide for clinical decisions. The way antihypertensive drugs impact peripheral blood pressure can often be very different from the way they impact central aortic pressure. If the heart is stopped, blood pressure falls, but it does not fall to zero. The remaining pressure measured after cessation of

1120-517: A systolic blood pressure of 130–139 mmHg with a diastolic pressure of 80–89 mmHg is "stage one hypertension". For those with heart valve regurgitation, a change in its severity may be associated with a change in diastolic pressure. In a study of people with heart valve regurgitation that compared measurements two weeks apart for each person, there was an increased severity of aortic and mitral regurgitation when diastolic blood pressure increased, whereas when diastolic blood pressure decreased, there

1190-446: A systolic/diastolic blood pressure decrease of >20/10 mmHg) is termed orthostatic hypotension (postural hypotension) and represents a failure of the body to compensate for the effect of gravity on the circulation. Standing results in an increased hydrostatic pressure in the blood vessels of the lower limbs. The consequent distension of the veins below the diaphragm (venous pooling) causes ~500 ml of blood to be relocated from

1260-426: Is a consistent difference greater than 10 mmHg which may need further investigation, e.g. for peripheral arterial disease , obstructive arterial disease or aortic dissection . There is no accepted diagnostic standard for hypotension, although pressures less than 90/60 are commonly regarded as hypotensive. In practice blood pressure is considered too low only if symptoms are present. In pregnancy , it

1330-418: Is a risk factor for atrial fibrillation . Both high systolic pressure and high pulse pressure (the numerical difference between systolic and diastolic pressures) are risk factors. Elevated pulse pressure has been found to be a stronger independent predictor of cardiovascular events, especially in older populations, than has systolic, diastolic, or mean arterial pressure. In some cases, it appears that

1400-443: Is a risk factor for many diseases, including stroke , heart disease , and kidney failure . Long-term hypertension is more common than long-term hypotension. Blood pressure measurements can be influenced by circumstances of measurement. Guidelines use different thresholds for office (also known as clinic), home (when the person measures their own blood pressure at home), and ambulatory blood pressure (using an automated device over

1470-427: Is also regulated by neural regulation from the brain (see Hypertension and the brain ), as well as osmotic regulation from the kidney. Differences in mean blood pressure drive the flow of blood around the circulation. The rate of mean blood flow depends on both blood pressure and the resistance to flow presented by the blood vessels. In the absence of hydrostatic effects (e.g. standing), mean blood pressure decreases as

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1540-418: Is approximately 120 millimetres of mercury (16 kPa) systolic over 80 millimetres of mercury (11 kPa) diastolic, denoted as "120/80 mmHg". Globally, the average blood pressure, age standardized, has remained about the same since 1975 to the present, at approximately 127/79 mmHg in men and 122/77 mmHg in women, although these average data mask significantly diverging regional trends. Traditionally,

1610-405: Is consistently 60 mmHg or greater is likely to be associated with disease, and a pulse pressure of 50 mmHg or more increases the risk of cardiovascular disease as well as other complications such as eye and kidney disease. Pulse pressure is considered low if it is less than 25% of the systolic. (For example, if the systolic pressure is 120 mmHg, then the pulse pressure would be considered low if it

1680-618: Is less than 30 mmHg, since 30 is 25% of 120.) A very low pulse pressure can be a symptom of disorders such as congestive heart failure . Elevated pulse pressure has been found to be a stronger independent predictor of cardiovascular events, especially in older populations, than has systolic, diastolic, or mean arterial pressure. This increased risk exists for both men and women and even when no other cardiovascular risk factors are present. The increased risk also exists even in cases in which diastolic pressure decreases over time while systolic remains steady. A meta-analysis in 2000 showed that

1750-478: Is one of the risk factors for strokes , heart attacks , heart failure , and arterial aneurysms , and is the leading cause of chronic kidney failure . Even moderate elevation of arterial pressure leads to shortened life expectancy . At severely high pressures, mean arterial pressures 50% or more above average, a person can expect to live no more than a few years unless appropriately treated. For people with high blood pressure, higher heart rate variability (HRV)

1820-445: Is served by TGV, through Dijon or Lyon . There is a comprehensive "traditional" shopping area clustered around the central square with a focus on gourmet food, fashion, and wine, while large supermarkets, business parks, etc., are situated on the outskirts of town. Beaune has a major fine food market on Saturdays, where there are a large number of stall holders supplying a broad selection of products and specialties from Burgundy and

1890-709: Is small, although it may profoundly decrease downstream flow. Substances called vasoconstrictors reduce the caliber of blood vessels, thereby increasing blood pressure. Vasodilators (such as nitroglycerin ) increase the caliber of blood vessels, thereby decreasing arterial pressure. In the longer term a process termed remodeling also contributes to changing the caliber of small blood vessels and influencing resistance and reactivity to vasoactive agents. Reductions in capillary density, termed capillary rarefaction, may also contribute to increased resistance in some circumstances. In practice, each individual's autonomic nervous system and other systems regulating blood pressure, notably

1960-416: Is some evidence that different antihypertensive agents have different effects on blood pressure variability; whether these differences translate to benefits in outcome is uncertain. During each heartbeat, blood pressure varies between a maximum (systolic) and a minimum (diastolic) pressure. The blood pressure in the circulation is principally due to the pumping action of the heart. However, blood pressure

2030-417: Is the average of blood pressure over a cardiac cycle and is determined by the cardiac output (CO), systemic vascular resistance (SVR), and central venous pressure (CVP): In practice, the contribution of CVP (which is small) is generally ignored and so MAP is often estimated from measurements of the systolic pressure, P sys {\displaystyle \!P_{\text{sys}}} and

2100-447: Is the blood pressure at the root of the aorta . Elevated aortic pressure has been found to be a more accurate predictor of both cardiovascular events and mortality, as well as structural changes in the heart, than has peripheral blood pressure (such as measured through the brachial artery ). Traditionally it involved an invasive procedure to measure aortic pressure, but now there are non-invasive methods of measuring it indirectly without

2170-547: Is the fetal heart and not the mother's heart that builds up the fetal blood pressure to drive blood through the fetal circulation. The blood pressure in the fetal aorta is approximately 30 mmHg at 20 weeks of gestation, and increases to approximately 45 mmHg at 40 weeks of gestation. The average blood pressure for full-term infants: In children the normal ranges for blood pressure are lower than for adults and depend on height. Reference blood pressure values have been developed for children in different countries, based on

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2240-602: Is the wine capital of Burgundy in the Côte d'Or department in eastern France . It is located between Lyon and Dijon . Beaune is one of the key wine centers in France, and the center of Burgundy wine production and business. The annual wine auction of the Hospices de Beaune is the primary wine auction in France . The town is surrounded by some of the world's most famous wine villages, while

2310-783: Is this climate which creates the unique environment for which the Côte d'Or is known. Founded in 1442 by Nicolas Rolin , chancellor of the Duke of Burgundy , and his wife, the Hospices are a charity running hospitals and other services for the needy. Following from past donations, they own vineyards in Burgundy . At the end of WWI the American Expeditionary Forces University was established in Beaune, complete with its own chapter of Phi Beta Kappa . Faculty included Walter M. Chandler ,

2380-458: The Climats, terroirs of Burgundy site. Beaune is one of the wine communes of the Côte de Beaune subregion of the Burgundy wine region, which bears the name of this town. Although Beaune is lacking a Grand cru vineyard in the commune, it is the hub of the region's wine business, as most of Burgundy's major négociants are here. Beaune is renowned for its annual charity wine auction on behalf of

2450-413: The Hospices de Beaune . It is on the route des Grands Crus tourist trail among the vineyards. The road runs north from Beaune to Gevrey Chambertin and Nuits-Saint-Georges and south to Nolay , Saisy and Autun . Beaune is the centre for wine industry services (such as tractors and equipment for vat-rooms) as well as a number of wine-related institutes and education facilities. The train station

2520-399: The cardiac output , i.e. the heartbeat. The magnitude of the pulse pressure is usually attributed to the interaction of the stroke volume of the heart, the compliance (ability to expand) of the arterial system—largely attributable to the aorta and large elastic arteries—and the resistance to flow in the arterial tree . A healthy pulse pressure is around 40 mmHg. A pulse pressure that

2590-634: The circulating blood moves away from the heart through arteries and capillaries due to viscous losses of energy. Mean blood pressure drops over the whole circulation, although most of the fall occurs along the small arteries and arterioles . Pulsatility also diminishes in the smaller elements of the arterial circulation, although some transmitted pulsatility is observed in capillaries. Gravity affects blood pressure via hydrostatic forces (e.g., during standing), and valves in veins, breathing , and pumping from contraction of skeletal muscles also influence blood pressure, particularly in veins. A simple view of

2660-656: The end-diastolic volume or filling pressure of the ventricle acting via the Frank–Starling mechanism —this is influenced by blood volume ; 2) cardiac contractility ; and 3) afterload , the impedance to blood flow presented by the circulation. In the short-term, the greater the blood volume, the higher the cardiac output. This has been proposed as an explanation of the relationship between high dietary salt intake and increased blood pressure; however, responses to increased dietary sodium intake vary between individuals and are highly dependent on autonomic nervous system responses and

2730-405: The hemodynamics of systemic arterial pressure is based around mean arterial pressure (MAP) and pulse pressure. Most influences on blood pressure can be understood in terms of their effect on cardiac output , systemic vascular resistance , or arterial stiffness (the inverse of arterial compliance). Cardiac output is the product of stroke volume and heart rate. Stroke volume is influenced by 1)

2800-472: The history of cinema . He was also a pioneer in establishing a variety of graphical techniques for the display and interpretation of quantitative data from physiological measurement. Marey started by studying blood circulation in the human body. Then he shifted to analyzing heart beats, respiration, muscles (myography), and movement of the body. To aid his studies he developed many instruments for precise measurements. For example, in 1859, in collaboration with

2870-501: The renin–angiotensin system , changes in plasma osmolarity may also be important. In the longer-term the relationship between volume and blood pressure is more complex. In simple terms, systemic vascular resistance is mainly determined by the caliber of small arteries and arterioles. The resistance attributable to a blood vessel depends on its radius as described by the Hagen-Poiseuille's equation (resistance∝1/radius ). Hence,

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2940-500: The right atrium and 8 mmHg in the left atrium. Variants of venous pressure include: Normally, the pressure in the pulmonary artery is about 15 mmHg at rest. Increased blood pressure in the capillaries of the lung causes pulmonary hypertension , leading to interstitial edema if the pressure increases to above 20 mmHg, and to pulmonary edema at pressures above 25 mmHg. Aortic pressure , also called central aortic blood pressure, or central blood pressure,

3010-473: The Latinised Gaulish word "Belena", which was the name of a spring around which the settlement was established. That name in turn is derived from "Belen" or "Belenos", a god of fast-flowing water. A Roman fort was built there in the first century A.D. and it was already a prosperous wine-growing region in the 13th century. The town is served by a small watercourse, the "Bouzaise" (or "Bouzaize") of which

3080-511: The age of 40. Consequently, in many older people, systolic blood pressure often exceeds the normal adult range, if the diastolic pressure is in the normal range this is termed isolated systolic hypertension . The rise in pulse pressure with age is attributed to increased stiffness of the arteries . An age-related rise in blood pressure is not considered healthy and is not observed in some isolated unacculturated communities. Pulmonary capillary wedge pressure Blood pressure generally refers to

3150-419: The arterial pressure in the systemic circulation . However, measurement of pressures in the venous system and the pulmonary vessels plays an important role in intensive care medicine but requires invasive measurement of pressure using a catheter . Venous pressure is the vascular pressure in a vein or in the atria of the heart . It is much lower than arterial pressure, with common values of 5 mmHg in

3220-597: The better predictive value of ambulatory blood pressure measurements has led some authorities, such as the National Institute for Health and Care Excellence (NICE) in the UK, to advocate for the use of ambulatory blood pressure as the preferred method for diagnosis of hypertension. Various other factors, such as age and sex , also influence a person's blood pressure. Differences between left-arm and right-arm blood pressure measurements tend to be small. However, occasionally there

3290-443: The brain becomes critically compromised (i.e., the blood supply is not sufficient), causing lightheadedness , dizziness , weakness or fainting . Usually this failure of compensation is due to disease, or drugs that affect the sympathetic nervous system . A similar effect is observed following the experience of excessive gravitational forces (G-loading), such as routinely experienced by aerobatic or combat pilots ' pulling Gs ' where

3360-621: The chest and upper body. This results in a rapid decrease in central blood volume and a reduction of ventricular preload which in turn reduces stroke volume, and mean arterial pressure. Normally this is compensated for by multiple mechanisms, including activation of the autonomic nervous system which increases heart rate , myocardial contractility and systemic arterial vasoconstriction to preserve blood pressure and elicits venous vasoconstriction to decrease venous compliance . Decreased venous compliance also results from an intrinsic myogenic increase in venous smooth muscle tone in response to

3430-580: The city walls with around five chain hotels on the outskirts. Beaune is one of a number of towns in Europe asserting a key role in the "invention of film"; a number of murals and other tourist attractions reflect this. Technically Beaune is a commune in eastern France, a sub-prefecture of department 21, the Côte-d'Or department , in the Bourgogne-Franche-Comté region . The name "Beaune" derives from

3500-506: The diastolic pressure, P dias {\displaystyle \!P_{\text{dias}}}   using the equation: MAP ≊ P dias + k ( P sys − P dias ) {\displaystyle \!{\text{MAP}}\approxeq P_{\text{dias}}+k(P_{\text{sys}}-P_{\text{dias}})} where k = 0.333 although other values for k have been advocated. The endogenous , homeostatic regulation of arterial pressure

3570-432: The distribution of blood pressure in children of these countries. In adults in most societies, systolic blood pressure tends to rise from early adulthood onward, up to at least age 70; diastolic pressure tends to begin to rise at the same time but start to fall earlier in mid-life, approximately age 55. Mean blood pressure rises from early adulthood, plateauing in mid-life, while pulse pressure rises quite markedly after

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3640-478: The documentation that witnesses the collaboration of Marey with Anton Dohrn is the archive at the zoological station which preserves photos where the two appear together during an excursion and show Marey on board Dohrn's boat. The usage of the chronophotographic gun, which Marey used to aim at birds, but without shooting, appeared unusual to local people who referred to Marey sometimes as the "silly from Posillipo" ("lo scemo di Posillipo"). He proposed "Marey's Law",

3710-399: The elevated pressure in the veins of the lower body. Other compensatory mechanisms include the veno-arteriolar axon reflex , the ' skeletal muscle pump ' and ' respiratory pump '. Together these mechanisms normally stabilize blood pressure within a minute or less. If these compensatory mechanisms fail and arterial pressure and blood flow decrease beyond a certain point, the perfusion of

3780-887: The extreme hydrostatic pressures exceed the ability of the body's compensatory mechanisms. Some fluctuation or variation in blood pressure is normal. Variation in blood pressure that is significantly greater than the norm is known as labile hypertension and is associated with increased risk of cardiovascular disease brain small vessel disease, and dementia independent of the average blood pressure level. Recent evidence from clinical trials has also linked variation in blood pressure to mortality, stroke, heart failure, and cardiac changes that may give rise to heart failure. These data have prompted discussion of whether excessive variation in blood pressure should be treated, even among normotensive older adults. Older individuals and those who had received blood pressure medications are more likely to exhibit larger fluctuations in pressure, and there

3850-404: The facilities and cellars of many producers, large and small, are situated in the historic center of Beaune itself, as they have been since Roman times. With a rich historical and architectural heritage, Beaune is considered the "Capital of Burgundy wines ". It is an ancient and historic town on a plain by the hills of the Côte d'Or, with features remaining from the pre-Roman and Roman eras, through

3920-494: The famous study about cats always landing on their feet. He conducted very similar studies with a chicken and a dog and found that they could do almost the same. Marey also studied human locomotion . He published another book Le Mouvement in 1894. In 1885 Marey mentioned how he could playback the animation from his gun using the phenakistiscope. In 1889 he developed the chronophotographe camera which took images on film at even spacing. He however did not manage to play it back as he

3990-501: The heart beat and redistribution of blood throughout the circulation is termed the mean systemic pressure or mean circulatory filling pressure; typically this is proximally ~7 mmHg. Disorders of blood pressure control include high blood pressure , low blood pressure , and blood pressure that shows excessive or maladaptive fluctuation. Arterial hypertension can be an indicator of other problems and may have long-term adverse effects. Sometimes it can be an acute problem, such as in

4060-401: The kidney, respond to and regulate all these factors so that, although the above issues are important, they rarely act in isolation and the actual arterial pressure response of a given individual can vary widely in the short and long term. The pulse pressure is the difference between the measured systolic and diastolic pressures, The pulse pressure is a consequence of the pulsatile nature of

4130-494: The medieval and renaissance periods. Beaune is a walled city, with about half of the battlements, ramparts, and the moat, having survived in good condition. The central "old town" or "vieille ville" is extensive. Historically Beaune is intimately connected with the Dukes of Burgundy . The 15th-century Hospices de Beaune , in the town center, is one of the best preserved renaissance buildings in Europe. Other landmarks in Beaune include

4200-616: The observation and photography of smoke trails. This research was partially funded by Samuel Pierpont Langley under the auspices of the Smithsonian Institution , after the two met in Paris at the Exposition Universelle (1900) . In 1901 he was able to build a smoke machine with 58 smoke trails. It became one of the first aerodynamic wind tunnels . Beaune Beaune ( French pronunciation: [bon] )

4270-518: The old market (les Halles), the Beffroi (clock tower), and the collegiate church of Notre Dame. Beaune is the main center for the "Burgundian tile" polychrome renaissance roofing style of the region. Because of its historical importance in wine production and the unique system of terroir in the region, the town of Beaune was inscribed on the UNESCO World Heritage List in 2015 as part of

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4340-491: The physiologist Auguste Chauveau and the watch manufacturer Breguet , he developed a wearable Sphygmograph to measure the pulse . This sphygmograph was an improvement on an earlier and more cumbersome design by the German physiologist Karl von Vierordt . In 1869 Marey constructed a very delicate artificial insect to show how an insect flies and to demonstrate the figure-8 shape it produced during movement of its wings. He fixed

4410-435: The short term, blood pressure is regulated by baroreceptors , which act via the brain to influence the nervous and the endocrine systems. Blood pressure that is too low is called hypotension , pressure that is consistently too high is called hypertension , and normal pressure is called normotension. Both hypertension and hypotension have many causes and may be of sudden onset or of long duration. Long-term hypertension

4480-538: The smaller the radius, the higher the resistance. Other physical factors that affect resistance include: vessel length (the longer the vessel, the higher the resistance), blood viscosity (the higher the viscosity, the higher the resistance) and the number of vessels, particularly the smaller numerous, arterioles and capillaries. The presence of a severe arterial stenosis increases resistance to flow, however this increase in resistance rarely increases systemic blood pressure because its contribution to total systemic resistance

4550-480: The source is in a public park at the north-east boundary. Beaune has a semi-continental climate with an oceanic tendency. The oceanic influence is seen with frequent rains in each season (though autumn has the most and summer the least) and many weather changes. On the other hand, one sees the semi-continental influence with one of the greatest seasonal temperature differences, characterized by cold winters with frequent snowfall, and hot summers with violent storms. It

4620-470: The surrounding regions. For example, Bresse chickens, Jura cheeses, small goods, spices, produce of every variety as well as seasonal specialties such as truffles. There is a smaller market on Wednesday, and special-event markets and fetes are held throughout the year. Although Beaune is not primarily a tourist town but one centred on the wine industry, it nevertheless attracts a large amount of tourists. About five traditional smaller hotels are located within

4690-648: The warm climate, and Marey followed her. Marey and madame Vilbort bought villa Maria in Posillipo in 1880. Marey accomplished in Naples part of his studies aimed at the realization of his pre-cinematographic tools and in the Dohrn zoological station studied the movement of fishes hosted in the aquarium's tanks. In a letter dated 1 November 1876 Marey requested the Stazione Zoologica to provide live ray fishes for his studies. Among

4760-536: Was a decreased severity. Blood pressure that is too low is known as hypotension . This is a medical concern if it causes signs or symptoms, such as dizziness, fainting, or in extreme cases in medical emergencies, circulatory shock . Causes of low arterial pressure include sepsis , hypovolemia , bleeding , cardiogenic shock , reflex syncope , hormonal abnormalities such as Addison's disease , eating disorders – particularly anorexia nervosa and bulimia . A large fall in blood pressure upon standing (typically

4830-427: Was right when he wrote that a galloping horse for a brief moment had all four hooves off the ground. Muybridge published his photos in 1879 and received some public attention. Marey hoped to merge anatomy and physiology . To better understand his chronophotographic images, he compared them with images of the anatomy, skeleton , joints , and muscles of the same species. Marey produced a series of drawings showing

4900-399: Was unable to move between the frames in an even manner. Edison visited Marey in 1889 and was able to solve the problem using a sprocketed film advance mechanism along with W.L. Dickison who was developing something using the cylindrical model of the phonograph. Towards the end of his life he returned to studying the movement of quite abstract forms, like a falling ball. His last great work was

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