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23-1184: [REDACTED] Look up Beutler in Wiktionary, the free dictionary. Beutler (German for sacker , bagger or bag maker ) is a surname. Notable people with the surname include: Andreas Beutler (born 1963), ice hockey player Annette Beutler (born 1976), Swiss cyclist August Frederik Beutler (c. 1728), ensign in the employ of the Dutch East India Company Betsy Beutler , American actress Bruce Beutler (born 1957), American immunologist and geneticist Chris Beutler (born 1944), Nebraska state senator, 1978–1986 and 1990–2006 Ernest Beutler (1928–2008), German hematologist and biomedical scientist Heinz Beutler , Swiss curler Jaime Herrera Beutler (born 1978), U.S. Representative from Washington Larry E. Beutler (born 1941), clinical psychologist Rolf Beutler (born 1940), Swiss sport shooter Companies [ edit ] Carrosserie Beutler , Swiss coachbuilder See also [ edit ] Beutler test , also known as

46-409: A chance observation. Beutler also developed an early interest in iron metabolism, prompted by his clinical observation of the rapid symptomatic improvement of iron deficient patients treated with iron: an improvement that preceded any major hematologic change, and showed that numerous enzymes were sensitive to iron deficiency. After completing his residency (1953), Beutler applied for a commission as

69-467: A few days before his death. Not long after moving to California, Beutler made one of his most important contributions. A new colleague at the City of Hope and ultimately a lifelong friend, Susumu Ohno had recently demonstrated that the histologically observable Barr body present in the nuclei of mammalian female cells was a hyperchromatic X chromosome. Beutler immediately recognized that this might account for

92-607: A lieutenant in the U.S. Army, and was assigned to the Army Malaria Research Program. During this period, he worked at Joliet Prison in Illinois (1953–1954), investigating anemia produced by antimalarial drugs. In the course of his work, he identified glucose-6-phosphate dehydrogenase (G-6-PD) deficiency as a genetic defect that leads to the lysis of red blood cells under conditions of oxidative stress. This work hinged on his demonstration that red blood cell glutathione

115-469: A publishing scientist, Beutler also wrote the software for the first comprehensive bibliographic retrieval system used by publishing scientists. Later commercialized as Reference Manager , it is still in wide use today. He authored more than 800 publications, 19 books, and over 300 book chapters over a 55-year scientific career. Beutler was a president of both the American Society of Hematology and

138-472: A screening test for galactosemia , which is used to this day to detect the disease in neonates, and prevent its severe consequences. Beutler was the first to attempt pharmacologic intervention in sickle cell disease by increasing methemoglobin levels, carboxyhemoglobin levels, and fetal hemoglobin levels. The latter approach depended on administration of estrogen, progesterone and human chorionic gonadotropin. These attempts were unsuccessful, but presaged

161-459: Is different from Wikidata All set index articles Beutler [REDACTED] Look up Beutler in Wiktionary, the free dictionary. Beutler (German for sacker , bagger or bag maker ) is a surname. Notable people with the surname include: Andreas Beutler (born 1963), ice hockey player Annette Beutler (born 1976), Swiss cyclist August Frederik Beutler (c. 1728), ensign in

184-520: Is different from Wikidata All set index articles Ernest Beutler Born in Berlin , to a Jewish family, his family home was located on Reichskanzlerplatz, renamed “Adolf Hitler Platz” after Hitler's ascent to power, and then Theodor Heuss Platz after the Second World War. Both of his parents (Alfred and Kaethe, née Italiener) were physicians. His mother, a pediatrician, was in pre-war times

207-756: The Department of Medicine of the City of Hope National Medical Center in Duarte, California, and in 1979 assumed the chairmanship of the Department of Clinical Research at the Scripps Clinic and Research Foundation. Three years later, he was asked to become Chairman of a merged department (the Department of Molecular and Experimental Medicine) at Scripps, which later became The Scripps Research Institute in La Jolla, CA. He maintained his position as Chairman until his 80th birthday, only

230-715: The Western Association of Physicians. He also received a Doctor Philosophiae Honoris Causa, Tel Aviv University . He was also elected to the United States National Academy of Sciences and was presented with the inaugural Award for Lifetime Achievement from The American Society of Hematology . He was a recipient of the American Society of Hematology 's E. Donnall Thomas Prize in 2003. Married to Brondelle May Fleisher in 1950, Beutler had four children (Steven Merrill Beutler, Earl Bryan Beutler , Bruce Alan Beutler, and Deborah Ann Beutler). Bruce A. Beutler , also

253-407: The age of 21. He was a member of Pi Lambda Phi and the valedictorian of his graduating class. Beutler pursued a remarkably eclectic research career, and made fundamental contributions in many different areas of science over 56 years of active publication. His first scientific paper was published in 1952, and concerned the effect of X-irradiation on susceptibility to influenza virus in mice. This

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276-668: The employ of the Dutch East India Company Betsy Beutler , American actress Bruce Beutler (born 1957), American immunologist and geneticist Chris Beutler (born 1944), Nebraska state senator, 1978–1986 and 1990–2006 Ernest Beutler (1928–2008), German hematologist and biomedical scientist Heinz Beutler , Swiss curler Jaime Herrera Beutler (born 1978), U.S. Representative from Washington Larry E. Beutler (born 1941), clinical psychologist Rolf Beutler (born 1940), Swiss sport shooter Companies [ edit ] Carrosserie Beutler , Swiss coachbuilder See also [ edit ] Beutler test , also known as

299-581: The fluorescent spot test, a screening test used to identify enzyme defects [REDACTED] Surname list This page lists people with the surname Beutler . If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name (s) to the link. Retrieved from " https://en.wikipedia.org/w/index.php?title=Beutler&oldid=1240307808 " Categories : Surnames German-language surnames Hidden categories: Articles with short description Short description

322-581: The fluorescent spot test, a screening test used to identify enzyme defects [REDACTED] Surname list This page lists people with the surname Beutler . If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name (s) to the link. Retrieved from " https://en.wikipedia.org/w/index.php?title=Beutler&oldid=1240307808 " Categories : Surnames German-language surnames Hidden categories: Articles with short description Short description

345-408: The mid-1990s, Beutler attempted to positionally clone the mutation responsible for the common adult-onset form of hereditary hemochromatosis. He failed to identify the mutation before it was found by others to affect HFE, a member of the major histocompatibility complex family of proteins. However, in contrast to the reports of others, he found that only about 2% of males and no females homozygous for

368-399: The mutation showed severe clinical manifestations of the disease. This study depended upon genotypic and phenotypic analysis of more than 43,000 subjects. Beutler served as an editor of Williams Hematology, a widely used text in this medical specialty, for more than 20 years: from its inception until the last year of his life. In keeping with his editorial interests and his requirements as

391-536: The physician to Harald Quandt, son of Magda Quandt née Rietschel, later Magda Goebbels , wife of the German propaganda minister. The second of three children, Beutler was preceded by an older brother, Frederick (b. October 3, 1926, later a professor of mathematics at the University of Michigan), and followed by a younger sister, Ruth (b. November 23, 1932, later a clinical psychologist; d. July 14, 1993). In 1935, when Beutler

414-405: The standard approach to study of patients with these disorders. Beutler made major contributions to the understanding of Tay–Sachs disease. He purified the enzyme that is aberrant in this disease and demonstrated its multimeric structure. His group cloned the gene responsible for Gaucher disease and developed treatments for this disease, as well as diagnostic tests. Beutler also developed

437-557: The use of hydroxyurea as a treatment modality. In addition, Beutler designed the first artificial storage media for red blood cells, introduced the use of mannitol (still a mainstay in red cell preservation), and devised a variety of approaches to maintaining red cell ATP and 2,3-DPG levels and determined the viability of the cells in human volunteers. He also played a major role in pioneering new therapies for leukemia: bone marrow transplantation in acute leukemia, and 2-chorodeoxyadenosine in chronic leukemias and lymphomas. Beginning in

460-817: The variable expression of X-linked genes in females heterozygous for X-linked mutations. He soon determined that random X chromosome inactivation causes tissue mosaicism in female mammals, in that each somatic cell expresses one (but not both) of the alleles of X-linked genes with which it is endowed. This he accomplished by showing that two populations of erythrocytes exist in the blood of African American women who are heterozygous for G6PD deficiency. Mary F. Lyon independently hypothesized that variegated coat colors in mice might arise from random X chromosome inactivation. This, too, flowed from Ohno's observations. Beutler's seminal work on G6PD deficiency led him to further explore hemolytic anemias caused by various enzyme deficiencies. The systematic methodology that he developed became

483-430: Was an attempt to determine whether irradiated mice might offer a better experimental model in which to detect human viral infections. Not long afterward, he published a paper on the lag phase of E. coli , which is also influenced by X-irradiation. This work, carried out during his residency in the laboratory of Leon O. Jacobson , was aimed at the development of an assay for a humoral radioprotective factor, and reflected

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506-590: Was seven years of age, the family emigrated to the United States to escape Nazi persecution. Beutler was raised in Milwaukee, Wisconsin . At 15, Beutler enrolled in a special program at the University of Chicago , founded by Robert Hutchins , then President of the University. He completed his undergraduate, medical school and residency training at the University of Chicago, receiving his doctorate in medicine in 1950 at

529-623: Was unstable to oxidative stress. Later, he was to develop an assay for glutathione that was widely used in studies of red cell oxidative metabolism. He was later transferred to Camp Detrick in Frederick, Maryland (1954–1955), where he studied Q fever . He was honorably discharged from the Army with the rank of captain. Beutler then joined the faculty of the Department of Medicine at the University of Chicago , where he studied iron metabolism and red blood cell metabolism. In 1959, he became chairman of

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