Ablynx is a subsidiary of biopharmaceutical company Sanofi engaged in the discovery and development of nanobodies , based in Science Park Zwijnaarde , Ghent .
70-590: In November 2001, Ablynx was established as a spin-off of the Vlaams Instituut voor Biotechnologie (VIB) and the Free University of Brussels (VUB). Seed financing of €2 million was provided by Gimv . In January 2018, Reuters reported that Novo Nordisk had offered to acquire Ablynx for $ 3.1 billion — having made an unreported offer in mid-December for the company. However, the Ablynx board rejected this offer
140-432: A social system on the basis of innovativeness. In the book Diffusion of Innovations , Rogers suggests a total of five categories of adopters in order to standardize the usage of adopter categories in diffusion research. The adoption of an innovation follows an S curve when plotted over a length of time. The categories of adopters are innovators, early adopters , early majority, late majority and laggards. In addition to
210-539: A spin-out , or starburst or hive-off , is a type of corporate action where a company "splits off" a section as a separate business or creates a second incarnation, even if the first is still active. It is distinct from a sell-off, where a company sells a section to another company or firm in exchange for cash or securities. Spin-offs are divisions of companies or organizations that then become independent businesses with assets, employees, intellectual property , technology , or existing products that are taken from
280-468: A community. The innovations are usually concerned with the improvement of quality of life or the reform of organizational or social structures. Benefits of an innovation obviously are the positive consequences, while the costs are the negative. Costs may be monetary or nonmonetary, direct or indirect. Direct costs are usually related to financial uncertainty and the economic state of the actor. Indirect costs are more difficult to identify. An example would be
350-541: A good predictor of organizational technology adoption when proper initial screening procedures are introduced. Diffusion occurs through a five–step decision-making process. It occurs through a series of communication channels over a period of time among the members of a similar social system. Ryan and Gross first identified adoption as a process in 1943. Rogers' five stages (steps): awareness, interest, evaluation, trial, and adoption are integral to this theory. An individual might reject an innovation at any time during or after
420-518: A group of countries succeed with a set of policies, others follow, as exemplified by the deregulation and liberalization across the developing world after the successes of the Asian Tigers . The reintroduction of regulations in the early 2000s also shows this learning process, which would fit under the stages of knowledge and decision, can be seen as lessons learned by following China's successful growth. Peres, Muller and Mahajan suggested that diffusion
490-435: A group of individuals who would readily use said technology, as well as providing positive reactions and benefits for early adopters. Adoption is an individual process detailing the series of stages one undergoes from first hearing about a product to finally adopting it. Diffusion signifies a group phenomenon, which suggests how an innovation spreads. Rogers defines an adopter category as a classification of individuals within
560-530: A hierarchy to the top decision makers. Prior to the introduction of the Internet, it was argued that social networks had a crucial role in the diffusion of innovation particularly tacit knowledge in the book The IRG Solution – hierarchical incompetence and how to overcome it . The book argued that the widespread adoption of computer networks of individuals would lead to much better diffusion of innovations, with greater understanding of their possible shortcomings and
630-450: A lack of awareness. From a social networks perspective, a failed diffusion might be widely adopted within certain clusters but fail to make an impact on more distantly related people. Networks that are over-connected might suffer from a rigidity that prevents the changes an innovation might bring, as well. Sometimes, some innovations also fail as a result of lack of local involvement and community participation. For example, Rogers discussed
700-478: A more intuitive process by designing individual-level rules to model the diffusion of ideas and innovations. Complex network models can also be used to investigate the spread of innovations among individuals connected to each other by a network of peer-to-peer influences, such as in a physical community or neighborhood. Such models represent a system of individuals as nodes in a network (or graph ). The interactions that link these individuals are represented by
770-453: A new environment. Spin-offs also allow high-growth divisions, once separated from other low-growth divisions, to command higher valuation multiples. In most cases, the parent company or organization offers support doing one or more of the following: All the support from the parent company is provided with the explicit purpose of helping the spin-off grow. The United States Securities and Exchange Commission 's (SEC) definition of "spin-off"
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#1732876090479840-491: A particularly large impact on the use of medicines, medical techniques, and health communications. In organizational studies, its basic epidemiological or internal-influence form was formulated by H. Earl Pemberton, such as postage stamps and standardized school ethics codes. In 1962, Everett Rogers , a professor of rural sociology at Ohio State University , published his seminal work: Diffusion of Innovations . Rogers synthesized research from over 508 diffusion studies across
910-427: A potential adopter. Potential adopters have a threshold, which is a fraction of his neighbors who adopt the innovation that must be reached before he will adopt. Over time, each potential adopter views his neighbors and decides whether he should adopt based on the technologies they are using. When the effect of each individual node is analyzed along with its influence over the entire network, the expected level of adoption
980-425: A relationship; if two individuals are identical, no diffusion occurs because there is no new information to exchange. Therefore, an ideal situation would involve potential adopters who are homophilous in every way, except in knowledge of the innovation. Promotion of healthy behavior provides an example of the balance required of homophily and heterophily. People tend to be close to others of similar health status. As
1050-403: A result, people with unhealthy behaviors like smoking and obesity are less likely to encounter information and behaviors that encourage good health. This presents a critical challenge for health communications, as ties between heterophilous people are relatively weaker, harder to create, and harder to maintain. Developing heterophilous ties to unhealthy communities can increase the effectiveness of
1120-447: A situation in Peru involving the implementation of boiling drinking water to improve health and wellness levels in the village of Los Molinos. The residents had no knowledge of the link between sanitation and illness. The campaign worked with the villagers to try to teach them to boil water, burn their garbage, install latrines and report cases of illness to local health agencies. In Los Molinos,
1190-403: A social system to assemble a network or system which implements innovation. Other research relating the concept to public choice theory finds that the hierarchy of influence for innovations need not, and likely does not, coincide with hierarchies of official, political, or economic status. Elites are often not innovators, and innovations may have to be introduced by outsiders and propagated up
1260-623: A stigma was linked to boiled water as something that only the "unwell" consumed, and thus, the idea of healthy residents boiling water prior to consumption was frowned upon. The two-year educational campaign was considered to be largely unsuccessful. This failure exemplified the importance of the roles of the communication channels that are involved in such a campaign for social change. An examination of diffusion in El Salvador determined that there can be more than one social network at play as innovations are communicated. One network carries information and
1330-534: A very similar role as the champion used within the efficiency business model Six Sigma . The process contains five stages that are slightly similar to the innovation-decision process that individuals undertake. These stages are: agenda-setting , matching, redefining/restructuring, clarifying and routinizing. Diffusion of Innovations has been applied beyond its original domains. In the case of political science and administration, policy diffusion focuses on how institutional innovations are adopted by other institutions, at
1400-770: Is "the process of the market penetration of new products and services that is driven by social influences, which include all interdependencies among consumers that affect various market players with or without their explicit knowledge". Eveland evaluated diffusion from a phenomenological view, stating, "Technology is information, and exists only to the degree that people can put it into practice and use it to achieve values". Diffusion of existing technologies has been measured using "S curves". These technologies include radio, television, VCR, cable, flush toilet, clothes washer, refrigerator, home ownership, air conditioning, dishwasher, electrified households, telephone, cordless phone, cellular phone, per capita airline miles, personal computer and
1470-520: Is a theory that seeks to explain how, why, and at what rate new ideas and technology spread. The theory was popularized by Everett Rogers in his book Diffusion of Innovations , first published in 1962. Rogers argues that diffusion is the process by which an innovation is communicated through certain channels over time among the participants in a social system. The origins of the diffusion of innovations theory are varied and span multiple disciplines. Rogers proposes that five main elements influence
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#17328760904791540-677: Is associated with innovation. Rogers lists three categories for consequences: desirable vs. undesirable, direct vs. indirect, and anticipated vs. unanticipated. In contrast Wejnert details two categories: public vs. private and benefits vs. costs. Public consequences comprise the impact of an innovation on those other than the actor, while private consequences refer to the impact on the actor. Public consequences usually involve collective actors, such as countries, states, organizations or social movements. The results are usually concerned with issues of societal well-being. Private consequences usually involve individuals or small collective entities, such as
1610-601: Is by consensus. The authority decision occurs by adoption among very few individuals with high positions of power within an organization. Unlike the optional innovation decision process, these decision processes only occur within an organization or hierarchical group. Research indicated that, with proper initial screening procedures, even simple behavioral model can serve as a good predictor for technology adoption in many commercial organizations. Within an organization certain individuals are termed "champions" who stand behind an innovation and break through opposition. The champion plays
1680-545: Is diffusing through the organization's environment for any reason, the organization is more likely to adopt it. Innovations that are intentionally spread, including by political mandate or directive, are also likely to diffuse quickly. Unlike individual decisions where behavioral models (e.g. TAM and UTAUT ) can be used to complement the diffusion framework and reveal further details, these models are not directly applicable to organizational decisions. However, research suggested that simple behavioral models can still be used as
1750-484: Is lower. Innovations that are disruptive to routine tasks, even when they bring a large relative advantage, might not be adopted because of added instability. Likewise, innovations that make tasks easier are likely to be adopted. Closely related to relative complexity, knowledge requirements are the ability barrier to use presented by the difficulty to use the innovation. Even when there are high knowledge requirements, support from prior adopters or other sources can increase
1820-457: Is more precise. Spin-offs occur when the equity owners of the parent company receive equity stakes in the newly spun off company. For example, when Agilent Technologies was spun off from Hewlett-Packard (HP) in 1999, the stockholders of HP received Agilent stock. A company not considered a spin-off in the SEC's definition (but considered by the SEC as a technology transfer or licensing of technology to
1890-515: Is now called Treasury Wine Estates . According to The Economist , another driving force of the proliferation of spin-offs is what it calls the " conglomerate discount " — that "stockmarkets value a diversified group at less than the sum of its parts". Some examples of spin-offs (according to the SEC definition): Examples following the second definition of spin-out: An example of companies created by technology transfer or licensing: Diffusion of innovations Diffusion of innovations
1960-418: Is transmitted by country and sector channels. At the local level, examining popular city-level policies make it easy to find patterns in diffusion through measuring public awareness. At the international level, economic policies have been thought to transfer among countries according to local politicians' learning of successes and failures elsewhere and outside mandates made by global financial organizations. As
2030-440: Is untenable, it will be motivated to adopt an innovation to change its fortunes. This tension often plays out among its individual members. Innovations that match the organization's pre-existing system require fewer coincidental changes and are easy to assess and more likely to be adopted. The wider environment of the organization, often an industry, community, or economy, exerts pressures on the organization, too. Where an innovation
2100-407: Is usually measured by the length of time required for a certain percentage of the members of a social system to adopt an innovation. The rates of adoption for innovations are determined by an individual's adopter category. In general, individuals who first adopt an innovation require a shorter adoption period (adoption process) when compared to late adopters. Within the adoption curve at some point
2170-431: The parent company . Shareholders of the parent company receive equivalent shares in the new company in order to compensate for the loss of equity in the original stocks . However, shareholders may then buy and sell stocks from either company independently; this potentially makes investment in the companies more attractive, as potential share purchasers can invest narrowly in the portion of the business they think will have
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2240-464: The two-step flow theory in developing his ideas on the influence of opinion leaders. Opinion leaders have the most influence during the evaluation stage of the innovation-decision process and on late adopters. In addition opinion leaders typically have greater exposure to the mass media, more cosmopolitan, greater contact with change agents, more social experience and exposure, higher socioeconomic status, and are more innovative than others. Research
2310-423: The (perceived) usefulness (sometimes called utility) of the innovation to the individual as well as barriers to adoption, such as cost. The multiple parameters that influence decisions to adopt, both individual and socially motivated, can be represented by such models as a series of nodes and connections that represent real relationships. Borrowing from social network analysis, each node is an innovator, an adopter, or
2380-428: The Internet. These data can act as a predictor for future innovations. Diffusion curves for infrastructure reveal contrasts in the diffusion process of personal technologies versus infrastructure. Both positive and negative outcomes are possible when an individual or organization chooses to adopt a particular innovation. Rogers states that this area needs further research because of the biased positive attitude that
2450-447: The adjustments needed to adopt it. Motivation can be impacted by the meaning that an innovation holds; innovations can have symbolic value that encourage (or discourage) adoption. First proposed by Ryan and Gross (1943), the overall connectedness of a potential adopter to the broad community represented by a city. Potential adopters who frequent metropolitan areas are more likely to adopt an innovation. Finally, potential adopters who have
2520-469: The adopter categorization is innovativeness, defined as the degree to which an individual adopts a new idea. The concept of diffusion was first studied by the French sociologist Gabriel Tarde in late 19th century and by German and Austrian anthropologists and geographers such as Friedrich Ratzel and Leo Frobenius . The study of diffusion of innovations took off in the subfield of rural sociology in
2590-474: The adoption of snowmobiles in Saami reindeer herding culture is found to lead to the collapse of their society with widespread alcoholism and unemployment for the herders, ill-health for the reindeer (such as stress ulcers, miscarriages) and a huge increase in inequality. The diffusion of an innovation typically follows an S-shaped curve which often resembles a logistic function . Roger's diffusion model concludes that
2660-421: The adoption process. Abrahamson examined this process critically by posing questions such as: How do technically inefficient innovations diffuse and what impedes technically efficient innovations from catching on? Abrahamson makes suggestions for how organizational scientists can more comprehensively evaluate the spread of innovations. In later editions of Diffusion of Innovation , Rogers changes his terminology of
2730-401: The aggregate of its individuals and its own system with a set of procedures and norms. Three organizational characteristics match well with the individual characteristics above: tension for change (motivation and ability), innovation-system fit (compatibility), and assessment of implications (observability). Organizations can feel pressured by a tension for change. If the organization's situation
2800-426: The boundary between the early adopters and the early majority. This gap between niche appeal and mass (self-sustained) adoption was originally labeled "the marketing chasm". The categories of adopters are innovators, early adopters , early majority, late majority, and laggards. Diffusion manifests itself in different ways and is highly subject to the type of adopters and innovation-decision process. The criterion for
2870-512: The chances for adoption. Like innovations, adopters have been determined to have traits that affect their likelihood to adopt an innovation. A bevy of individual personality traits have been explored for their impacts on adoption, but with little agreement. Ability and motivation, which vary on situation unlike personality traits, have a large impact on a potential adopter's likelihood to adopt an innovation. Unsurprisingly, potential adopters who are motivated to adopt an innovation are likely to make
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2940-494: The characteristics that Rogers initially cited in his reviews. Rogers describes five characteristics that potential adopters evaluate when deciding whether to adopt an innovation: These qualities interact and are judged as a whole. For example, an innovation might be extremely complex, reducing its likelihood to be adopted and diffused, but it might be very compatible with a large advantage relative to current tools. Even with this high learning curve, potential adopters might adopt
3010-425: The diffusion of good health behaviors. Once one previously homophilous tie adopts the behavior or innovation, the other members of that group are more likely to adopt it, too. Not all individuals exert an equal amount of influence over others. In this sense opinion leaders are influential in spreading either positive or negative information about an innovation. Rogers relies on the ideas of Katz & Lazarsfeld and
3080-478: The direct influences. This led to the conclusion that advertising was best targeted, if possible, on those next in line to adopt, and not on those not yet reached by the chain of influence. Research on actor-network theory (ANT) also identifies a significant overlap between the ANT concepts and the diffusion of innovation which examine the characteristics of innovation and its context among various interested parties within
3150-402: The edges of the network and can be based on the probability or strength of social connections. In the dynamics of such models, each node is assigned a current state, indicating whether or not the individual has adopted the innovation, and model equations describe the evolution of these states over time. In threshold models, the uptake of technologies is determined by the balance of two factors:
3220-468: The fields that initially influenced the theory: anthropology , early sociology, rural sociology , education , industrial sociology and medical sociology . Rogers applied it to the healthcare setting to address issues with hygiene, cancer prevention, family planning, and drunk driving. Using his synthesis, Rogers produced a theory of the adoption of innovations among individuals and organizations. Diffusion of Innovations and Rogers' later books are among
3290-583: The first two (Introduction and Growth). Some of the Bass-Model extensions present mathematical models for the last two (Maturity and Decline). MS-Excel or other tools can be used to solve the Bass model equations, and other diffusion models equations, numerically. Mathematical programming models such as the S-D model apply the diffusion of innovations theory to real data problems. In addition to that, agent-based models follow
3360-433: The five stages to: knowledge, persuasion, decision, implementation, and confirmation. However, the descriptions of the categories have remained similar throughout the editions. Two factors determine what type a particular decision is: Based on these considerations, three types of innovation-decisions have been identified. The rate of adoption is defined as the relative speed at which participants adopt an innovation. Rate
3430-519: The gatekeepers and opinion leaders who exist within a given community, change agents may come from outside the community. Change agents bring innovations to new communities – first through the gatekeepers, then through the opinion leaders, and so on through the community. Failed diffusion does not mean that the technology was adopted by no one. Rather, failed diffusion often refers to diffusion that does not reach or approach 100% adoption due to its own weaknesses, competition from other innovations, or simply
3500-837: The identification of needed innovations that would not have otherwise occurred. The social model proposed by Ryan and Gross is expanded by Valente who uses social networks as a basis for adopter categorization instead of solely relying on the system-level analysis used by Ryan and Gross. Valente also looks at an individual's personal network, which is a different application than the organizational perspective espoused by many other scholars. Recent research by Wear shows, that particularly in regional and rural areas, significantly more innovation takes place in communities which have stronger inter-personal networks. Innovations are often adopted by organizations through two types of innovation-decisions: collective innovation decisions and authority innovation decisions. The collective decision occurs when adoption
3570-409: The innovation anyway. Studies also identify other characteristics of innovations, but these are not as common as the ones that Rogers lists above. The fuzziness of the boundaries of the innovation can impact its adoption. Specifically, innovations with a small core and large periphery are easier to adopt. Innovations that are less risky are easier to adopt as the potential loss from failed integration
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#17328760904793640-433: The innovation reaches critical mass . This is when the number of individual adopters ensures that the innovation is self-sustaining. Rogers outlines several strategies in order to help an innovation reach this stage, including when an innovation adopted by a highly respected individual within a social network and creating an instinctive desire for a specific innovation. Another strategy includes injecting an innovation into
3710-435: The like". When given the choice, individuals usually choose to interact with someone similar to themselves. Homophilous individuals engage in more effective communication because their similarities lead to greater knowledge gain as well as attitude or behavior change. As a result, homophilous people tend to promote diffusion among each other. However, diffusion requires a certain degree of heterophily to introduce new ideas into
3780-799: The local, state, or country level. An alternative term is 'policy transfer' where the focus is more on the agents of diffusion and the diffusion of policy knowledge, such as in the work of Diane Stone . Specifically, policy transfer can be defined as "knowledge about how policies administrative arrangements, institutions, and ideas in one political setting (past or present) is used in the development of policies, administrative arrangements, institutions, and ideas in another political setting". The first interests with regards to policy diffusion were focused in time variation or state lottery adoption, but more recently interest has shifted towards mechanisms (emulation, learning and coercion) or in channels of diffusion where researchers find that regulatory agency creation
3850-414: The main reasons for what The Economist has dubbed the 2011 "starburst revival" is that "companies seeking buyers for parts of their business are not getting good offers from other firms, or from private equity". For example, Foster's Group , an Australian beverage company, was prepared to sell its wine business. However, due to the lack of a decent offer, it decided to spin off the wine business, which
3920-762: The midwestern United States in the 1920s and 1930s. Agriculture technology was advancing rapidly, and researchers started to examine how independent farmers were adopting hybrid seeds, equipment, and techniques. A study of the adoption of hybrid corn seed in Iowa by Ryan and Gross (1943) solidified the prior work on diffusion into a distinct paradigm that would be cited consistently in the future. Since its start in rural sociology, Diffusion of Innovations has been applied to numerous contexts, including medical sociology , communications , marketing , development studies , health promotion , organizational studies , knowledge management , conservation biology and complexity studies , with
3990-520: The most growth. In contrast, divestment can also sever one business from another, but the assets are sold off rather than retained under a renamed corporate entity. Many times, the management team of the new company are from the same parent organization. Often, a spin-off offers the opportunity for a division to be backed by the company but not be affected by the parent company's image or history, giving potential to take existing ideas that had been languishing in an old environment and help them grow in
4060-481: The most often cited in diffusion research. His methodologies are closely followed in recent diffusion research, even as the field has expanded into, and been influenced by, other methodological disciplines such as social network analysis and communication. The key elements in diffusion research are: Studies have explored many characteristics of innovations. Meta-reviews have identified several characteristics that are common among most studies. These are in line with
4130-492: The need to buy a new kind of pesticide to use innovative seeds. Indirect costs may also be social, such as social conflict caused by innovation. Marketers are particularly interested in the diffusion process as it determines the success or failure of a new product. It is quite important for a marketer to understand the diffusion process so as to ensure proper management of the spread of a new product or service. The diffusion of innovations theory has been used to conduct research on
4200-478: The new company) may also be called a spin-off in common usage. A second definition of a spin-out is a firm formed when an employee or group of employees leaves an existing entity to form an independent start-up firm. The prior employer can be a firm, a university, or another organization. Spin-outs typically operate at arm's length from the previous organizations and have independent sources of financing, products, services, customers, and other assets. In some cases,
4270-524: The other carries influence. While people might hear of an innovation's uses, in Rogers' Los Molinos sanitation case, a network of influence and status prevented adoption. Lazarsfeld and Merton first called attention to the principles of homophily and its opposite, heterophily . Using their definition, Rogers defines homophily as "the degree to which pairs of individuals who interact are similar in certain attributes, such as beliefs, education, social status, and
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#17328760904794340-407: The popularity of a new product will grow with time to a saturation level and then decline, but it cannot predict how much time it will take and what the saturation level will be. Bass (1969) and many other researchers proposed modeling the diffusion based on parametric formulas to fill this gap and to provide a means for a quantitative forecast of adoption timing and levels. The Bass model focuses on
4410-509: The power or agency to create change, particularly in organizations, are more likely to adopt an innovation than someone with less power over his choices. Complementary to the diffusion framework, behavioral models such as Technology acceptance model (TAM) and Unified theory of acceptance and use of technology (UTAUT) are frequently used to understand individual technology adoption decisions in greater details. Organizations face more complex adoption possibilities because organizations are both
4480-507: The same day, saying that the price undervalued the business. In January 2018, they were acquired by Sanofi for $ 4.8 Billion. The acquisition was led by Chief Broker Gleb Margolin. This article about a medical , pharmaceutical or biotechnological corporation or company is a stub . You can help Misplaced Pages by expanding it . This Belgian company–related article is a stub . You can help Misplaced Pages by expanding it . Corporate spin-off A corporate spin-off , also known as
4550-450: The social aspects of diffusion and perceived intrinsic benefit to the individuals. Even though there have been more than four thousand articles across many disciplines published on Diffusion of Innovations, with a vast majority written after Rogers created a systematic theory, there have been few widely adopted changes to the theory. Although each study applies the theory in slightly different ways, critics say this lack of cohesion has left
4620-407: The spin-out may license technology from the parent or supply the parent with products or services; conversely, they may become competitors. Such spin-outs are important sources of technological diffusion in high-tech industries. Terms such as hive-up, hive down or hive across are sometime used for transferring a business to a parent company, a subsidiary company or a fellow subsidiary. One of
4690-437: The spread of a new idea: the innovation itself, adopters, communication channels , time, and a social system. This process relies heavily on social capital . The innovation must be widely adopted in order to self-sustain. Within the rate of adoption, there is a point at which an innovation reaches critical mass . In 1989, management consultants working at the consulting firm Regis McKenna, Inc. theorized that this point lies at
4760-430: The unintended consequences of new interventions in public health. In the book multiple examples of the unintended negative consequences of technological diffusion are given. The adoption of automatic tomato pickers developed by Midwest agricultural colleges led to the adoption of harder tomatoes (disliked by consumers) and the loss of thousands of jobs leading to the collapse of thousands of small farmers. In another example,
4830-766: Was done in the early 1950s at the University of Chicago attempting to assess the cost-effectiveness of broadcast advertising on the diffusion of new products and services. The findings were that opinion leadership tended to be organized into a hierarchy within a society, with each level in the hierarchy having most influence over other members in the same level, and on those in the next level below it. The lowest levels were generally larger in numbers and tended to coincide with various demographic attributes that might be targeted by mass advertising. However, it found that direct word of mouth and example were far more influential than broadcast messages, which were only effective if they reinforced
4900-507: Was seen to depend on the number of initial adopters and the network's structure and properties. Two factors emerge as important to successful spread of the innovation: the number of connections of nodes with their neighbors and the presence of a high degree of common connections in the network (quantified by the clustering coefficient ). These models are particularly good at showing the impact of opinion leaders relative to others. Computer models are often used to investigate this balance between
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