A549 cells are adenocarcinomic human alveolar basal epithelial cells , and constitute a cell line that was first developed in 1972 by D. J. Giard, et al. through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58-year-old caucasian male. The cells are used as models for the study of lung cancer and the development of drug therapies against it.
5-470: A549 may refer to: A549 (cell line) , a carcinomic human alveolar basal epithelial cell A549 road (Wales) , a road in Great Britain [REDACTED] Topics referred to by the same term This disambiguation page lists articles associated with the same title formed as a letter–number combination. If an internal link led you here, you may wish to change
10-445: A type II pulmonary epithelial cell model for drug metabolism and as a transfection host. When grown for a sufficiently long time in cell culture, A549 cells may begin to differentiate , as signaled by the presence of multilamellar bodies . A549 cells have served as models of alveolar Type II pulmonary epithelium , finding utility in research examining the metabolic processing of lung tissue and possible mechanisms of drug delivery to
15-411: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=A549&oldid=932668712 " Category : Letter–number combination disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages A549 (cell line) A549 cells, as found in
20-444: The lung tissue of their origin, are squamous and responsible for the diffusion of some substances, such as water and electrolytes, across alveoli . If A549 cells are cultured in vitro , they grow as a monolayer; adherent or attaching to the culture flask. The cells are able to synthesize lecithin and contain high levels of unsaturated fatty acids, which are important to maintain membrane phospholipids . A549 cells are widely used as
25-550: The tissue. In context of lung cancer drug development , the cells have served as testing grounds for novel drugs - such as paclitaxel , docetaxel , and bevacizumab - both in vitro and in vivo through cell culture and xenografting , respectively. Single-cell tracking of A549 has enabled the elaboration of pedigree-tree profiles and demonstrate correlations in behavior among sister cells and their descendants. Such observations of correlations can be used as proxy measurements to identify cellular stress and inheritance as
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