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5-479: 73835 ENSG00000206013 ENSMUSG00000025489 A6NNB3 O88728 NM_001025295 NM_053088 NP_001020466 NP_444318 Interferon-induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization. The gene is located on the short arm of the Crick strand of chromosome 11 (11p15.5). It is located with a cluster of interferon inducible genes but
10-566: Is itself not interferon inducible. The gene is 1,327 bases in length and encodes a protein of 132 amino acids with a predicted molecular weight of 14378 daltons. Expression in adults is bone specific and highest in osteoblasts . The homolog in the mouse is located on chromosome 7. A homolog is also known to be present in lizards . The gene first appeared in bony fish and its bone specific expression appears to be limited to therian mammals . The protein has two transmembrane domains. It associates with FK506 binding protein 11. Mutations in
15-424: The number of genes on each chromosome varies (for technical details, see gene prediction ). Among various projects, the collaborative consensus coding sequence project ( CCDS ) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes . The following is a partial list of genes on human chromosome 11. For complete list, see
20-411: The gene are associated with osteogenesis imperfecta type 5. Chromosome 11 Chromosome 11 is one of the 23 pairs of chromosomes in humans . Humans normally have two copies of this chromosome. Chromosome 11 spans about 135 million base pairs (the building material of DNA ) and represents between 4 and 4.5 percent of the total DNA in cells . The shorter arm (p arm) is termed 11p while
25-481: The longer arm (q arm) is 11q . At about 21.5 genes per megabase , chromosome 11 is one of the most gene-rich, and disease-rich, chromosomes in the human genome . More than 40% of the 856 olfactory receptor genes in the human genome are located in 28 single-gene and multi-gene clusters along the chromosome. The following are some of the gene count estimates of human chromosome 11. Because researchers use different approaches to genome annotation their predictions of
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