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74-442: Celgene was originally a unit of Celanese . In 1986, Celanese completed the corporate spin-off of Celgene following the merger of Celanese with American Hoechst . In August 2000, Celgene acquired Signal Pharmaceuticals, Inc., a privately held company that developed pharmaceuticals to regulate disease-related genes. Signal Pharmaceuticals was rebranded as Celgene Research San Diego. In December 2002, Celgene acquired Anthrogenesis,

148-483: A specialty drug , lenalidomide is only available through the a distribution network consisting of specialty pharmacies contracted by the company. In March 2008, Celgene acquired Pharmion Corporation for $ 2.9 billion. In January 2010, Celgene acquired Gloucester Pharmaceuticals. In June 2010, Celgene agreed to acquire Abraxis BioScience. It purchased the biotechnology company for $ 2.9 billion in its expansion into drugs that attack solid tumors. Abraxis produced Abraxane,

222-548: A 122.5% premium to its last closing price), helping to boost its complement of cancer drugs, specifically repotrectinib . That same month, the company announced it would be investing $ 180m in French AI company Owkin , to design potentially more precise and efficient clinical trials. The collaboration will initially focus on cardiovascular diseases, and has the potential to extend into projects in other therapeutic areas. In August 2023, Bristol Myers Squibb partnered with Cellares for

296-575: A deferred prosecution agreement, the company was placed under the oversight of a monitor appointed by the U.S. attorney in New Jersey. In addition, the former head of the Pharma group, Richard Lane, and the ex-CFO, Fred Schiff, were indicted for federal securities violations. In July 2006, an investigation of the company was made public, and the FBI raided the company's corporate offices. The investigation centered on

370-598: A lifetime of 50 years service. According to the lawsuit, scientists from the defendants allegedly reported that the PB plumbing systems would degrade even when exposed to low concentrations of chlorine typically found in municipal water systems. The lawsuit claimed that in spite of this knowledge, the defendants concealed the information and continued to market these products (Shell supplying PB resins to water pipe manufacturers and Hoechst Celanese providing acetal resins to manufacturers of pipe fittings) until approximately 1996. The lawsuit

444-507: A market capitalization of US$ 67 billion, and stock appreciation of 107%, Celgene was Forbes Magazine 's number 2 ranked drug company of 2013. In 2014, Celgene and OncoMed Pharmaceuticals joined a cancer stem cell therapeutic development agreement with demcizumab and five other biologics from OncoMed's pipeline. That same year, Sutro Biopharma entered into an agreement with Celgene Corporation to discover and develop multispecific antibodies and antibody drug conjugates (ADCs). This followed

518-413: A monopoly on Taxol , its cancer treatment, and it was again sued for the antitrust lawsuit five years later, which cost the company $ 125 million for settlement. Also in 2002, Bristol-Myers Squibb was involved in an accounting scandal that resulted in a significant restatement of revenues from 1999 to 2001. The restatement was the result of an improper booking of sales related to " channel stuffing " as

592-425: A multiyear program of on-going layoffs. This was part of a business strategy launched in 2007 to transform the company from a large, diversified pharmaceutical company to a specialty biopharma company, which also included the closure of half of their manufacturing facilities. As another cost-cutting measure, Bristol-Myers Squibb also reduced health-care subsidies for retirees and planned to freeze their pension plan at

666-517: A new company, Celanese AG. In 1999, Hoechst spun off Celanese AG as a publicly traded German corporation, cross-listed on both the Frankfurt and New York stock exchanges as "CZZ" and "CZ", respectively. On 16 December 2003, the U.S. private equity firm Blackstone Group announced a takeover offer for Celanese, after two years of wooing management. Shareholders formally approved the offer from Blackstone on 16 June 2004, and Blackstone completed

740-415: A number of illnesses. Hoechst Celanese asked the courts to dismiss these charges as spurious, claiming that its discharges have not caused substantial harm to anyone or to the environment, and further asserting that a 3-year limit on tort claims had expired, relieving the company of any responsibility for damages which might be eventually discovered. Acetyl intermediates is Celanese's largest segment, with

814-455: A privately held New Jersey–based biotherapeutics company and cord blood banking business, which is developing technology for the recovery of stem cells from placental tissues following the completion of full-term successful pregnancies. Anthrogenesis was rebranded as Celgene Cellular Therapeutics. In 2006, Celgene certified McKesson Specialty, a specialty pharmacy , as one of a group of pharmacies contracted to launch lenalidomide (Revlimid). As

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888-511: A product range consisting of basic chemicals such as acetic acid , acetic anhydride , and vinyl acetate . Customers of acetyl intermediates and industrial specialties are in the chemical, paint and coatings, construction, and adhesive industries for polymerization . Advanced engineered materials offers plastic polymers to customers in the automotive, electronics, telecommunications, and medical industries. Major products include engineered plastics for fuel system components (provided by Ticona ,

962-721: A proposed guaranteed access procedure like the one proposed by Dr. Reddy's. Celgene further argued that requiring innovator companies to sell their products to potential generic competitors would violate its intellectual property rights and subject it to liability risks in the event that patients were harmed in Dr. Reddy's studies. In 2018, Celgene was at the top of a list of companies that the FDA identified as refusing to release samples to competitors to create generics. Generic manufacturer Lannett Company initiated antitrust litigation that accused Celgene of using its REMS for THALOMID ( thalidomide ) to violate

1036-649: A refresher to the company's pipeline, helping to overcome from declining sales of Opdivo relative to competitor Keytruda . Under the terms of the deal, Celgene shareholders would receive one BMS share as well as $ 50 in cash for each Celgene share held, valuing Celgene at $ 102.43 a share; representing a 54% premium to the previous days closing price. Investor opposition to this acquisition, leading into an 12 April shareholder vote, appeared when BMS's second-largest investor, Wellington Management , voiced its opposition, followed by investor Starboard Value . In April 2019 BMS announced that 75% of its shareholders voted to approve

1110-764: A share; representing a 54% premium to the previous days closing price. The activist investor Starboard Value LP opposed the deal, nominating five alternative potential directors on the Bristol-Myers board. The deal was approved by shareholders in April 2019. In August 2019, Amgen announced it would acquire the Otezla drug programme from Celgene for $ 13.4 billion, as part of Celgene and Bristol-Myers Squibb's merger deal. The Bristol-Myers acquisition closed on November 20, 2019. In November 2019, Bristol-Myers Squibb (BMS) announced that it has completed its acquisition of Celgene following

1184-401: A stake in the company, signaling a potential future takeover from the likes of Gilead Sciences . In April 2018, the company reported net income of $ 1.5 billion, or 91 cents per share, for the first quarter of the year, thanks to the increased sales of their cancer drug Opdivo. In August 2009, during a major restructuring activity, BMS acquired the biotechnology firm Medarex as part of

1258-485: A treatment for patients with multiple myeloma who have received at least one prior therapy by the European Commission. In 2009, Dr. Reddy's Laboratories requested, and Celgene refused to provide, a samples of Celgene's anticancer drug THALOMID ( thalidomide ). Dr. Reddy's Laboratories sought the material for bioequivalency studies required to bring its own, generic, version of thalidomide to market. In response to

1332-701: Is a hydrocarbon-based ethanol production process developed and marketed by Celanese and launched in November 2010. Celanese researchers developed the TCX Technology to create a fuel that helps countries reduce their need to import oil and gas. Celanese plans to invest $ 700 million to build one-to-two plants in China and one in Texas that will produce TCX-based ethanol. Bristol-Myers Squibb The Bristol-Myers Squibb Company , doing business as Bristol Myers Squibb ( BMS ),

1406-1401: Is an American multinational pharmaceutical company . Headquartered in Princeton, New Jersey , BMS is one of the world's largest pharmaceutical companies and consistently ranks on the Fortune 500 list of the largest U.S. corporations. For fiscal 2022, it had a total revenue of $ 46.2 billion. Bristol Myers Squibb manufactures prescription pharmaceuticals and biologics in several therapeutic areas, including cancer , HIV/AIDS , cardiovascular disease , diabetes , hepatitis , rheumatoid arthritis , and psychiatric disorders . BMS's primary research and development (R&D) sites are located in Lawrence, New Jersey (formerly Squibb, near Princeton ), Summit, New Jersey , formerly HQ of Celgene , New Brunswick, New Jersey , Redwood City, California , and Seville in Spain, with other sites in Devens and Cambridge, Massachusetts , Braine-l'Alleud , Belgium, Tokyo , Japan, Hyderabad ; Bangalore , India and Wirral , United Kingdom. BMS previously had an R&D site in Wallingford, Connecticut (formerly Bristol-Myers). The Squibb corporation

1480-634: Is an American technology and specialty materials company headquartered in Irving , Texas . It is a Fortune 500 corporation. The company is the world's leading producer of acetic acid , producing about 1.95 million tonnes per year, representing approximately 25% of global production. Celanese is also the world's largest producer of vinyl acetate monomer (VAM). Celanese operates 25 production plants and six research centers in 11 countries, mainly in North America, Europe, and Asia. The company owns and operates

1554-726: Is one of the world's largest producers of cellulose acetate . Acetate products are primarily used in cigarette filters , as well as in the production of fashion apparel and linings . Celanese also manufactures Clarifoil cellulose acetate film that is wood pulp based and certified biodegradable and compostable in home and industrial composting conditions. Industrial specialties, using the feedstock from acetyl intermediates, manufactures polymer and emulsions such as polyvinyl acetate emulsions, and specialty chemicals as ethylene vinyl acetate . Major end-use markets include polyvinyl alcohol producers, paper, mortar and gypsum, textiles, paints, coatings, and adhesives manufacturers. TCX Technology

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1628-491: Is the first novel type of treatment for the devitalizing, chronic mental disorder in the last 70 years. The following is an illustration of the company's major mergers and acquisitions and historical predecessors: For the fiscal year 2018,Bristol Myers Squibb reported earnings of US$ 1.007 billion, with an annual revenue of US$ 20.776 billion, an increase of 6.9% over the previous fiscal cycle. Bristol-Myers Squibb's shares traded at over $ 55 per share, and its market capitalization

1702-595: The FDA accepted Karuna Therapeutics' NDA for KarXT, for the treatment of schizophrenia in adults. The acquisition of Karuna Therapeutics was completed in March 2024. The company entered into an agreement to purchase RayzeBio, for approximately $ 4.1 billion, in December 2023. On 26 September 2024, The Food and Drug Administration has given approval to one of Bristol Myers Squibb’s most anticipated schizophrenia drugs named Cobenfy which

1776-482: The National Medal of Technology , the nation's highest recognition for technological achievement, "for extending, and enhancing human life through innovative pharmaceutical research and development and for redefining the science of clinical study through groundbreaking and hugely complex clinical trials that are recognized models in the industry." In 2002, the company was involved in a lawsuit of illegally maintaining

1850-549: The 1890s, the company introduced its first nationally recognized product Sal Hepatica , a laxative mineral salt, followed by Ipana toothpaste in 1901. Other divisions were Clairol (hair colors and haircare) and Drackett (household products such as Windex and Drano ). In 1943, Bristol-Myers acquired Cheplin Biological Laboratories, a producer of acidophilus milk in East Syracuse, New York , and converted

1924-514: The 7.3-mile main line of the abandoned Rahway Valley Railroad . Some have advocated for the railbed's conversion to a pedestrian and cyclist linear park and rail trail . In January 2019, the company announced it would be acquired by Bristol-Myers Squibb for $ 74 billion ($ 95 billion including debt), a deal that would become the largest pharmaceutical company acquisition ever. Celgene shareholders would receive one BMY share as well as $ 50 in cash for each Celgene share held, valuing Celgene at $ 102.43

1998-753: The British chemicals firm Imperial Chemical Industries in 1982. This included the Fiber Industries Incorporated plant in Salisbury, North Carolina , a part of Invista since 2004. In 1983, Celanese built a $ 20 million plant in Rock Hill, South Carolina , to produce polybenzimidazole (PBI), a material used to fabricate high-performance protective apparel used in firefighter's gear and astronaut space suits . Celanese spun off its pharmaceutical business as Celgene in 1986. In 1987, Celanese Corporation

2072-652: The December 2012 collaboration between the two companies and focused on the field of immuno-oncology. In April 2015, Celgene announced a collaboration with AstraZeneca , worth $ 450 million, to study their Phase III immuno-oncology drug candidate MEDI4736. That same month, Celgene announced it would acquire Quanticel for up to $ 485 million in order to enhance its cancer drug pipeline. Celgene had invested in Quanticel in April 2011. In June 2015, Celgene announced it had licensed Lyceras RORgamma agonist portfolio for up to $ 105 million to develop its Phase I lead compound LYC-30937 for

2146-616: The FDA to market Revlimid for the treatment of patients with transfusion-dependent anemia due to Low- or Intermediate-1-risk MDS associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities. Focalin XR was later launched by Celgene and Novartis in 2005. In May 2006, Celgene received approval for Thalomid in combination with dexamethasone for the treatment of patients with newly diagnosed multiple myeloma. In June 2007, Celgene received full marketing authorization for Revlimid in combination with dexamethasone as

2220-605: The New York Stock Exchange under the symbol "CE". When Blackstone sold the last of its shares in 2007, it had made five times what it had invested and it, and its co-investors collected a $ 2.9 billion profit. In June 2009, the company sold its polyvinyl alcohol (PVOH) business to Sekisui Chemical Co., Ltd . Celanese has a process to make ethanol from natural gas . In late 2020, Celanese sold their 45% stake in Polyplastics to Daicel , who already owned 55% of

2294-469: The acquisition of Celanese AG. The company was delisted from the New York Stock Exchange , and Blackstone changed the entity's name back to Celanese Corporation. Under Blackstone, a number of streamlining initiatives were undertaken, and several acquisitions were made. On 21 January 2005, Celanese Corporation conducted an initial public offering and became a publicly traded corporation traded on

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2368-567: The anti-monopolization provisions of the Sherman Act. In early 2011, the district court denied Celgene's motion to dismiss. The case was set for trial beginning in February 2012, but the parties settled before the trial began, thereby postponing further judicial review of antitrust claims premised on alleged abuse of REMS distribution restrictions. In July 2017, Celgene agreed to pay $ 280 million to government agencies to settle allegations that it caused

2442-518: The business announced it would acquire Forbius and its TGF-beta 1 & TGF-beta 3 inhibitors. In October, BMS announced it would acquire cardiology company MyoKardia for $ 13.1 billion ($ 225 per share) gaining control of mavacamten, a cardiovascular drug for obstructive hypertrophic cardiomyopathy (HCM), and the development of two key treatments: danicamtiv (MYK-491) and MYK-224 . In June 2022, BMS announced it would acquire Turning Point Therapeutics Inc for $ 4.1 billion in cash ($ 76 per share,

2516-425: The cancer-fighting drug that can be given in high doses. In November 2011, Celgene relocated its United Kingdom headquarters from Windsor, Berkshire , to Stockley Park , near Heathrow airport which is also the home of GlaxoSmithKline 's UK operations. In January 2012, Celgene agreed to acquire Avila Therapeutics, Inc., a privately held biotechnology company for $ 925 million, with $ 350 million in cash. Citing

2590-484: The company acquired IFM Therapeutics for $ 300 million upfront, with contingency payments of $ 1.01 billion due on certain milestones – allowing BMS to better compete against Merck & Co 's cancer rival treatment, Keytruda . In early January 2019, the company announced it would acquire Celgene (NASDAQ:CELG) for $ 74 billion ($ 95 billion including debt ), in a deal that would become the largest pharmaceutical-company acquisition ever. The Celgene acquisition aimed to be

2664-442: The company acquired ZymoGenetics , securing an existing product, as well as pipeline assets in hepatitis C, cancer, and other therapeutic areas. Bristol Myers Squibb agreed to pay around $ 2.5 billion in cash to buy Inhibitex Inc. in attempt to compete with Gilead / Pharmasset to produce hepatitis C drugs. The settlement will be finished in 2 months for its Inhibitex's shareholders acceptance of 126% premium price of its price over

2738-567: The company acquired EngMab AG for $ 600 million. In January 2017, the company announced it would acquire Delinia for $ 775 million, increasing the company's autoimmune disease therapy offerings. In January 2018, Celgene announced it would acquire Impact Biomedicines for $ 7 billion, adding fedratinib , a kinase inhibitor with potential to treat myelofibrosis. Also in January 2018, the company announced it would acquire Juno Therapeutics for $ 9 billion. The company's Summit headquarters are located along

2812-602: The company acquired the cardiovascular disease drug developer Cardioxyl for up to $ 2.075 billion. The deal strengthens the BMS' critical pipelines with the phase II candidate for acute decompensated heart failure , CXL-1427 . In March 2016, the company announced it would acquire Padlock Therapeutics for up to $ 600 million. In early July, the company announced it would acquire Cormorant Pharmaceuticals for $ 520 million, boosting BMS' oncology offering through Cormorants monoclonal antibody targeted against interleukin-8 . In August 2017

2886-482: The company for matters covered by the DPA. Under CEO Jim Cornelius, who was CEO following Dolan until May 2010, all executives involved in the "channel-stuffing" and generic competition scandals have since left the company. In 2009, the company began a major restructuring focusing on the pharmaceutical business and biologic products, along with productivity initiatives and cost-cutting and streamlining business operations through

2960-534: The company in 2008. Dr. Fouse has been voted out by the board of directors on 2 April 2018. For the fiscal year 2017, Celgene reported earnings of US$ 2.539 billion, with an annual revenue of US$ 13.003 billion, an increase of 15.8% over the previous fiscal cycle. Celgene's shares traded at over $ 74 per share, and its market capitalization was valued at over US$ 51.8 billion in November 2018. As of 2019, Celgene focused on oncology and immunology. Cancer drugs include Revlimid ( lenalidomide ) and Pomalyst ( pomalidomide ) and

3034-569: The company obtained an exclusive opportunity to both licence and commercialise PROSTVAC , Bavarian Nordic 's phase III prostate-specific antigen targeting cancer immunotherapy. Bavarian Nordic would receive an upfront payment of $ 60 million and incremental payments up to $ 230 million, if the overall survival of test patients exceeds that seen in Phase II tests. Bavarian could also receive milestone payments of between $ 110 million and $ 495 million, dependent on regulatory authorization, and these payments have

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3108-484: The company's "String of Pearls" strategy of alliances, partnerships, and acquisitions. In November 2009, Bristol Myers Squibb announced that it was "splitting off" Mead Johnson Nutrition by offering BMY shareholders the opportunity to exchange their stock for shares in Mead Johnson. According to Bristol Myers Squibb, this move was expected to further sharpen the company's focus on biopharmaceuticals. In October 2010,

3182-604: The company's products of "uniformity, purity, efficacy, and reliability based on research." Squibb Corporation served as a major supplier of medical goods to the Union Army during the American Civil War , providing portable medical kits containing morphine , surgical anesthetics, and quinine for the treatment of malaria (which was endemic in most of the Eastern United States at that time). In 1944, Squibb opened

3256-605: The company. This transaction resulted in Daicel attaining full ownership of Polyplastics. In 1985, Hoechst Celanese was named along with Shell Oil and US Brass as a defendant in a class action lawsuit for $ 7 billion in both past and potential future damages for which they were accused of being liable because of leaks in their polybutylene (PB) plumbing systems. The lawsuit alleged a complex scheme to mislead buyers into believing that PB plumbing systems were suitable for use as potable water distribution systems and purportedly enjoying

3330-561: The distribution of Plavix and charges of collusion . On 12 September 2006, the monitor, former Federal Judge Frederick B. Lacey , urged the company to remove then-CEO Peter Dolan over the Plavix dispute. Later that day, BMS announced that Dolan would indeed step down. The deferred prosecution agreement expired in June 2007 and the Department of Justice did not take any further legal action against

3404-535: The end of 2009. BMS is a Fortune 500 Company (#114 in 2010 list). Newsweek's 2009 Green Ranking recognized Bristol-Myers Squibb as eighth among 500 of the largest United States corporations. Also, BMS was included in the 2009 Dow Jones Sustainability North America Index of leading sustainability-driven companies. Lamberto Andreotti was named CEO in 2010; he had previously served as "president and COO responsible for all pharmaceutical operations worldwide." In 2010, Lou Schmukler joined Bristol-Myers Squibb as

3478-676: The engineering polymer business of Celanese), conveyor belts, electronics, safety systems, emissions filtration, and fluid handling. Polymer production is improved by the acquisition of SO.F.TER Group, Forlì , in Italy in 2016. The food ingredients business Nutrinova produces the high intensity sweetener Sunett ( acesulfame K ), the preservatives Nutrinova, potassium sorbate , and sorbic acid , and other food ingredients. Major end-use markets include beverages, confections, baked goods, and dairy products. In 2021, Celanese ranked 7th on FoodTalks' Global Top 20 Food Preservative Companies list. Celanese

3552-449: The fundamentals of pharmacy are found in many medical papers of the late 1800s. The American Journal of Pharmacy published more than one hundred papers of Squibb's research surrounding the industry. The sons of Edward Squibb sold the company to Lowell M. Palmer and Theodore Weicker in 1905, who incorporated the company. Around this time, the Squibb logo was developed, which represented

3626-534: The immunology drug Otezla ( apremilast ) accounted for around 90% of the company's total revenue as of 2019. In July 1998, Celgene received approval from the FDA to market Thalomid for the acute treatment of the cutaneous manifestations of moderate to severe ENL. In April 2000, Celgene reached an agreement with Novartis Pharma AG to license d-MPH, Celgene's chirally pure version of RITALIN. The FDA subsequently granted approval to market d-MPH, or Focalin, in November 2001. In December 2005, Celgene received approval from

3700-452: The pending merger with Celgene. Transaction to close in the third quarter of 2019, subject to regulatory approvals. Newly issued BMS shares and CVRs will commence trading on the New York Stock Exchange, with the CVRs trading under the symbol 'BMYRT'. The strategic divestment of the company's consumer health business, UPSA, to Taisho completed in 2019. UPSA focused product delivery on France and

3774-785: The plant to produce penicillin for the World War II Allied forces . After the war, the company renamed the plant Bristol Laboratories in 1945 and entered the civilian antibiotics market, where it faced competition from Squibb. Penicillin production at the East Syracuse plant ended in 2005, when it became less expensive to produce overseas. As of 2010, the facility was used for the manufacturing process development and production of other biologic medicines for clinical trials and commercial use. In 1989, Bristol-Myers and Squibb merged and became Bristol-Myers Squibb. In 1999, then-U.S. President Bill Clinton awarded Bristol-Myers Squibb

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3848-430: The potential to total up to $ 975 million. In May 2015, Dr. Giovanni Caforio became CEO of the company; Caforio was formerly the company's COO and succeeded Andreotti upon his retirement. Andreotti subsequently succeeded James Cornelius as executive chairman upon his retirement. In late February 2017, The Wall Street Journal and Fortune , among others, reported that activist investor Carl Icahn had taken

3922-797: The practice of offering excess inventory to customers to create higher sales numbers. The company has since settled with the United States Department of Justice and Securities and Exchange Commission , agreeing to pay $ 150 million, while neither admitting nor denying guilt. On 24 October 2002, Bristol-Myers Squibb Co. restated earnings downward for parts of 2000 and 2001, while revising 2002 earnings upward because of its massive inventory backlog imbroglio that spurred two government investigations. On 15 March 2004, Bristol-Myers Squibb Co. adjusted upward its fourth-quarter and full-year 2003 results after reversing an earlier decision about how to deal with accounting errors made in prior years. As part of

3996-424: The president of global product development and design. Schmukler led the team that completed the company's strategic transformation to a specialty biopharmaceutical company that had begun in 2007. As of 2011, the company had a dozen manufacturing facilities and six product development sites. Citing major developments and a market capitalization of US$ 87 billion and stock appreciation of 61.4%, Bristol-Myers Squibb

4070-497: The previous 20 trading days ended on 6 January. On 29 June, BMS extended its portfolio of diabetes treatments when it agreed to buy Amylin Pharmaceuticals for around US$ 5.3 billion in cash and pay US$ 1.7 billion to Eli Lilly to cover Amylin's debt and its outstanding collaboration-related obligations. AstraZeneca , which already collaborated on several diabetes treatments with BMS, agreed to pay US$ 3.4 billion in cash for

4144-441: The receipt of regulatory approval from all government authorities required by the merger agreement and, as announced on April 12, 2019, approval by Bristol-Myers Squibb and Celgene stockholders. The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list): In March 2016, Bob Hugin , the company's long serving CEO , retired from his position and took

4218-484: The refusal, Dr. Reddy's Laboratories filed a Citizen's Petition with the FDA asking the Agency to adopt procedures that would ensure generic applicants the right to buy sufficient samples to perform bioequivalence testing of drugs that were subject to REMS distribution restrictions. Celgene denied that it had behaved anti-competitively, arguing that the legislative history strongly suggested that Congress considered and rejected

4292-534: The rest of Europe. As early as 2005, the company had divested individual consumer products, and its US- and Canada-focused consumer products business. In August, the Amgen announced it would acquire the Otezla drug programme from Celgene for $ 13.4 billion, as part of Celgene and BMS's merger deal. In February 2020, BMS and partner Biomotiv launched a new company called Anteros Pharmaceuticals, which focuses on creating inflammation and fibrosis medicines. In August,

4366-402: The right to continue development of Amylin's products. Two years later, the company divested Amylin to AstraZeneca. In April 2014, BMS announced its acquisition of iPierian for up to $ 725 million. In February 2015, the company acquired Flexus Biosciences for $ 1.25 billion. As part of this deal, BMS will gain full rights to Flexus' lead small molecule IDO1-inhibitor , F001287. In November,

4440-426: The robotic production of CAR-T treatments of which it has two approved. In September 2023, BMS announced it would pay Zenas BioPharma $ 50m upfront for a strategic license and collaboration to develop and commercialise obexelimab , a novel, bi-functional antibody for autoimmune diseases. In October 2023, BMS agreed to acquire Mirati Therapeutics , an American biotechnology company that develops targeted therapies for

4514-498: The role of executive chairman . Bob Hugin was succeeded in the CEO role by Mark Alles. At the same time, Jacqualyn Fouse was named as the company's president and COO ; Fouse had joined the company in 2010 as the CFO . Effective June 30, 2017, Dr. Fouse will purportedly step down and be succeeded by Scott Smith, president of the company's Global Inflammation & Immunology Franchise, who joined

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4588-525: The submission of false claims or fraudulent claims for non-reimbursable uses of its drugs Revlimid and Thalomid to Medicare and state Medicaid programs. In its July 2017 10-Q, Celgene disclosed that it resolved the matter in full for $ 315 million, including fees and expenses. The case was brought under the False Claims Act by Beverly Brown, a former Celgene sales representative. Celanese Celanese Corporation , formerly known as Hoechst Celanese ,

4662-467: The treatment of cancer, in an all-cash deal worth $ 4.8 billion, and an additional $ 1 billion in milestone payment. The acquisition was completed in January 2024. In December 2023, BMS signed an agreement for the acquisition of Karuna Therapeutics for an equity value totaling $ 14 billion. The acquisition included Karuna's lead asset, KarXT , an investigational muscarinic antipsychotic combination of Xanomeline and Trospium . In November 2023,

4736-429: The treatment of inflammatory bowel disease. The licensing opportunity gave Celgene the option to acquire Lycera. In July 2015, the company announced it would acquire Receptos for $ 7.2 billion in a move to strengthen the company's inflammation and immunology areas. In May 2016, the company announced it would launch partnership with Agios Pharmaceuticals , developing metabolic immuno-oncology therapies. In October 2016,

4810-589: The world's largest penicillin plant in New Brunswick, New Jersey . In 1887, Hamilton College graduates William McLaren Bristol and John Ripley Myers purchased the Clinton Pharmaceutical company of Clinton , New York. In May 1898, they decided to rename it Bristol, Myers and Company . Following Myers' death in 1899, Bristol changed the name to the Bristol-Myers Corporation . During

4884-746: The world's three largest acetic acid plants: one in the Clear Lake area of Pasadena , Texas , one on Jurong Island in Singapore , and a third in Nanjing , China . In 1918, the American Cellulose & Chemical Manufacturing Company (known as Amcelle) was founded in New York City by Swiss chemist Camille Dreyfus . The American Cellulose and Chemical Manufacturing Co. Ltd plant in Cumberland, Maryland ,

4958-414: Was acquired by Hoechst and merged with its American subsidiary, American Hoechst, to form Hoechst Celanese Corporation. In 1998, in a $ 2.7 billion deal, Hoechst Celanese sold its Trevira division to a consortium between Houston -based KoSa, a joint venture of Koch Industries , IMASAB S.A., and Grupo Xtra , both of Mexico. Also in 1998, Hoechst combined most of its industrial chemical operations into

5032-480: Was closed in 1983, and was later torn down to provide a space for a new state prison. The company had introduced the word “Celanese,” a combination of “cellulose” and “ease” in 1925, seeking to promote the ease of cleaning and care of their acetate yarn, or artificial silk, fabrics. They officially took this name in 1927, becoming Celanese Corporation of America. In 1947, Celanese started producing acetate fiber at its plant near Ocotlán, Jalisco, Mexico . The plant

5106-477: Was closed in 2019. By 1958, Celanese had 13 domestic plants, three research and development centers, some 30 groups of products, and approximately 13,000 employees. In 1959, Celanese commissioned Edward Durell Stone , a 20th-century American architect , to build the “ Celanese House ,” a model home in New Canaan, Connecticut , to showcase the company's new materials and styles. Celanese bought operations of

5180-600: Was founded in 1858 by Edward Robinson Squibb in Brooklyn , New York. Squibb was known as an advocate of quality control and high purity standards early within the pharmaceutical industry. He went on to self-publish an alternative to the U.S. Pharmacopeia titled Squibb's Ephemeris of Materia Medica, after failing to convince the American Medical Association to incorporate higher purity standards. Materia Medica , Squibb products, and Edward Squibb's opinion on

5254-478: Was ranked as the best drug company of 2013 by Forbes magazine . In December 2014, the company received FDA approval for the use of the PD-1 inhibitor nivolumab (Opdivo) in treating patients whose skin cancer cannot be removed or have not responded to previous drug therapies. In February 2015, the company initiated a research partnership with Rigel Pharmaceuticals which could generate more than $ 339 million. In March,

5328-532: Was set up during World War I to produce cheaper fabric for airplane manufacturing. The plant location was chosen inland to protect against Zeppelin attacks. It was also situated in proximity to a ready source of water at the Potomac River and easy access to coal supplies and railroad lines. After a series of delays, production began on Christmas Day, 1924 with a series of cellulose acetate commercial fabrics and yarns intended as alternatives to silk . The plant

5402-583: Was settled in 1995 for US$ 950,000,000. In January 2014, a class action lawsuit was filed on behalf of the citizens of Cannon's Campground, seeking relief from health and environmental dangers posed by groundwater and surface water contamination emanating from the Hoechst-Celanese manufacturing plant in Spartanburg, South Carolina . The lawsuit alleged the dumping of a number of toxic chemicals into local waters, which has diminished property values and caused

5476-457: Was valued at over US$ 81.6 billion in October 2018. In 2018, 85% of the company's revenues came from just five products. In 2018, Bristol-Myers Squibb spent 36% of its total revenue on R&D expenses. Bristol-Myers Squibb ranked 145th on the Fortune 500 list of the largest United States corporations by revenue in 2018. Bristol Myers Squibb reported Total CO2e emissions (Direct + Indirect) for

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